Shop By
Catalog No.
Product Name
Application
Product Information
Citations
-
NOS Inhibitor
1,4-PBIT dihydrobromide is a potent inhibitor of nitric oxide synthases (NOS), demonstrating Ki values of 7.6 nM for inducible NOS (iNOS), 360 nM for endothelial NOS (eNOS), and 16 nM for neuronal NOS (nNOS). This compound serves as a valuable tool for investigating nitric oxide signaling pathways and assessing the role of NOS in various biological contexts. It is applicable in studies related to inflammation, neurobiology, and cardiovascular research. -
iNOS Inhibitor
AE-ITU dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS). This compound has been shown to attenuate liver dysfunction induced by endotoxaemia in rat models, demonstrating its potential in studies related to inflammatory responses and liver pathology. AE-ITU dihydrobromide is valuable for researchers investigating the role of nitric oxide in various biological processes and therapeutic interventions. -
NO Synthase Inhibitor
Curvularin is a potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a half-maximal inhibitory concentration (IC50) of 9.5 µM. Isolated from the fungus Curvularia lunata, this mycotoxin is utilized in research to explore its effects on nitric oxide production in inflammatory responses. Curvularin's unique properties make it a valuable tool for investigating various biological processes and therapeutic applications related to iNOS inhibition. -
iNOS Inhibitor
L-NIL hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrated to have an IC50 of 3.3 μM in murine models. By inhibiting iNOS, L-NIL hydrochloride effectively reduces the production of nitric oxide, a key mediator in various inflammatory processes. This compound is utilized in research focused on inflammation, neurodegeneration, and associated pathologies where modulation of nitric oxide levels is critical. -
iNOS Inhibitor
AMT hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS), with a Ki value of 4.2 nM. This compound effectively modulates nitric oxide production, making it a valuable tool for studying inflammatory responses and related signaling pathways. It is applicable in research examining the role of iNOS in various physiological and pathological conditions. -
NOS Inhibitor
D-NAME hydrochloride is a potent nitric oxide synthase (NOS) inhibitor. By inhibiting NOS activity, D-NAME hydrochloride effectively reduces nitric oxide production, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. This reagent can be applied in research related to cardiovascular disease, neurodegeneration, and inflammatory responses. -
Nonenzyme Glycation Inhibitor
Flazin is a non-enzymatic protein glycation inhibitor that targets glycation processes and peroxynitrite (ONOO-). It exhibits an IC50 value of 85.31 μM in inhibiting bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin is valuable in research related to diabetes and neurodegenerative disorders and functions as a lipid droplet regulator, making it relevant for studies on lipid metabolism disorders. Additionally, it serves as an inhibitor of xanthine oxidase (XOD), further expanding its utility in various biochemical applications. -
NO Inhibitor
Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger, facilitating the rapid reaction with NO to generate nitrogen dioxide (NO2). This compound demonstrates significant biological activity in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. Carboxy-PTIO serves as a valuable tool in research focused on the roles of nitric oxide in various physiological and pathological processes. -
NO Synthase Inhibitor
Syzalterin is a potent inhibitor of nitric oxide synthase, demonstrating an IC50 value of 1.87 μg/mL. This compound effectively reduces NO production, making it valuable for research focused on nitric oxide-related signaling pathways and their implications in various physiological and pathological processes. Syzalterin can be utilized in studies exploring cardiovascular function, neurobiology, and inflammatory responses. -
NO Synthase Inhibitor
Cauloside C is a triterpene glycoside that acts as an inhibitor of nitric oxide synthase (NOS). It demonstrates significant anti-inflammatory properties by reducing the expression of inducible nitric oxide synthase (iNOS) and downregulating proinflammatory cytokines. This compound is a valuable tool for research focused on inflammation and related signaling pathways. -
NO Inhibitor
