Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic
Tylvalosin is a macrolide antibiotic that exhibits broad-spectrum antimicrobial activity. Primarily utilized as an antiviral agent, Tylvalosin is effective in studying Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. This compound also induces apoptosis and possesses anti-inflammatory properties, helping to mitigate oxidative stress and acute lung injury by inhibiting NF-κB activation. Its diverse biological activities make Tylvalosin valuable for research in infectious diseases and inflammation. -
SDHI Inhibitor
Boscalid is a succinate dehydrogenase inhibitor that exhibits significant antifungal activity. By binding to the ubiquinone-binding site of mitochondrial complex II in fungi, Boscalid disrupts ATP production and aerobic respiration, effectively controlling a range of plant fungal diseases, such as gray mold, sclerotinia rot, and powdery mildew. In addition to its agricultural applications, research indicates that Boscalid induces apoptosis and alters lipid metabolism while causing mitochondrial dysfunction, oxidative stress, and ROS accumulation in zebrafish models. Furthermore, it demonstrates chronic toxicity and impacts foraging behavior in honeybees, alongside exhibiting genotoxic and cytotoxic effects in cellular systems. -
Antimicrobial Peptide
Protegrin-1 is an antimicrobial peptide that exhibits potent antibacterial activity by activating ERK, COX2, and NFκB pathways, while inhibiting apoptosis and nitric oxide production. It demonstrates significant bactericidal effects against various pathogens, including Staphylococcus aureus, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, with minimal inhibitory concentrations ranging from 10 to 20 µM. Additionally, Protegrin-1 shows antiviral activity against the dengue virus NS2B-NS3 and possesses anti-inflammatory properties, making it a valuable tool in the research of inflammatory diseases and infections. -
Antibiotic
Tylvalosin tartrate is a broad-spectrum macrolide antibiotic primarily targeting bacterial infections. This compound exhibits significant antimicrobial activity and is effective in studying Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infections. Additionally, Tylvalosin tartrate induces apoptosis, demonstrates anti-inflammatory properties, relieves oxidative stress, and mitigates acute lung injury by inhibiting NF-κB activation. It serves as a valuable tool for research into viral pathogenesis and cellular responses. -
Antimicrobial Agent
Dipyrithione is a potent antimicrobial agent primarily targeting fungal pathogens. It exhibits significant antifungal and antiproliferative activities, inducing apoptosis and G1 phase cell cycle arrest. Additionally, Dipyrithione demonstrates anti-inflammatory effects in vivo and exhibits anti-tumor potential. This compound is of particular interest for research applications related to dermatophytosis and other fungal infections. -
Bacterial Inhibitor
Citrinin is a mycotoxin known for its role as a bacterial inhibitor. It exhibits a range of biological activities, including the regulation of immune cell populations, induction of apoptosis and autophagy in immune cells, and modulation of toll-like receptor expression and cytokine production. Citrinin also induces oxidative stress, leading to apoptosis in oocytes, while low doses demonstrate neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. This compound's diverse mechanisms make it a valuable reagent for research in immunology, neurobiology, and antibacterial applications. -
Macrocyclic Ellagitannin
Oenothein B is a dimeric macrocyclic ellagitannin known for its potent inhibition of poly(ADP-ribose) glycohydrolase. It exhibits a range of biological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects. This compound serves as a valuable tool in research applications focusing on cellular stress responses, inflammation, and cancer therapeutics. -
Anti-bacterial Agent
Pinosylvin is a stilbenoid toxin derived from the heartwood of Pinus species, exhibiting significant anti-bacterial activity. As a resveratrol analogue, it has been shown to induce apoptosis and autophagy in leukemia cells, making it a valuable agent for research in cancer therapy and infectious disease studies. Its unique properties position Pinosylvin as a promising candidate for further exploration in the development of anti-microbial and anti-cancer compounds. -
Virus Protease Inhibitor
Anthraquinone acts primarily as a viral protease inhibitor, exhibiting multifaceted biological activities including anticancer, anti-inflammatory, diuretic, anti-arthritic, antifungal, antibacterial, antimalarial, and antioxidant properties. This compound plays a crucial role in plant metabolism by impacting the electron transport chain, thereby inhibiting energy transfer during photosynthesis. Additionally, anthraquinone intercalates into DNA and inhibits topoisomerase II, leading to cell death through apoptosis. This diverse profile supports its applications in various fields of chemical and biological research. -
Antibiotic
