Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic
Erythromycin A dihydrate is a macrolide antibiotic that targets the bacterial 50S ribosomal subunit, effectively inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. It possesses a broad spectrum of antimicrobial activity and is commonly used in microbiological research. Additionally, Erythromycin A dihydrate has demonstrated antitumor and neuroprotective effects, making it valuable for diverse applications in biological research. -
Antibiotic
Erythromycin stearate is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, leading to the inhibition of RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. It exhibits a broad spectrum of antimicrobial activity against various gram-positive and some gram-negative bacteria. In addition to its antibacterial properties, erythromycin stearate has been investigated for its potential antitumor and neuroprotective effects, making it suitable for diverse research applications in microbiology and cancer studies. -
DENV NS5 RdRp Inhibitor
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is a nucleotide analog that serves as a potent inhibitor of DENV NS5 RNA-dependent RNA polymerase (RdRp). Functioning as a chain terminator, it effectively suppresses RNA synthesis, making it a valuable tool in virology research. With an IC50 of 0.02 μM against DENV NS5 RdRp, this compound is crucial for studies focusing on antiviral mechanisms and the development of therapeutic strategies targeting dengue virus infections. -
HIV-1 Inhibitor
SJP-L-5 is an HIV-1 capsid dissociation inhibitor that targets the HIV-1 viral capsid, preventing its normal function. It demonstrates significant inhibitory activity against various HIV-1 strains, with an EC50 ranging from 0.16 to 0.97 μg/mL. By effectively blocking the entry of HIV-1 viral DNA into the nucleus, SJP-L-5 offers valuable potential for applications in HIV-1 infection research and development of antiviral therapies. -
Antibacterial Agent
A-65282 is an antibacterial agent that inhibits P4 DNA unknotting, exhibiting an IC50 value of 8 µg/mL. This compound induces DNA breakage through the action of calf thymus topoisomerase II, making it a valuable tool for studying DNA replication and repair mechanisms. Its targeted enzymatic disruption highlights its potential in antibacterial research contexts. -
Antibiotic
Eponemycin is an antibiotic with significant antitumor properties, targeting cancer cell proliferation. It demonstrates potent cytotoxicity against various cancer cell lines including B16-F10, L1210, P388, and HCT-116, with IC50 values of 0.0017, 0.01, 0.031, and 0.0097 µg/mL, respectively. Additionally, Eponemycin effectively inhibits DNA synthesis in the B16-F10 cell line, exhibiting an IC50 of 0.1 µg/mL, thereby demonstrating its utility in cancer research applications focused on DNA replication and cell viability. -
Antibacterial Agent
Anti-MRSA agent 28 is an antibacterial agent specifically designed to target multidrug-resistant (MDR) gram-positive bacterial strains. With minimum inhibitory concentrations (MICs) ranging from 0.06 to 0.125 μg/mL, it effectively inhibits bacterial growth by targeting DNA polymerase IIIC, demonstrating an IC50 of 3.80 μg/mL. This compound exhibits strong antibacterial activity and has anti-inflammatory properties, making it a valuable tool for research applications related to the treatment of gram-positive infections. -
Antiviral Agent
Antiviral agent 67 (compound PC6) is a potent inhibitor of the dengue virus (DENV) NS5 RNA-dependent RNA polymerase, exhibiting a Ki value of 1.12 nM. It demonstrates significant antiviral activity, making it a valuable tool for research focused on DENV replication and antiviral drug discovery. This compound is suitable for studies aimed at understanding the mechanisms of antiviral action and evaluating potential therapeutic strategies against dengue virus infections. -
Antitumor Antibiotic
2-Hydroxyaclacinomycin A is an anthracycline antibiotic that exerts its antitumor effects through the inhibition of RNA and DNA synthesis. It demonstrates potent cytotoxic activity against leukemia L-1210 cells, with IC50 values of 0.10 μg/mL and 0.95 μg/mL for RNA and DNA synthesis, respectively. This compound is valuable for research focused on cancer therapeutics and the cellular mechanisms of anthracycline antibiotics. -
Antitumor Antibiotic
1-Hydroxyoxaunomycin is an antitumor antibiotic that targets cellular proliferation. It effectively inhibits U210 cell growth, demonstrating IC50 values of 0.0005 μg/mL for cell growth, 1.00 μg/mL for DNA synthesis, and 0.76 μg/mL for RNA synthesis. This compound is primarily utilized in cancer research to explore mechanisms of action related to nucleic acid synthesis and cellular function. -
