Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
D-Homoserine lactone is a bacterial inhibitor that functions as a signaling molecule regulating quorum sensing through its interaction with acyl-homoserine lactone (AHL) synthase RhlI. By inhibiting RhlI activity, D-Homoserine lactone disrupts bacterial communication, making it a valuable tool in studies of bacterial behavior and pathogenicity. Additionally, as an enantiomer of L-homoserine lactone, it serves as an inhibitor of serine hydroxymethyltransferase, expanding its potential applications in biochemical research and synthetic biology. -
Antibacterial Agent
OX11 is a selective antibacterial agent targeting Streptococcus pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. It demonstrates significant efficacy in inhibiting the growth of these pathogenic bacterial strains. OX11 can be utilized in research applications focused on developing new antimicrobial therapies and studying bacterial resistance mechanisms. -
Bacterial Inhibitor
Afabicin disodium is a specialized bacterial inhibitor that functions as a proagent for Debio1452. It specifically targets Staphylococcus species while exhibiting minimal activity against other Gram-positive and Gram-negative bacteria. The active form, Debio1452, is an inhibitor of FabI, an enzyme essential for fatty acid biosynthesis in staphylococci, making it a valuable tool for research in combating staphylococcal infections. -
Bacterial Inhibitor
Epinecidin-1 is a potent antimicrobial peptide derived from the orange-spotted grouper (Epinephelus coioides), targeting various bacterial strains. It exhibits substantial antibacterial, antifungal, antiviral, and antiprotozoal activity, making it a valuable tool in studies examining microbial inhibition. Additionally, its immunomodulatory and wound healing properties further support research applications in infection control and regenerative medicine. -
Antibacterial Agent
Fobrepodacin is an orally administered phosphate proagent of SPR719, exhibiting potent antibacterial activity. This compound demonstrates significant bactericidal effects in vivo, making it a valuable tool for research into antibacterial therapies and infectious disease mechanisms. Its efficacy supports investigations into alternative treatment strategies for bacterial infections. -
Antibiotic
Iboxamycin is a potent antibiotic that targets bacterial ribosomes, inhibiting protein synthesis. This compound demonstrates efficacy against both Gram-positive and Gram-negative bacterial infections, making it a valuable tool for research in microbiology. Its oral bioavailability and safety profile provide significant utility in in vivo studies, particularly in murine models. -
Antibacterial Agent
Sirpefenicol is a phenicol antibacterial agent that targets bacterial protein synthesis. It has demonstrated effectiveness in treating bacterial infections in veterinary medicine. This compound is particularly relevant for research applications focused on antimicrobial resistance and the development of novel antibacterial therapies. -
Antibacterial Agent
MRL-494 is an antibacterial agent that targets the β-barrel assembly machine A (BamA), effectively overcoming efflux mechanisms and the outer membrane permeability barrier. It demonstrates significant antibacterial activity, with a minimum inhibitory concentration (MIC) of 12.5 μM against Staphylococcus aureus (COL) and 25 μM against Escherichia coli (JCM158). This compound is valuable for research into novel antibacterial therapies and mechanisms of resistance in both Gram-positive and Gram-negative bacteria. -
Bacterial Inhibitor
Tuberculosis Inhibitor 3 (Compound 2i) is a potent antibacterial agent targeting Mycobacterium tuberculosis, demonstrating a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL against both sensitive and resistant strains. This compound exhibits favorable pharmacokinetic properties, including adequate oral bioavailability, making it a promising candidate for further research and development in tuberculosis treatment strategies. -
Antibacterial Agent
Octenidine is a potent antibacterial agent that targets multidrug-resistant Gram-negative pathogens. It effectively inhibits the expression of biofilm-associated genes, thereby disrupting biofilm formation. This compound is valuable for research applications focused on combating bacterial resistance and studying biofilm dynamics in various infectious environments. -
Bacterial Translation Inhibitor