Futoquinol is a neolignan that acts as a nitric oxide (NO) inhibitor, derived from the dried aerial parts of Piper kadsura. This compound demonstrates potent inhibition of NO production in microglial cells, highlighting its potential in modulating neuroinflammatory processes. Futoquinol is valuable for research applications focused on neuroinflammation and related neurological disorders. -
NO Inhibitor
Panaxcerol B is a monogalactosyl monoacylglyceride characterized as a nitric oxide (NO) inhibitor. It exhibits an IC50 of 59.4 μM in inhibiting NO production in lipopolysaccharide-stimulated RAW264.7 macrophage cells. This compound is valuable for research applications focused on inflammatory responses and related signaling pathways. -
NO Synthase Inhibitor
3-Amino-1,2,4-triazine acts as an inhibitor of nitric oxide (NO) synthase, thereby impacting NO production and modulating associated cellular signaling pathways. This compound is relevant for studying the role of NO in various biological processes and may aid in research applications focused on vascular function, neurobiology, and inflammation. Its inhibitory effects on nitrite secretion further enhance its utility in investigating nitric oxide-related mechanisms in biological systems. -
NO Inhibitor
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid is a lanostane triterpenoid that serves as a nitric oxide (NO) inhibitor, demonstrating potent inhibitory effects on LPS-induced BV-2 microglia cells with an IC50 of 9.55 µM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research applications focused on neuroinflammation and related pathways. -
iNOS Inhibitor
BYK 191023 dihydrochloride is a selective inhibitor of inducible nitric-oxide synthase (iNOS), targeting the enzyme's catalytic center. This compound plays a critical role in research focused on the regulation of nitric oxide production and its implications in inflammatory responses. Its application is vital for studying both in vitro and in vivo effects mediated by iNOS, making it an essential tool for investigations into related pathological conditions. -
hDDAH-1 Inhibitor
hDDAH-1-IN-1 is a potent and selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), functioning through non-amino acid catalytic site inhibition, with an inhibition constant (Ki) of 18 μM. By inhibiting DDAH, this compound regulates the metabolism of asymmetric dimethylarginine (ADMA), influencing nitric oxide production. This makes hDDAH-1-IN-1 valuable in research applications related to cardiovascular diseases, neurodegenerative disorders, and conditions where nitric oxide dysregulation plays a critical role. -
hDDAH-1 Inhibitor
hDDAH-1-IN-2 sulfate is a selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1). This compound has demonstrated low toxicity and high cell viability, making it suitable for advanced research applications. It is valuable for investigating the role of hDDAH-1 in cardiovascular diseases and other physiological processes influenced by nitric oxide metabolism. -
iNOS Inhibitor
L-NIL dihydrochloride is an inducible nitric oxide synthase (iNOS) inhibitor, exhibiting an IC50 value of 3.3 μM for miNOS. This compound demonstrates significant biological activity by curtailing nitric oxide production, which plays a critical role in inflammatory processes. L-NIL dihydrochloride is widely utilized in research to investigate the implications of nitric oxide in various pathophysiological conditions, making it an essential tool for studies related to inflammation and immune response. -
hDDAH-1 Inhibitor
hDDAH-1-IN-1 TFA is a selective non-amino acid inhibitor targeting human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), exhibiting a Ki of 18 μM. This compound demonstrates potent inhibition of the enzyme's catalytic activity, making it a valuable tool for studying the regulation of nitric oxide synthase and the metabolism of asymmetric dimethylarginines. Research applications include investigations into cardiovascular diseases, endothelial function, and polyamine metabolism. -
iNOS Inhibitor
iNOS inhibitor-10 is a selective inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 65 nM. It exhibits antiproliferative effects against triple-negative breast cancer cells, making it a valuable tool for research on cancer biology and therapeutic approaches targeting the iNOS pathway. Its application in studying the role of nitric oxide in tumor progression highlights its potential relevance in cancer research. -
NO Synthase Inhibitor