Antibacterial Agent
DV-7751A is a fluoroquinolone antibiotic that primarily inhibits the supercoiling activity of DNA gyrases. This compound demonstrates significant antimicrobial activity against a range of bacterial strains, including Streptococcus pneumoniae, Streptococcus pyogenes, and Peptostreptococcus species. Additionally, DV-7751A exhibits a rapid bactericidal effect against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, making it a valuable reagent for research in antibacterial therapeutics. -
Antibiotic
Erythromycin glutamate is a macrolide antibiotic that primarily targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis by blocking transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity against various bacterial pathogens. In addition to its antibiotic properties, erythromycin glutamate has shown potential antitumor and neuroprotective effects, making it valuable for diverse research applications in microbiology, oncology, and neurobiology. -
AntibioticAgent
GSK299423 is an antibiotic agent primarily targeting DNA gyrase. It exhibits potent inhibition of supercoiling in Staphylococcus aureus with an IC50 of 14 nM and in Escherichia coli with an IC50 of 100 nM. This compound is suitable for research applications focused on antibacterial mechanisms and the evaluation of DNA-targeting therapies. -
Antibiotic
Viquidacin is an antibiotic that primarily targets topoisomerase IV and DNA gyrase. It demonstrates significant antibacterial activity against gram-positive bacteria, particularly Staphylococcus aureus, by inhibiting supercoiling, decatenation, and relaxation processes. Viquidacin also exhibits activity against Escherichia coli and shows a minimum inhibitory concentration (MIC) range of 2-128 mg/L against wild-type and mutant strains of S. aureus, making it a valuable reagent for antibacterial research applications. -
Antibiotic
Erythromycin hydrochloride is a macrolide antibiotic that acts as a protein synthesis inhibitor, targeting bacterial ribosomes. It demonstrates broad-spectrum activity against both Gram-positive and some Gram-negative bacteria, making it effective in treating various bacterial infections, including respiratory and skin infections. Additionally, erythromycin hydrochloride has been implicated in the inhibition of mammalian mRNA splicing, indicating potential roles in research related to gene expression and cellular function. This compound is widely utilized in biomedical research for its antibacterial properties and mechanisms. -
Anti-HIV Agent
3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analog that serves as an anti-HIV agent by acting as a chain terminator. Incorporated into the nascent DNA strand by HIV reverse transcriptase, AZddCTP halts DNA synthesis due to its lack of a 3'-hydroxyl group, effectively inhibiting viral replication. With IC50 values of 15.6 μM against wild-type HIV and 160.8 μM for AZTR HIV, 3′-Azido-2′,3′-dideoxy-CTP demonstrates significant antiviral activity, making it a valuable tool in HIV research. -
Insecticide/Antibacterial Agent
Satranidazole is an orally active insecticide and antimicrobial agent that primarily targets DNA through the formation of reduced nitro intermediates. By inducing helix instability and strand breakage, it exhibits notable antitrichomonal activity against organisms such as Trichomonas vaginalis and Trichomonas foetus, as well as antiamoebic effects in rodent models of hepatic and caecal amoebiasis. Additionally, Satranidazole has been shown to inhibit the replication of bacteriophage φX174 DNA. This compound is valuable for research exploring caecal amoebiasis, trichomoniasis, and anaerobic bacterial infections. -
Anticancer Agent
Endusamycin is an anticancer agent that inhibits protein and nucleic acid synthesis in Ehrlich ascites carcinoma cells. This selective activity contributes to its efficacy as a potential therapeutic for cancer research, while exhibiting no antibacterial or antifungal effects. Endusamycin is suitable for studies aimed at understanding cancer cell metabolism and the development of new cancer treatment strategies. -
FgGpmk1 Inhibitor
FgGpmk1-IN-1 is a selective inhibitor of the Fusarium graminearum mitogen-activated protein kinase (FgGpmk1), exhibiting an EC50 value of 3.46 μg/mL. This compound is valuable for investigating the biological role of FgGpmk1 in fungal pathogenesis and offers potential applications in the study of plant-fungal interactions. Researchers can utilize FgGpmk1-IN-1 to explore therapeutic strategies against Fusarium-related diseases. -
Heterocyclic Compound