Maduramicin ammonium is a potent antibiotic derived from the actinomycete Actinomadura rubra, primarily functioning as an anticoccidial agent. It effectively targets Eimeria spp., including E. adenoeides, E. gallopavonis, and E. dispersa, making it valuable in the treatment of coccidiosis. Additionally, Maduramicin ammonium has been shown to induce apoptosis in chicken myocardial cells through both intrinsic and extrinsic pathways, underscoring its utility in biological research involving cell viability and apoptosis mechanisms. -
Antitumor Antibiotic
Neocarzinostatin (solution) is a potent antitumor antibiotic that primarily targets double-stranded DNA through the recognition of DNA bulges, leading to the induction of double strand breaks (DSBs). This mechanism initiates apoptosis in cancer cells, making Neocarzinostatin an important reagent for studying DNA damage response and cancer biology. It exhibits potential in the treatment of EpCAM-positive cancers, providing a valuable tool for researchers investigating therapeutic strategies in oncology. -
Fungal Inhibitor
Mancozeb is a potent fungicide that operates primarily by inhibiting fungal growth in a variety of agricultural products, including cereals, vegetables, fruits, and ornamental plants. In addition to its antifungal properties, Mancozeb has been shown to activate the Keap1/Nrf2 signaling pathway, leading to liver damage in mice. It alters cellular metabolism through the upregulation of lactate dehydrogenase and cytochrome c, resulting in induced apoptotic pathways, particularly in ovarian cells. This compound is of significant interest in studies related to reproductive toxicity and cellular metabolism. -
Antibacterial Agent
5-Fluoroindole is a fluorinated indole derivative that serves as an antibacterial agent. It has been shown to induce reactive oxygen species (ROS) accumulation and initiate apoptosis in bacterial cells. 5-Fluoroindole effectively inhibits the growth of pan-susceptible Mycobacterium tuberculosis H37Rv strains and demonstrates significant bactericidal activity against Pseudomonas syringae pv. actinidiae, with an EC50 of 15.34 µg/mL. This compound is valuable for research focused on tuberculosis and bacterial infections in kiwifruit. Additionally, its fluorinated structure makes it suitable for protein labeling applications. -
Apoptosis Inducer
Falcarindiol is an orally active polyacetylenic oxylipin that functions as an apoptosis inducer by activating PPARγ and enhancing the expression of the cholesterol transporter ABCA1 in cells. This compound exhibits significant biological activities, including anti-inflammatory, antifungal, anticancer, and antidiabetic effects. Additionally, as a click chemistry reagent, Falcarindiol contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various research applications. -
Antibiotic
Levofloxacin hydrochloride is a fluoroquinolone antibiotic that primarily targets DNA gyrase and topoisomerase IV, leading to the inhibition of bacterial DNA replication and subsequent apoptosis. This compound exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative pathogens, making it suitable for research on infectious diseases, including tuberculosis and chronic periodontitis. Additionally, Levofloxacin hydrochloride demonstrates anticancer effects against lung cancer, along with potential anti-acnegenic, anxiogenic, and analgesic properties. Its effects on sleep duration in murine models further support its utility in various biomedical research applications. -
Apoptosis Inducer
δ-Cadinene is a sesquiterpene primarily known for its role as an apoptosis inducer. It exhibits significant antiproliferative and pro-apoptotic effects specifically in human ovarian cancer (OVCAR-3) cells. Additionally, δ-Cadinene demonstrates broad-spectrum bioactivity, including trichomonacidal, antimicrobial, antifungal, and anticancer properties, making it a valuable compound for various research applications in cancer biology and infectious disease studies. -
HIV Protease Inhibitor
Indinavir is a selective inhibitor of HIV-1 protease, displaying a Ki value of 0.54 nM, making it a potent antiviral agent. In addition to its primary role in HIV treatment, Indinavir has demonstrated anticancer properties by inhibiting matrix metalloproteinases (MMPs) and promoting anti-angiogenic effects, alongside inducing apoptosis in cancer cells. Furthermore, Indinavir has shown inhibitory activity against the SARS-CoV 3CL protease, expanding its potential applications in viral research. -
Bacterial/Fungal Inhibitor, Preservative Agent
Methylisothiazolinone is a potent bacterial and fungal inhibitor with significant applications as a preservative agent. It activates matrix metalloproteinases (MMPs) in human bronchial epithelial cells, leading to apoptosis and an inflammatory response. Additionally, this compound is linked to the exacerbation of atopic dermatitis in mice through the disruption of Th2/Th17-related immune responses. Furthermore, Methylisothiazolinone has been shown to induce mitochondrial damage in the endothelium of rat cerebral blood vessels, highlighting its potential impact on vascular health. -
Antibiotic
