Lalistat 1 is a selective and competitive inhibitor of lysosomal acid lipase (LAL), demonstrating an IC50 of 68 nM against purified human LAL. It also inhibits immunoglobulin A1 protease (IgA1P) from Haemophilus influenzae while exhibiting minimal effects on other serine hydrolases such as trypsin and β-lactamase. This compound is valuable for investigating Niemann-Pick type C (NPC) disease and related metabolic disorders.
Lalistat 1 is a selective and competitive inhibitor of lysosomal acid lipase (LAL), demonstrating an IC50 of 68 nM against purified human LAL. It also inhibits immunoglobulin A1 protease (IgA1P) from Haemophilus influenzae while exhibiting minimal effects on other serine hydrolases such as trypsin and β-lactamase. This compound is valuable for investigating Niemann-Pick type C (NPC) disease and related metabolic disorders.
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