NOSO-502 is a bacterial translation inhibitor that targets ribosomal activity in Enterobacteriaceae. It demonstrates potent antibacterial properties while maintaining a favorable safety profile. This compound is suitable for research applications focused on bacterial protein synthesis and the development of novel antimicrobial agents. -
Antibacterial Agent
Antibacterial agent 111 targets tyrosyl-tRNA synthetase, displaying potent antibacterial activity with minimum inhibitory concentration (MIC) values of 3.90 μg/mL against Bacillus cereus and 0.49 μg/mL against Klebsiella pneumoniae. This compound is suitable for research applications focused on resistance mechanisms and the development of novel antibacterial therapies. Its specific action on tRNA synthetase provides insight into protein synthesis inhibition pathways in bacterial pathogens. -
Antibacterial Agent
Miocamycin is a macrolide antibiotic derived from midecamycin, a natural product isolated from Streptomyces mycarofaciens. It exhibits significant antibacterial activity, making it a valuable tool for research in microbiology and antibiotic development. Miocamycin can be utilized to investigate the efficacy of macrolide compounds against various bacterial strains and contribute to the understanding of antibiotic resistance mechanisms. -
Bacterial Inhibitor
Antitubercular agent-10 is a bacterial inhibitor that demonstrates potent antitubercular activity, exhibiting a minimum inhibitory concentration (MIC) of 30 nM. This compound is primarily utilized in research focused on combating tuberculosis, enabling investigations into its mechanisms of action and potential therapeutic strategies. Its effectiveness makes it a valuable tool for studying mycobacterial infections and the development of novel antitubercular therapies. -
Antimycobacterial Agent
Amycolatopsin A is a 20-membered macrolide that acts as an effective antimycobacterial agent. It demonstrates notable inhibitory activity against Mycobacterium bovis (BCG) and Mycobacterium tuberculosis (H37Rv), with IC50 values of 0.4 µM and 4.4 µM, respectively. This compound could be valuable for research applications focused on tuberculosis and related mycobacterial infections. -
Bacterial Inhibitor
CGI-17341 is a 5-nitroimidazole antibacterial agent targeting bacterial pathogens, specifically Mycobacterium tuberculosis. This compound demonstrates significant inhibitory activity against both sensitive and multidrug-resistant strains of M. tuberculosis in vitro. In vivo studies indicate that CGI-17341 can prolong the survival time of infected mice in a dose-dependent manner, making it a valuable tool for research on tuberculosis and related bacterial infections. -
Antibacterial Agent
Antibacterial agent 87 (Compound 4h) is a potent antibacterial compound targeting bacterial cell wall synthesis. It exhibits minimal inhibitory concentration (MIC) values of 0.125 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA), 0.0625 μg/mL against methicillin-resistant Staphylococcus epidermidis (MRSE), and 0.0625 μg/mL against Staphylococcus aureus. This reagent is suitable for research applications focused on combating antibiotic-resistant bacterial infections and studying bacterial pathogenesis. -
Antibacterial Peptide
Astacidin 1 is an antibacterial peptide that exerts its effects through targeted activity against a wide range of bacterial pathogens. Produced via proteolytic cleavage from hemocyanin under acidic conditions, Astacidin 1 demonstrates broad-spectrum antibacterial activity, effectively inhibiting the growth of both Gram-positive and Gram-negative bacteria. This peptide serves as a valuable tool for antimicrobial research and the development of new therapeutic strategies. -
Bacterial Inhibitor
Cephabacin M4 is a cephalosporin derivative, specifically a 7-methoxydesacetylcephalosporin, that functions as a bacterial inhibitor. It exhibits significant antimicrobial activity against a range of bacterial pathogens, making it valuable for research involving antibiotic development and bacterial resistance studies. Isolated from the culture filtrate of Xanthomonas lactamica, Cephabacin M4 serves as a useful tool in exploring cephalosporin efficacy and mechanisms of action. -
Antibacterial Agent
Sampsone B is a dihydrodibenzodioxinone-type antibacterial agent that exhibits activity against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of ≥128 μg/mL. This compound can be naturally sourced from the aerial parts of Hypericum sampsonii, including its stems and leaves. Sampsone B is valuable for research focused on antibiotic resistance and the development of new antibacterial therapies. -
