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Catalog No.
Product Name
Application
Product Information
Citations
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HSV Inhibitor
HN0037 is a selective helicase-primase inhibitor targeting the herpes simplex virus (HSV). By interfering with the viral helicase-primase complex composed of UL5, UL52, and UL8 proteins, HN0037 effectively inhibits HSV replication. Its mechanism of action makes it a valuable research tool for studying antiviral therapies and HSV pathogenesis. -
HSV Inhibitor
5'-Ethynyl-2'-deoxycytidine is a potent inhibitor of herpes simplex virus (HSV), effectively reducing the cytopathic effects of HSV-1 in primary rabbit kidney cells with a minimum inhibitory concentration (MIC) of 0.2 μg/mL. Additionally, this compound demonstrates anti-proliferative activity against leukemia L1210 cells, exhibiting an IC50 value of 64.5 μg/mL. It serves as a valuable tool for researchers investigating viral infections and cancer biology. -
HSV Inhibitor
Stearyl gallate, an alkyl gallate with an 18-carbon long alkyl chain, primarily functions as an antiviral agent against herpes simplex virus type 1 (HSV-1). This compound exhibits notable antioxidant properties, making it a useful tool in research focused on viral inhibition and oxidative stress. Its multifaceted biological activity positions stearyl gallate as a candidate for further investigation in the development of therapeutic agents targeting viral infections. -
HSV Inhibitor
Tromantadine is an effective inhibitor of herpes simplex virus (HSV) replication, specifically targeting HSV-1 and HSV-2. As a derivative of Amantadine, it demonstrates significant antiherpetic activity, making it suitable for research applications focused on viral infection mechanisms and potential therapeutic interventions. -
HSV Inhibitor
Ganoderone A is a triterpene compound known for its inhibitory activity against herpes simplex virus (HSV). With an IC50 value of 0.3 µg/mL, it demonstrates significant antiviral properties. Ganoderone A shows promise for applications in the treatment of viral infections and may also have relevance in cancer research. -
HSV Inhibitor
11-Deoxymogroside IIE is a cucurbitane glycoside derived from the fruits of Siraitia grosvenorii, primarily targeting viral inhibition. It exhibits notable inhibitory effects against the activation of the Epstein-Barr virus (EBV-EA) when induced by TPA. Additionally, it demonstrates a weak inhibitory effect on the nitric oxide donor, NOR1. This compound serves as a valuable tool for research focused on viral infections and their mechanisms. -
HSV-1/2 Inhibitor
Peniterphenyl A is a potent inhibitor of herpes simplex virus types 1 and 2 (HSV-1/2) through direct interaction with the viral envelope glycoprotein D. It effectively blocks the entry of the virus into host cells, thereby preventing infection by disrupting virus adsorption and membrane fusion processes. This natural product, derived from a deep-sea Penicillium species, represents a promising lead compound for further research and development in the field of antiviral therapeutics against HSV-1 and HSV-2. -
HSV-1 Inhibitor
WAY-150138 is a selective inhibitor of herpes simplex virus type 1 (HSV-1), functioning by obstructing the incorporation of DNA-packaging proteins into viral capsids during assembly. This compound demonstrates potent antiviral activity against HSV-1 and may serve as a valuable tool for studying the mechanisms of viral replication and the development of antiviral therapies. Its application in research on HSV-1 will aid in understanding the virus's life cycle and identifying potential therapeutic interventions. -
HSV-1/2 Inhibitor
HSV-1/HSV-2-IN-2 is an inhibitor of both HSV-1 and HSV-2, displaying effective antiviral activity with EC50 values of 6.8 µM and 8.9 µM, respectively. This compound is also active against Varicella Zoster Virus (VV), with an EC50 value of 8.9 µM. HSV-1/HSV-2-IN-2 is suitable for research applications focused on understanding herpesvirus biology and potential therapeutic strategies. -
HSV-1/HSV-2 Inhibitor
HSV-1/HSV-2-IN-1 is a potent inhibitor targeting both HSV-1 and HSV-2 with EC50 values of 7.6 µM for HSV-1 (KOS) and 7.6 µM for HSV-2 (G). It also demonstrates activity against HSV-1 TK- KOS ACVr and vaccinia virus, showing EC50 values of 4 µM and 12 µM, respectively, in human embryonic lung fibroblast cell cultures. This compound is suitable for research focused on antiviral therapies and the mechanisms of herpesvirus infection. -
HSV Inhibitor
