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Catalog No.
Product Name
Application
Product Information
Citations
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Neuraminidase Inhibitor
Neuraminidase-IN-3 is a potent inhibitor of influenza neuraminidase, exhibiting IC50 values of 0.73 nM, 0.26 nM, and 0.63 nM against H1N1, H5N1, and H5N8 neuraminidases, respectively. This compound is critical for research focused on antiviral drug development and studying the mechanisms of influenza virus infection and resistance. Its high potency makes it a valuable tool for elucidating neuraminidase functions in viral pathogenesis and therapeutics. -
Influenza Virus Inhibitor
D715-2441 is an influenza virus RNA polymerase inhibitor with an IC50 range of 1.7-4.4 μM. This compound demonstrates broad-spectrum antiviral activity against various influenza A strains. D715-2441 serves as a valuable tool for research pertaining to seasonal influenza and the study of influenza virus dynamics. -
Influenza A Virus Inhibitor
M2WJ332 is a potent inhibitor of the M2 proton channel in the Influenza A virus, specifically targeting the M2S31N mutant variant. With an IC50 of 16 μM, M2WJ332 effectively prevents plaque formation in Influenza A virus carrying the M2S31N mutation. This compound is suitable for research applications focused on understanding and combating Influenza A virus infections. -
Influenza Viru Inhibitor
Laninamivir TFA is a long-acting neuraminidase inhibitor that effectively targets influenza A and B viruses. This antiviral compound exhibits both inhibitory and prophylactic activity, making it a valuable tool for influenza research. Administered via nasal inhalation, Laninamivir TFA demonstrates promising safety and efficacy profiles in the inhibition of viral replication, supporting its application in studies of influenza virus dynamics and treatment strategies. -
Influenza A Inhibitor
Influenza A virus-IN-17 is a selective inhibitor targeting Influenza A viruses, demonstrating effective inhibition with EC90 values of 3.5 μM for H3N2 and 2.6 μM for H1N1. This compound effectively disrupts the cap-snatching polymerase activity, as indicated by an EC90 of 2.1 μM against U2-PB2 chimeric mRNA. Influenza A virus-IN-17 is suitable for research in antiviral drug development and understanding Influenza A virus mechanisms. -
H1N1 Hemagglutinin Inhibitor
RO5464466 is a potent inhibitor of hemagglutinin (HA) in H1N1 influenza viruses. It effectively inhibits HA-mediated hemolysis of chicken erythrocytes, demonstrating an IC50 value of 0.29 μM. This compound is valuable for research applications focused on influenza virus entry mechanisms and the development of antiviral strategies. -
PIV-3 Inhibitor
Caesalmin E is a natural cassane furanoditerpene that acts as a potent inhibitor of the Parainfluenza virus type 3 (PIV-3). Its antiviral properties make it a valuable compound for research focused on combating viral infections, specifically in studies targeting PIV-3-related pathologies. This compound may be utilized in investigations of viral replication mechanisms and as a potential therapeutic agent against respiratory infections. -
Influenza Virus Fusion Inhibitor
BMS-199945 is an influenza virus fusion inhibitor that targets the viral fusion process. It demonstrates significant inhibitory activity with IC50 values of 0.57 μM against influenza A/WSN/33 virus-induced hemolysis in chicken red blood cells and approximately 1 μM in the trypsin protection assay. This reagent is applicable for research into antiviral therapies and the mechanisms of influenza virus pathogenesis. -
NA Inhibitor
ent-Oseltamivir, the enantiomer of Oseltamivir, serves as a neuraminidase (NA) inhibitor targeting influenza virus. Its primary biological activity involves inhibiting viral replication, making it a valuable tool for studying influenza virus infections. Research applications include evaluating antiviral efficacy and resistance mechanisms, contributing to the development of effective therapeutic strategies against influenza. -
Matriptase Inhibitor Intermediate
Sodium 3-iodobenzenesulfonate serves as an intermediate in the synthesis of Matriptase inhibitors, specifically those derived from 3-amidinophenylalanine. This reagent is valuable for research applications involving the inhibition of Matriptase and has been implicated in studies related to the H9N2 influenza virus. Its utility in chemical research makes it an important compound for exploring therapeutic avenues targeting Matriptase and associated viral infections. -
