Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Agent
Antifungal Agent 152 is an antifungal compound targeting fungal pathogens. It demonstrates significant antifungal activity against Cryptococcus neoformans, Candida albicans, and Candida glabrata, with minimum inhibitory concentrations (MICs) of 4 μg/mL, 16 μg/mL, and 16 μg/mL, respectively. This reagent is useful in research applications focused on fungal infections and therapeutic development. -
Antifungal Antibiotic
Filipin complex is a potent polyene macrolide antifungal antibiotic that primarily targets membrane cholesterol. By inserting into cellular membranes, it sequesters cholesterol, thereby inhibiting the entry of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The complex comprises approximately 75.8% Filipin III, 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I, making it a valuable tool in antifungal research and viral entry studies. Its characteristic fluorescence spectrum (Ex/Em = 380/430 nm) further enhances its utility in biological applications. -
Fungal Inhibitor
Filipin III is a pentaene macrolide antifungal antibiotic featuring a 28-membered ring, primarily derived from various Streptomyces species including S. filipinensis, S. avermitilis, and S. miharaensis. This compound targets membrane sterols, leading to significant alterations in membrane structure, which disrupts fungal cell integrity. Filipin III is widely utilized in research to study fungal infections and to explore mechanisms of antifungal resistance. -
Antibiotic
Nourseothricin sulfate is a broad-spectrum antibiotic that targets the outer membrane of Gram-negative bacteria, effectively disrupting their integrity. This compound inhibits protein biosynthesis in prokaryotic cells and demonstrates significant antifungal activity against eukaryotic organisms. It is widely utilized as a selective marker in various applications, including the transformation of bacteria, yeast, filamentous fungi, and plant cells, facilitating research in microbiology and molecular biology. -
Actin Polymerization Inhibitor
Latrunculin B is an actin polymerization inhibitor commonly derived from marine algae. It modulates the electrophysiological properties of pulmonary veins and has been shown to reduce stretch-induced arrhythmias. Additionally, Latrunculin B exhibits antifungal and antiprotozoal activities, making it a valuable reagent for research in cell biology and pharmacology. -
Fungal Inhibitor
Phenazine-1-carboxylic acid functions as a potent antifungal agent, targeting fungal pathogens effectively. In addition to its antifungal properties, it demonstrates anticancer activity by promoting apoptosis in cancer cells through the modulation of reactive oxygen species (ROS) generation. Phenazine-1-carboxylic acid also influences cytokine expression, upregulating IL-8 and ICAM-1 while inhibiting RANTES and MCP-1 release, indicating potential immunomodulatory effects. This compound is valuable for research in anti-infection strategies, cancer therapy, and immune response modulation. -
Antifungal Agent
Manogepix is a first-in-class, broad-spectrum antifungal agent that acts by inhibiting the biosynthesis of glycosylphosphatidylinositol (GPI) in fungi. This mechanism disrupts essential cellular processes, leading to effective antifungal activity. Researchers can utilize Manogepix for investigating antifungal resistance mechanisms and exploring novel treatment strategies for fungal infections. -
Echinocandin
Rezafungin acetate is a next-generation echinocandin with a broad-spectrum antifungal mechanism, primarily targeting fungal cell wall synthesis. It exhibits strong activity against various pathogens, including Candida spp., Aspergillus spp., and Pneumocystis spp. This compound is valuable for research in antifungal drug development and exploring mechanisms of fungal resistance. -
Antimicrobial Agent
Pyrithione is an antimicrobial agent that primarily inhibits membrane transport processes in fungi. It exhibits potent antibiotic activity against various fungal species, including Penicillium. When incubated with Penicillium mycelia, pyrithione significantly reduces the activity of multiple independently regulated transport systems, making it valuable for research in antifungal mechanisms and microbial resistance studies. -
Fungal
Conalbumin, also known as ovotransferrin, is a monomeric glycoprotein that primarily targets iron transport and is encoded by the avian transferrin gene. This protein, predominantly found in chicken egg white, exhibits a distinct glycosylation pattern that enhances its functionality compared to serum transferrin. Conalbumin demonstrates significant antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory activities. Its diverse biological properties make it suitable for various research applications, including studies on iron metabolism, and as an ingredient in infant formulas and food additives to promote animal health. -
