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Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
Sarothralin G is a potent antibacterial compound derived from Hypericum japonicum Thunb. It exhibits exceptional activity against Gram-positive bacteria, including Staphylococcus aureus, Bacillus subtilis, and Nocardia species. With its unique phenolic and aromatic acid structure, Sarothralin G demonstrates superior antibacterial efficacy compared to related compounds such as Sarothralen A, B and Saroaspidin A, B, C. This compound is valuable for research in antibiotic development and the study of bacterial resistance mechanisms. -
AgrA Quorum-sensing Inhibitor
Apicidin D2 is a specific inhibitor of the accessory gene regulator A (AgrA), which plays a pivotal role in bacterial quorum sensing. This fungal metabolite demonstrates notable anti-virulence properties by effectively suppressing AgrA activation in Staphylococcus aureus, including methicillin-resistant strains (MRSA), without exhibiting biocidal effects. Apicidin D2 is a valuable reagent for research focused on understanding MRSA infections and developing strategies to combat quorum-sensing related pathogenicity. -
Bacterial Inhibitor
INF55 is a multidrug resistance pump inhibitor targeting bacterial efflux mechanisms. By inhibiting the NoA pump, INF55 enhances the antibacterial efficacy of compounds such as berberine, reducing their efflux and overcoming bacterial resistance. Structural variants of INF55 demonstrate diverse NoA inhibitory activities, which can influence the antibacterial effectiveness of their respective heterocomplexes. This versatility makes INF55 and its derivatives valuable tools in the study and development of novel antimicrobial strategies. -
Bacterial Inhibitor
Racemomycin B is a potent bacterial inhibitor derived from Streptomyces lavendulae OP-2, characterized as a streptothricin antibiotic with three β-lysine groups. It demonstrates significant antimicrobial activity against plant pathogenic microorganisms, effectively inhibiting the root growth of Brassica rapa L. at a concentration of 50 ppm. Racemomycin B exhibits a minimum inhibitory concentration (MIC) of 0.4 μg/ml against Pseudomonas syringae pv. tabaci IFO-3508 and a MIC range of 0.1-2.0 μg/ml against various strains of Fusarium oxysporum. The biological efficacy of this compound is enhanced by the increasing number of β-lysine groups, making it a valuable tool for agricultural research. -
Bacterial Inhibitor
(R,R)-Ethambutol is a bacterial inhibitor primarily targeting Mycobacterium tuberculosis, exhibiting significant antituberculosis activity. It is commonly utilized in combination therapies to enhance the therapeutic efficacy against tuberculosis. Additionally, (R,R)-Ethambutol demonstrates effectiveness in inhibiting infections caused by Mycobacterium avium complex and Mycobacterium kansasii, making it a valuable reagent for research in mycobacterial infections. -
β-lactamase Inhibitor
CB-618 is a β-lactamase inhibitor that reversibly covalently interacts with Ambler class A, C, and select class D serine β-lactamases. While it exhibits limited antibacterial activity on its own, CB-618 notably enhances the effectiveness of Meropenem against enzyme-producing Enterobacteriaceae. This compound is a valuable tool for research focused on combating drug-resistant bacterial strains. -
β-Lactamase Inhibitor
LN-1-255 sodium is a β-lactamase inhibitor designed to effectively combat resistance in bacteria. It exhibits a broad-spectrum inhibitory effect on type D carbapenemases, demonstrating an IC50 of 3 nM against OXA-48, while also showing strong activity against OXA-23 and OXA-24/40. The compound enhances the efficacy of carbapenem antibiotics through a synergistic mechanism. LN-1-255 sodium is a valuable tool for researching the challenges posed by carbapenem-hydrolyzing class D β-lactamases (CHDLs) in bacterial resistance. -
Bacterial Inhibitor
Fenvalerate-d6 is a deuterium-labeled derivative of Fenvalerate, primarily targeting bacterial inhibition. This compound exhibits potent antibacterial activity, making it valuable for research applications focused on elucidating bacterial resistance mechanisms and evaluating the efficacy of antibacterial agents. Its isotopic labeling enables tracking and quantification in metabolic studies and pharmacokinetic investigations. -
Bacterial Inhibitor
(E/Z)-Aureusidin is a flavonoid compound that functions as a bacterial inhibitor through its antioxidant properties. It effectively inhibits the production of reactive oxygen species, thereby reducing cellular damage and inflammation by lowering the expression of inflammatory factors. Additionally, (E/Z)-Aureusidin exhibits broad-spectrum antimicrobial activity, highlighting its potential applications in combating bacterial infections and studying inflammatory responses. -