Karalicin is an antiviral agent that functions as an inhibitor of herpes simplex virus (HSV-1 and HSV-2), vaccinia virus, and poliovirus type I. It exhibits potent inhibitory activity, with IC50 values of 0.004 μg/mL for HSV-1, 0.008 μg/mL for HSV-2, and 0.016 μg/mL for both vaccinia virus and poliovirus type I. This compound is valuable for research into antiviral therapies and the mechanistic study of viral infections. -
HSV-1/2 Inhibitor
5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin is a porphyrin compound that targets herpes simplex viruses 1 and 2 (HSV-1/2). It demonstrates potent virucidal activity, achieving inhibition rates of 85% against HSV-1 and 60% against HSV-2, with a maximum noncytotoxic concentration of 5 μg/mL on Vero cells. This compound serves as a valuable tool for studying antiviral mechanisms and can facilitate the synthesis of derivatives with enhanced antiviral efficacy. -
HSV-1 Inhibitor
17,17-Ethylendioxyandrost-5-en-3β-ol acts as an inhibitor of herpes simplex virus type 1 (HSV-1), displaying an EC50 value of 629 μM. This compound is relevant for research focused on viral infections and can be utilized to explore mechanisms of viral replication and potential therapeutic strategies against HSV-1. -
HSV-2 Inhibitor
SCH-43478 is a non-nucleoside antiviral agent that targets herpes simplex virus type 2 (HSV-2). It exhibits potent and selective activity with an IC50 of 1.8 μg/mL in Vero cells. Additionally, SCH-43478 shows significant efficacy in preclinical models of HSV infection, specifically in the guinea pig genital model, making it a valuable tool for research on antiviral therapies. -
HSV-1/HSV-2 Inhibitor
HSV-1/HSV-2-IN-3 is a potent inhibitor of the herpes simplex virus (HSV) helicase-primase complex, effectively disrupting the DNA unwinding and primer synthesis necessary for viral genome replication. It demonstrates an EC50 of 7.0 nM against HSV-2 in gD-immunofluorescence assays, and 1.1 nM in qPCR replication assays, highlighting its potent antiviral activity. Additionally, HSV-1/HSV-2-IN-3 exhibits high selectivity for viral targets, with an IC50 of approximately 2.9 µM for human carbonic anhydrase II, making it a valuable tool for anti-HSV research applications. -
HSV Inhibitor
(S)-HN0037 is a selective helicase-primase inhibitor that effectively targets the viral helicase-primase complex, thereby inhibiting herpes simplex virus (HSV) replication. Its oral bioactivity makes it a valuable tool for studying HSV pathology and developing antiviral therapies. Researchers can utilize (S)-HN0037 in various experimental models to investigate mechanisms of viral replication and explore potential therapeutic interventions against HSV infections. -
HSV Inhibitor
C-AFG is a novel herpes simplex virus (HSV) inhibitor that demonstrates potent activity against both HSV-1 and HSV-2. This compound exhibits high selectivity, making it a valuable tool for research on viral infections and the mechanisms of antiviral action. C-AFG is suitable for studies focusing on therapeutic strategies against herpesvirus-related diseases. -
HSV Inhibitor
HSV-1-IN-3 is a potent inhibitor of herpes simplex virus (HSV) with demonstrated antiviral activity against both Acyclovir-sensitive and -resistant HSV strains. This compound has potential applications in virology research, particularly in studies focused on understanding and developing treatments for HSV infections. Its effectiveness against resistant strains makes it a valuable tool in the search for new antiviral therapies. -
HSV-1 Inhibitor
Woodorien is a potent inhibitor of herpes simplex virus type 1 (HSV-1), demonstrating strong antiviral activity. Isolated from the plant Woodwardia orientalis, Woodorien functions as a glucoside that impacts viral replication. This compound serves as a valuable tool for studying HSV-1 infection mechanisms and the development of antiviral therapies. -
Endonuclease Inhibitor
AV5116 is a cap-dependent endonuclease inhibitor that specifically targets the active site of the cap-dependent endonuclease (CEN) within the N-terminal domain of polymerase acidic. This compound demonstrates potent inhibitory activity against various influenza viruses, including types A, B, and C. AV5116 is valuable for research investigating influenza virus infections and the mechanisms of antiviral action. -
Influenza Virus Inhibitor
β-Cyclodextrin is a cyclic polysaccharide that targets influenza virus inhibition, specifically effective against the H1N1 strain. Its primary mechanism involves enhancing the solubility of various compounds, making it a valuable tool in virology research. Additionally, β-Cyclodextrin demonstrates significant antiviral activity, providing potential therapeutic applications in the treatment of influenza. -
