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Catalog No.
Product Name
Application
Product Information
Citations
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NOS inhibitor
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.- Raul Salinas, .et al. , PLoS One, 2023, Mar 2;18(3):e0282155 PMID: 36862634
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NOS inhibitor
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor. -
GPR3 agonist/NOS/ NADPH oxidases inhibitor
Diphenyleneiodonium chloride has been shown to be a potent irreversible inhibitor of NOS2 (iNOS) from macrophages and NOS3 (eNOS) from endothelial cells. -
GTP cyclohydrolase I inhibitor
2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production. -
INOS inhibitor
1400W Dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. -
nNOS inhibitor
3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). -
NO synthase inhibitor
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. -
nitric oxide synthases inhibitor
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively. -
iNOS Inhibitor
1400W is a selective inhibitor of inducible nitric-oxide synthase (iNOS) with a Kd value of ≤ 7 nM, demonstrating slow and tight binding characteristics. This compound effectively inhibits iNOS induction in microglial cells, leading to reduced nitric oxide production, which in turn helps alleviate oxidative stress and neuronal apoptosis in the rat cerebral cortex. 1400W's ability to ameliorate spatial memory dysfunction associated with acute hypobaric hypoxia-reoxygenation makes it a valuable tool for research in neuroprotection and neurodegenerative disease studies. -
iNOS Inhibitor
iNOS-IN-5 (Compound BN-4) is a potent inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 0.1707 μM, effectively reducing nitric oxide levels in LPS-induced RAW264.7 cells. This compound demonstrates protective properties against hypoxic injury by decreasing reactive oxygen species (ROS) and lactate dehydrogenase expression, exhibiting significant anti-necrosis and anti-apoptosis effects. Additionally, iNOS-IN-5 has shown neuroprotective activity and protective effects against cerebral ischemia in SD rat models, while also being capable of penetrating the blood-brain barrier. -
nNOS inhibitor
7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. -
NO Synthase Inhibitor
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM. -
NOS inhibitor
L-NMMA acetate (NG-monomethyl-L-arginine acetate) is a non-selective nitric oxide synthase (NOS) inhibitor that targets all three NOS isoforms: neuronal (nNOS/NOS1), endothelial (eNOS/NOS3), and inducible (iNOS/NOS2). It exhibits Ki values of approximately 0.18 µM for rat nNOS, 0.4 µM for human eNOS, and 6 µM for mouse iNOS, making it a valuable tool for studying nitric oxide–mediated physiological and pathological processes. -
ROS/iNOS/TNF-α/COX-2 Inhibitor
Callistephin chloride is an anthocyanin that functions as an inhibitor of reactive oxygen species (ROS) and nitric oxide synthase (iNOS), as well as tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2). This compound regulates the expression of inflammatory and apoptosis-related proteins by inhibiting p38 phosphorylation, thereby enhancing the protective effects against microglial cell damage. Callistephin chloride also significantly reduces ROS levels, mitigates glutamate excitotoxicity, and provides neuroprotection to cerebellar granule neurons. Additionally, it inhibits the proliferation and metastasis of breast cancer cells through the induction of apoptosis. -
nNOS Inhibitor
NXN-188 is a selective nNOS inhibitor that also acts as an agonist for the 5HT-1B/1D receptors. This compound exhibits potential in modulating neurogenic inflammation and is particularly relevant in research focused on migraine pathophysiology and treatment strategies. Its dual action supports investigations into the intricate mechanisms underlying headache disorders. -
iNOS Inhibitor
Myricadenin A is an inhibitor of inducible nitric oxide synthase (iNOS), demonstrating effective inhibition of nitric oxide production with an EC₅₀ value of 18.1 μM. Additionally, it exhibits moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and shows weak antibacterial activity against tuberculosis (MIC = 80.0 μg/mL). Myricadenin A is suitable for studies focused on inflammation and oxidative stress. -
iNOS/COX-2 Inhibitor