Bacterial Inhibitor
AGS1286 sodium, an organosulfur compound, functions as a bacterial inhibitor by targeting enzymatic activities and metabolic pathways influenced by sulfur-containing compounds. This reagent is utilized in research to examine the regulatory effects on bacterial growth and gene expression, making it valuable for studies in microbiology and metabolic regulation. Its unique structural features provide insights into the role of sulfur in microbial dynamics and enzymatic processes. -
Bacterial Inhibitor
VCC234718 is a selective inhibitor of inosine monophosphate dehydrogenase (GuaB2), effectively targeting Mycobacterium tuberculosis (Mtb) to inhibit its growth. With a K value of 100 nM, VCC234718 exhibits non-competitive inhibition involving both IMP and NAD+, demonstrating its ability to disrupt enzymatic function through direct interactions with these metabolites. This compound is valuable for studying mycobacterial infections and developing new treatments for tuberculosis. -
Bacterial Inhibitor
Antitubercular agent-47 (compound 5C) is a potent bacterial inhibitor specifically targeting Mycobacterium tuberculosis. It demonstrates significant efficacy against drug-sensitive (DS), multidrug-resistant (MDR), and extensively drug-resistant (XDR) clinical isolates. This compound is valuable for research applications focused on tuberculosis treatment and drug resistance mechanisms. -
LasB Inhibitor, Antibacterial Activity
Elastase LasB-IN-1 is a selective inhibitor of elastase LasB, exhibiting a potent IC50 value of 76 nM. This compound demonstrates significant antibacterial activity, making it an important tool for research applications focused on bacterial infections. Its specificity for LasB facilitates investigations into the role of elastolytic enzymes in microbial pathogenesis. -
Bacterial Inhibitor
Antibacterial agent 149 is a potent laccase inhibitor that exhibits significant antibacterial properties. This compound is particularly effective against bacterial pathogens and has demonstrated high fungicidal activity, making it a valuable tool for studying rice sheath blight and related diseases. Its mechanism of action and specificity enhance its utility in researching bacterial inhibition and plant pathogenic interactions. -
Bacterial Inhibitor
15-Methylhexadeca Sphinganine is an iso-branched sphingolipid that acts as a bacterial inhibitor. It is identified as a component of ceramide-containing phospholipids in bacterial cell membranes. This compound is valuable for research applications focused on understanding bacterial lipid metabolism and exploring potential therapeutic strategies against bacterial infections. -
Bacterial Inhibitor
Chevalone B is a bacterial inhibitor derived from the marine sponge-associated fungus Aspergillus similanensis. It exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as Candida albicans and multidrug-resistant environmental strains. Its potential applications in antimicrobial research highlight its significance in the development of novel therapeutic agents. -
Beta-lactamase Inhibitor
Relebactam sodium is a potent and selective β-lactamase inhibitor that functions to inhibit the enzymatic breakdown of β-lactam antibiotics. By binding to a diverse range of β-lactamases, Relebactam sodium enhances the effectiveness of these antibiotics and delays the emergence of bacterial resistance. This compound is particularly valuable in research focusing on combating complex bacterial infections and improving antibiotic therapeutic options. -
HSV-1 Inhibitor
Cycloviracin B1 is a potent inhibitor of herpes simplex virus type 1 (HSV-1), demonstrating significant antiviral activity against this pathogen. In addition to its primary application in virology, it exhibits weak anti-Gram-positive bacterial activity, which may provide further avenues for research. This compound is valuable for studies focused on HSV-1 infection and potential therapeutic interventions. -
Beta-lactamase Inhibitor
Ent-Avibactam sodium is a β-lactamase inhibitor designed to combat a wide range of bacterial infections. It effectively inhibits Ambler A and C type β-lactamases produced by Enterobacteriaceae, enhancing the efficacy of β-lactam antibiotics like Cefazidime. With an IC50 value significantly lower than other commonly used β-lactamase inhibitors, ent-Avibactam sodium demonstrates superior potency against TEM-1 and P99 enzymes, making it a valuable tool for bacterial resistance research and antibiotic development. -
Bacterial Ribosome Inhibitor
Capreomycin IA is a bactericidal agent that inhibits bacterial ribosomes, primarily affecting mycobacterial species. By blocking the translocation of peptidyl-transfer RNA from the A to the P site, Capreomycin IA effectively interrupts protein synthesis. This compound demonstrates significant antimicrobial activity against Mycobacterium tuberculosis and is useful for research applications related to tuberculosis and other mycobacterial infections. -