Anti-Mycobacterial Agent
BM635 mesylate is an MmpL3 inhibitor exhibiting potent anti-mycobacterial activity. It demonstrates a MIC50 of 0.6 μM against Mycobacterium tuberculosis H37Rv, highlighting its efficacy in combating tuberculosis. The mesylate form enhances bioavailability compared to the free-base variant, making it a significant candidate for tuberculosis research applications. -
Bacterial
AHU1 is a specific inhibitor of Shiga toxin type 2 expression in Escherichia coli O157:H7, exerting its effects through the modulation of the SOS response via interactions with the RecA protein. This compound demonstrates a dose-dependent reduction in toxin activity, making it a valuable tool for studying bacterial toxin regulation and pathogenesis. AHU1 is suitable for research applications focused on bacterial infections and microbial resistance mechanisms. -
Antibacterial Agent
Antibacterial Agent 121 primarily targets bacterial infections as a potent antibacterial agent. It exhibits significant anti-mycobacterial properties along with anti-inflammatory effects, making it valuable in the study of tuberculosis (TB). This compound is especially relevant for research focused on developing new therapeutic strategies for bacterial infections and understanding inflammation-related mechanisms associated with TB. -
Antibacterial Agent
Ashimycin A is a Streptomyces-derived antibiotic that exhibits broad-spectrum antibacterial activity. It targets bacterial cell wall synthesis, making it effective against various gram-positive and gram-negative bacteria. This compound is primarily used in research focused on antimicrobial resistance, providing insights into potential new therapeutic strategies. -
Antibacterial Agent
α/β-Hydrolase-IN-1 is a potent antibacterial agent that demonstrates effective inhibitory activity against key mycobacterial strains. It exhibits minimum inhibitory concentrations (MICs) of 50 μM against Mycobacterium smegmatis and 16 μM against Mycobacterium tuberculosis H37Ra. This compound serves as a valuable tool for researching antibacterial mechanisms and developing new therapies targeting mycobacterial infections. -
Antibacterial Agent
Sulfaperin, also known as Methylsulfadiazin, functions as an antibacterial agent by inhibiting bacterial folic acid synthesis. This compound demonstrates effective activity against a broad spectrum of Gram-positive and Gram-negative bacteria. It is commonly utilized in microbiological research and studies focused on antibiotic resistance mechanisms. -
Antimicrobial
4-Ethoxycoumarin is a coumarin derivative with demonstrated antimicrobial activity. It exerts its effects by targeting and inhibiting microbial growth, making it valuable for research into antibacterial and antifungal mechanisms. This compound is frequently utilized in studies assessing the efficacy of antimicrobial agents and investigating potential therapeutic applications in infectious diseases. -
Anticancer/antibacterial/antimalarial Agent
25-Hydroperoxycycloart-23-en-3β-ol is a multifunctional compound with notable anticancer, antibacterial, and antimalarial properties. Isolated from Blepharodon nitidum, it demonstrates significant cytotoxic effects against various tumor cell lines, including large cell lung cancer, melanoma, colon adenocarcinoma, and chronic myelogenous leukemia. Additionally, this compound exhibits anti-Mycobacterium tuberculosis and antileishmanial activities, making it a valuable tool for research in cancer therapeutics and infectious disease studies. -
Bacterial
Antibacterial agent 72 selectively targets bacterial membranes, exerting potent antibacterial activity. This compound can be utilized in research applications focused on bacterial pathogenesis, resistance mechanisms, and the development of novel antimicrobial therapies. Its mechanism of action makes it a valuable tool in understanding bacterial cell integrity and function. -
Antibacterial Agent
Antibacterial agent 86 (Compound A11) functions as a potent bacteriostatic agent against methicillin-resistant Staphylococcus aureus (MRSA). It exhibits exceptional activity with minimum inhibitory concentration (MIC) values as low as 0.00191 μg/mL, outperforming traditional antibiotics such as tiamulin and retapamulin by 162 and 32 times, respectively. This compound is suitable for research applications focusing on antibiotic resistance and the development of new therapeutic strategies against MRSA infections. -
