2,5-Dimethylcyclohexanol is a volatile organic compound with significant antineoplastic and antiviral properties, particularly through its inhibition of SARS-CoV-2 Mpro. Additionally, it exhibits potent antifungal activity against Pseudogymnoascus destructans, compromising cell wall and membrane integrity while disturbing energy metabolism. This compound increases reactive oxygen species (ROS), ATP, superoxide anions, and glutathione (GSH) levels, while reducing catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, 2,5-Dimethylcyclohexanol influences the expression of virulence-related ribosomal genes and disrupts MAPK signaling pathways, leading to fungal cell apoptosis.
2,5-Dimethylcyclohexanol is a volatile organic compound with significant antineoplastic and antiviral properties, particularly through its inhibition of SARS-CoV-2 Mpro. Additionally, it exhibits potent antifungal activity against Pseudogymnoascus destructans, compromising cell wall and membrane integrity while disturbing energy metabolism. This compound increases reactive oxygen species (ROS), ATP, superoxide anions, and glutathione (GSH) levels, while reducing catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, 2,5-Dimethylcyclohexanol influences the expression of virulence-related ribosomal genes and disrupts MAPK signaling pathways, leading to fungal cell apoptosis.
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