Adefovir-d4 is a deuterium-labeled form of Adefovir, an adenosine monophosphate analog that serves as an antiviral agent. Upon intracellular conversion to Adefovir diphosphate, it effectively inhibits HBV DNA polymerase, exhibiting an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir demonstrates significant antiviral activity against a range of viruses, including hepatitis B virus (HBV) and various herpesviruses. Its isotopic label makes Adefovir-d4 ideal for tracer studies in viral research and pharmacokinetic evaluations.
Adefovir-d4 is a deuterium-labeled form of Adefovir, an adenosine monophosphate analog that serves as an antiviral agent. Upon intracellular conversion to Adefovir diphosphate, it effectively inhibits HBV DNA polymerase, exhibiting an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir demonstrates significant antiviral activity against a range of viruses, including hepatitis B virus (HBV) and various herpesviruses. Its isotopic label makes Adefovir-d4 ideal for tracer studies in viral research and pharmacokinetic evaluations.
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