Antibacterial Agent
E-3709 is an antibacterial agent that targets Gram-positive bacteria. It demonstrates potent inhibitory activity against a range of pathogens, including Staphylococcus aureus (MRSA), Enterococcus faecalis, various streptococci, Clostridia, and diphtheroids. This compound is suitable for research applications focused on Gram-positive bacterial infections, providing valuable insights into potential therapeutic strategies. -
Antibacterial Agent
Neoabietic acid is an abietic-type acid derived from the oleoresin and rosin of Pinus palustris, exhibiting significant antibacterial properties. Its mechanism involves the disruption of bacterial cell membranes, leading to cell death. This compound is valuable in research focused on antibacterial agents and their potential applications in drug development and infection control. -
Anti-tuberculosis Drug
MMV676584 is an investigational anti-tuberculosis drug that demonstrates inhibitory activity against Mycobacterium tuberculosis. This compound exhibits potential as a therapeutic agent for the treatment of eumycetoma, a chronic fungal infection. Its ability to combat tuberculosis positions MMV676584 as a promising candidate for further research in anti-infective therapies. -
Antibiotic
2'-Amino-2'-deoxyguanosine is a nucleoside antibiotic that targets bacterial replication. It demonstrates lethal activity against specific strains of Escherichia coli, with its antibacterial effects reversible by guanosine and other purine nucleosides. This compound is suitable for studying bacterial infections and understanding the mechanisms of antibiotic resistance. -
Antimycobacterial Agent
AB131 is a potent inhibitor of MSMEG 6649 and Rv2172c, with dissociation constants (Kd) of 0.16 μM and 0.02 μM, respectively. This compound enhances the efficacy of antitubercular agents, making it a valuable tool for researchers studying antimycobacterial mechanisms. Its ability to sensitize mycobacterial infections presents potential applications in therapeutic development and drug resistance studies. -
Antibacterial Agent
Antibacterial Agent 59 is a potent antibacterial compound that targets a range of bacterial strains. It demonstrates significant antibacterial activity, making it suitable for research applications focused on infection control and the development of new antimicrobial therapies. This reagent provides valuable insights into the mechanisms of bacterial resistance and can aid in the discovery of novel antibiotics. -
Bacterial Inhibitor
Antibacterial agent 202 (compound 45c) is a bacterial inhibitor that targets Gram-negative bacteria, demonstrating significant antibacterial activity against strains such as Escherichia coli, Klebsiella pneumoniae, and especially Pseudomonas aeruginosa, with a minimum inhibitory concentration (MIC) ranging from 7.8 to 31.25 μM. This compound functions by disrupting the integrity of bacterial cell membranes, making it a valuable tool for research into bacterial infections and potential therapeutic applications. -
Antibacterial Agent
Antibacterial Agent 49 targets bacterial pathogens, exhibiting potent antimicrobial properties. This compound demonstrates significant activity against a range of Gram-positive and Gram-negative bacteria, making it valuable for research in infectious disease and antibiotic resistance. Its efficacy in disrupting bacterial growth positions it as a promising candidate for the development of new antibacterial therapies. -
Antibacterial Agent
Antibacterial Agent 40 is a potent antibacterial compound that targets bacterial cell wall synthesis, leading to disruption of cellular integrity. This agent exhibits significant activity against a broad spectrum of bacterial pathogens, making it valuable for research in antibiotic development and the study of bacterial resistance mechanisms. It is useful for evaluating the efficacy of new antibacterial treatments and understanding bacterial biology. -
Bacterial
Cefbuperazone sodium is a broad-spectrum antibacterial agent targeting various bacterial infections. It exhibits potent antimicrobial activity and a linear pharmacokinetic profile, ensuring reliable dosing parameters in clinical applications. Following intravenous administration, Cefbuperazone sodium achieves peak plasma concentrations, reflecting its rapid absorption and distribution. The compound is primarily eliminated unchanged through the renal system, underscoring its effectiveness in treating infections. -
Antibacterial Agent
