Catalog No.
Product Name
Application
Product Information
Citations
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Drug Derivative
UDP-rhamnose is the activated form of rhamnose that plays a crucial role in the synthesis of rhamnose-containing glycans in fungi. This nucleotide sugar acts as a key substrate for glycosyltransferases, enabling the assembly of polysaccharides involved in the fungal cell wall. UDP-rhamnose is utilized in research focused on understanding fungal pathogenesis and the development of therapeutics for fungal infections. -
Fungicide
Pyrimethanil is an anilinopyrimidine fungicide that primarily targets the biosynthesis of methionine and other amino acids in Botrytis cinerea. This broad-spectrum contact fungicide effectively controls Botrytis spp. on a variety of crops, including fruits, vegetables, and ornamental plants. Pyrimethanil is utilized in research focused on the prevention of mold infections and the management of fungal diseases in agricultural settings. -
Lignin Intermediate
Coniferyl alcohol is a key intermediate in lignin biosynthesis with antifungal properties. It has been shown to specifically inhibit the growth of fungi such as Verticillium longisporum, as well as impede the growth of Nicotiana benthamiana seedlings. Additionally, coniferyl alcohol demonstrates potential benefits in improving cardiac dysfunction associated with renovascular hypertension and cardiac inflammation, making it valuable for research in both plant pathology and cardiovascular studies. -
Building Block
2,5-Furandimethanol serves as a versatile building block in the enzymatic synthesis of bio-based polyesters. This compound is also a significant metabolite derived from the fungus Phellinus linteus, which has been implicated in the treatment of leukemia. Additionally, 2,5-Furandimethanol may provide insights in the study of fungal infections, making it a valuable reagent in various biological research applications. -
Antifungal Agent
D-Gluconic acid potassium is a carboxylic acid that exhibits antifungal activity through its antiseptic and chelating properties. This compound is suitable for research applications in the field of mycology and can aid in the study of fungal infections and their treatment mechanisms. Its ability to chelate metal ions further enhances its potential utility in various biochemical assays. -
β-1,3-Glucan Inhibitor
Ibrexafungerp is an orally active β-1,3-glucan synthesis inhibitor with demonstrated antifungal properties. Its mechanism targets the cell wall biosynthesis pathway of fungi, making it valuable in research on Candida and Aspergillus infections. This compound is a promising candidate for studies focused on antifungal resistance and the development of new antifungal therapies. -
Antifungal
Prochloraz is an imidazole antifungal agent that primarily functions as a dual antagonist of estrogen receptors (ER) and androgen receptors (AR), as well as an aromatase inhibitor with IC50 values of 25 μM, 4 μM, and 0.3 μM, respectively. Additionally, Prochloraz activates the aryl hydrocarbon receptor (AhR) with an EC50 of 1 μM. This compound is useful in research focused on endocrine disruption and antifungal activity, making it a valuable tool for studies in toxicology and pharmacology. -
Antifungal Agent
2-Phenylethyl isothiocyanate is a potent antifungal agent targeting fungal growth and development. It significantly inhibits spore germination and mycelial growth of Alternaria alternata, exhibiting a minimum inhibitory concentration (MIC) of 1.22 mM. The antifungal action of 2-Phenylethyl isothiocyanate involves the reduction of toxin levels and disruption of cell membrane integrity, making it a valuable compound for research into fungal pathogens and potential therapeutic applications. -
Antifungal/Antibacterial/Antiviral Agent
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide that serves as a broad-spectrum antibacterial, antiviral, and antifungal agent. It is particularly effective in inhibiting aflatoxin production in Aspergillus flavus and exhibits significant antibacterial activity against multi-drug resistant bacteria, especially in its cis configuration. Additionally, Cyclo(L-Leu-L-Pro) demonstrates notable antiviral properties, specifically inhibiting the influenza A virus H3N2. This compound is valuable for research applications focused on infectious diseases and microbial resistance. -
Volatile Organic Compound