Furin Inhibitor
Furin-IN-3 is a potent and selective inhibitor of the proprotein convertase furin, exhibiting a Ki of 12.4 nM. Additionally, it demonstrates a Ki of 278 nM for PC7. This compound has been shown to exert significant antiviral activity against the furin-dependent H7N7 influenza A virus strain SC35M by inhibiting the cleavage and activation of the viral hemagglutinin (HA), thereby preventing viral membrane fusion with host cells and inhibiting viral replication. Furin-IN-3 is a valuable tool for research into viral infections, particularly those related to influenza. -
Influenza Inhibitor
6-Epi-albassitriol is a potent influenza inhibitor derived from Aspergillus sp. FH-A 6357. It effectively disrupts cholesterol synthesis, achieving an inhibition rate of 40% at a concentration of 10 nM in HepG2 cells. Additionally, 6-Epi-albassitriol demonstrates significant antiviral activity against both influenza A virus and parainfluenza virus, with a minimum inhibitory concentration (MIC) ranging from 44.4 to 133.3 µg/mL, making it a valuable compound for research in antiviral therapeutics. -
IAV Inhibitor
IAV replication-IN-1 is a potent inhibitor of influenza A virus (IAV) replication. This compound effectively reduces the upregulation of inflammatory factors and apoptosis associated with IAV infection, providing potential protective effects against lung injury induced by the virus. It is suitable for research applications focused on viral pathogenesis, inflammation, and therapeutic interventions in respiratory diseases. -
Influenza A Inhibitor
Pimodivir hydrochloride hemihydrate (VX-787) is an orally bioavailable inhibitor targeting the influenza A virus polymerase by specifically interfering with the PB2 subunit. This compound demonstrates significant antiviral activity against various strains of the influenza A virus, making it a valuable tool for research in virology and antiviral drug development. Its mechanism of action paves the way for studying the dynamics of viral replication and the efficacy of potential therapeutic interventions. -
Influenza Virus Inhibitor
M090 is a potent inhibitor of hemagglutinin, specifically targeting the influenza A virus. It effectively inhibits multiple strains of influenza, demonstrating an EC50 in the micromolar range. This compound is essential for research applications involving antiviral drug development and the study of influenza virus pathogenesis. -
Hemagglutinin Inhibitor
F0045(S) is an effective inhibitor of influenza hemagglutinin, demonstrating a KD value of 6.1 µM. This compound is utilized in biological research to investigate its protective effects against influenza virus infections in human cells, making it a valuable tool for antiviral studies and the development of therapeutic strategies. -
RSV/IAV Inhibitor
RSV/IAV-IN-2 is a potent dual inhibitor targeting respiratory syncytial virus (RSV) and influenza A virus (IAV). This compound demonstrates reduced cytotoxicity compared to the established antiviral Ribavirin, making it a valuable candidate for studies focused on RSV and/or IAV infections. Its efficacy in inhibiting viral replication supports its use in antiviral research and therapeutic development against these respiratory pathogens. -
RSV/IAV Inhibitor
RSV/IAV-IN-1 is a potent dual inhibitor targeting respiratory syncytial virus (RSV) and influenza A virus (IAV). This compound exhibits reduced cytotoxicity compared to the clinical antiviral agent Ribavirin, making it a valuable tool for studying RSV and IAV infections. RSV/IAV-IN-1 facilitates research into antiviral mechanisms and therapeutic strategies against these viral pathogens. -
Influenza Virus Inhibitor
CEF6 is a 9-amino acid peptide derived from residues 418-426 of the nucleocapsid protein of influenza A virus (H1N1). It functions as an inhibitor of influenza virus, demonstrating key antiviral activity through interference with the viral life cycle. This peptide is valuable for research applications focused on studying viral replication mechanisms and the development of antiviral therapeutics targeting influenza infections. -
Parasite Inhibitor
Methylene blue trihydrate is an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and nitric oxide synthase (NOS). This compound exhibits a range of biological activities including antinociceptive, antimalarial, antidepressant, and anxiolytic effects. Methylene blue trihydrate is utilized in research applications related to methemoglobinemias, neurodegenerative disorders, and treatment of ifosfamide-induced encephalopathy. Additionally, it serves as a dye in various medical procedures, highlighting its versatility in scientific investigations. -