Ermanin is a flavonoid extracted from Tanacetum microphyllum, known for its potent inhibitory effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Its biological activities include anti-inflammatory, anti-tuberculous, and anti-viral/bacterial properties, making it a valuable reagent in research related to inflammation and infectious diseases. Ermanin is useful for exploring the pathways associated with nitric oxide production and prostaglandin synthesis in various biological contexts. -
iNOS/ PKC-θ Dual Inhibitor
(Rac)-Anemonin is a dual inhibitor targeting inducible nitric oxide synthase (iNOS) and protein kinase C theta (PKC-θ). It selectively inhibits iNOS while also reducing the stability of the PKC-θ protein, showcasing significant biological activity. Research indicates that (Rac)-Anemonin can alleviate symptoms in dextran sodium sulfate-induced acute ulcerative colitis in murine models, making it valuable for studying inflammation-related diseases. -
iNOS/ PKC-θ Dual Inhibitor
Anemonin is a dual inhibitor targeting inducible nitric oxide synthase (iNOS) and protein kinase C theta (PKC-θ). This compound significantly reduces the translation and enhances the protein stability of PKC-θ, demonstrating potent anti-inflammatory effects. Anemonin has been shown to alleviate symptoms of dextran sodium sulfate-induced acute ulcerative colitis in murine models, making it a valuable tool for researching inflammation-related diseases. -
iNOS Inhibitor
S-Methylisothiourea sulfate serves as a potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). This compound has demonstrated significant biological activity in reducing nitric oxide production and exhibits protective effects in rodent models of septic shock. Its role in modulating iNOS activity makes it a valuable reagent for research focused on inflammation and immune response mechanisms. -
iNOS/COX-2 Inhibitor
Rehmapicrogenin is a selective inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This compound, derived from the root of Rehmannia glutinosa, demonstrates significant anti-inflammatory properties, making it a valuable tool for research focused on inflammation pathways. Its ability to inhibit pro-inflammatory mediators such as IL-6 further underscores its relevance in studies aimed at understanding and treating inflammatory diseases. -
NO Production Inhibitor
N-Phthaloyl-L-glutamic acid is a nitric oxide production inhibitor that effectively reduces lipopolysaccharide (LPS)-induced nitric oxide synthesis in murine spleen cells. This compound serves as a potential anti-inflammatory agent, demonstrating low cytotoxicity in vitro against tumor cells and in BALB/c mice spleen cell cultures. N-Phthaloyl-L-glutamic acid is suitable for research investigating mechanisms of inflammation and associated therapeutic approaches. -
NO Inhibitor
Carboxy-PTIO potassium is a potent nitric oxide (NO) inhibitor that facilitates the rapid reaction with NO to yield nitrogen dioxide (NO2). This compound exhibits significant biological activity by preventing hypotension and alleviating endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. It serves as a valuable reagent for researchers investigating the role of nitric oxide in various physiological and pathophysiological processes. -
NO Synthase Inhibitor
L-Canavanine sulfate is a selective inhibitor of inducible nitric oxide synthase (iNOS). It demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying inflammatory pathways and the role of iNOS in various disease models. This compound is utilized in research applications focused on neurodegeneration, cancer, and cardiovascular disease, providing insights into the mechanisms of nitric oxide-mediated signaling. -
iNOS Inhibitor
Asperuloside is an iridoid compound derived from Hedyotis diffusa, primarily known for its role as an inducible nitric oxide synthase (iNOS) inhibitor. This compound exhibits notable anti-inflammatory properties by suppressing the NF-κB and MAPK signaling pathways. Asperuloside is valuable in studying inflammatory processes and developing therapeutic strategies for related diseases. -
CaV1.2 Channel Inhibitor
Demethylsuberosin, a coumarin derivative isolated from Angelica gigas Nakai, primarily targets the L-type CaV1.2 channel as an inhibitor. This compound demonstrates significant antihypertensive effects, in addition to possessing antioxidant and anti-inflammatory properties. Notably, Demethylsuberosin offers neuroprotective effects against glutamate-induced cytotoxicity in primary cultured rat cortical cells, making it a valuable reagent for research in cardiovascular and neurological studies. -
iNOS Inhibitor