2,5-Dimethylcyclohexanol is a volatile organic compound with significant antineoplastic and antiviral properties, particularly through its inhibition of SARS-CoV-2 Mpro. Additionally, it exhibits potent antifungal activity against Pseudogymnoascus destructans, compromising cell wall and membrane integrity while disturbing energy metabolism. This compound increases reactive oxygen species (ROS), ATP, superoxide anions, and glutathione (GSH) levels, while reducing catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, 2,5-Dimethylcyclohexanol influences the expression of virulence-related ribosomal genes and disrupts MAPK signaling pathways, leading to fungal cell apoptosis. -
Fungicide
(Rac)-Epoxiconazole is a chiral triazole fungicide that exhibits inhibitory activity against a wide range of fungal pathogens. This compound demonstrates long-lasting fungicidal effects, making it suitable for agricultural applications where persistent protection is essential. Its persistence in soil is noteworthy, with a reported half-life exceeding 300 days, indicating prolonged efficacy in reducing fungal populations in treated areas. -
Antifungal Agent
Sertaconazole is a broad-spectrum topical antifungal agent that primarily targets fungal cell membranes. It exhibits significant anti-inflammatory activity by activating the p38-COX-2-PGE2 signaling pathway. Additionally, Sertaconazole functions as a microtubule inhibitor, demonstrating antiproliferative effects, and inducing apoptosis and autophagy. Its ability to inhibit cellular migration makes it valuable in various research applications related to fungal infections and inflammatory conditions. -
Ras Inhibitor
(-)-Rasfonin is a natural fungal secondary metabolite that acts as an inhibitor of small G protein Ras. It exhibits significant biological activities, including the induction of apoptosis, necrosis, and autophagy in ACHN cells, a renal carcinoma cell line. This compound is instrumental for research focused on cellular death pathways and therapeutic strategies targeting Ras-mediated signaling in cancer. -
Azoxystrobin Enantiomer
(Z)-Azoxystrobin is an enantiomer of Azoxystrobin, a broad-spectrum β-methoxyacrylate fungicide. It functions by inhibiting mitochondrial respiration through binding to the Qo site of the cytochrome bc1 complex, thereby disrupting electron transfer. The compound is known to induce the production of reactive oxygen species (ROS), ultimately leading to cell apoptosis. It is primarily used in research applications involving fungal inhibition and the study of mitochondrial function. -
Superoxide Anion Inhibitor
Tanzawaic acid B is a potent inhibitor of superoxide anion production, derived from the fungal source Penicillium citrinum. This compound has been demonstrated to mitigate oxidative stress by targeting superoxide radicals, making it valuable for research in oxidative damage and related pathologies. Its biological activity provides a useful tool for studying the effects of reactive oxygen species in various cellular models. -
Anticancer Agent
Endusamycin is an anticancer agent that inhibits protein and nucleic acid synthesis in Ehrlich ascites carcinoma cells. This selective activity contributes to its efficacy as a potential therapeutic for cancer research, while exhibiting no antibacterial or antifungal effects. Endusamycin is suitable for studies aimed at understanding cancer cell metabolism and the development of new cancer treatment strategies. -
Antifungal compound
Amorolfine hydrochloride, is a morpholine antifungal reagent that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. -
antifungal
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines. -
Fungicide
Pyraclostrobin is a strobilurin fungicide that functions by inhibiting mitochondrial respiration in fungi. It exhibits broad-spectrum antifungal activity, effectively controlling various crop diseases. Additionally, Pyraclostrobin has been shown to induce oxidative DNA damage and activate AMPK/mTOR signaling pathways, leading to mitochondrial dysfunction and autophagy. Its applications extend to agricultural settings for the management of fungal pathogens. -
Short-chain Fatty Acid
Magnesium acetate tetrahydrate acts primarily as a short-chain fatty acid (SCFA). It is known to activate AMP-activated protein kinase (AMPK) and increase reactive oxygen species (ROS) levels, leading to the cleavage of caspase 9 and the modulation of peroxisome proliferator-activated receptor alpha (PPARα). Additionally, it downregulates the expression of sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP), and demonstrates antifungal activity against Saccharomyces cerevisiae. Magnesium acetate tetrahydrate has shown promising anticancer effects in gastric cancer and may regulate energy metabolism while exhibiting potential therapeutic effects in ulcerative colitis and hepatic steatosis. -
Large Cyclic Mucor Toxin.