Antibacterial Agent 107 is a potent antibacterial compound primarily targeting Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. This agent exhibits low hemolytic activity and high membrane selectivity, demonstrating rapid bactericidal effects. Additionally, Antibacterial Agent 107 has shown effective in vivo efficacy in murine models of bacterial keratitis caused by Staphylococcus aureus ATCC29213, highlighting its potential for therapeutic applications in bacterial infections. -
Antibacterial Agent
4'-O-Methyl-8-prenylnaringenin is a prenylated flavonoid known for its antibacterial activity. It enhances cell penetration and disrupts bacterial cell membranes or walls, effectively targeting various bacteria. Minimum inhibitory concentrations (MICs) have been reported as 32 μg/mL for Staphylococcus aureus and Bacillus subtilis, and 128 μg/mL for Pseudomonas aeruginosa, highlighting its potential for research applications in antimicrobial studies. -
Antibacterial agent
FtsZ-IN-9 is an antibacterial agent targeting the essential protein FtsZ, which is critical for bacterial cell division. By specifically inhibiting the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ), FtsZ-IN-9 disrupts bacterial proliferation. This compound is valuable for research focused on developing novel antimicrobial therapies and understanding bacterial cell division mechanisms. -
Bacterial Inhibitor
BPH-651 is a bacterial inhibitor that targets dehydrosqualene synthase, an essential enzyme involved in bacterial terpenoid biosynthesis. This compound exhibits potent antibacterial activity by binding to multiple sites on the enzyme, revealing structural insights into the mechanism of action and inhibition of head-to-head prenyltransferase. BPH-651 is useful for research focused on designing new antibacterial agents and studying bacterial resistance mechanisms. -
Bacterial Inhibitor
Antistaphylococcal agent 1 functions as a bacterial inhibitor, specifically targeting Staphylococcus species. This compound exhibits significant antimicrobial activity, making it a valuable tool in the study of bacterial infections and resistance mechanisms. Its application can aid in the development of novel therapeutic strategies against staphylococcal infections. -
Anti-Bacterial Agent
Furanomycin is an anti-bacterial agent that exhibits broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria. This compound inhibits the bacteriophage of Escherichia coli and acts as a competitive antagonist of L-isoleucine, making it a valuable tool for exploring bacterial resistance mechanisms and characterizing amino acid transport pathways. Its diverse biological activity supports a range of research applications in microbiology and antibiotic discovery. -
Anti-bacterial Agent
8-Br-GTP is a GTP analog that serves as a competitive inhibitor of FtsZ polymerization and GTPase activity, exhibiting a Ki value of 31.8 μM. This compound demonstrates antibacterial properties and can be utilized for nucleic acid modification in various research applications, particularly in the study of bacterial cell division and antibiotic resistance mechanisms. -
Antibacterial Agent
ATD-3169 is an antibacterial agent that functions by enhancing endogenous reactive oxygen species (ROS), including superoxide radicals. This mechanism of action effectively inhibits the growth of Mycobacterium tuberculosis (Mtb). ATD-3169 is a valuable tool for research applications aimed at understanding and combating tuberculosis infections. -
Bacterial Inhibitor
(Rac)-DNDI-8219 is a bacterial inhibitor with demonstrated efficacy against Leishmania species. This compound exhibits potent antituberculosis and anti-leishmanial activities, showcasing significant effectiveness in both the Leishmania donovani mouse model and the Leishmania infantum hamster model. Interestingly, the R-6 candidate form of (Rac)-DNDI-8219 offers excellent oral bioavailability and efficacy in the hamster model, making it a valuable tool for research focused on treating leishmaniasis and tuberculosis. -
Antibacterial Agent
CYP3A4 enzyme-IN-1 is a potent antibacterial agent that specifically targets and inhibits bacterial growth, demonstrating a minimum inhibitory concentration (MIC) of 1 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Additionally, this compound exhibits low to moderate inhibitory effects on various cytochrome P450 enzymes, including CYP1A2, CYP2E1, CYP2D6, and CYP3A4. It serves as a valuable tool for studying antibacterial mechanisms and exploring potential therapeutic applications in infectious diseases.
