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Nicotinamide-d3

Stable Isotope

Nicotinamide-d3 is a deuterium-labeled form of Nicotinamide, a vital derivative of vitamin B3. It functions primarily by inhibiting SIRT1 and SIRT2 activity, with an IC50 of 2 μM for SIRT2. Biological studies show that Nicotinamide-d3 enhances cellular levels of NAD+, ATP, and reactive oxygen species (ROS), exhibiting potential anti-tumor effects and improved survival outcomes in various contexts. Additionally, this compound is recognized for its anti-hepatitis B virus (HBV) activity, making it valuable for research in metabolism and cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2162970-00-3
Applications	Stable Isotope
Formula	C₆H₃D₃N₂O
Molecular Weight	125.14
Synonyms	Niacinamide-d3; Nicotinic acid amide-d3
SMILES	O=C(N)C1=C(C([2H])=C(N=C1)[2H])[2H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.