Satratoxin G is a large cyclic mucor toxin that primarily induces apoptosis through the activation of caspases. This compound exhibits potent biological activity, making it a valuable tool for studying apoptosis and cell signaling pathways. Satratoxin G is commonly utilized in research concerning fungal toxins and their effects on mammalian cells, providing insights into potential therapeutic interventions for toxin-related diseases. -
Microbial Metabolite
Oosporein is a microbial metabolite characterized as a red crystalline toxin produced by various fungi. It demonstrates significant biological activity by inhibiting insect immunity, thereby promoting fungal reproduction within host organisms. Additionally, Oosporein exhibits antibacterial, antiviral (specifically against herpes simplex virus), and insecticidal properties. Its effects on plant growth inhibition and its ability to induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage make it a valuable compound for research in multiple fields, including mycology, agriculture, and oncology. -
Myrothecium Fungus Metabolite
Verrucarin J, a metabolite derived from the Myrothecium fungus, primarily targets the induction of reactive oxygen species (ROS) in various cancer cell lines. It has demonstrated significant apoptotic activity in A549, HCT 116, and SW-620 cells. Additionally, Verrucarin J exhibits antifungal properties against Candida albicans and Mucor miehei, and effectively inhibits the arenavirus Junin (JUNV) with an IC50 value of 1.2 ng/mL, highlighting its potential for research in oncology and virology. -
Antiphlogistic Agent
Tomentosin is an orally active natural sesquiterpenoid lactone with primary applications as an antiphlogistic agent. It demonstrates a range of biological activities, including anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant, and neuroprotective effects. Tomentosin has been shown to inhibit tumor cell proliferation, migration, and invasion, while also inducing apoptosis. This compound is valuable for research related to tumors, inflammatory conditions, and neurological disorders. -
Antifungal Agent
Reveromycin A is a benzoquinoid antibiotic that exhibits antifungal properties through its mechanism as a selective inhibitor of protein synthesis in eukaryotic cells. It effectively inhibits bone resorption by inducing apoptosis in osteoclasts and demonstrates antiproliferative activity against various tumor cell lines. This compound is valuable for research applications in studying fungal infections and bone metabolism. -
Antithrombotic/Antifungal Agent
Ajoene is a garlic-derived compound that functions as both an antithrombotic and antifungal agent. It exhibits significant inhibition of cell proliferation and induction of apoptosis in human leukemia cells, including HL-60, U937, HEL, and OCIM-I. This compound is relevant for research in cancer biology and antifungal therapies. -
Apoptosis Activator
Nortrachelogenin, also known as (-)-Wikstromol, is an apoptosis activator isolated from Partrinia scabiosaefolia. It has been shown to induce apoptotic responses in the fungal pathogen Candida albicans, making it a valuable reagent for research on fungal apoptosis and related cellular processes. This compound can facilitate the investigation of therapeutic strategies targeting fungal infections. -
Anticancer/Antifungal Agent
Ilicicolin H is a selective inhibitor of phosphoglycerate kinase 1 (PGK1) and mitochondrial cytochrome bc1 reductase, with an IC50 of 9.02 μM and 2-3 ng/mL, respectively. It effectively inhibits cell proliferation and induces apoptosis in cancer cells, particularly hepatocellular carcinoma (HCC), by reducing lactate production and glucose uptake. Additionally, Ilicicolin H displays broad antifungal activity against pathogens such as Candida albicans, Cryptococcus species, and Aspergillus fumigatus. This compound is suitable for research applications in oncology and infectious diseases. -
Styryl Lactone
Goniothalamin is a styryl lactone that demonstrates insecticidal, anti-tumor, and antibacterial properties. It induces cell cycle arrest and apoptosis in tumor cells, while exhibiting larvicidal effects against Culex quinquefasciatus larvae and cytotoxicity against brine shrimp larvae. Additionally, Goniothalamin shows antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as antifungal efficacy against pathogens such as Candida albicans and Trichophyton species. This compound is relevant for research in breast cancer, lymphatic filariasis, and the treatment of bacterial and fungal infections. -