Bacterial Inhibitor
Timcodar mesylate is a bacterial efflux pump inhibitor that targets multidrug-resistant strains by directly inhibiting ethidium bromide efflux in Staphylococcus aureus. This compound enhances the effectiveness of antibiotic treatments by reducing the minimum inhibitory concentration required against Gram-positive pathogens, including Staphylococcus aureus, Enterococcus, and Streptococcus pneumoniae. Timcodar mesylate serves as a valuable tool in microbial resistance studies and antibiotic synergy research. -
Bacterial Inhibitor
Anti-MRSA agent 24 is a potent antimicrobial compound specifically targeting methicillin-resistant Staphylococcus aureus (MRSA), with particular efficacy against penicillin-resistant strains. This reagent demonstrates significant antibacterial activity, making it essential for research applications focused on combating resistant bacterial infections and studying mechanisms of antibiotic resistance. -
Bacterial Inhibitor
Streptovitacin A is a potent antibacterial agent derived from microorganisms, designed to inhibit a wide range of bacterial strains and demonstrate antiproliferative effects on tumor cells. Its primary mechanism involves interference with essential bacterial processes, making it a valuable tool in microbiological research and cancer studies. Researchers can utilize Streptovitacin A to explore bacterial resistance mechanisms and evaluate its therapeutic potential in oncology. -
Antibacterial Inhibitor
HA5 is an antibacterial inhibitor that targets biofilm formation in Streptococcus mutans. It demonstrates a potent inhibitory effect with an IC50 value of 6.42 μM, selectively disrupting biofilm structure without impacting bacterial growth. Additionally, HA5 reduces glucan production and extracellular DNA levels, making it a valuable tool for studying bacterial pathogenesis and potential therapeutic interventions in dental caries research. -
Bacterial Inhibitor
7-O-Methylaloeresin A is a 5-methylchromone glycoside isolated from Commiphora socotrana, acting primarily as a bacterial inhibitor. It demonstrates significant antimicrobial activity against methicillin-resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255), with minimum inhibitory concentrations (MIC) of 0.72 mM and 0.18 mM, respectively. Additionally, 7-O-Methylaloeresin A exhibits antioxidant properties, with IC50 values of 0.026 mM for the DPPH assay and 0.021 mM for the 2-deoxyribose degradation assay, making it useful in studies related to microbial resistance and oxidative stress. -
Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-8 is a potent reversible and competitive inhibitor of metallo-β-lactamases (MβLs), exhibiting IC50 values of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM against L1, ImiS, IMP-1, and VIM-2 respectively. This compound demonstrates significant antibacterial activity, making it a valuable tool for studying β-lactam resistance mechanisms in bacterial pathogens. Its ability to inhibit a broad spectrum of MβLs highlights its potential for research applications in antimicrobial resistance and drug development. -
Bacterial Inhibitor
1,4,6-Trihydroxy-5-methoxy-7-prenylxanthone is a bacterial inhibitor derived from the genus Garcinia. This compound exhibits significant antimicrobial activity against Staphylococcus aureus and Bacillus cereus, with minimum inhibitory concentration (MIC) values of 128 μg/mL and 200 μg/mL, respectively. It serves as a valuable tool in research applications aimed at understanding bacterial resistance and developing new antimicrobial therapies. -
Bacterial Inhibitor
Urease-IN-1 is a specific urease inhibitor, demonstrated by an IC50 value of 2.21 ± 0.45 µM. This compound is primarily used for research into bacterial inhibition and is relevant for studies investigating the role of urease in microbial metabolism and pathogenesis. Further applications may include exploring its potential in controlling microbial infections associated with urease-producing bacteria. -
Bacterial Inhibitor
CysHHC10 is a synthetic antimicrobial peptide that acts as a bacterial inhibitor by disrupting the integrity of microbial membranes. This compound demonstrates potent antibacterial activity against a range of both Gram-positive and Gram-negative bacteria, with minimum inhibitory concentrations (MIC) of 10.1 mM for E. coli, 20.2 mM for P. aeruginosa, 2.5 mM for S. aureus, and 1.3 mM for S. epidermidis. CysHHC10 is valuable for research applications focused on combating bacterial infections and studying microbial resistance mechanisms. -
Bacterial Inhibitor
