Catalog No.
Product Name
Application
Product Information
Citations
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Antibacterial Agent
Antibacterial Agent 69 is a novel antimicrobial compound that targets and inhibits the growth of multidrug-resistant bacteria. With a reported minimum inhibitory concentration (MIC) of 2.978 μM, it demonstrates significant antibacterial activity. This agent is primarily employed in research focused on combating antibiotic resistance and developing new therapeutic strategies against challenging bacterial infections. -
Antibiotic
Methicillin is a narrow-spectrum β-lactam antibiotic that targets and inhibits penicillin-binding proteins (PBPs). Its efficacy is primarily observed against Staphylococcus aureus and Staphylococcus epidermidis strains that exhibit resistance to other penicillins. Methicillin is utilized in research investigating various conditions, including skin infections, osteomyelitis, and endocarditis. -
Antibiotic
Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis. Effective against Staphylococcus aureus and Staphylococcus epidermidis, particularly strains resistant to other penicillins, it is utilized in researching conditions such as skin infections, osteomyelitis, and endocarditis. -
Stable Isotope
Loratadine-d4 is a deuterated form of Loratadine, a selective inverse agonist of peripheral histamine H1 receptors. With an IC50 greater than 32 μM, Loratadine demonstrates significant anti-dengue virus (DENV) activity and can inhibit the immunologic release of inflammatory mediators. This stable isotope is valuable in pharmacokinetic studies and for the development of analytical methods in chemical research. -
Anti-inflammatory/Antioxidant/Antibacterial Agent
Eukovoside is a cinnamic acid derivative that primarily exerts anti-inflammatory, antioxidant, and antibacterial effects. This compound shows potential in the study of hyperglycemic diseases and is useful for investigating various inflammatory conditions, including eye inflammation and respiratory tract disorders. Additionally, Eukovoside may contribute to research focused on allergic responses such as hay fever and conjunctivitis, as well as infections like colds, influenza, and sinusitis. -
Stable Isotope
Loratadine-d4-1 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral H1-histamine receptors. With an IC50 value exceeding 32 μM, Loratadine exhibits significant biological activity, including anti-dengue virus (DENV) effects and the inhibition of immunologic release of inflammatory mediators. This stable isotope reagent is valuable for mechanistic studies, pharmacokinetic evaluations, and research applications in allergy and inflammatory response investigations. -
BTK/MNK Dual Inhibitor
QL-X-138 is a selective dual inhibitor of Bruton's tyrosine kinase (BTK) and MAPK-interacting kinase (MNK), demonstrating potent covalent binding to BTK and non-covalent binding to MNK. It exhibits IC50 values of 9.4 nM for BTK, and 107.4 nM and 26 nM for MNK1 and MNK2, respectively. Additionally, QL-X-138 displays antiviral activity against dengue virus serotype 2, with an IC50 of 3.5 μM. This compound is valuable for research involving B-cell malignancies and related therapeutic investigations. -
Purine Nucleoside Analog
2-Thiouridine is a purine nucleoside analog that enhances the stability of U:A base pairs while destabilizing U:G wobble base pairs. This modification significantly boosts the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. Additionally, 2-Thiouridine exhibits notable antiviral activity against a range of positive-sense single-stranded RNA viruses, including Dengue Virus (DENV2), Zika Virus (ZIKV), Yellow Fever Virus (YFV), Japanese Encephalitis Virus (JEV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), and various human coronaviruses, such as SARS-CoV and MERS-CoV. -
Antibiotic
Rifalazil, a rifamycin derivative, targets bacterial DNA-dependent RNA polymerase, specifically inhibiting the β-subunit to disrupt RNA synthesis and induce bacterial cell death. This antibiotic demonstrates exceptional potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, Chlamydia pneumoniae, and Chlamydia trachomatis, with MIC values ranging from 0.00025 to 0.0025 μg/ml. Rifalazil shows promising potential for applications in treating Chlamydia infections, Clostridium difficile-associated diarrhea (CDAD), and tuberculosis (TB). -
Antibiotic
Phleomycin is a copper-dependent antibiotic known for its DNA-damaging properties. It exerts its biological activity by binding to DNA and generating reactive oxygen species (ROS) in the presence of reducing agents, leading to both single-strand and double-strand breaks. This compound is extensively utilized in cancer research, microbial genetic transformation, serving as a screening marker to enhance fungal transformation efficiency, and the study of DNA repair mechanisms. -