Cytochrome P450 Inhibitor
Thujopsene is a potent inhibitor of cytochrome P450 enzymes, specifically targeting CYP2B6, CYP3A4, CYP2C19, CYP2C8, and CYP2C9, with IC50 values of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. In addition to its role as a metabolic inhibitor, thujopsene binds to PKM2, disrupting cancer cell metabolic pathways and inducing apoptosis in MKN45 cells, thereby demonstrating significant antitumor activity. This compound also exhibits notable anti-termite and antifungal properties through its autoxidation process, broadening its potential applications in both cancer research and pest control. -
Apoptosis Inducer
2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections. -
Antifungal Peptide
Periplanetasin-2 is an antifungal peptide that exerts its effects primarily through the induction of oxidative stress by generating reactive oxygen species (ROS) and promoting lipid peroxidation. In addition to its antifungal activity, Periplanetasin-2 can also trigger apoptosis in target cells. This compound is valuable for research applications aimed at understanding fungal pathogenesis and evaluating potential therapeutic strategies against fungal infections. -
FASN Inhibitor
Cerulenin is a potent natural inhibitor of fatty acid synthase (FASN), derived from the fungus Cephalosporium caeruleus. It acts by inhibiting topoisomerase I catalytic activity, consequently enhancing apoptosis induced by SN-38. Cerulenin exhibits both antifungal and antitumor properties, making it a valuable tool for research in cancer therapies and fungal infections. -
Antifungal Agent
Iturin A is a cyclic lipopeptide that exhibits potent antifungal activity. Iturin A disrupts fungal cell membranes and induces the production of reactive oxygen species (ROS), leading to apoptosis and autophagy in tumor cells. This compound holds promise for research applications in antifungal therapeutics and cancer biology, showcasing notable antitumor effects. -
Fungicide Agent
Epoxiconazole is a demethylation inhibitor targeting the Ergosterol biosynthesis pathway. It demonstrates significant inhibitory activity against both carbendazim-resistant and phenamacril-resistant fungal isolates. This compound is widely utilized in agricultural research for the control of various crop diseases, contributing to effective crop management strategies. -
Fungicide
Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide that primarily targets the cytochrome bc1 complex, inhibiting mitochondrial respiration through binding at the Qo site. This mechanism disrupts electron transfer, leading to the generation of reactive oxygen species (ROS) and subsequent induction of apoptosis in fungal cells. Azoxystrobin is essential for research applications focusing on fungal physiology, plant pathology, and the development of disease management strategies. -
Fungicide
Fludioxonil is a phenylpyrrole fungicide that targets fungal cell growth by inhibiting the development of plant pathogens such as Sclerotinia sclerotiorum. It exhibits significant biological activity through its ability to disrupt cytoskeletal integrity, induce DNA damage, and promote apoptosis in mouse glioma cells. Additionally, Fludioxonil has been observed to influence tumor growth and metastasis, alongside potential cardiotoxic effects. This compound serves as a valuable tool in agricultural research and studies related to cellular mechanisms of toxicity and cancer progression. -
Antifungal Agent
Isavuconazonium sulfate (BAL8557-002) is an orally active, broad-spectrum antifungal prodrug that is rapidly hydrolyzed in vivo to yield the active triazole compound **Isavuconazole**. It exhibits potent antifungal activity by inhibiting lanosterol 14α-demethylase, a key enzyme in the ergosterol biosynthesis pathway, thereby disrupting fungal cell membrane integrity. Isavuconazonium sulfate is effective against a wide range of pathogenic fungi, including *Aspergillus* and *Mucorales* species, and is used in the study and treatment of invasive aspergillosis, mucormycosis, blastomycosis, and *Acanthamoeba* keratitis. Its excellent oral bioavailability and favorable safety profile make it a valuable therapeutic and research tool in antifungal pharmacology. -
Glucosinolate
Sinigrin, a glucosinolate primarily found in cruciferous vegetables, exhibits significant biological activities including anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, along with the inhibition of fat synthesis. This compound is of particular interest in cancer research, as well as studies focused on inflammatory and metabolic diseases. Its diverse therapeutic potential makes it a valuable reagent for exploring various biological pathways. -