GW274150 phosphate is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent inhibition with an IC50 of 2.19 μM and a Kd of 40 nM in human iNOS, as well as an ED50 of 1.15 μM in rat iNOS. This compound exhibits reduced potency against endothelial and neuronal NOS isoforms. GW274150 phosphate has been shown to provide protective effects in models of acute lung injury and inflammation, making it a valuable tool for researchers studying inflammatory responses and related pathways. -
NO Synthase Inhibitor
Kuwanon A is a flavone derivative that serves as an inhibitor of nitric oxide synthase. It effectively reduces nitric oxide production with an IC50 of 10.5 μM. This compound is relevant for research applications investigating vascular function, inflammatory processes, and the pathophysiology of various diseases linked to nitric oxide signaling. -
NOS Inhibitor
S-MTC dihydrochloride is a selective inhibitor of type I nitric oxide synthase (NOS). It effectively reduces nitric oxide production, making it a valuable tool for studies investigating the role of NOS in various physiological and pathological processes. This compound is commonly utilized in research applications related to cardiovascular health, neurobiology, and inflammation. -
nNOS Inhibitor
Nω-Propyl-L-arginine is a highly selective and potent competitive inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a Ki value of 57 nM. With a 149-fold selectivity for nNOS over endothelial nitric oxide synthase (eNOS), this compound is invaluable for studying nNOS-related pathways and neurobiology. Its use is pertinent in elucidating the role of nNOS in various physiological and pathological processes, making it a crucial reagent for research applications in neuroscience and pharmacology. -
nitric oxide synthase Inhibitor
Aminopicoline is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes, including iNOS, nNOS, and eNOS. By competing with arginine at the substrate-binding site, it effectively reduces cellular nitric oxide production and inhibits the elevation of plasma nitrate levels, which can influence mean arterial pressure. This compound serves as a valuable tool in research focused on diseases related to septic shock, joint and intestinal inflammation, as well as central nervous system (CNS) inflammation. -
NOS3 Inhibitors
Kihadanin A is a limonoid that functions as an inhibitor of nitric oxide synthase 3 (NOS3). Isolated from the methanol extract of Dictamnus dasycarpus root bark, Kihadanin A demonstrates potential therapeutic applications in the study of hyperuricemia (HUA). This compound can be utilized in research aimed at understanding the biochemical pathways related to nitric oxide production and its implications in various physiological conditions. -
NOS Inhibitor
nNOS-IN-1 is a selective inhibitor of nitric oxide synthases (NOS), demonstrating potent inhibitory activity against neuronal, inducible, and endothelial NOS with IC50 values of 2.5, 5.7, and 13 μM, respectively. This compound serves as a valuable tool for elucidating the roles of nitric oxide in various biological processes and has potential applications in neurobiology and cardiovascular research. By selectively targeting NOS, nNOS-IN-1 can aid in the investigation of pathological conditions associated with dysregulated nitric oxide signaling. -
nNOS Inhibitor
Nω-Propyl-L-arginine hydrochloride is a selective inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a competitive inhibition profile with a Ki value of 57 nM. This compound offers significant selectivity, displaying a 149-fold preference for nNOS over endothelial nitric oxide synthase (eNOS). Nω-Propyl-L-arginine hydrochloride is primarily utilized in research applications focused on the modulation of nitric oxide pathways and the study of nNOS-related physiological and pathological processes. -
NO Synthase Inhibitor
2-Iminobiotin hydrobromide is a reversible inhibitor of nitric oxide synthase (NOS), specifically exhibiting Kis of 21.8 μM for murine inducible NOS (iNOS) and 37.5 μM for rat neuronal NOS (n-cNOS). This compound has demonstrated potential neuroprotective effects, providing protection to human neuronal cells against hypoxia-induced cell damage. It is valuable for research in neurobiology and the study of nitric oxide signaling pathways. -
iNOS Inhibitor
AR-C102222 hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS) with a competitive mechanism of action. Demonstrating an IC50 of 37 nM, it exhibits notable antinociceptive and anti-inflammatory properties. This compound is valuable for research into pain modulation and inflammatory diseases, providing insights into the role of nitric oxide in these biological processes. -