Parasites Inhibitor
Dehydroemetine is an orally active antiparasitic agent that targets and inhibits parasites, particularly Entamoeba histolytica. It exhibits key biological activity in combating parasitic infections and is used in research applications related to various parasitic diseases, including visceral leishmaniasis. -
Parasite Inhibitor
Trans-4-Methylcyclohexanamine is a key intermediate utilized in the development of inhibitors targeting Trypanosoma cruzi enzymes. This compound demonstrates significant biological activity against the parasite, making it a valuable tool for research in parasitology and drug discovery. Its applications extend to the exploration of therapeutic options for parasitic infections, particularly Chagas disease. -
Parasite Inhibitor
Diazinon is an irreversible acetylcholinesterase (AChE) inhibitor with primary applications in pest control as an insecticide. By inhibiting AChE, Diazinon leads to the accumulation of acetylcholine, resulting in overstimulation of acetylcholine receptors and disruption of nervous system function. Additionally, Diazinon generates reactive oxygen species (ROS), contributing to oxidative stress across various biological tissues. This compound is predominantly utilized in agricultural settings but may also hold implications for human and animal health research. -
Chitinase Inhibitor
Argifin is a potent chitinase inhibitor that demonstrates sub-nanomolar activity, targeting multiple chitinase enzymes. It exhibits impressive IC50 values of 0.025 μM for SmChiA from Serratia marcescens, 6.4 μM for SmChiB, 1.1 μM for Aspergillus fumigatus chitinase B1, and 4.5 μM for human chitotriosidase. Argifin is instrumental in studies exploring chitin metabolism and offers potential applications in antifungal research and elucidation of chitinase-related diseases. -
Parasite Inhibitor
Licoflavone B is a flavonoid derived from Glycyrrhiza inflata, acting as a specific inhibitor of Schistosoma mansoni ATPase and ADPase, with IC50 values of 23.78 µM and 31.50 µM, respectively. This compound demonstrates significant anti-schistosomiasis activity, making it a valuable tool for researchers investigating therapeutic strategies against schistosomiasis. Its mechanism of action and inhibition of key enzymatic pathways underline its potential in parasitic disease research. -
Parasite Inhibitor
Aklomide (2-Chloro-4-nitrobenzamide) is a potent coccidiostat that targets protozoan parasites. Its primary biological activity involves inhibiting the growth and reproduction of coccidia, making it effective in preventing and controlling coccidiosis in poultry, particularly in chickens. Aklomide is valuable for researchers investigating parasite biology and developing strategies for managing coccidial infections. -
Parasite Inhibitor
8-Deoxygartanin, a prenylated xanthone derived from Garcinia mangostana, serves as a selective inhibitor of butyrylcholinesterase (BChE). This compound demonstrates significant antiplasmodial activity, with an IC50 value of 11.8 μM against the W2 strain of Plasmodium falciparum. Additionally, 8-Deoxygartanin inhibits NF-κB (p65) activation, displaying an IC50 of 11.3 μM, making it a valuable reagent for research in parasitic infections and inflammation pathways. -
Parasite Inhibitor
Dibenzosuberol is an effective inhibitor of Trypanosoma thiol reductase (TryR), showing significant biological activity against the parasite T. brucei with an EC50 value of 51.3 μM. This compound serves as a crucial intermediate in the synthesis of various compounds aimed at treating parasitic infections. Its properties make it valuable for research applications targeting trypanosomiasis and related diseases. -
Parasite Inhibitor
ACT-451840 is a potent oral inhibitor specifically targeting Plasmodium falciparum, including both sensitive and resistant strains. This compound demonstrates significant activity against all asexual blood stages of the parasite, characterized by a rapid onset of action. ACT-451840 exhibits a mechanism of action akin to that of artemisinin derivatives, effectively facilitating the elimination of the malaria pathogen. It serves as a valuable research tool for studies related to malaria treatment and resistance. -
SARS-CoV Inhibitor