Glucosinolate
Sinigrin hydrate is an allyl-glucosinolate known for its diverse biological activities, primarily targeting glucosinolate pathways. This compound exhibits anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, as well as the ability to inhibit fat synthesis. Sinigrin hydrate is valuable for research into tumor biology, inflammatory processes, and metabolic disorders. -
Furofuran Type Lignan
(+)-Medioresinol is a furofuran-type lignan that exhibits notable antifungal and antibacterial activities. It enhances the efficacy of antibiotics through its antimicrobial and antibiofilm properties and promotes intracellular reactive oxygen species (ROS) accumulation, leading to mitochondrial-mediated apoptosis in Candida albicans. Additionally, (+)-Medioresinol inhibits LPS-stimulated IL-12p40 production and acts as a PGC-1α activator, providing protection against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. This compound is valuable for research into fungal and bacterial infections, inflammatory responses, and ischemic stroke mechanisms. -
Fungicide
Triadimefon is an orally active fungicide targeting various fungal species. It has been shown to significantly reduce the phosphorylation of AKT1 and ERK1/2, while increasing levels of phosphorylated AMPK without affecting total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis impacting testosterone synthesis, and affects fetal adrenal development in rodent models. Additionally, it induces metabolic alterations in hepatocytes and impairs spatial learning and memory. -
Iron Chelator
Desferricoprogen is a hydrophobic fungal iron chelator that targets iron metabolism. It has been shown to reduce atherosclerotic plaque formation and inhibit lipid peroxidation in the aortic roots of ApoE−/− mice on an atherogenic diet. Additionally, Desferricoprogen effectively lowers levels of oxidized LDL (oxLDL) and inhibits the expression of oxLDL-induced genes such as HO-1, CD36, and TNF-α. Furthermore, it prevents TNF-α-induced endothelial cell activation and maintains endothelial monolayer integrity, making it a valuable tool for research on atherosclerosis. -
Anticancer/Antifungal Agent
Schinifoline is a 4-quinolinone that primarily targets cancer cell proliferation and fungal infections. It exhibits potent anticancer activity by inducing G2/M phase arrest and promoting apoptosis in cancer cells, as well as enhancing their radiosensitivity. Additionally, Schinifoline demonstrates significant antifungal properties, making it relevant for research in cancer therapies and infections, particularly regarding lung cancer and Candida albicans. -
Antifungal Agent
Fosravuconazole L-lysine ethanolate, a prodrug of Ravuconazole, acts as an orally bioavailable broad-spectrum antifungal agent. It demonstrates significant efficacy against various fungal infections, making it a valuable tool for research on candidiasis, onychomycosis, and parasitemia. This compound is instrumental in exploring antifungal therapies and evaluating treatment outcomes in fungal-related diseases. -
Fungicide
Kresoxim-methyl is a Strobilurin-based fungicide that primarily targets the cytochrome bc1 complex, inhibiting respiration at complex III. It demonstrates high affinity binding to yeast complex III with an apparent Kd of 0.07 μM. This compound is widely utilized in agricultural research to assess its antifungal activity and its mechanisms in pathogen resistance management. -
jRdRp Inhibitopr
Kulactone is a natural bioflavonoid that functions as an inhibitor of the RNA-dependent RNA polymerase (jRdRp). This compound demonstrates significant antifungal, antibacterial, and antiplasmodial activities, making it a valuable tool in infectious disease research. Additionally, Kulactone is noted for its inability to cross the blood-brain barrier, which may limit its central nervous system effects and enhance its application in peripheral infections. -
Fungicide
Dimethomorph is a fungicide classified as a sterol biosynthesis inhibitor. It effectively disrupts fungal cell wall formation, thereby impeding fungal growth. Additionally, Dimethomorph has been shown to inhibit androgen receptor (AR) activity in MDA-kb2 cells with an IC20 value of 0.263 µM, making it relevant for studies on hormone receptor signaling and fungal pathogenesis.