Fungal Inhibitor
Sakuranetin is a cherry flavonoid phytoalexin that acts as a potent fungal inhibitor. It exhibits strong antifungal properties, along with notable anti-inflammatory and antioxidative activities. Additionally, Sakuranetin has demonstrated efficacy in ameliorating LPS-induced acute lung injury, making it a valuable compound for research in inflammation and respiratory disorders. -
Growth Regulator
Epocholeone is a growth regulator that targets various physiological processes in plants. It exhibits significant efficacy in controlling fungal infections and mitigating physiological diseases in crops, enhancing overall plant health and yield. This compound is ideal for use in agricultural research focusing on plant pathology and growth enhancement strategies. -
Antibiotic
Aurachin D is an antibiotic that primarily targets Gram-positive bacteria and certain fungi. It functions by inhibiting NADH oxidation in beef heart submitochondrial particles, which disrupts cellular respiration and energy production. This compound is valuable for research applications focused on understanding bacterial and fungal resistance mechanisms as well as exploring metabolic pathways. -
Antifungal Agent
T-2307 is an arylamidine with potent antifungal activity, demonstrating efficacy against a wide range of clinically important pathogens. It exhibits broad-spectrum activity with minimum inhibitory concentrations (MIC) ranging from 0.00025 to 0.0078 μg/ml against Candida species, 0.0039 to 0.0625 μg/ml against Cryptococcus neoformans, and 0.0156 to 4 μg/ml against various Aspergillus species. T-2307 is valuable for research applications focused on antifungal development and therapeutic intervention. -
Antifungal Agent
Fosmanogepix is a novel antifungal agent that selectively inhibits the Gwt1 enzyme, essential for the proper localization of glycosylphosphatidylinositol-anchored mannoproteins in fungal cells. By disrupting the localization of these critical cell wall components, Fosmanogepix compromises fungal cell wall integrity, inhibits biofilm formation, and impedes germ tube morphogenesis, ultimately curtailing fungal growth. This compound is primarily utilized in research focused on invasive fungal infections, offering valuable insights into therapeutic strategies. -
Tropone Derivatives; Tyrosinase Inhibitor; Virus Inhibitor; Funga Inhibitor
Tropolone is a seven-membered non-benzenoid aromatic compound recognized for its role as a tyrosinase inhibitor, exhibiting an IC50 value of 0.4 μM. This compound demonstrates significant anti-viral and anti-fungal properties, making it effective in a variety of therapeutic applications. Additionally, Tropolone shows enhanced effects when used in conjunction with nucleos(t)ide analogs. Its potential for research in osteosarcoma emphasizes its importance in the exploration of new treatments. -
Antifungal Antibiotic/Complex III Inhibitor
Myxothiazol is an antifungal antibiotic that acts as an inhibitor of mitochondrial electron transport chain complex III (bc1 complex). It demonstrates potent antifungal activity against various yeasts and fungi, exhibiting effective growth inhibition at concentrations ranging from 0.01 to 3 μg/ml. This compound is valuable for research applications focused on mitochondrial function and the mechanisms of antifungal resistance. -
Antifungal Cyclic Dipeptide
Cyclo(L-Phe-L-Pro) is an antifungal cyclic dipeptide that selectively targets the retinoic-acid-inducible gene-I (RIG-I) pathway, thereby inhibiting IFN-β production. Isolated from cell-free culture supernatants of Pseudomonas fluorescens and Pseudomonas alcaligenes, this compound demonstrates significant free-radical scavenging ability, with an IC50 of 24 µM in the DPPH assay. It serves as a valuable reagent in studies related to antifungal mechanisms and oxidative stress response. -
Drug Derivative
UDP-rhamnose is the activated form of rhamnose that plays a crucial role in the synthesis of rhamnose-containing glycans in fungi. This nucleotide sugar acts as a key substrate for glycosyltransferases, enabling the assembly of polysaccharides involved in the fungal cell wall. UDP-rhamnose is utilized in research focused on understanding fungal pathogenesis and the development of therapeutics for fungal infections. -
Fungicide
Pyrimethanil is an anilinopyrimidine fungicide that primarily targets the biosynthesis of methionine and other amino acids in Botrytis cinerea. This broad-spectrum contact fungicide effectively controls Botrytis spp. on a variety of crops, including fruits, vegetables, and ornamental plants. Pyrimethanil is utilized in research focused on the prevention of mold infections and the management of fungal diseases in agricultural settings. -
Antibiotic Fungicide
