S-Isopropylisothiourea hydrobromide is a potent nitric oxide synthase (NOS) inhibitor that effectively penetrates the blood-brain barrier. With IC50 values of 0.66, 0.75, and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic, and porcine endothelial cell NOS, it demonstrates a significant blood pressure-raising effect while preserving vital organ perfusion. This compound is utilized in research focused on hemorrhagic shock and the modulation of pain responses, particularly in models utilizing formalin-induced late-phase pain.
S-Isopropylisothiourea hydrobromide is a potent nitric oxide synthase (NOS) inhibitor that effectively penetrates the blood-brain barrier. With IC50 values of 0.66, 0.75, and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic, and porcine endothelial cell NOS, it demonstrates a significant blood pressure-raising effect while preserving vital organ perfusion. This compound is utilized in research focused on hemorrhagic shock and the modulation of pain responses, particularly in models utilizing formalin-induced late-phase pain.
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