Quinolone Antibiotic
Danofloxacin is a quinolone antibiotic that primarily targets bacterial DNA gyrase, leading to the inhibition of DNA replication and transcription. This mechanism disrupts the growth and proliferation of bacteria. Danofloxacin is effective against a range of bacterial infections, including those caused by Escherichia coli, Mycoplasma, and other pathogenic organisms, making it a valuable tool for related research applications. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design. -
Macrolide Antibiotic
Erythromycin lactobionate is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis through obstruction of transpeptidation and/or translocation processes. This compound demonstrates a broad spectrum of antimicrobial activity, making it valuable for various bacterial infections. Additionally, erythromycin lactobionate has shown potential antitumor and neuroprotective effects, presenting opportunities for research in oncology and neurobiology. -
Dengue Virus Protease Inhibitor
SP-471P is a potent inhibitor of the dengue virus (DENV) protease, exhibiting EC50 values of 5.9 μM, 1.4 μM, 5.1 μM, and 1.7 μM against DENV1, DENV2, DENV3, and DENV4, respectively, with a CC50 exceeding 100 μM. This compound effectively reduces DENV viral RNA synthesis, making it a valuable tool for research in dengue virus biology and antiviral therapeutic development. -
Antibiotic
Pefloxacin is a broad-spectrum antibiotic that targets DNA gyrase, effectively inhibiting DNA replication. It exhibits significant antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis, with MIC90 values of 0.12, 4, and 16 mg/L, respectively. In addition to its antibacterial properties, Pefloxacin has demonstrated efficacy in reducing Plasmodium yoelii infections and may enhance UVA-induced edema and immunosuppression. This compound is suitable for various infection-related research applications. -
Bacteria Antibiotic
Nogalamycin is an anthracyclinone antibiotic that primarily targets Gram-positive bacteria. It exhibits significant antibacterial activity along with cytotoxic effects against specific tumor cells. Derived from Streptomyces nogalater var. nogalater, Nogalamycin selectively inhibits RNA synthesis by binding to the DNA template. This compound is valuable for research into anticancer therapeutics and bacterial resistance mechanisms. -
Antibacterial Agent
Ostruthin is a natural coumarin compound that exerts antibacterial and antimycobacterial activities. It effectively inhibits the growth of mycobacteria and Staphylococcus aureus, making it valuable in studies of bacterial pathogenesis. Additionally, ostruthin suppresses vascular smooth muscle cell proliferation and de novo DNA synthesis, positioning it as a pertinent tool for research related to mycobacterial infections and cardiovascular as well as cerebrovascular diseases. -
Ansamycin Antibiotic
Rifamycin is an orally active ansamycin antibiotic that primarily inhibits DNA-dependent RNA synthesis. It demonstrates significant antibacterial activity against Mycobacterium tuberculosis and can also affect hepatic bile acid metabolism. Additionally, Rifamycin exhibits anti-inflammatory properties, making it useful in the study of infections caused by Mycobacterium tuberculosis and Bacteroides fragilis, as well as in research involving lipopolysaccharide-induced inflammation. -
Bacterial Inhibitor
Mequindox is an antimicrobial agent that functions as a bacterial inhibitor by selectively targeting and inhibiting DNA synthesis. This compound demonstrates significant genotoxic and carcinogenic effects in murine models, making it a valuable tool for studying bacterial resistance mechanisms and the potential impacts of antimicrobial agents on genetic material. Its applications extend to research on the safety and efficacy of antimicrobial treatments in various biological systems. -
Bacterial Inhibitor
Silver sulfadiazine is a sulfonamide antibiotic that functions as a bacterial inhibitor through dual mechanisms. The sulfa moiety inhibits bacterial folate absorption, thereby disrupting essential DNA synthesis. Additionally, silver ions released from silver sulfadiazine bind to and disrupt DNA structures, preventing bacterial DNA replication. This compound is widely used in research applications focusing on bacterial growth inhibition and antimicrobial studies. -
Antibiotic
Holomycin is a secondary metabolite belonging to the dithiolopyrrolone class, recognized for its broad-spectrum antibiotic properties. It exhibits notable antitumor activity and functions by inhibiting RNA synthesis in vivo. Holomycin serves as a valuable tool in pharmaceutical research, particularly in studies related to antimicrobial resistance and cancer therapeutics. -
Antibacterial Agent
