iKIX1 is an antifungal agent that targets the KIX domain of the mediator subunit CgGal11A, interrupting its interaction with the activation domain of CgPdr1. This compound effectively resensitizes drug-resistant Candida glabrata to azole antifungals in vitro, with inhibition constants IC50 and Ki values of 190.2 μM and 18 μM, respectively. iKIX1 is utilized in research focused on understanding multidrug resistance mechanisms and addressing C. glabrata infections.
iKIX1 is an antifungal agent that targets the KIX domain of the mediator subunit CgGal11A, interrupting its interaction with the activation domain of CgPdr1. This compound effectively resensitizes drug-resistant Candida glabrata to azole antifungals in vitro, with inhibition constants IC50 and Ki values of 190.2 μM and 18 μM, respectively. iKIX1 is utilized in research focused on understanding multidrug resistance mechanisms and addressing C. glabrata infections.
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