Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Agent
Bis(methylthio)gliotoxin is an antifungal agent with enhanced stability compared to gliotoxin, making it a more reliable biomarker for invasive aspergillosis. Its application in clinical diagnostics provides improved accuracy in the identification of Aspergillus infections, facilitating timely intervention and management. This compound is essential for research into fungal pathogenesis and the development of antifungal therapies. -
Antifungal Agent
Amphotericin X1 is a 13-O-methyl derivative of Amphotericin B, acting as a potent antifungal agent. It demonstrates significant inhibitory activity against various fungal pathogens, including Candida albicans, C. parapsilosis, Cryptococcus neoformans, Aspergillus niger, and A. fumigatus, with minimum inhibitory concentration (MIC) values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL, and 2 μg/mL, respectively. This compound is particularly valuable for research applications focused on fungal infections and the development of antifungal therapies. -
Antibacterial And Antifungal Agent
5CF2PB is an antibacterial and antifungal agent that targets the 5O4L protein. This compound demonstrates potent activity against a range of bacterial and fungal pathogens, particularly exhibiting significant efficacy against Pseudomonas aeruginosa and Aspergillus niger. 5CF2PB is valuable for research applications focused on infections and resistance mechanisms in microbial agents. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 3 is a selective inhibitor of chitin synthase, exhibiting an IC50 value of 0.16 mM. This compound demonstrates significant antifungal activity, with a minimum inhibitory concentration (MIC) of 1 µg/mL against Candida albicans. It is primarily utilized in research applications focusing on antifungal drug development and the study of chitin biosynthesis pathways in pathogenic fungi. -
Antifungal Agent
Antifungal agent 73 (compound A32) is an effective antifungal agent targeting azole-resistant candidiasis. It disrupts the integrity of the fungal cell wall and cell membrane, demonstrating significant in vivo antifungal activity against pathogenic fungi, including fluconazole-resistant strains. This compound is valuable for research applications focusing on antifungal resistance mechanisms and therapeutic strategies. -
Anticancer/antibacterial Agent
Antioxidant/anticancer agent 1 is a pyrimidine-derivatized Schiff base derived from pyrimidine hydroxy-1-naphthaldehyde, targeting multiple biological pathways. This compound exhibits significant antibacterial, antioxidant, antifungal, and anticancer activities, making it a valuable reagent for diverse research applications. Its multifaceted biological properties position it as a candidate for further investigation in cancer and infectious disease studies. -
Antifungal Agent
Galanolactone is a natural compound derived from the seeds of Alpinia galanga, primarily recognized for its antifungal properties. This agent exhibits significant cytotoxic effects against KB cells, with an EC50 value of 38.5 µg/ml. Galanolactone serves as a valuable tool in research focused on fungal inhibition and cytotoxicity studies. -
Antifungal Agent
Antifungal Agent 37 is a heterocyclic disulfide compound that exhibits significant antifungal activity. It is primarily utilized in research focused on fungal pathogens, providing insights into mechanisms of action and potential therapeutic applications. This compound serves as an essential tool in the development of novel antifungal agents for combating resistant strains. -
Antibiotic
Malolactomycin C is a macrolide antifungal antibiotic targeting fungal pathogens. Isolated from Streptomyces strain KP-3144, it demonstrates potent inhibitory activity against Botrytis cinerea, a key agent of gray mold in plants. This compound is valuable for research in plant disease management and the development of antifungal agents. -
Antifungal Agent
Antifungal agent 51 (Compound 5c) is a potent antifungal agent primarily targeting various Candida species, including Candida albicans, Candida parapsilosis, and Candida tropicalis. It exhibits exceptional antifungal activity with a minimum inhibitory concentration (MIC) of less than 0.063 μg/mL. Notably, it demonstrates low cellular toxicity and possesses no carcinogenic properties, making it a valuable tool for antifungal research and development. -
Antifungal Agent
Antifungal Agent 84 is a potent antifungal compound that targets candidiasis through a CNB1-dependent mechanism. This reagent effectively reduces the viability of Candida albicans biofilms, making it a valuable tool for research in fungal pathogenesis and biofilm formation. Its application is particularly relevant in studies focused on antifungal resistance and treatment strategies. -
Antifungal Agent