Validamycin A acts as an antibiotic fungicide primarily targeting fungal pathogens. Isolated from Streptomyces hygroscopicus var. limoneus, it exhibits significant inhibitory effects against Aspergillus flavus, with a minimum inhibitory concentration (MIC) of 1 µg/mL. Additionally, Validamycin A demonstrates potent inhibition of trehalase in Rhizoctonia solani, with an IC50 value of 72 µM. It also functions as a reversible inhibitor of tyrosinase, exhibiting a Ki value of 5.893 mM, making it a valuable reagent for agricultural and biochemical research applications. -
Lignin Intermediate
Coniferyl alcohol is a key intermediate in lignin biosynthesis with antifungal properties. It has been shown to specifically inhibit the growth of fungi such as Verticillium longisporum, as well as impede the growth of Nicotiana benthamiana seedlings. Additionally, coniferyl alcohol demonstrates potential benefits in improving cardiac dysfunction associated with renovascular hypertension and cardiac inflammation, making it valuable for research in both plant pathology and cardiovascular studies. -
Building Block
2,5-Furandimethanol serves as a versatile building block in the enzymatic synthesis of bio-based polyesters. This compound is also a significant metabolite derived from the fungus Phellinus linteus, which has been implicated in the treatment of leukemia. Additionally, 2,5-Furandimethanol may provide insights in the study of fungal infections, making it a valuable reagent in various biological research applications. -
Antifungal Agent
D-Gluconic acid potassium is a carboxylic acid that exhibits antifungal activity through its antiseptic and chelating properties. This compound is suitable for research applications in the field of mycology and can aid in the study of fungal infections and their treatment mechanisms. Its ability to chelate metal ions further enhances its potential utility in various biochemical assays. -
β-1,3-Glucan Inhibitor
Ibrexafungerp is an orally active β-1,3-glucan synthesis inhibitor with demonstrated antifungal properties. Its mechanism targets the cell wall biosynthesis pathway of fungi, making it valuable in research on Candida and Aspergillus infections. This compound is a promising candidate for studies focused on antifungal resistance and the development of new antifungal therapies. -
Antifungal
Prochloraz is an imidazole antifungal agent that primarily functions as a dual antagonist of estrogen receptors (ER) and androgen receptors (AR), as well as an aromatase inhibitor with IC50 values of 25 μM, 4 μM, and 0.3 μM, respectively. Additionally, Prochloraz activates the aryl hydrocarbon receptor (AhR) with an EC50 of 1 μM. This compound is useful in research focused on endocrine disruption and antifungal activity, making it a valuable tool for studies in toxicology and pharmacology. -
Antifungal Agent
2-Phenylethyl isothiocyanate is a potent antifungal agent targeting fungal growth and development. It significantly inhibits spore germination and mycelial growth of Alternaria alternata, exhibiting a minimum inhibitory concentration (MIC) of 1.22 mM. The antifungal action of 2-Phenylethyl isothiocyanate involves the reduction of toxin levels and disruption of cell membrane integrity, making it a valuable compound for research into fungal pathogens and potential therapeutic applications. -
Antifungal/Antibacterial/Antiviral Agent
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide that serves as a broad-spectrum antibacterial, antiviral, and antifungal agent. It is particularly effective in inhibiting aflatoxin production in Aspergillus flavus and exhibits significant antibacterial activity against multi-drug resistant bacteria, especially in its cis configuration. Additionally, Cyclo(L-Leu-L-Pro) demonstrates notable antiviral properties, specifically inhibiting the influenza A virus H3N2. This compound is valuable for research applications focused on infectious diseases and microbial resistance. -
Volatile Organic Compound
2,5-Dimethylcyclohexanol is a volatile organic compound with significant antineoplastic and antiviral properties, particularly through its inhibition of SARS-CoV-2 Mpro. Additionally, it exhibits potent antifungal activity against Pseudogymnoascus destructans, compromising cell wall and membrane integrity while disturbing energy metabolism. This compound increases reactive oxygen species (ROS), ATP, superoxide anions, and glutathione (GSH) levels, while reducing catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, 2,5-Dimethylcyclohexanol influences the expression of virulence-related ribosomal genes and disrupts MAPK signaling pathways, leading to fungal cell apoptosis. -
Antitumor Antibiotic
Peplomycin sulfate is an antitumor antibiotic that acts by inducing DNA strand breaks, thereby promoting apoptosis in cancer cells. It exhibits significant antitumor activity while displaying relatively low pulmonary toxicity. Additionally, Peplomycin sulfate has been shown to induce various skin abnormalities and can lead to pulmonary fibrosis. This compound is valuable for research applications related to cancer, pulmonary fibrosis, and other associated diseases. -