SCH-538415 is an acyl carrier protein synthase inhibitor that disrupts bacterial cell functions by targeting the AcpS enzyme. It demonstrates significant antibacterial activity, specifically against Staphylococcus aureus, with an IC50 value of 4.19 μM in enzymatic assays. This compound is valuable for research focused on bacterial inhibition mechanisms and the development of new antimicrobial agents. -
Bacterial Inhibitor
(±)-Heraclenol is a coumarin compound known for its antibacterial properties. Isolated from the fruits of Angelica lucida, it demonstrates effective inhibition against various bacterial strains. This compound is utilized in research applications focused on understanding bacterial resistance mechanisms and exploring novel antimicrobial agents. -
Bacterial Inhibitor
Pyrithione sodium primarily targets bacterial inhibition and exhibits antimicrobial properties. This compound is commonly utilized in research applications related to skin microbiome studies and the development of anti-fungal and anti-bacterial treatments. While it is noted for its effectiveness in inhibiting bacterial growth, its limited skin penetration should be considered in experimental designs. -
Bacterial Biofilm Inhibitor
Antibacterial synergist 1 (compound 20P) is an effective bacterial biofilm inhibitor. It specifically inhibits the production of pyocyanin and biofilm formation in Pseudomonas aeruginosa with IC50 values of 8.6 μM and 4.5 μM, respectively. This compound is valuable for researching therapeutic strategies against P. aeruginosa infections, particularly in the context of chronic infections characterized by biofilm development. -
Bacterial Inhibitor
Eupatarone, also known as Caleprunin B, is a bacterial inhibitor derived from Calea platylepis. This compound exhibits significant antibacterial activity, making it a valuable tool in research focused on combating bacterial infections. Its ability to inhibit bacterial growth positions Eupatarone as an important reagent in microbiological studies and drug discovery efforts targeting antibiotic resistance. -
Bacterial Inhibitor
Bombinin-Like Peptide (BLP-1) is an antimicrobial peptide derived from Bombina species, primarily functioning as a bacterial inhibitor. This peptide exhibits potent activity against a range of bacterial strains, making it a valuable tool for research in antimicrobial resistance and the development of new therapeutic agents. Its unique mechanism and efficacy position it as an important candidate for studies focused on infection control and peptide-based drug design. -
Bacterial Inhibitor
Antimicrobial agent-21 is a potent bacterial inhibitor that demonstrates significant activity against both gram-positive and gram-negative bacteria. This compound serves as a valuable tool in microbiological research and antibiotic development, aiding in the study of bacterial resistance mechanisms and the efficacy of new antimicrobial strategies. Its broad-spectrum activity makes it applicable in various experimental settings focused on understanding bacterial pathogenesis and treatment. -
β-lactamase/PBP Inhibitor
FPI-1465 is a dual inhibitor targeting serine β-lactamases and penicillin-binding proteins (PBPs). This compound effectively inhibits PBP2 with an IC50 value of 1.0 µg/mL, demonstrating significant activity against β-lactamase enzymes CTX-M-15 and OXA-48, with Kd values of 0.011 µM and 5.3 µM, respectively. FPI-1465 is suitable for research applications focused on antibiotic resistance and the modulation of β-lactam antibiotic efficacy. -
Bacterial Inhibitor
Carbendazim mixture with flusilazole is a potent bacterial inhibitor utilized in the management of sooty mold, particularly attributable to Botrytis narcissicola. This fungicide combination demonstrates efficacy in diminishing lesion size and alleviating secondary sooty mold symptoms, especially when employed alongside other fungicides. In field trials conducted in regions such as Cambridgeshire and Lincolnshire, the application of this mixture significantly controlled sooty mold and enhanced bulb production by employing a strategic spray program that alternated fungicides with varying modes of action. This research emphasizes the importance of selecting appropriate fungicides and methodologies to optimize disease management while minimizing the required applications. -
Bacterial Inhibitor
Cellocidin is a bacterial inhibitor that targets the α-ketoglutarate-succinate system in Xanthomonas species. This agricultural antibiotic demonstrates preventive activity against rice bacterial leaf blight, offering a valuable tool for managing bacterial infections in crop production. Its mechanism of action makes it an essential reagent for research into plant-pathogen interactions and the development of sustainable agricultural practices. -
Bacterial Inhibitor