Indazole, a heterocyclic aromatic compound, exhibits significant biological activity through its diverse derivatives. These derivatives are known for their anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal, and antitumor properties. Indazole and its derivatives are valuable tools for research into cancer, neurological disorders, cardiovascular diseases, and gastrointestinal diseases, highlighting their potential in various therapeutic applications. -
Antibiotic
Luisol A is an anthraquinone antibiotic analog derived from an aromatic tetraol, recognized as a major metabolite of Streptomyces, a marine actinomycete. This compound exhibits significant antibacterial activity, making it a valuable tool in the study of antibiotic mechanisms and resistance. Its application in research aids in the exploration of novel antimicrobial agents and their effects on various bacterial strains. -
Bacterial Inhibitor
Aniline-MPB-amino-C3-PBD is a cytotoxic agent targeting bacterial cells through minor-groove binding of DNA. This sequence-selective compound serves as an effective payload for antibody-drug conjugates (ADCs), enhancing their therapeutic efficacy. Its antimicrobial properties make it a valuable tool for research in bacterial inhibition and related applications. -
Antibiotic
Agrochelin is an alkaloid antibiotic with cytotoxic properties, derived from the fermentation of marine Agrobacterium species. This compound exhibits significant cytotoxic activity against various tumor cell lines, making it a valuable tool in cancer research. Agrochelin's mechanism of action may provide insights into antibiotic efficacy and the development of novel therapeutic strategies for oncological applications. -
Bacterial Inhibitor
Py-MPB-amino-C3-PBD is a cytotoxic agent that functions as a bacterial inhibitor. This compound serves as a payload for antibody-drug conjugates (ADCs) and exhibits significant antimicrobial activity. Its unique structure, characterized by a non-alkylating group, makes it a valuable tool for research applications aimed at targeting bacterial infections and developing therapeutics in the field of microbiology. -
Recombinant Bacterial Clones Chromogenic Substrate
X-GalNAc is a chromogenic substrate that specifically targets N-acetyl-β-galactosidase. This reagent is utilized in molecular biology to detect the presence of cloned DNA inserts in bacterial colonies cultured on agar plates. The enzymatic hydrolysis of X-GalNAc results in a distinct color change, facilitating easy identification of recombinant bacterial clones in various genetic research applications. -
Bacterial Inhibitor
Resazurin sodium is a non-toxic, stable redox indicator that targets bacterial activity through its membrane-permeable properties. It serves as a vital tool for assessing cell viability, proliferation, and toxicity in various cell types, including human, plant, animal, bacterial, and fungal cells. Upon reduction, Resazurin sodium transforms into Resorufin, a highly fluorescent compound, enabling sensitive detection and quantification of cellular processes under fluorescent microscopy or spectrophotometry. -
Antibacterial Agent
ANS ammonium is a potent antibacterial agent that also serves as a textile dye. It functions as a fluorescence probe, enabling the detection of various biological interactions. Additionally, ANS ammonium is known to inhibit the binding of triiodothyronine to thyroxine binding globulin, making it useful in radioimmunoassays for triiodothyronine analysis. -
Bacterial Inhibitor
4-Methylherniarin, a coumarin derivative, exhibits antibacterial activity by effectively inhibiting both gram-positive and gram-negative bacterial strains. It demonstrates significant antimicrobial efficacy against B. subtilis and S. sonnei, with IC50 values of 11.76 μg/ml and 13.47 μg/ml, respectively. This compound serves as a valuable tool for research applications focused on combating bacterial infections and elucidating mechanisms of action in microbial resistance. -
Antibiotic Agent
Polyketomycin is a tetracyclic quinone glycoside antibiotic derived from Streptomyces sp. or Streptomyces diastatochromogenes, targeting Gram-positive bacteria with a minimal inhibitory concentration (MIC) of less than 0.2 µg/mL. This compound exhibits notable antibacterial, anticancer, and antimalarial activities, making it a valuable tool in microbiological and pharmacological research. Its diverse biological applications support investigations in antibiotic efficacy, cancer treatment, and antimalarial drug development. -
Antitumor Antibiotic
Sandramycin is a cyclic depsipeptide antibiotic with a primary mechanism of action as an antitumor agent. It exhibits potent DNA intercalation and binding, functioning effectively as a cytotoxin in antibody-drug conjugates (ADCs). Sandramycin demonstrates significant activity against Gram-positive bacteria and is recognized for its strong antitumor efficacy, making it a valuable reagent for cancer research and the development of targeted therapies. -