Narasin is a cationic ionophore antibiotic that effectively targets various microbial pathogens and acts as a coccidiostat agent. Its biological activity includes the inhibition of NF-κB signaling, leading to the induction of apoptosis in tumor cells. Narasin also exhibits antimicrobial, antiviral, and anticancer properties, specifically inhibiting tumor metastasis and the growth of ERα-positive breast cancer cells by inactivating the TGF-β/SMAD3 and IL-6/STAT3 signaling pathways, making it a valuable tool for cancer research and therapeutic applications. -
Bacterial Inhibitor
Oligomycin B is an antibiotic derived from marine Streptomyces, primarily acting as an inhibitor of ATP synthase in eukaryotic cells. Its mechanism of action leads to a decrease in ATP production, resulting in cellular stress and the induction of apoptosis. Oligomycin B is widely utilized in research focused on mitochondrial function, energy metabolism, and apoptosis-related studies. -
Bacterial Inhibitor
Lactoferrin (17-41) acetate is a peptide derived from residues 17-41 of bovine lactoferrin, primarily functioning as a bacterial inhibitor. It exhibits potent antimicrobial activity against various microorganisms, including Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi. In addition to its antimicrobial properties, Lactoferrin (17-41) acetate also demonstrates antitumor activities, making it a valuable reagent in studies related to infection control and cancer research. -
Apoptosis Inducer
Damnacanthal is an anthraquinone that primarily functions as an apoptosis inducer through selective inhibition of p56lck tyrosine kinase activity. Demonstrating significant anticancer properties, Damnacanthal effectively inhibits p56lck autophosphorylation and the phosphorylation of exogenous substrates, with IC50 values of 46 nM and 220 nM, respectively. Additionally, Damnacanthal exhibits antinociceptive and anti-inflammatory effects in murine models, along with antifungal activity against Candida albicans. This compound is valuable for research into cancer biology and related therapeutic pathways. -
Antibiotic
Nonactin is a macrotetrolide antibiotic that functions primarily as a mitochondrial uncoupler. It exhibits antibacterial, insecticidal, and acaricidal properties by acting as an ionophore for monovalent cations such as K+ and NH4+. Additionally, Nonactin inhibits the surface expression of endogenous HSP60 and can induce apoptosis in β-catenin mutant tumor cells, demonstrating its potential for anti-tumor applications. This compound is valuable for research in antibiotic resistance and cancer biology. -
Antibiotic
Quinocetone is an orally active antibiotic that targets various pathogenic microorganisms, making it effective as an animal feed additive to enhance meat production in livestock and poultry. It demonstrates antibacterial activity while also exhibiting tissue-specific toxicity, notably in the liver and lymphocytes. Quinocetone induces autophagy through the ATF6/DAPK1 pathway and activates the NF-κB and iNOS pathways, resulting in cell apoptosis and hepatocyte vacuolar degeneration. Furthermore, it can inhibit the Nrf2/HO-1 pathway and promote the production of reactive oxygen species (ROS), contributing to oxidative stress and DNA damage. -
Antibiotic
Pyoluteorin is an antibiotic with a primary mechanism of inhibiting Oomycete fungi, specifically targeting the plant pathogen Pythium ultimum. This compound effectively suppresses diseases caused by this pathogen in plants. Additionally, Pyoluteorin has been shown to induce apoptosis in human triple-negative breast cancer MDA-MB-231 cells in vitro, making it a valuable reagent for research in human triple-negative breast cancer. -
Antibiotic
2,4-Diacetylphloroglucinol is a polyketide antibiotic that primarily targets a range of pathogenic organisms. This compound demonstrates broad-spectrum antimicrobial activity, effective against bacteria, fungi, oomycetes, and nematodes. Additionally, 2,4-Diacetylphloroglucinol is known to inhibit plant pathogens and can influence root development in tomato seedlings, making it valuable for agricultural research and pathogen control studies. -
Antifungal Potentiator
Polygodial is a sesquiterpene known for its role as an antifungal potentiator. It exhibits significant anti-hyperalgesic properties, making it a valuable compound in research focused on pain modulation and fungal infections. Polygodial has potential applications in developing therapeutic strategies targeting antifungal resistance and enhancing pain relief mechanisms. -
Fluxapyroxad Metabolite
M700F048 is a primary metabolite of the fungicide Fluxapyroxad, targeting the inhibition of succinate dehydrogenase in fungal respiration. This compound is essential for studying the metabolic pathways and environmental behavior of Fluxapyroxad. It has significant applications in toxicological research and understanding the efficacy and degradation of fungicides in agricultural settings. -
Fungicide