Neuraminidase Inhibitor
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid is a potent inhibitor of neuraminidase enzymes, functioning primarily through competitive inhibition. This compound demonstrates significant inhibitory effects on human neuraminidase isoforms NEU1, NEU2, NEU3, and NEU4, with IC50 values of 143, 43, 61, and 74 μM, respectively. Its inhibitory activity positions it as a valuable tool for researching anti-influenza virus mechanisms and for studying sialidase-related biological processes. -
Influenza Viru Inhibitor
Desaminotyrosine is an influenza virus inhibitor that enhances type I interferon signaling. This microbial metabolite plays a crucial role in the immune response against influenza, offering protective effects by promoting antiviral activity. Its mechanism of action makes it valuable for research into antiviral therapies and immune modulation strategies. -
Influenza Viru Inhibitor
L-Norleucine, a derivative of leucine, primarily functions as an antiviral agent by inhibiting protein synthesis, particularly in the context of influenza virus infections. Its activity interferes with viral replication, making it a valuable reagent for research applications focused on viral biology and therapeutic interventions against influenza. L-Norleucine can be utilized in studies exploring mechanisms of protein synthesis modulation and the development of antiviral strategies. -
MTr1 Inhibitor
Trifluoromethyl-tubercidin (TFMT) is an inhibitor of the enzyme 2'-O-ribose methyltransferase 1 (MTr1). This compound effectively disrupts the cap-snatching mechanism utilized by influenza A and B viruses, thereby inhibiting viral replication. TFMT demonstrates notable antiviral activity with minimal toxicity, making it a valuable reagent for studies in virology and antiviral research. -
Influenza Virus Inhibitor
Epigoitrin is a natural alkaloid that exhibits antiviral activity against influenza viruses by inhibiting attachment and replication of the influenza A1 virus FM1 in vitro. This compound enhances the host's resistance to influenza infection, particularly under stress conditions. Additionally, Epigoitrin demonstrates lipid-lowering effects, making it a potential candidate for research in infectious diseases and metabolic health. -
Influenza Virus Inhibitor
2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that serves as a potent inhibitor of influenza viruses, exhibiting an effective concentration (EC90) of less than 0.35 μM against both influenza A and B strains. This compound disrupts the replication process of the influenza virus in the upper respiratory tract, resulting in reduced fever and alleviated nasal inflammation. Its antiviral properties make it a valuable tool for research on influenza virus pathogenesis and therapeutic intervention strategies. -
Influenza Virus Inhibitor
Rupestonic acid is a sesquiterpene that acts as an inhibitor of the influenza virus. This compound demonstrates significant antiviral activity, making it a valuable tool for research focused on influenza virus pathogenesis and therapeutic interventions. Its ability to disrupt viral replication holds potential for the development of novel antiviral strategies. -
Kinase Inhibitor
3-Deoxysappanchalcone is a potent kinase inhibitor that selectively targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, thrombin, FXa, and influenza virus neuraminidase, modulating key signaling pathways. This compound is known to induce cell cycle arrest, reactive oxygen species (ROS) production, and apoptosis, demonstrating significant biological activities. Its anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic properties make it valuable for research in gefitinib-resistant lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infections. -
Influenza Virus Inhibitor
Oseltamivir-d3 is a deuterium-labeled derivative of Oseltamivir, which functions as a neuraminidase inhibitor targeting the influenza virus. This compound demonstrates potent antiviral activity against various influenza strains, including A/H3N2, A/H1N2, A/H1N1, and B, with mean IC50 values of 0.67, 0.9, 1.34, and 13 nM, respectively. Oseltamivir-d3 is valuable for research applications focused on influenza virus studies, antiviral drug development, and mechanistic investigations of neuraminidase inhibition. -
CEN Inhibitor