Dengue Protease Inhibitor
Carbonic anhydrase inhibitor 16 is a potent dengue protease inhibitor that targets human carbonic anhydrases I and II, exhibiting inhibitory constants (Ki) of 28.5 nM and 2.2 nM, respectively. This compound demonstrates significant biological activity in hindering dengue virus replication by disrupting protease function. It may be utilized in research applications aimed at elucidating mechanisms of dengue virus pathogenesis and developing antiviral therapeutics. -
Bacterial Inhibitor
Procodazole is a potent bacterial inhibitor that enhances immune response, offering protection against various viral and bacterial infections. In addition to its broad-spectrum antibacterial effects, Procodazole demonstrates antiparasitic activity and serves as a carbonic anhydrase inhibitor, contributing to its antitumor properties. This compound is suitable for research applications focused on infectious diseases and cancer biology. -
Nucleoside Antibiotic
Dealanylascamycin is a nucleoside antibiotic that functions as a carbonic anhydrase (CA) inhibitor, exhibiting Ki values of 167, 65.2, 234, and 143 nM for human CA isoforms I, II, IV, and IX, respectively. This compound demonstrates broad-spectrum antibacterial activity, notably effective against pathogens such as Xanthomonas citri with a minimum inhibitory concentration (MIC) of 0.4 μg/mL. Additionally, Dealanylascamycin displays significant cytotoxicity, making it a substance of interest for various biological research applications, particularly in the study of antimicrobial effects and CA inhibition. -
HIV Inhibitor
ZL0580 is an HIV inhibitor that functions by selectively binding to the BD1 domain of BRD4, leading to epigenetic suppression of the virus. This compound effectively inhibits Tat transactivation and transcription elongation while promoting a repressive chromatin structure at the HIV promoter. ZL0580 is valuable for research applications focused on HIV therapies and the mechanisms of viral transcription regulation. -
HIV-1 LRA
UMB-136 is a bromodomain inhibitor targeting HIV-1 latency. It serves as a promising latency-reversing agent (LRA) for the eradication of HIV-1, effectively reactivating the virus in various cell models. UMB-136 enhances HIV-1 transcription and promotes viral production by facilitating the release of P-TEFb, thereby contributing to research in HIV treatment strategies. -
Phytoestrogen
3,7-Dihydroxyflavone is a flavonoid phytoestrogen that modulates estrogen receptors, making it a valuable compound for research in hormonal signaling pathways. It serves as an inhibitor of the human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase, demonstrating redox inhibitory activity with IC50 values of 0.6 μM and 6.0 μM, respectively. Additionally, 3,7-Dihydroxyflavone exhibits fluorescence properties, acting as a binding substrate for human serum albumin with specific excitation and emission wavelengths, rendering it useful for biochemical assays and studies related to protein binding interactions. -
Bacterial Metabolite
12-Tridecenoic acid is a bacterial metabolite that plays a crucial role in the regulation of lipid metabolism. It promotes the expression of acetyl-CoA carboxylase α (ACC) while inhibiting carnitine palmitoyltransferase 1A (CPT1A), contributing to the development of hepatic steatosis. This compound is relevant for research in metabolic diseases and cellular lipid regulation. -
Antibacterial Agent
Metioprim is a competitive inhibitor of bacterial dihydrofolate reductase (DHFR), targeting critical pathways in bacterial folate metabolism. It exhibits potent antibacterial activity against anaerobic bacteria and demonstrates synergistic effects when combined with DDS against E. coli and various mycobacterial strains. This reagent is valuable for antibacterial research and development, particularly in studies focused on antibiotic resistance and the efficacy of combination therapies. -
Antibacterial Agent
AR-102 is an antibacterial agent that exhibits potent inhibitory activity against Staphylococcus aureus. It demonstrates competitive inhibition of the F98Y mutant dihydrofolate reductase (DHFR) with a Ki value of 0.22 nM. Structural studies have characterized AR-102 as forming a ternary complex with NADPH in both wild-type and TMP-resistant F98Y mutant S. aureus DHFR, making it a valuable compound for research on antibacterial resistance mechanisms. -
Mitotic kinesin Inhibitor
Mitotic kinesin-IN-1 hydrochloride is a potent inhibitor of mitotic kinesin, specifically designed to disrupt the process of mitosis. This compound effectively impairs cell proliferation and has applications in cancer research, as well as investigations into cardiac hypertrophy, immune and inflammatory disorders, and fungal infections. Its ability to hinder mitotic activity makes it a valuable tool for studying various cellular processes and pathways related to these conditions. -