Propiconazole is a triazole compound primarily used as a fungicide, targeting fungal sterol biosynthesis by inhibiting the enzyme lanosterol demethylase. Its biological activity is characterized by effective control over various fungal pathogens in agricultural applications. However, it has been identified as a hepatotoxicant and hepatocarcinogen in experimental models, with reported adverse effects on reproduction and development in animals. This information is critical for researchers in toxicology and agricultural sciences assessing the safety and efficacy of fungicidal agents. -
Triazole Fungicide
Difenoconazole is a triazole fungicide that acts as a sterol demethylation inhibitor. It selectively binds to the heme group of fungal cytochrome P450 51, disrupting mycelial growth and inhibiting spore germination. This compound is utilized in research applications focused on pathogenic fungi, offering insights into fungal growth mechanisms and resistance management strategies. -
Stable Isotope
Loratadine-d5 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral histamine H1 receptors. It has demonstrated an IC50 of over 32 μM and exhibits anti-Dengue virus (DENV) activity. Loratadine also inhibits the immunologic release of inflammatory mediators, making Loratadine-d5 a valuable reagent for research in pharmacology and immunology. -
Antifungal Agent
Moracin D is a flavonoid derived from Morus alba, known for its antifungal properties. This compound exhibits significant biological activity, including the induction of cell apoptosis, hypoglycemic effects, and antiadipogenic action. Moracin D is primarily utilized in research involving fungal infections and breast cancer, making it a valuable reagent in the investigation of therapeutic strategies. -
Antifungal Agent
Xanthochymol is an antifungal agent derived from Clusia rosea, primarily targeting fungal cells. This compound demonstrates the ability to induce apoptosis in fungi, making it a valuable tool for investigating fungal cell death mechanisms. It is applicable in research focused on antifungal therapies and the study of fungal pathogen responses to stress. -
Antibiotic
Ascochlorin is an isoprenoid antibiotic that primarily targets the STAT3 signaling cascade, leading to the suppression of tumor growth. It has demonstrated the ability to induce apoptosis in cancer cells while exhibiting anti-inflammatory properties. This compound is valuable for research applications focusing on cancer biology, inflammation, and the modulation of intracellular signaling pathways. -
Cation Ionophore
Calcimycin hemicalcium salt is a potent cation ionophore that primarily facilitates the transport of divalent cations such as calcium and magnesium across cellular membranes. This compound is known to induce Ca2+-dependent cell death by elevating intracellular calcium concentrations, making it valuable for research into apoptosis and autophagy mechanisms. Additionally, Calcimycin hemicalcium salt exhibits antibacterial activity against Gram-positive bacteria and some fungal species, while also inhibiting ATPase activity and uncoupling oxidative phosphorylation in mammalian cells. Its diverse biological effects make it a useful reagent for various biochemical and cellular studies. -
Antifungal Agent
Melittin free acid is a 26-amino-acid polypeptide and a potent activator of phospholipase A2 (PLA2) with significant antifungal activity. It demonstrates broad-spectrum antifungal efficacy, displaying minimum inhibitory concentration (MIC) values between 0.4-60 μM. Melittin free acid exerts its biological effects by promoting fungal cell apoptosis, inhibiting (1,3)-β-D-glucan synthase, and engaging in various other cellular pathways, making it a valuable reagent for research in antifungal mechanisms and therapeutic applications. -
HIV Protease Inhibitor
Indinavir sulfate ethanolate is a selective inhibitor of HIV-1 protease, demonstrating a potent Ki of 0.54 nM for the target enzyme. Beyond its antiviral activity, this compound has shown potential in anticancer research through the inhibition of MMPs-2 activation, anti-angiogenic effects, and promotion of apoptosis. Additionally, Indinavir sulfate ethanolate acts as an inhibitor of the SARS-CoV 3CLpro enzyme, highlighting its diverse biological activity and relevance in multiple research applications. -
Antitumor Antibiotic
Peplomycin is an analog of bleomycin that functions as an antitumor antibiotic. It demonstrates significant antitumor activity while exhibiting lower pulmonary toxicity compared to its parent compound. Peplomycin is known to induce apoptosis in oral squamous cell carcinoma (SSCKN) cells and may lead to skin abnormalities and pulmonary fibrosis. This compound is valuable for research related to tumors, pulmonary fibrosis, and associated diseases. -
Photosensitizer
Elsinochrome A is a perylene quinone photosensitizer that generates reactive oxygen species (ROS) upon light excitation, thereby inducing apoptosis and autophagy in targeted cells. This compound demonstrates effective antifungal activity against Candida albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A is suitable for research applications in photodynamic therapy (PDT), particularly with excitation wavelengths around 460 nm. -
Antibiotic Agent