Anisocoumarin H is a coumarin derivative known for its antifungal activity. It effectively inhibits the growth of fungal pathogens, including Microsporum gypseum, Trichophyton rubrum, and Trichophyton mentagrophytes, with minimum inhibitory concentrations (MICs) of 62.5 µg/mL. This compound is valuable for research applications in studying fungal infections and developing antifungal therapeutics. -
Antifungal Activity
1,5-Hexadien-3-ol is a green leaf volatile (GLV) alcohol known for its antifungal activity, specifically targeting Botrytis cinerea. This compound plays a significant role in plant defense mechanisms, particularly in tomato plants, where it offers protection against grey mould disease. Its applications extend to research focused on fungal pathogens and plant resilience, making it a valuable tool for investigating plant defense strategies. -
Fungal Inhibitor
Antifungal Agent 16 is a potent fungal inhibitor, demonstrating significant antifungal activity compared to established agents such as ciprofloxacin and fluconazole. This compound is ideal for research aimed at exploring new antifungal therapies and addressing drug resistance in fungal pathogens. Its robust efficacy makes it a valuable tool in the investigation of fungal infections and therapeutics. -
Antimicrobial Agent
Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent targeting a range of microbial pathogens. It demonstrates significant antibacterial and antifungal activities, effectively eliminating harmful bacteria and fungi. With a high binding energy value of −10.0 kcal/mole against its target enzyme, Antimicrobial agent-4 is a valuable tool for research applications in microbiology and infectious diseases. -
Antifungal Agent
Medicagenic acid 3-O-glucoside is a monosaccharide-chain triterpenoid saponin that acts as an antifungal agent, primarily targeting fungal cell membranes. With a minimum inhibitory concentration (MIC) of 0.03 mg/mL and a minimum fungicidal concentration (MFC) of 0.125 mg/mL against *Pyricularia oryzae*, it disrupts membrane permeability, leading to cell rupture and growth inhibition. This compound is suitable for research applications focused on rice blast disease and fungal pathogenicity studies. -
Anti-bacterial Agent
(±)-Lomatin, a coumarin-type secondary metabolite derived from Coleonema album, exhibits significant antibacterial activity. It is primarily researched for its efficacy against bacterial, mycobacterial, and fungal infections. This compound serves as a valuable tool in investigating microbial pathogenesis and the development of novel antimicrobial therapies. -
Fungal Inhibitor
Antifungal agent 12 is a fluconazole-based compound that functions as a fungal inhibitor by disrupting fungal cell membrane synthesis. It demonstrates significant antifungal activity, making it suitable for research applications focused on fungal infections and resistance mechanisms. This compound can be utilized in studies aimed at developing new antifungal therapies. -
Fungal Inhibitor
3,5-Dimethyl-4-phenylisoxazole acts as a fungal inhibitor by disrupting fungal cell function. This heterocyclic compound demonstrates significant anti-fungal activity, making it a valuable tool for research in mycology and infectious disease studies. Additionally, it has shown promise in anti-inflammatory and anti-bacterial applications, indicating its potential for broader biological research. Its ability to modulate immune responses further highlights its versatility in various scientific investigations. -
Fungal
Alternapyrone is an α-pyrone compound with significant antifungal properties, predominantly derived from certain fungal species. This compound is known to affect wheat seed germination, exhibiting phytotoxicity that can be valuable for research into plant-fungal interactions and phytopathology. Its biosynthesis involves a simple enzymatic pathway, making it of interest for studies on metabolic processes in fungi. -
Antibacterial Agent
Bacimethrin (NSC 66577) is an antibacterial agent that acts as an antagonist of thiamin biosynthesis. This compound effectively inhibits the growth of various bacteria and yeast, making it a valuable tool in microbiological research. Its application extends to studies investigating bacterial resistance mechanisms and the development of new antibacterial therapies. -
Ribosome/EF2 Stabilizer
Sordarin is an antifungal agent that specifically targets Elongation Factor 2 (EF2). It possesses a tetracyclic diterpene structure and is derived from the fungus Sordaria araneosa. Sordarin exhibits strong antifungal activity against Saccharomyces cerevisiae and Candida albicans by inhibiting protein synthesis in fungi. It does so by preventing the translocation of the ribosome along mRNA during elongation, effectively stabilizing the ribosome/EF2 complex. This compound is valuable for research focused on fungal protein synthesis and antifungal drug development. -
Antimicrobial/Anticancer Agent