Amicoumacin B is an antibacterial agent produced by the actinomycete strain 04-5195T, primarily targeting bacterial quorum sensing mechanisms. It demonstrates significant inhibitory activity against Chromobacterium violaceum, with a minimum inhibitory concentration (MIC) of 250 µg/mL. Additionally, Amicoumacin B upregulates the expression of bone morphogenetic protein 2 (BMP-2) while simultaneously inhibiting the expression of essential quorum sensing operons vioA, vioB, vioD, and vioE, and enhancing vioC expression. These properties make Amicoumacin B a valuable tool in microbiological research and the study of bacterial communication. -
Antibiotic
10,11-Dehydrocurvularin is an antibiotic derived from fungi, known for its ability to activate the heat shock response. This compound exhibits significant inhibition of the TGF-β signaling pathway, demonstrating anti-tumorigenic properties. Its biological activities make it a valuable reagent for research in antibiotic efficacy and cancer biology. -
Antitumor Antibiotic
Dinactin is an antibiotic ionophore derived from Streptomyces species, primarily targeting the Wnt/β-catenin signaling pathway in cancer cells. This compound exhibits significant inhibition of HCT-116 cell proliferation, with an IC50 value of 1.1 μM, demonstrating its anti-proliferative effects in an apoptosis-independent manner. Additionally, Dinactin serves as a valuable tool in research related to neuropathic pain. -
Antitumor Antibiotic
Sibiromycin is a glycosylated pyrrolobenzodiazepine (PBD) that functions as a potent antitumor antibiotic. It exerts its biological activity by covalently binding to DNA in the minor groove, specifically targeting the amino group of guanine. This mechanism contributes to its effectiveness in cancer research, making it a valuable tool for studies involving DNA interactions and antitumor mechanisms. -
Antineoplastic Antibiotic
Cytogenin, an antineoplastic antibiotic, demonstrates significant antitumor activity by inhibiting the growth of Ehrlich ascites tumors in mouse models. This compound also regulates inflammatory cytokines, effectively reducing levels of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and interleukin-6 (IL-6) in murine macrophages. Additionally, Cytogenin exhibits antidiabetic effects, making it a valuable reagent for research in cancer biology and inflammation. -
Bacterial Inhibitor
Fenvalerate is a highly effective bacterial inhibitor, primarily functioning as a protein phosphatase 2B (calcineurin) inhibitor, with an IC50 of 2-4 nM for PP2B-Aα. As a pyrethroid ester, it exhibits significant insecticidal and acaricidal properties. This compound is utilized in various research applications to study protein phosphatase signaling pathways and to explore potential therapeutic targets in bacterial infections. -
Nephrotoxin
Orellanine is a potent fungal nephrotoxin primarily known for its mechanism as a competitive inhibitor of alkaline phosphatase. This compound effectively induces apoptosis in proximal tubular cells and clear cell renal cell carcinoma (ccRCC) cell lines. Orellanine serves as a valuable tool for research focused on nephrotoxicity and the pathophysiology of ccRCC. -
Antibiotic
Fostriecin is a triene antibiotic that primarily targets topoisomerase II and inhibits protein phosphatase PP2A. It exhibits potent antibacterial activity and has been employed in research focused on mechanisms of antibiotic resistance and cancer therapy. Its unique mechanism of action makes it a valuable tool for studying cellular processes related to gene expression and cell cycle regulation. -
Calcineurin Phosphatase Inhibitor
Dibefurin is a potent inhibitor of calcineurin phosphatase, a critical regulator of calcium-dependent signaling pathways. This fungal metabolite has demonstrated significant biological activity in various cellular processes, making it a valuable tool for studying immune response and neuronal signaling. Its application extends to research focused on autoimmune diseases and neurodegenerative disorders, where calcineurin activity plays a pivotal role. -
IMPase Inhibitor
L-671776 is a non-competitive inhibitor of inositol monophosphatase (IMPase), a critical enzyme in the phosphoinositide signaling pathway. This compound, derived from the fungal strain ATCC 20928B, exhibits significant potential for modulating inositol levels and can be utilized in studies investigating mood disorders, neurodegenerative diseases, and other conditions linked to inositol metabolism. Its application in biochemical research can help elucidate the role of IMPase in cellular signaling processes. -
PTP1B Inhibitor
