GW274150 dihydrochloride is a selective and potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating an IC50 of 2.19 μM and a Kd of 40 nM, alongside an ED50 of 1.15 μM for rat iNOS. This compound exhibits reduced activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS). Research applications include studying inflammatory responses and evaluating protective effects in models of acute lung injury.
GW274150 dihydrochloride is a selective and potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating an IC50 of 2.19 μM and a Kd of 40 nM, alongside an ED50 of 1.15 μM for rat iNOS. This compound exhibits reduced activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS). Research applications include studying inflammatory responses and evaluating protective effects in models of acute lung injury.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
