SPSB2-iNOS inhibitory cyclic peptide-2

Catalog No.: A65229
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-2 is a selective inhibitor of the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity with a KD of 21 nM. This cyclic peptide is both reduction-resistant and oxidatively stable, making it suitable for various biological assays. Its ability to inhibit SPSB2-iNOS interactions positions it as a valuable tool in research focused on nitric oxide signaling and related pathophysiological processes.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSPSB2-iNOS inhibitory cyclic peptide-2 is a selective inhibitor of the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity with a KD of 21 nM. This cyclic peptide is both reduction-resistant and oxidatively stable, making it suitable for various biological assays. Its ability to inhibit SPSB2-iNOS interactions positions it as a valuable tool in research focused on nitric oxide signaling and related pathophysiological processes.
Product Information
Catalog NumA65229
FormulaC36H49N11O12
Molecular Weight827.84
CAS Number1989528-33-7
Sequencecyclo{Trp-Asp-Ile-Asn-Asn-Asn-βAla}
Sequence shorteningcyclo{WDINNN-βAla}
SMILESC(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N3)[H]
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