Fungicide
(Rac)-Epoxiconazole is a chiral triazole fungicide that exhibits inhibitory activity against a wide range of fungal pathogens. This compound demonstrates long-lasting fungicidal effects, making it suitable for agricultural applications where persistent protection is essential. Its persistence in soil is noteworthy, with a reported half-life exceeding 300 days, indicating prolonged efficacy in reducing fungal populations in treated areas. -
Anti-tumour Antibiotic
Boanmycin is an anti-tumor antibiotic that exerts its biological activity by inducing cellular senescence and apoptosis in cancer cells. This compound is primarily utilized in research to explore mechanisms of tumor suppression and to assess its potential therapeutic applications in oncology. Its ability to promote programmed cell death makes it a valuable tool for studying cancer biology and developing novel treatment strategies. -
Antifungal Agent
Sertaconazole is a broad-spectrum topical antifungal agent that primarily targets fungal cell membranes. It exhibits significant anti-inflammatory activity by activating the p38-COX-2-PGE2 signaling pathway. Additionally, Sertaconazole functions as a microtubule inhibitor, demonstrating antiproliferative effects, and inducing apoptosis and autophagy. Its ability to inhibit cellular migration makes it valuable in various research applications related to fungal infections and inflammatory conditions. -
Antibiotic
4-Epianhydrotetracycline hydrochloride is an antibiotic that serves as a significant intermediate in tetracycline synthesis. It demonstrates cytotoxic effects and induces apoptosis in zebrafish embryos, highlighting its potential for developmental toxicology studies. Furthermore, it exhibits antimicrobial activity against Shewanella, Escherichia coli, and Pseudomonas aeruginosa, with minimum inhibitory concentrations of 2 mg/L, 1 mg/L, and 64 mg/L, respectively, indicating its utility in microbial resistance research. -
Bacterial Metabolite Xie
Collismycin A is a bacterial metabolite targeting multiple cellular pathways, originally isolated from Streptomyces. Exhibiting antibacterial, antiproliferative, and neuroprotective properties, it demonstrates activity against various bacteria and fungi (MICs ranging from 6.25 to 100 μg/mL). Notably, Collismycin A inhibits the proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells, with IC50 values of 0.3, 0.6, and 0.3 μM, respectively, while demonstrating minimal impact on MDA-MB-231 breast cancer cells (IC50 > 100 μM). Furthermore, it forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, where the presence of iron ions can attenuate its antiproliferative effects in HeLa cells, and it exhibits protective effects against neuronal cell death in zebrafish larvae models. -
Antibacterial Agent/eEF2K Inhibitor
Cefatrizine is a broad-spectrum cephalosporin antibiotic that primarily targets bacterial infections while also acting as an eEF2K inhibitor. This compound exhibits anti-proliferative activity in human breast cancer cells, inducing endoplasmic reticulum stress and subsequent cell death. Cefatrizine is a valuable reagent for research applications in understanding mechanisms of cancer therapy and exploring antibacterial efficacy. -
Ras Inhibitor
(-)-Rasfonin is a natural fungal secondary metabolite that acts as an inhibitor of small G protein Ras. It exhibits significant biological activities, including the induction of apoptosis, necrosis, and autophagy in ACHN cells, a renal carcinoma cell line. This compound is instrumental for research focused on cellular death pathways and therapeutic strategies targeting Ras-mediated signaling in cancer. -
Antibiotic
Deoxynybomycin is an antibiotic that acts as an inhibitor of DNA gyrase and Topoisomerase I. It demonstrates significant antibacterial activity against Staphylococcus aureus and induces the expression of p21/WAF1. Additionally, Deoxynybomycin exhibits cytotoxic effects and promotes apoptosis in various cancer cell lines, including Saos-2, TMK-1, and THP-1, making it a valuable tool for research in antimicrobial and cancer biology. -
Anti-tumour Antibiotic
Boanmycin hydrochloride is an anti-tumor antibiotic that exhibits significant cytotoxic effects against various cancer cell lines. It functions by inducing cellular senescence and apoptosis, making it a valuable tool for studying mechanisms of tumor progression and resistance. This compound is useful in cancer research and can aid in the development of therapeutic strategies targeting malignant cells. -
Antibiotic