HIV Protease Inhibitor
Palinavir is a potent inhibitor of HIV-1 and HIV-2 proteases, exhibiting an IC50 range of 0.5-30 nM. It demonstrates significant antiviral activity, making it valuable for research focused on HIV treatment strategies and drug development. Palinavir's mechanism of action targets the viral protease enzyme, disrupting the replication cycle of the virus and providing insights into HIV pathogenesis and therapeutic interventions. -
HIV-1 Protease Inhibitor
Lasinavir (CGP 61755) is a selective inhibitor of HIV-1 protease, exhibiting an IC50 value of 1 nM. This compound demonstrates significant antiviral activity against HIV-1, making it a valuable tool for studying HIV-1 infection and pathogenesis. Lasinavir is applicable in research focused on antiretroviral therapies and the mechanism of protease inhibition in viral replication. -
HIV Protease Inhibitor
L-689502 is a potent HIV protease inhibitor with an IC50 of 1 nM. This compound effectively disrupts the proteolytic activity of HIV-1 protease, thereby inhibiting viral replication. L-689502 is valuable for research into antiretroviral therapies and mechanisms of HIV resistance. -
Chitinase Inhibitor
Argifin is a potent chitinase inhibitor that demonstrates sub-nanomolar activity, targeting multiple chitinase enzymes. It exhibits impressive IC50 values of 0.025 μM for SmChiA from Serratia marcescens, 6.4 μM for SmChiB, 1.1 μM for Aspergillus fumigatus chitinase B1, and 4.5 μM for human chitotriosidase. Argifin is instrumental in studies exploring chitin metabolism and offers potential applications in antifungal research and elucidation of chitinase-related diseases. -
Antiplasmodial Agent
19,20-Epoxycytochalasin D is a cytochalasin derived from the fungal species Nemania sp. It exhibits significant in vitro antiplasmodial activity, making it a valuable compound for malaria research. Additionally, it demonstrates phytotoxic properties, indicating its potential use in studies related to plant biology and herbicide development. -
SDH Inhibitor
Succinate dehydrogenase-IN-2 is a potent inhibitor targeting succinate dehydrogenase (SDH) with an IC50 value of 1.22 mg/L. This compound demonstrates significant antifungal activity, effectively inhibiting a range of fungal pathogens including S. sclerotiorum, V. mali, G. graminis, R. solani, and B. cinerea, with EC50 values in the range of 0.52-3.42 mg/L. It is a valuable tool for research applications focusing on fungal infections and metabolic pathways involving SDH. -
HIV-1 Capsid Inhibitor
Lenacapavir is an HIV-1 capsid inhibitor that targets the interface between capsid hexamers and CA monomers, disrupting capsid assembly and viral maturation. This compound inhibits the nuclear translocation of HIV-1 DNA and interferes with CA-mediated protein-protein interactions, resulting in reduced formation of 2-LTR circles and pre-integration proviruses. Additionally, Lenacapavir induces aberrant capsids and decreases the production of mature HIV-1. It demonstrates efficacy against various HIV-1 subtypes and clinical isolates, making it a valuable reagent for research on HIV-1 infection. -
HIV-1 RT Inhibitor
Tenofovir diphosphate disodium is a potent inhibitor of HIV-1 reverse transcriptase, with a Ki value of 1.55 μM for DNA and 0.022 μM for RNA. This compound exhibits key biological activity as an antiretroviral agent, making it a valuable tool for the study of HIV and AIDS. It is suitable for research applications focused on understanding viral replication and developing therapeutic strategies against HIV infection. -
HIV-1 TAT Peptide
TAT (YGRKKRRQRRR) is a cell-penetrating peptide derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1). It enhances the solubility and yield of heterologous proteins, making it a valuable tool in research applications related to protein expression and purification. TAT's ability to facilitate cellular uptake has made it a useful reagent in studies exploring intracellular delivery mechanisms and molecular therapeutics. -
HIV-1 Inhibitor
PYR01 is a non-nucleoside reverse transcriptase inhibitor that targets HIV-1 by activating the death of infected cells. It exhibits significant antiviral activity, demonstrating IC50 values of 27.5 nM and 39.7 nM for cytotoxic and antiviral effects, respectively. By promoting HIV-1 Gag-Pol dimerization and intracellular activation of HIV-1 protease, PYR01 induces selective cytotoxicity in HIV-1-infected cells. This compound is valuable for research focused on HIV biology and therapeutic strategies.