iNOS Inhibitor
BBS-4 is a highly potent and selective inhibitor of inducible nitric oxide synthase (iNOS, NOS2) dimerization, demonstrating an IC50 of 0.49 nM. This compound is primarily utilized in research focused on cardiovascular dysfunction, notably offering protective effects in murine models of sepsis. Its selective inhibition of iNOS makes BBS-4 a valuable tool for investigating nitric oxide-related pathologies and potential therapeutic interventions. -
nNOS Inhibitor
NOS1-IN-1 is a selective and cell-permeable inhibitor of neuronal nitric oxide synthase (nNOS), displaying a Ki of 120 nM. This compound demonstrates significant selectivity, with a 2617-fold preference over endothelial nitric oxide synthase (eNOS) and a 325-fold selectivity over inducible nitric oxide synthase (iNOS), evidenced by Ki values of 39 μM and 325 μM, respectively. NOS1-IN-1 is valuable for research on neurological disorders, including cerebral palsy, by enabling the exploration of nNOS-related pathways in disease mechanisms. -
NO Synthase Inhibitor
NOS-IN-1 is a potent and orally bioavailable inhibitor of nitric oxide synthase (NOS) isoforms, demonstrating inhibitory constants (IC50) of 0.1 μM for human inducible NOS (hiNOS), 1.1 μM for endothelial NOS (heNOS), and 0.2 μM for neuronal NOS (hnNOS). This compound is valuable for studying nitric oxide signaling pathways and exploring therapeutic options in diseases associated with dysregulated nitric oxide levels, such as cardiovascular disorders and neurodegenerative diseases. Its selective inhibition of NOS isoforms can aid in elucidating the specific roles of nitric oxide in various biological processes. -
NOS Inhibitor
TRIM is a potent nitric oxide synthase (NOS) inhibitor, selectively targeting neuronal nitric oxide synthase (nNOS) in mouse cerebellar samples and inducible nitric oxide synthase (iNOS) in rat lung tissues, with IC50 values of 28.2 µM and 27.0 µM, respectively. This compound exhibits significant antidepressant and anxiolytic-like properties, making it valuable for research into depression and anxiety disorders. TRIM serves as an important tool for investigations into NOS-related pathways and their implications in neuropsychiatric conditions. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-1 is a potent inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (KD) of 4.4 nM. This cyclic peptide demonstrates resistance to proteolytic degradation by pepsin, trypsin, and α-chymotrypsin, ensuring stability in biological environments. Additionally, it maintains stability in human plasma and oxidative conditions, making it a valuable tool for studying iNOS-related pathways in inflammation and other biological processes. -
iNOS/Nf-Κb Inhibitor
Hymenoxin is a dual inhibitor of inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-κB), exhibiting IC50 values of 42.7 μM and 85.5 μM, respectively. This compound demonstrates the capacity to reduce oxidative stress by 16% at a concentration of 125 μg/mL. Hymenoxin is primarily utilized in research focused on inflammatory responses and related signaling pathways. Its inhibitory effects on key regulators make it valuable for studies investigating the roles of iNOS and NF-κB in various disease models. -
NOS Inhibitor
Vinyl-L-NIO hydrochloride is a selective inhibitor of nitric oxide synthase (NOS), effectively reducing nitric oxide production. By targeting the NOS enzyme, this compound serves as a valuable tool for investigating the role of nitric oxide in various biological processes. Its application extends to studies related to cardiovascular function, neurobiology, and inflammation research. -
NOS1Inhibitor
ARL 17477 is a dual inhibitor targeting neuronal nitric oxide synthase (NOS1) and the autophagy-lysosomal system. This compound exhibits significant anticancer activity and effectively inhibits tumor growth, particularly in KRAS-mutated cancers. Its potential applications include studies on cancer progression and therapeutic resistance, making it a valuable tool in cancer research. -
NO Synthase Inhibitor
Asymmetric dimethylarginine dihydrochloride is a potent inhibitor of nitric oxide synthase (NOS). By decreasing nitric oxide (NO) production, it plays a significant role in the study of endothelial dysfunction and related cardiovascular diseases. This compound is instrumental in research focused on elucidating the pathways involved in vascular health and hypertension.