AV5124 is an orally active cap-dependent endonuclease (CEN) inhibitor, functioning as a prodrug of AV5116. It exhibits potent antiviral activity by inhibiting the endonuclease function essential for influenza virus replication. This compound is primarily utilized in research focused on developing antiviral strategies against influenza and understanding viral RNA synthesis mechanisms. -
IAV Inhibitor
VNT-101 is an orally active inhibitor of influenza A virus (IAV) that targets the nucleoprotein (NP) and disrupts NP-NP protein-protein interactions, leading to the destabilization of the viral ribonucleoprotein complex. This compound demonstrates potent antiviral activity across various IAV subtypes, with EC50 values ranging from 4-5 nM in cellular cytopathic effect assays, 4-8 nM in neuraminidase assays, and 21-45 nM in ribonucleoprotein assays. Additionally, VNT-101 shows significant in vivo antiviral efficacy in mice infected with lethal H1N1 virus, making it a valuable tool for studying influenza A infection and potential therapeutic interventions. -
PA endonuclease Inhibitor
L-742001 hydrochloride is an inhibitor of the influenza virus PA endonuclease, specifically targeting the viral RNA polymerase complex. It demonstrates an effective EC90 of 4.3 μM for vRNP activity in HEK293T cells. This compound is valuable for research applications focused on antiviral drug development and understanding viral replication mechanisms. -
H1N1 Inhibitor
CBS1117 is a potent inhibitor of the H1N1 influenza A virus, exhibiting an IC50 of 70 nM. It specifically targets the hemagglutinin (HA) protein, disrupting the viral entry process by interfering with HA-mediated fusion. This compound is valuable for research applications focused on understanding influenza virus entry mechanisms and developing antiviral strategies. -
Cap-dependent Endonuclease Inhibitor
Pixavir marboxilo is a potent orally active cap-dependent endonuclease inhibitor that targets the viral polymerase complex. This compound is primarily utilized in influenza research to investigate viral replication mechanisms and evaluate potential therapeutic strategies. Its high efficacy makes it a valuable tool for studying the pathogenesis of influenza and developing antiviral treatments. -
Influenza A Virus Inhibitor
Influenza A virus-IN-1 is a dihydropyrrolidone derivative that serves as a potent inhibitor of various subtypes of influenza A virus (IAV), exhibiting IC50 values ranging from 3.11 μM to 7.13 μM. This compound effectively inhibits IAV replication and enhances the expression of key antiviral cytokines, including IFN-β, as well as the antiviral protein MxA. Its mechanisms make it a valuable tool for research in antiviral drug development and the study of host immune responses to viral infections. -
NA Inhibitor
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a reversible noncompetitive neuraminidase (NA) inhibitor with significant antiviral activity. It demonstrates potent inhibitory effects against influenza virus strains, with IC50 values of 34.6 µM for H1N1, 39.5 µM for H3N2, and 50.5 µM for H9N2. This compound, derived from the dried heartwood of Caesalpinia sappan L., serves as a valuable reagent for research applications focusing on influenza virus inhibition and related studies in virology. -
Neuraminidase Inhibitor
AV-5080 is an orally active neuraminidase inhibitor that targets the enzyme involved in the life cycle of influenza viruses. By inhibiting neuraminidase, AV-5080 effectively reduces viral replication and spread, making it a valuable tool in the study of influenza A and B viruses. This compound is suitable for research applications aimed at understanding viral pathogenesis and developing antiviral strategies. -
Influenza Neuraminidase Enzymes Inhibitor
Ganoderic acid TR is an inhibitor of influenza neuraminidase enzymes (NAs), demonstrating significant antiviral activity. It exhibits IC50 values of 10.9 μM and 4.6 μM against H5N1 and H1N1 strains, respectively, making it a promising candidate for further research in influenza treatment. However, Ganoderic acid TR is associated with cytotoxicity and shows limited efficacy against Oseltamivir-resistant H1N1 and influenza B viruses. -
Influenza A Virus Inhibitor
MBX2546 is an inhibitor of the Influenza A virus, specifically targeting H1 and H3 Hemagglutinin with Kd values of 5.3 μM and greater than 100 μM, respectively. This compound demonstrates potential for antiviral research and therapeutic development aimed at combating Influenza A infections. Its selective mechanism of action makes it a valuable tool for studying hemagglutinin-mediated viral entry and host cell interactions. -