Deoxyfunicone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 24.3 µM through direct active site binding. This secondary fungal metabolite exhibits notable anti-inflammatory properties, making it a valuable tool for research into metabolic regulation and the treatment of inflammatory diseases. Its mechanism of action positions it as a significant compound for studies focused on diabetes and obesity-related conditions. -
HIV Integrase Inhibitor
Equisetin is an N-methylserine-derived acyl tetramic acid that functions as a potent HIV integrase inhibitor. It specifically interferes with the activity of HIV-1 integrase and demonstrates notable inhibition of 11β-HSD1 and Dnp-stimulated ATPase, with an IC50 of approximately 8 nmol per mg of protein. Additionally, Equisetin exhibits significant antibacterial properties, anti-inflammatory effects, and potential benefits in managing lipid-associated disorders while also showcasing cytotoxic activity. This compound is valuable for research applications focused on HIV treatment and the exploration of antimicrobial and anti-inflammatory mechanisms. -
Antibacterial Peptide
Golotimod hydrochloride is an immunomodulating peptide that targets antibacterial pathways. This compound enhances the efficacy of antituberculosis therapy by promoting thymic and splenic cell proliferation and improving macrophage functionality. Additionally, Golotimod hydrochloride inhibits STAT3 signaling, thereby modulating the severity and duration of oral mucositis in animal models subjected to radiation or combined treatments. Furthermore, it shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Antibacterial Peptide
Golotimod TFA is an immunomodulating peptide primarily known for its antibacterial properties. This compound enhances the efficacy of antituberculosis therapy and promotes thymic and splenic cell proliferation while improving macrophage function. It inhibits STAT3 signaling, demonstrating potential in mitigating the duration and severity of oral mucositis in irradiated animal models. Additionally, Golotimod TFA shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Anti-inflammatory/antibacterial Agent
Plumericin is an anti-inflammatory and antibacterial agent that primarily targets key signaling pathways involved in inflammation and cellular stress response. It has been shown to reduce apoptosis, activate Nrf-2, and inhibit both NF-κB and AhR activation, while also blocking STAT3 signaling. Plumericin exhibits inhibitory effects on Mycobacterium tuberculosis growth, making it a valuable compound for studying chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis. -
Antibiotic
Tigecycline hydrochloride is a broad-spectrum glycylcycline antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits significant antibacterial activity against a variety of gram-positive and gram-negative pathogens, including Escherichia coli and Acinetobacter baumannii, with mean inhibitory concentrations (MIC) of approximately 125 ng/mL for E. coli and MIC50 and MIC90 values of 1 and 2 mg/L for A. baumannii, respectively. Tigecycline hydrochloride is commonly used in research settings to investigate antibiotic resistance mechanisms and to study the efficacy of antimicrobial agents. -
Antibiotic
DCAP is a broad-spectrum antibiotic that targets the membranes of both Gram-positive and Gram-negative bacteria. It exhibits significant antibacterial activity by disrupting autophagic processes, specifically blocking the maturation of autophagolysosomes and interrupting autophagic flux. This compound is utilized in research applications focused on bacterial infections and autophagy regulation. -
Antibiotic
Tigecycline mesylate is a broad-spectrum glycylcycline antibiotic that targets bacterial protein synthesis. It exhibits significant inhibitory activity against various Gram-positive and Gram-negative bacteria, with a mean inhibitory concentration (MIC) for E. coli (MG1655 strain) of approximately 125 ng/mL. For Acinetobacter baumannii, the MIC50 and MIC90 values are 1 mg/L and 2 mg/L, respectively, making it valuable for research focused on antibiotic resistance and infection control. -
HIV NNRTI
(Rac)-Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1. It demonstrates significant antiviral activity with a Ki of 2.93 nM for the inhibition of the wild-type HIV-1 reverse transcriptase and an IC95 of 1.5 nM against HIV-1 replication in cultured cells. This compound is suitable for research applications focusing on HIV-1 therapy and the development of antiretroviral drugs. -
Antibiotic
nTZDpa is a partial agonist of PPARG and functions as an antibiotic. It exhibits significant antibacterial activity, particularly against both growing and persistent strains of Staphylococcus aureus, through the mechanism of lipid bilayer disruption. This compound is valuable for research applications focused on antibiotic resistance and the exploration of novel therapeutic strategies against bacterial infections. -
Antibacterial Agent/Growth-promoting Agent