Harzianol L is an inhibitor of nitric oxide (NO) synthase, derived from the Trichoderma species SCSIOW21. This compound has demonstrated the ability to inhibit NO production, contributing to its anti-inflammatory effects. Harzianol L is useful in research applications focused on studying inflammatory processes and the regulation of nitric oxide in various biological contexts. -
DDAH Inhibitor
Methyl-L-NIO hydrochloride is a selective inhibitor of dimethylarginine dimethylaminohydrolase (DDAH), exhibiting an IC50 value of 70 μM. This compound also demonstrates inhibitory effects on nitric oxide synthase (NOS) isoforms, with inhibition rates at 100 μM of 77% for neuronal NOS (nNOS), 20% for endothelial NOS (eNOS), and 72% for inducible NOS (iNOS). At a concentration of 1 mM, Methyl-L-NIO achieves 100% inhibition of both nNOS and iNOS, and 85% inhibition of eNOS. This reagent is valuable for research applications involving the modulation of nitric oxide signaling pathways and the study of DDAH activity. -
NO Synthase Inhibitor
Harzianol K is a harziane-type diterpene derivative that acts as an inhibitor of nitric oxide synthase (NO Synthase). This compound demonstrates significant inhibitory effects on nitric oxide production, making it a valuable tool for research in the anti-inflammatory field. Its unique origin from deep-sea sediment fungus Trichoderma sp. SCSIOW21 adds to its potential for exploring various biological pathways associated with inflammation. -
NO Synthase Inhibitor
Camstatin is a potent inhibitor of neuronal nitric oxide (NO) synthase, functioning through its interaction with calmodulin. This 25-residue fragment derived from the IQ motif of PEP-19 demonstrates significant activity in modulating NO production. Camstatin is valuable for research applications focusing on nitric oxide signaling pathways and their role in various neurological conditions. -
iNOS Inhibitor
GW274150 dihydrochloride is a selective and potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating an IC50 of 2.19 μM and a Kd of 40 nM, alongside an ED50 of 1.15 μM for rat iNOS. This compound exhibits reduced activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS). Research applications include studying inflammatory responses and evaluating protective effects in models of acute lung injury. -
NOS Inhibitor
Iromycin A is a potent inhibitor of nitric oxide synthases (NOS), derived from Streptomyces sp. It effectively modulates nitric oxide production, making it valuable for research on vascular biology and inflammatory processes. This compound serves as a critical tool in studying the physiological and pathological roles of nitric oxide in various biological systems. -
NO Synthase Inhibitor
Trichaspside F is a sesquiterpene aminoglycoside that serves as a selective inhibitor of nitric oxide synthase. This compound effectively reduces nitric oxide production, exhibiting an IC50 value of 54.8 µM in RAW 264.7 macrophage cells. Its potential applications include studies related to anti-inflammatory mechanisms and the modulation of nitric oxide-related pathways in various biological contexts. -
NO Inhibitor
Staphylionoside D is a nitric oxide (NO) inhibitor derived from Annona squamosa L. It demonstrates significant anti-inflammatory activity by effectively reducing NO production. This compound is of interest for research applications focused on inflammation-related pathways and the modulation of nitric oxide signaling in various biological contexts. -
NO Synthase Inhibitor
Harzianol J is a harziane-type diterpene identified as a nitric oxide synthase inhibitor. Exhibiting significant anti-inflammatory properties, it achieves an 81.8% inhibition of nitric oxide production at a concentration of 100 µM, with an IC50 value of 66.7 µM. This compound is suitable for research applications focused on investigating anti-inflammatory mechanisms and potential therapeutic interventions. -
iNOS Inhibitor
ATV399 is an allosteric inhibitor of inducible nitric oxide synthase (iNOS) that effectively reduces nitric oxide (NO) production by preventing iNOS dimerization. This compound offers protective effects on rat pancreatic islet β-cells by mitigating cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 is suitable for research applications focused on type 1 diabetes and related metabolic disorders. -
nNOS Inhibitor
