PAN endonuclease-IN-1 is a potent inhibitor of PAN endonuclease, showing Kd values of 277 μM, 384 μM, and 328 μM for wild-type, I38T, and E23K variants, respectively. Targeting the RNA-dependent RNA polymerase acidic N-terminal endonuclease, this compound plays a critical role in disrupting influenza viral replication. It is a valuable tool for studying antiviral strategies and the effects of PAN endonuclease inhibition on influenza virus biology.
PAN endonuclease-IN-1 is a potent inhibitor of PAN endonuclease, showing Kd values of 277 μM, 384 μM, and 328 μM for wild-type, I38T, and E23K variants, respectively. Targeting the RNA-dependent RNA polymerase acidic N-terminal endonuclease, this compound plays a critical role in disrupting influenza viral replication. It is a valuable tool for studying antiviral strategies and the effects of PAN endonuclease inhibition on influenza virus biology.
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