Catalog No.: A11025

Hsp90 inhibitor


Geldanamycin Chemical Structure

CAS NO. 30562-34-6

Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422

Biological Activity

Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.
p185 HSP90 (N-terminal domain) HSP90
70 nM0.78 μM(Kd)1.2 μM(Kd)
In vitro DMSO Warmed: 32 mg/mL (57.08 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.19 mL 178.38 mL
0.5 mM 3.57 mL 17.84 mL 35.68 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11025
Actions Inhibitor
CAS No. 30562-34-6
Formula C29H40N2O9
M. Wt 560.6
Purity >98%
SMILES C[[email protected]]1C[[email protected]@H]([[email protected]@H]([[email protected]](/C=C(/[[email protected]@H]([[email protected]](/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)\C)OC)OC(=O)N)\C)C)O)OC

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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