Quindoxin is an antibacterial agent that acts by disrupting bacterial cell function. It demonstrates significant growth-promoting activity, particularly in livestock, and has been shown to exhibit dose-dependent mutagenicity against Salmonella typhimurium strains TA98 and TA100. Additionally, Quindoxin is associated with potential DNA damage, highlighting its relevance in studies related to genotoxicity and carcinogenicity. -
Bacterial Transcription Inhibitor
GKL003 is a bacterial transcription inhibitor that targets the interaction interface of RNA polymerase (RNAP) and the sigma factor, with a Ki value of 5.79 nM. By specifically binding to the RNAP β' clamp helix region at the σA factor binding site, GKL003 disrupts the formation of the RNAP holoenzyme and inhibits bacterial transcription initiation complexes. This compound effectively inhibits the growth of both Gram-positive and Gram-negative bacterial strains, including those that are drug-resistant, making it a valuable tool for research applications in microbiology and antibiotic resistance studies. -
FXR Antagonist
(-)-(E)-Guggulsterone is a natural stereoisomer of Guggulsterone that functions as a Farnesoid X Receptor (FXR) antagonist with an IC50 of 24.06 μM. This compound exhibits significant hypolipidemic effects and demonstrates the ability to suppress dengue virus (DENV) replication by enhancing antiviral interferon responses through the activation of Nrf2 and upregulation of HO-1 expression. Additionally, (-)-(E)-Guggulsterone displays antibacterial properties against various strains, including Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa, as well as offering cardiac protective and antioxidant benefits in rat models. -
Antibiotic
CPPD-Q is an antimicrobial agent that primarily targets bacterial pathogens. It demonstrates potent antibacterial activity with an EC50 value of 6.98 mg/L against Vibrio fischeri. Additionally, CPPD-Q exhibits insecticidal properties in Caenorhabditis elegans, where it induces the generation of reactive oxygen species (ROS) in the intestines at concentrations of 1 or 10 µg/mL. This compound is suitable for research applications focused on antimicrobial resistance and the mechanisms of insecticidal action. -
Antitumor/ Antibacterial Agent
Epanorin is a secondary metabolite derived from the Acarospora lichenic species, primarily targeting tumor cells and bacterial pathogens. It exhibits potent antitumor activity by inhibiting cancer cell proliferation, reducing reactive oxygen species (ROS) production, and inducing cell cycle arrest in the G0/G1 phase. Additionally, Epanorin demonstrates antibacterial properties, making it valuable for research applications focused on cancer treatment and bacterial infections, including studies on breast cancer and Streptococcus pneumoniae infections. -
Antibacterial Agent
Deoxymikanolide is an orally active antibacterial agent that primarily targets catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. It enhances glycan and phosphorus metabolism, increases electrical conductivity, and elevates levels of intrabacterial reactive oxygen species (ROS) and malondialdehyde (MDA). These actions result in cell shrinkage, cytoplasmic damage, and disruption in Ralstonia solanacearum. Additionally, Deoxymikanolide demonstrates efficacy in inhibiting acetic acid-induced writhing in mice, making it a valuable tool for research on bacterial wilt. -
Antibacterial Peptide
KSL-W is a multifunctional antibacterial peptide primarily targeting immune regulation. It exhibits significant chemotactic effects on neutrophils and promotes F-actin polymerization through the Gαi protein signaling pathway. Additionally, KSL-W effectively inhibits the production of reactive oxygen species (ROS) in neutrophils. This peptide is valuable for research focused on infection control and the regulation of inflammatory processes. -
Antibacterial Agent
Aloe vera, a natural herbal extract, exhibits significant antibacterial activity. It is recognized for its anti-inflammatory and antioxidant properties, making it a valuable candidate for research applications in areas such as tumor biology, diabetes, bone disorders, and cardiovascular health. Its diverse biological effects support its potential use as a therapeutic agent in various biomedical studies. -
Antibacterial Agent
ROS inducer 9 is an antibacterial agent that functions by inhibiting glutathione (GSH) activity and elevating reactive oxygen species (ROS) levels. With a minimum inhibitory concentration (MIC) of 0.25 μg/mL against E. coli, it demonstrates potent antibacterial properties. Additionally, ROS inducer 9 exhibits low toxicity to erythrocytes and RAW 264.7 cells, making it suitable for various biological research applications in exploring oxidative stress responses in bacterial infections.
