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  • Immunology & Inflammation

Immunology & Inflammation

Items 1-50 of 3399

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  1. A15801
    Entrectinib

    TRK, ROS1, ALK inhibitor

    Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
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  2. A10457
    Hydrocortisone(Cortisol)
    Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.
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  3. A16946
    PMX-205

    C5a receptor antagonist

    PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50 = 31 nM).
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  4. A12258
    HPGDS inhibitor 1

    HPGDS inhibitor

    HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
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  5. A13343
    Zinc Protoporphyrin

    HO-1 inhibitor

    Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2.
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  6. A14433
    GKT137831

    NOX1/4 inhibitor

    GKT137831 is a first in class inhibitor targeting NOX1 and NOX4 enzymes.
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  7. A10469
    Imiquimod (Aldara)

    TLR7 agonist

    Imiquimod (Aldara) is a a heterocyclic imidazoquinoline amide that acts as an immune response modifier.
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  8. A10913
    Plerixafor 8HCl (DB06809)

    CXCR4 antagonist

    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
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  9. A12400
    MifaMurtide
    Mifamurtide is a liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities
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  10. A12043
    (-)-Epicatechin

    COX-1 inhibitor

    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1
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  11. A11768
    Radicicol

    Hsp90/SRC/COX-2 Inhibitor

    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2
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  12. A13074
    AMD3100 (Plerixafor)

    CXCR4 antagonist

    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
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  13. A15890
    Resiquimod

    TLR7/8 Agonist

    Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.
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  14. A10032
    Acetylcysteine

    Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Oral acetylcysteine is also used for the prevention of radiocontrast-induced nephropathy (a form of acute renal failure).

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  15. A21690
    (R)-Sulforaphane

    Keap1/Nrf2/ARE pathway inducer

    (R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.
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  16. A15381
    NFAT Inhibitor

    NFAT inhibitor

    NFAT Inhibitor, selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT).
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  17. A10461
    Ibuprofen (Advil)

    COX-1 inhibitor

    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.
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  18. A18591
    GB1107

    Gal-3 inhibitor

    GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.
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  19. A19399
    CADD522

    RUNX2-DNA binding inhibitor

    CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM. CADD522 exhibits antitumor activity.
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  20. A11953
    AMD 3465 Hexahydrobromide

    CXCR4 antagonist

    AMD 3465 is a potent, selective CXCR4 antagonist.
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  21. A10929
    6-Thioguanine
    6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent,
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  22. A10030
    Acetaminophen

    COX inhibitor

    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
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  23. A11989
    Apocynin (Acetovanillone)

    NADPH-oxidase inhibitor

    Apocynin is a NADPH oxidase inhibitor
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  24. A17172
    ML-385

    NRF2 inhibitor

    ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2) with IC50 value of 1.9 μM.
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  25. A15163
    MK-0591 (Quiflapon)

    FLAP inhibitor

    MK-0591 is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50 value of 1.6 nM in a FLAP binding assay.
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  26. A16333
    Dinoprost (Prostaglandin F2α)
    Prostaglandin F2α is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
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  27. A11127
    MK-0812

    CCR2 antagonist

    MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.
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  28. A12383
    Reparixin

    CXCL8/CXCR1/2 Inhibitor

    Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).
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  29. A20224
    Mito-TEMPO
    Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties.
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  30. A10371
    Etodolac (AY-24236)

    COX inhibitor

    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM).
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  31. A17160
    TLR2-IN-C29

    TLR Inhibitor

    TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling.
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  32. A18704
    Asymmetric dimethylarginine

    NOS inhibitor

    Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.
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  33. A10474
    Indomethacin (Indocid, Indocin)

    COX inhibitor

    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
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  34. A10556
    Maraviroc (UK-427857)

    CCR antagonist

    Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.
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  35. A10614
    Mycophenolic acid
    Mycophenolic Acid is an immunosuppressant small molecule isolated as a fermentation product from several Penicillium species.
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  36. A11555
    SCH-527123 (Navarixin)

    CXCR1/CXCR2 antagonist

    SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively.
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  37. A21984
    Sulforaphane

    HDAC inhibitor

    Sulforaphane activates Nrf2 and inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling. Sulforaphane has shown anti-cancer and anti-inflammatory activities.
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  38. A10782
    Rapamycin (Sirolimus)

    mTOR Inhibitors

    Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2).
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  39. A10749
    Pravadoline (WIN 48098)

    COX inhibitor

    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).
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  40. A19383
    GSK5182

    ERRγ agonist

    GSK5182 is a highly selective inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM and does not interact with other nuclear receptors, including ERRα or ERα.
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  41. A18066
    Temoporfin
    Temoporfin(KW 2345) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. Target: Others Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. Patients can remain photosensitive for several weeks after treatment.
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  42. A13171
    NOD-IN-1

    NOD-like receptors inhibitor

    NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
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  43. A11697
    Licofelone

    COX/LOX inhibitor

    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both.
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  44. A10299
    Dexamethasone

    glucocorticoid receptor agonist

    Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of the naturally occurring hormone hydrocortisone and 4-5 times of prednisone.
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  45. A16139
    Loxoprofen
    Loxoprofen is a non-steroidal anti-inflammatory drug.
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  46. A10126
    Berberine HCl

    Berberine hydrochloride was novelly found that it has various beneficial effects on the cardiovascular system and significant anti-inflammatory activities. Berberine can effectively reduce intracellular superoxide levels in LPS-stimulated macrophages. Such a restoration of cellular redox by berberine is mediated by its selective inhibition of gp91phox expression and enhancement of SOD activity.

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  47. A13478
    MCC950 sodium

    NLRP3 inhibitor

    MCC950 sodium is a potent NLRP3 inflammasome inhibitor that inhibits IL-1beta production with IC50 value of 7.5 nm.
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  48. A15205
    Paradol

    COX-1 Inhibitor

    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects
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  49. A10408
    FTY720 (Fingolimod)

    S1P Receptor antagonist

    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.
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  50. A10971
    Vicriviroc Malate

    CCR5 antagonist

    Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC50 =1~10 nM to HIV isolates (n=52).
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Items 1-50 of 3399

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  1. Inhibitor 1427items
  2. Agonist 46items
  3. Antagonist 72items
  4. Activator 15items
  5. Modulator 8items
  6. Degrader 2items
  7. Inducer 3items
  8. Substrate 2items
  9. Potentiator 1item
  10. Ligand 4items
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  1. GAK 1item
  2. JAK3 1item
  3. STAT5 1item