hnNOS-IN-3 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki value of 0.32 μM, demonstrating competitive binding with L-arginine. This compound exhibits remarkable selectivity, with 115-fold increased affinity for nNOS over inducible nitric oxide synthase (iNOS, Ki=37 μM) and 29-fold greater affinity over endothelial nitric oxide synthase (eNOS, Ki=9.4 μM). hnNOS-IN-3 serves as a valuable tool for studying nNOS-related biological processes and potential therapeutic interventions in neurological disorders. -
NO Synthase Inhibitor
Cycloneroside A is a sesquiterpene aminoglycoside that functions as an inhibitor of nitric oxide synthase. It exhibits significant activity in reducing nitric oxide production, with an IC50 value of approximately 100 µM observed in RAW 264.7 macrophage cells. This compound is valuable for investigating anti-inflammatory mechanisms and the modulation of nitric oxide in various biological contexts. -
NO Synthase Inhibitor
Oxyphyllenone A is a selective inhibitor of nitric oxide synthase (NOS), effectively reducing nitric oxide production in lipopolysaccharide-activated macrophages. With an IC50 value of 28 μM, it serves as a valuable tool in investigating the roles of nitric oxide in inflammatory responses and related biological processes. Oxyphyllenone A is useful for research applications focused on immunology and cellular signaling pathways. -
NOS Inhibitor
7-Nitroindazole sodium is a selective inhibitor of nitric oxide synthase (NOS) that effectively penetrates the blood-brain barrier. It demonstrates significant inhibitory activity towards central NOS, with an IC50 of 0.47 μM measured in murine cerebellar tissue. This compound exhibits neuroprotective and anti-injurious properties, making it a valuable tool for research into neurodegenerative diseases and neuropharmacology. -
NO Synthase Inhibitor
Inflexuside A is a potent inhibitor of nitric oxide synthase. Isolated from the aerial parts of Isodon inflexus, this abietane diterpenoid effectively suppresses lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophage cells. Its significant biological activity makes Inflexuside A a valuable reagent for research into inflammatory responses and nitric oxide signaling pathways. -
iNOS Inhibitor
MEG hemisulfate is a selective and potent inducible nitric oxide synthase (iNOS) inhibitor, exhibiting EC50 values of 11.5 μM for iNOS, alongside higher values for endothelial and brain nitric oxide synthases. In addition to its role as an iNOS inhibitor, MEG hemisulfate functions as a robust scavenger of peroxynitrite, mitigating peroxynitrite-induced oxidative damage. This compound demonstrates protective effects in various inflammation-related models, including ischemia/reperfusion injury, periodontitis, and inflammatory bowel disease, making it a valuable tool for research in inflammatory processes and oxidative stress responses. -
NO Synthase Inhibitor
Cycloneroside B is a novel sesquiterpene aminoglycoside that functions as an inhibitor of nitric oxide synthase, effectively reducing nitric oxide production with an IC50 value of 50.7 µM. This compound is significant for research in the anti-inflammatory domain, providing valuable insight into pathways and mechanisms associated with inflammation. Its unique structure and activity make it a relevant tool for investigators exploring nitric oxide's role in various biological processes. -
NO Production Inhibitor
Idesin is a nitric oxide production inhibitor derived from the fruits of Idesia polycarpa. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide synthesis while exhibiting minimal cytotoxic effects. This compound is valuable in research applications focused on inflammation, immune response modulation, and studies exploring the roles of nitric oxide in various biological processes. -
NO Synthase Inhibitor
KLYP961 is a selective, orally active dual inhibitor of inducible and neuronal nitric oxide synthase (IC50 = 50-400 nM). This compound effectively reduces endotoxin-induced increases in plasma nitrates and alleviates pain behaviors in a mouse formalin model. KLYP961 is also shown to mitigate carrageenan-induced edema and inflammatory hyperalgesia, as well as the writhing response provoked by phenylbenzoquinone. It is suitable for research focused on neurological diseases and related inflammatory conditions. -
iNOS Inhibitor
iNOs-IN-3 is a selective inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 3.342 µM. This compound exhibits significant anti-inflammatory effects and is applicable in research related to LPS-induced acute lung injury (ALI). Its ability to modulate nitric oxide production makes it a valuable tool for exploring inflammatory pathways and potential therapeutic interventions. -