Influenza Virus Inhibitor
Amizon is an orally effective antiviral agent targeting the influenza virus. It inhibits viral replication and restricts RNA synthesis, while simultaneously reducing the mRNA expression of pro-inflammatory mediators such as COX-1, COX-2, NF-κB, TGF-β1, IL-1, and IL-6. Additionally, Amizon enhances the secretion and mRNA expression of the anti-inflammatory cytokine IL-10 and exhibits antioxidant properties, inhibiting the oxidative activity of macrophages. This compound is of interest in research focused on influenza and acute respiratory viral infections. -
Cap-dependent Endonuclease Inhibitor
Cap-dependent endonuclease-IN-6 is a potent inhibitor of cap-dependent endonuclease (CEN), a critical enzyme required for the replication of certain viruses, including influenza. This compound exhibits substantial antiviral activity, demonstrating an effective EC50 of 38.21 nM against the influenza virus. It serves as a valuable tool for researchers investigating viral mechanisms and developing antiviral therapies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-20 is an inhibitor of cap-dependent endonuclease (CEN), targeting the viral replication process. It exhibits antiviral activity against the influenza virus A/Hanfang/359/95 (H3N2), with an IC50 of 4.82 μM. This compound is useful for research in virology, particularly in the study of influenza virus mechanisms and the development of antiviral therapeutics. -
Influenza Virus Growth Inhibitor
BMY-27709 is an influenza virus growth inhibitor that primarily targets hemagglutinin proteins. It demonstrates significant antiviral activity with an IC50 value of 3-8 μM against the A/WSN/33 strain. BMY-27709 effectively inhibits the growth of H1 and H2 subtype viruses early in the infection process, making it a valuable tool for research into influenza virus pathogenesis and therapeutic development. However, it does not inhibit H3 subtype viruses or influenza B/Lee/40 strains. -
CEN Inhibitor
Cap-dependent endonuclease-IN-9 is a selective inhibitor of cap-dependent endonuclease (CEN), demonstrating significant efficacy against influenza viruses. This compound exhibits low cytotoxicity and favorable pharmacokinetic and pharmacodynamic properties in vivo. Cap-dependent endonuclease-IN-9 effectively inhibits the RNA polymerase activity of A viruses, making it a valuable tool for research in antiviral therapeutics and molecular biology studies. -
Endonuclease Inhibitor
Flutimide is a selective endonuclease inhibitor that targets the influenza virus. Demonstrating an IC50 value of 3 μM, Flutimide exhibits significant antiviral activity in cell culture assays. This compound is valuable for research focused on acute contagious respiratory diseases, particularly influenza, and can aid in the investigation of therapeutic strategies against viral infections. -
Influenza A Virus Inhibitor
3-epi-Dihydroscandenolide is a sesquiterpene lactone that serves as an inhibitor of influenza A virus. Isolated from the dried aerial parts of Mikania micrantha, this compound effectively inhibits the cytopathic effects induced by the virus. 3-epi-Dihydroscandenolide is valuable for research applications focused on influenza A and may aid in the development of antiviral strategies. -
A/M2 Inhibitor
3-Azaspiro[5.5]undecane hydrochloride is an inhibitor of the wild-type influenza A virus M2 ion channel. It demonstrates potent biological activity with an IC50 value of 1 μM, making it a valuable tool for studying influenza virus function and host-pathogen interactions. This compound is applicable in viral research and can aid in the development of antiviral strategies targeting M2. -
Hemagglutinin Inhibitor
Influenza virus-IN-5 is a potent inhibitor of influenza virus hemagglutinin (HA), demonstrating an EC50 of 1 nM against the influenza A/H3N2 strain. This compound is valuable for research applications focused on viral entry and infection mechanisms. Its high selectivity and efficacy make it an important tool for studying influenza virus pathogenesis and developing antiviral strategies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-26 is a selective inhibitor of cap-dependent endonuclease (CEN), exhibiting an IC50 of 286 nM. This compound demonstrates significant antiviral activity against various strains of influenza A and B, making it a valuable tool for research in antiviral therapy and mechanisms of viral replication. Its use may advance the understanding of CEN's role in viral RNA processing and contribute to the development of new antiviral strategies.