Nargenicin A1 is an antibiotic agent primarily targeting Gram-positive bacteria. It exhibits anti-inflammatory properties and has been shown to protect HINAE cells from DNA damage and apoptosis induced by Tacrolimus. Additionally, Nargenicin A1 is relevant for research applications related to acute myeloid leukemia, making it a valuable compound for studies in both infection and cancer biology. -
Antibiotic
Undecylprodigiosin is an antibiotic derived from the prodiginine family, known for its potent antibacterial properties. It has been shown to selectively induce apoptosis in human breast carcinoma cells independently of the p53 pathway, demonstrating its potential as an anticancer agent. Additionally, undecylprodigiosin possesses immunosuppressive and antimicrobial activities, making it a valuable tool in cancer research and antimicrobial studies. -
Antibacterial Agent
(±)-Trolline, also known as (±)-Oleracein E, is an isoquinoline alkaloid with notable antibacterial properties against respiratory pathogens. Additionally, it demonstrates antiviral activity against influenza viruses A and B. (±)-Trolline is also a potent inducer of hepatic stellate cell apoptosis, making it a valuable tool for studying liver fibrosis and associated liver disorders. -
Antibacterial Growth Promoter
Nitrovin is an antibacterial growth promoter that targets thioredoxin reductase 1 (TrxR1). It acts by inducing reactive oxygen species (ROS)-mediated non-apoptotic and apoptotic-like cell death. Nitrovin exhibits anticancer activity, demonstrating IC50 values ranging from 1.31 to 6.60 μM in various tumor and normal cell lines, making it a valuable tool for research in cancer and antibacterial studies. -
Deuterated Labeled Geraniol (Major)
Geraniol-d6 (Major) is a deuterated form of the terpene compound geraniol, which primarily functions as an olefin. This compound exhibits significant biological activities, including the inhibition of cell proliferation and the promotion of apoptosis. Geraniol-d6 (Major) is valuable for research applications related to diabetes, as well as studies focusing on its antibacterial, antifungal, antioxidant, anti-inflammatory, and antitumor properties. -
Antibiotic
Arisostatin A is a microbial secondary metabolite with antibiotic activity specifically against Gram-positive bacteria. It exhibits potent anti-tumor effects by inducing apoptosis through the activation of caspase-3 and the generation of reactive oxygen species (ROS) in AMC-HN-4 cells. This compound is valuable for research applications in cancer biology and antimicrobial studies. -
Antibacterial Agent
Antibacterial Agent 292 is a 3-pyrazolylindole derivative targeting bacterial pathogens. This compound exhibits potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 and 3.49 μg/mL, respectively. It suppresses biofilm formation, bacterial motility, and extracellular polysaccharide production while inducing morphological changes and promoting ROS accumulation, leading to bacterial apoptosis. Additionally, it down-regulates genes associated with the type VI secretion system (T6SS), making it a valuable tool for research on rice bacterial blight and citrus canker. -
Bacterial
(-)-Isoledene primarily functions as an antibacterial agent, exhibiting significant antibacterial and anti-inflammatory activities. This natural organic compound has been investigated for its role in the synthesis of various compound intermediates, highlighting its potential applications in compound development and pharmaceutical research. Its diverse biological activity positions it as a valuable reagent for studies related to bacterial infections and inflammation. -
Bacterial Inhibitor
(Z)-Methyl tetradec-9-enoate functions as a bacterial inhibitor, primarily exerting its cytotoxic effects in human prostate cancer LNCaP cells through the induction of apoptosis and necrosis. Isolated from S. repens fruit extract, this compound also demonstrates antifungal activity, effectively inhibiting the germination of Candida albicans with a minimum inhibitory concentration (MIC) of 9 μM in vivo. Its applications extend to studies in both cancer research and microbiology, making it a valuable reagent for understanding cellular processes and developing therapeutic strategies. -
CYP51 Inhibitor
Antifungal agent 136 is an irreversible inhibitor of fungal lanosterol 14α-demethylase (CYP51). It demonstrates potent antifungal activity against drug-resistant strains of Candida albicans and effectively downregulates IL-6 expression. This compound holds potential for research applications in the fields of fungal infection and inflammatory diseases. -
Antifungal Agent
(E)-2-Octenal is an antifungal agent that disrupts cell membrane integrity and induces reactive oxygen species (ROS) accumulation. It effectively decreases the activity of phosphofructokinase and pyruvate kinase, inhibiting the growth of Neofusicoccum parvum by impairing mitochondrial energy metabolism. Additionally, (E)-2-Octenal demonstrates broad-spectrum efficacy against various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, making it valuable for research on citrus blue mold and mango stem-end rot.