Phentolamine acetate is a bacterial inhibitor that targets and disrupts the growth of specific bacterial strains, including Staphylococcus aureus. This compound exhibits notable anti-inflammatory and anticancer properties, highlighting its potential for diverse biological applications. Its significant in vitro activity makes it a valuable tool for researchers studying bacterial infections and inflammation-related disorders. -
Beta-lactamase Inhibitor
Xeruborbactam is a potent boronic acid beta-lactamase inhibitor that targets both serine and metallo beta-lactamases with high efficacy. Demonstrating activity in the nanomolar range, it serves as an ultra-broad-spectrum agent in combating antibiotic resistance. Xeruborbactam is valuable for research applications focused on understanding beta-lactamase activity and developing novel antimicrobial strategies. -
Bacterial Inhibitor
Ethionamide hydrochloride is an antituberculosis agent that acts as a bacterial inhibitor. It disrupts mycobacterial cell wall synthesis by inhibiting fatty acid synthesis, leading to potential bacteriostatic or bactericidal effects based on concentration and microorganism susceptibility. Ethionamide hydrochloride forms an adduct with NAD+, which is crucial for its antimicrobial activity. This compound is primarily utilized in research for understanding tuberculosis treatment and the mechanisms of drug resistance in Mycobacterium tuberculosis. -
DGK Inhibitor
Cochlioquinone A is a potent diacylglycerol kinase (DGK) inhibitor, exhibiting ATP-competitive properties with a Ki value of 3.1 μM. Isolated from the fungal species Drechslera sacchari, Cochlioquinone A serves as a valuable tool for studying DGK's role in cellular signaling pathways. Its inhibitory effects on DGK activity make it pertinent for research in lipid signaling and related biological processes. -
ACAT Inhibitor
Phenylpyropene A is a potent inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), exhibiting an IC50 of 0.8 μM. This fungal metabolite has shown significant biological activity in modulating cholesterol esterification. Its application is particularly relevant in research focused on cholesterol metabolism and related disorders. -
ACAT Inhibitor
Terpendole I is a fungal indoloditerpene that functions as an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, exhibiting an IC50 value of 145 µM. This compound demonstrates significant biological activity in modulating cholesterol metabolism, making it a valuable tool for studying lipid regulation and related metabolic disorders. Terpendole I can be utilized in research focused on atherogenesis, cholesterol homeostasis, and the therapeutic exploration of cardiovascular diseases. -
Acyltransferase Inhibitor
Amidepsine D is an acyltransferase inhibitor derived from the fungal metabolite isolated from the culture broth of Humicola sp. FO-2942. It specifically inhibits diacylglycerol acyltransferases (DGAT), playing a crucial role in lipid metabolism regulation. This compound is valuable for research applications focused on examining lipid biosynthesis pathways and exploring potential therapeutic targets in metabolic disorders. -
ACAT Inhibitor
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), derived from the mycelial cake of Gibberella lateritium IFO 7188. This compound exhibits significant biological activity by inhibiting the growth of various human cancer cell lines, as well as displaying antibacterial effects against gram-positive bacteria and antifungal activity against Candida albicans. Lateritin is a valuable tool for research in cancer therapeutics and the study of lipid metabolism. -
ACAT Inhibitor
Glisoprenin A is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), targeting cholesterol metabolism. It has demonstrated significant activity in inhibiting the formation of appressorium on hydrophobic surfaces in the fungal pathogen Magnaporthe grisea. This compound is valuable for research into fungal plant pathogens and cholesterol metabolism dynamics. -
ACAT Inhibitor
Glisoprenin D is an ACAT inhibitor that selectively targets cholesterol acyltransferase, thereby influencing lipid metabolism. It has been shown to inhibit the formation of appressorium on the hydrophobic surfaces of Magnaporthe grisea, making it a valuable tool for studying fungal pathogenesis and plant-fungal interactions. This compound has potential applications in both basic and applied research within mycology and plant sciences. -
ACAT Inhibitor
Glisoprenin C is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism. By inhibiting ACAT, Glisoprenin C effectively disrupts cholesterol esterification, impacting the pathogenicity of organisms such as Magnaporthe grisea by preventing appressorium formation on hydrophobic surfaces. This compound is valuable in studying cholesterol-related pathways and evaluating potential therapeutic strategies against fungal pathogens.