Ivermectin B1a is a potent inhibitor of SARS-CoV, targeting viral replication. As a derivative of Avermectin B1a, it demonstrates significant antiviral activity and is explored as a potential therapeutic candidate against SARS-CoV-2 and COVID-19. This compound serves as an important tool in research aimed at understanding and combating viral infections. -
Parasite Inhibitor
2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone that acts as a parasite inhibitor, derived from Artemisia annua. This compound serves as an effective analog of Artemisinin, making it valuable in malaria research. Its properties contribute to the understanding of parasite biology and the development of potential therapeutic strategies against malaria. -
Parasite Inhibitor
Nepodin is a quinone oxidoreductase (PfNDH2) inhibitor derived from Rumex crispus. It exhibits significant antidiabetic and antimalarial activities by stimulating the translocation of GLUT4 to the plasma membrane via AMPK activation. This compound serves as a valuable tool for research into metabolic disorders and parasitic infections, facilitating studies on glucose metabolism and potential therapeutic interventions. -
Parasite Inhibitor
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid derived from Aconitum coreanum, functioning primarily as a parasite inhibitor. It exhibits significant antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1, exhibiting IC50 values of 4 µM and 3.6 µM, respectively. This compound is a valuable tool for research in malaria treatment and drug development. -
Parasite Inhibitor
1R-cis-Permethrin is a potent insecticide with neurotoxic properties that primarily targets sodium channels in neuronal membranes. By prolonging the activation state of these channels, it disrupts normal neuronal function, resulting in paralysis and death of target pests. This compound is utilized extensively in research for studying the mechanisms of insect neurotoxicity and developing pest control strategies. -
Parasite Inhibitor
Albendazole sulfone is a metabolism-derived compound of Albendazole, primarily targeting parasitic infections. It demonstrates significant anti-parasitic activity against Echinococcus multilocularis metacestodes, making it a valuable reagent for research focused on parasitic diseases and treatment efficacy. Its application extends to studies concerning drug resistance and therapeutic approaches in veterinary and human medicine. -
Parasite Inhibitor
Clofentezine is a potent growth inhibitor with primary activity against acarine pests, specifically targeting mites. This compound effectively disrupts the developmental stages of parasites, making it valuable for research applications in pest control and agricultural science. Its mechanism of action makes clofentezine an important reagent for studying mite population dynamics and developing strategies for management in agricultural settings. -
Parasite Inhibitor
Laetanine is a noraporphine alkaloid derived from Litsea laeta, known for its potent antiplasmodial activity. This compound is also present in the leaf extracts of Phoebe tavoyana (Meissn) Hook. Laetanine is primarily utilized in research applications targeting parasite inhibition, offering potential insights into therapeutic strategies against malaria and related diseases. -
Parasite Inhibitor
Cratoxylone is a potent antiplasmodial agent isolated from the bark of Cratoxylum cochinchinense. It exhibits activity against malaria-causing parasites, making it a valuable tool in the study of parasitic infections. Its biological properties may facilitate research into novel treatments for malaria and enhance understanding of parasite biology. -
Parasite Inhibitor
2-Benzoxazolinone is an anti-leishmanial compound that exhibits an LC50 of 40 μg/mL against Leishmania donovani. This small molecule serves as a versatile building block in chemical synthesis. Additionally, 1,3-Benzoxazol-2(3H)-one derivatives demonstrate significant antimicrobial activity against various Gram-positive and Gram-negative bacteria, as well as yeasts. Certain derivatives have also been identified as effective anti-quorum sensing agents, making them valuable for research applications in microbiology and infectious disease studies. -
Parasite Inhibitor
4′-Hydroxy-2′-methylacetophenone acts as a parasite inhibitor, demonstrating significant ciliate toxicity. This compound effectively inhibits the growth of Tetrahymena pyriformis, with an IC50 value of 0.65 mM. It is a valuable reagent for studies focused on parasitic biology and potential therapeutic applications targeting ciliate organisms. -