NO Production Inhibitor
iNOS-IN-2 is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing nitric oxide (NO) production with an IC50 of 6.4 μM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into chronic inflammatory conditions. Its ability to modulate NO levels positions iNOS-IN-2 as an important reagent for studying the roles of iNOS in various biological processes and potential therapeutic interventions. -
NOS Inhibitor
L-ENIPO hydrochloride is a selective inhibitor of nitric oxide synthases (NOS), specifically targeting inducible NOS (iNOS), neuronal NOS (nNOS), and endothelial NOS (eNOS) with Ki values of 17, 10.3, and 58.2 μM, respectively. It demonstrates reversible, tight-binding inhibition with a preference for iNOS, particularly at extended incubation periods. This compound is valuable in research applications focused on inflammation, neurodegenerative diseases, and vascular biology, providing insight into the role of nitric oxide in various physiological and pathological processes. -
iNOS Inhibitor
Cindunistat (hydrochloride) maleate is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS). This compound demonstrates significant anti-inflammatory activity, making it valuable for research into inflammatory diseases and associated pathways. Its oral bioavailability facilitates its use in in vivo studies, enabling deeper exploration of iNOS's role in various biological contexts. -
NO Synthase Inhibitor
Cycloneroside E is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. It demonstrates significant inhibitory activity on nitric oxide production, with an IC50 value of 48.0 µM in RAW 264.7 macrophage cells. This compound is valuable for research in the field of anti-inflammatory therapeutics, providing insights into the modulation of nitric oxide levels in inflammatory responses. -
NO Synthase Inhibitor
(-)-10,11-Dihydroxyfarnesol is a potent nitric oxide synthase inhibitor derived from the endolichenic fungus Cryptomarasmius aucubae. This compound demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying NO-related biological pathways and mechanisms. Its applications include research into vascular biology, neurobiology, and inflammation where modulation of nitric oxide signaling is critical. -
iNOS Inhibitor
Juncutol is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing iNOS protein expression stimulated by lipopolysaccharide (LPS). This compound plays a significant role in studies targeting inflammatory pathways, making it valuable for research in conditions characterized by excessive nitric oxide production, such as sepsis and neurodegenerative diseases. Its ability to modulate iNOS activity positions Juncutol as a crucial tool in understanding the regulation of nitric oxide in various biological contexts. -
NO Synthase Inhibitor
Isophysalin A is a potent inhibitor of inducible nitric oxide synthase (iNOS), targeting multiple cysteine residues on IKKβ and effectively diminishing nitric oxide (NO) production. Its mechanism involves binding to glutathione (GSH), which contributes to its anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
NO Inhibitor
8A8 is a potent inhibitor of nitric oxide (NO) with an IC50 value of 4.7 μM. This compound effectively suppresses lipopolysaccharide (LPS)-induced proliferation of HaCat cells, demonstrating significant anti-inflammatory effects. 8A8 is useful for research applications focused on understanding NO's role in inflammatory processes and related cellular responses. -
NO Synthase Inhibitor
Harzianol M is a potent nitric oxide synthase inhibitor derived from Trichoderma sp. SCSIOW21. This compound effectively reduces nitric oxide production, demonstrating significant anti-inflammatory properties. Harzianol M is useful in research applications focused on inflammation-related pathways and nitric oxide modulation. -
NOS Inhibitor
S-Isopropylisothiourea hydrobromide is a potent nitric oxide synthase (NOS) inhibitor that effectively penetrates the blood-brain barrier. With IC50 values of 0.66, 0.75, and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic, and porcine endothelial cell NOS, it demonstrates a significant blood pressure-raising effect while preserving vital organ perfusion. This compound is utilized in research focused on hemorrhagic shock and the modulation of pain responses, particularly in models utilizing formalin-induced late-phase pain.