Undecylprodigiosin hydrochloride is an antibiotic derived from the prodiginine class of compounds. It exhibits potent antimicrobial activity and selectively induces apoptosis in human breast carcinoma cells through a p53-independent mechanism. Additionally, this compound demonstrates immunosuppressive and anticancer properties, making it a valuable tool for research in cancer therapy and microbial studies. -
Antitumor Antibiotic
Antibiotic DC 81 is a potent antitumor antibiotic derived from Streptomyces species, classified as a pyrrolo[2,1-c][1,4]benzodiazepine (PBD). It functions primarily as an inhibitor of nucleic acid synthesis by recognizing and binding to specific DNA sequences, resulting in the formation of a labile covalent adduct. This ability to interact with DNA makes Antibiotic DC 81 valuable for research in cancer biology and the development of novel therapeutic agents targeting DNA. -
Antibacterial Agent
Chlorhexidine acetate hydrate is a cationic antimicrobial agent that targets microbial cell membranes. By non-specifically binding to cell membrane phospholipids, it disrupts membrane integrity, leading to leakage of cellular contents and bacterial cell death. This compound exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Its ability to interfere with membrane permeability and induce protein precipitation makes it valuable for research applications focused on microbial growth inhibition and mechanisms of cell death. -
Azoxystrobin Enantiomer
(Z)-Azoxystrobin is an enantiomer of Azoxystrobin, a broad-spectrum β-methoxyacrylate fungicide. It functions by inhibiting mitochondrial respiration through binding to the Qo site of the cytochrome bc1 complex, thereby disrupting electron transfer. The compound is known to induce the production of reactive oxygen species (ROS), ultimately leading to cell apoptosis. It is primarily used in research applications involving fungal inhibition and the study of mitochondrial function. -
Antibiotic
FSL-1 is a bacterial-derived agonist of toll-like receptor 2/6 (TLR2/6). It exhibits immunostimulatory activity that enhances resistance against experimental Herpes Simplex Virus Type 2 (HSV-2) infection. This compound is valuable for research applications focused on innate immunity and the development of therapeutic strategies for viral infections. -
Anti-HIV Agent
Moronic Acid is a triterpenoid compound that serves as an orally available anti-HIV agent, exhibiting significant anti-inflammatory properties. It demonstrates the ability to inhibit viral replication, with an EC50 value of less than 1 μg/mL. Moronic Acid can be isolated from Brazilian propolis and is utilized in research focused on HIV treatment and related viral studies. -
Antibacterial/anti-inflammatory Agent
Sinapaldehyde is a methoxyphenol that primarily functions as a selective COX-2 inhibitor with an IC50 of 47.8 µM. This compound exhibits notable antibacterial and anti-inflammatory properties, demonstrating efficacy against both Gram-positive and Gram-negative bacteria. Additionally, Sinapaldehyde possesses antioxidant activity through its ability to scavenge DPPH free radicals, with an IC50 of 172 μM, making it a valuable reagent for research in inflammation and microbial resistance. -
Antibacterial Agent
1-Tetradecanol is a straight-chain saturated fatty alcohol that serves as an effective antibacterial agent. Isolated from Myristica fragrans, it exhibits notable antibacterial and anti-inflammatory properties, particularly in the context of periodontitis. This compound can be utilized in research applications focusing on antimicrobial activity and the modulation of inflammatory responses. -
Antibacterial Agent
Terminolic acid is a pentacyclic triterpene glycoside that acts as an antibacterial agent. It exhibits significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) ranging from 64 to 256 μg/mL. Terminolic acid also demonstrates the ability to inhibit pro-inflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6, contributing to a reduction in IL-8 levels. This compound is utilized in research targeting colon cancer and inflammatory conditions. -
HIV-Ⅰ Inhibitor
HIV-IN-6 is an inhibitor of HIV-1 viral replication, specifically targeting Src family kinases (SFKs) that associate with the viral Nef protein, including Hck. This compound has demonstrated significant antiviral activity by disrupting the functional interactions necessary for viral pathogenesis. Its application in research includes the study of HIV infection mechanisms and the exploration of novel therapeutic strategies against HIV-1. -
Antitumor Antibiotic
Herbimycin B is an ansamycin antibiotic targeting Src family tyrosine kinases. It exhibits significant antitumor activity by inhibiting cell proliferation in various cancer cell lines, including HeLa and Ehrlich cells. Additionally, Herbimycin B demonstrates a herbicidal effect on both monocotyledons and dicotyledons and can inhibit the tobacco mosaic virus (TMV), making it relevant for studies in plant pathology and cancer research.