Parasite Inhibitor
Fenbendazole analog-1 is an antiparasitic compound that functions by inhibiting rat brain tubulin polymerization. This analog demonstrates significant activity against the protozoa Giardia lamblia and Entamoeba histolytica, as well as the helminth Trichinella spiralis. It serves as a valuable tool for studies focused on parasitic infections and tubulin-targeting therapies. -
SARS-CoV Inhibitor
SARS-CoV-IN-1 is a potent inhibitor of SARS-CoV replication, demonstrating significant antiviral activity with an EC50 of 4.9 μM in Vero cells. Additionally, SARS-CoV-IN-1 displays inhibitory effects on the 3D7 and W2 strains of Plasmodium falciparum, with IC50 values of 15.4 nM and 133.2 nM, respectively. This compound is valuable for research applications focused on both antimalarial and antiviral therapies. -
Parasite Inhibitor
Dodecamethylpentasiloxane acts as a parasite inhibitor, showcasing insecticidal properties specifically against bed bugs. This siloxane compound is utilized in various applications due to its effectiveness in pest management and control. Its unique chemical structure allows it to disrupt the physiological processes of target organisms, making it a valuable reagent in research focused on overcoming insect infestations. -
Parasite Inhibitor
Arprinocid, a purine analog, selectively targets and inhibits the growth of the parasite Toxoplasma gondii in murine models. Its unique mechanism of action interferes with nucleotide metabolism, thereby exhibiting significant antiparasitic activity. This compound is valuable for research applications focused on the pathogenesis and treatment of Toxoplasmosis. -
Parasite Inhibitor
D-Phenothrin is a synthetic pyrethroid classified as a Type II insecticide, primarily targeting insect nervous systems. It exhibits potent insecticidal activity against a variety of pests, including mosquitoes and human lice, making it valuable in both agricultural and veterinary settings. This compound is extensively utilized for pest control in crops and animal husbandry, contributing to effective vector management and enhancing public health. -
Parasite Inhibitor
Tectol is a farnesyltransferase inhibitor, effectively targeting the enzyme in both human and Trypanosoma brucei systems. With IC50 values of 2.09 μM and 1.73 μM respectively, Tectol demonstrates potent antitumor activity against human leukemia cell lines HL60 and CEM. In addition, it exhibits significant inhibitory effects on the drug-resistant strain of Plasmodium falciparum (FcB1), with an IC50 of 3.44 μM, making it a valuable tool for researching parasitic and cancer biology. -
SARS-CoV Inhibitor
Ivermectin B1b is a minor component of Ivermectin with notable activity as a SARS-CoV inhibitor. This compound has demonstrated the ability to inhibit the replication of SARS-CoV-2 in cell culture, making it a valuable reagent for research applications focused on viral infection and antiviral drug development. Its anti-parasitic properties further enhance its relevance in studies addressing a wide range of biological processes. -
PfGSK3/PfPK6 Inhibitor
PfGSK3/PfPK6-IN-1 is a selective inhibitor targeting PfGSK3 and PfPK6, with IC50 values of 97 nM and 8 nM, respectively. This compound effectively inhibits the proliferation of blood-stage Plasmodium falciparum 3D7 parasites, making it a valuable tool for malaria research. Additionally, PfGSK3/PfPK6-IN-1 exhibits low cytotoxicity in hepatocyte cultures at concentrations up to 200 nM, with a significant reduction in cell viability observed at 2 μM. Its dual action enhances its potential in studying malaria-related mechanisms and potential therapeutic strategies. -
Parasite Inhibitor
Melarsonyl, also known as Melarsonic acid, is an anthelmintic agent that targets and inhibits parasitic organisms. It exhibits potent activity against a variety of parasites, making it valuable in research aimed at understanding and combating parasitic infections. This compound is utilized in the study of helminthic diseases and other related areas in parasitology. -
Parasite Inhibitor
Piperazine adipate is an effective anthelmintic agent that targets parasitic worms in mammals. Its broad-spectrum activity makes it suitable for treating various helminth infections, thereby providing significant therapeutic benefits in veterinary and clinical settings. This compound is utilized in research to explore mechanisms of helminth resistance and to develop novel treatment protocols against parasitic infections.