Isocryptomerin primarily targets fungal membranes as a membrane-active antifungal compound derived from Selaginella tamariscina. It exerts its antimicrobial effects by depolarizing the plasma membrane of fungi. Additionally, isocryptomerin demonstrates notable anticancer and antibacterial activities, making it a valuable agent for research in both oncology and infectious diseases. -
Antimycobacterial Drug
Antituberculosis agent-7 is an oxetanyl-quinoline derivative primarily targeting mycobacterial infections. It exhibits potent antimycobacterial activity, demonstrating a minimum inhibitory concentration (MIC) of 3.41 μM against Mycobacterium tuberculosis H37Rv. Additionally, it displays notable antibacterial effects against Proteus mirabilis with an MIC of 31.25 μM and antifungal activity against Aspergillus niger with an MIC of 62.5 μM. This compound holds potential for research in antimicrobial susceptibility and drug development against various infectious diseases. -
Antifungal Agent
D0870 is an antifungal agent that effectively inhibits Candida neoformans, as well as strains associated with vaginal candidiasis and other viable yeasts. Its primary mechanism involves disrupting fungal cell viability, making it a valuable tool for research into fungal infections and developing therapeutic applications against opportunistic fungal pathogens. D0870 is suitable for studies aimed at understanding antifungal resistance and the mechanisms underlying yeast-related infections. -
Antifungal Agent
Antifungal Agent 86 (Compound 41F5) is an effective antifungal targeting pathogenic fungi. It demonstrates significant activity against Histoplasma yeast and Cryptococcus neoformans, with a MIC50 range of 0.4-0.8 μM. This compound is valuable for research focusing on fungal infections and developing therapeutic strategies against fungal pathogens. -
Antibiotic
Fenpicoxamid is an antibiotic that targets and inhibits the growth of the fungus Zymoseptoria tritici, demonstrating an effective EC50 value of 0.051 mg/L. This compound is utilized in research applications focused on fungal disease management in crops, providing insights into the mechanisms of fungicide action and resistance. These properties make Fenpicoxamid a valuable tool for studies in plant pathology and agricultural biotechnology. -
Amides
Dehydropipernonaline is an amide compound that exhibits significant cytotoxicity against L5178Y mouse lymphoma cells, with an IC50 value of 8.9 μM. This compound is valuable in research applications involving antifungal screening and the investigation of cytotoxic agents. -
Antifungal Agent
Nudicaucin B is a triterpenoid saponin extracted from Hedyotis nudicaulis, primarily known for its antifungal properties. This compound demonstrates significant activity against various fungal strains, making it a valuable tool for research focused on antifungal drug development and identifying potential therapeutic agents for fungal infections. Its unique structure and biological activity contribute to its relevance in exploring new treatments in mycology and related fields. -
Antioxidant
Dihydro-N-caffeoyltyramine is a phenolic amide known for its potent antioxidant properties. It exhibits strong antioxidant activity and demonstrates antifungal effects. Mechanistically, Dihydro-N-caffeoyltyramine downregulates cyclooxygenase-2 expression by inhibiting the activity of C/EBP and AP-1 transcription factors, making it a valuable compound for research in oxidative stress and inflammatory responses. -
Antifungal Agent
Antifungal Agent 70 is a dihydroeugenol-imidazole compound that demonstrates potent activity against multi-resistant Candida auris, with an MIC of 36.4 μM. This agent effectively inhibits fungal growth and is valuable in research applications focused on developing treatments for resistant fungal infections. Its unique mechanism makes it a promising candidate for further exploration in antifungal drug development. -
Fungal Inhibitor
Fumigaclavine A is a clavine alkaloid that acts as a fungal inhibitor targeting Aspergillus species. This mycotoxin, produced by Aspergillus fumigatus, is significant in studies related to fungal contamination and plant disease management. Research applications include investigating the pathogenicity of A. fumigatus and assessing the efficacy of antifungal agents in various environments. -
Fungal Inhibitor
(-)-Zonarol is a potent antifungal agent that targets and inhibits fungal growth. This compound exhibits diverse translational potential in research applications, particularly in the study of fungal infections and resistance mechanisms. As an isomer of Zonarol and related to the natural product (-)-Yahazunol, (-)-Zonarol provides valuable insights into fungal biology and therapeutic strategies. -
Antifungal Agent
Antifungal Agent 33 is a potent inhibitor of Lanosterol 14α-demethylase (CYP51), exhibiting an IC50 of 0.19 μg/mL. This compound demonstrates significant antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 16 μg/mL. Antifungal Agent 33 is valuable for research applications focused on the development of new antifungal therapies and the study of fungal resistance mechanisms. -
Antibiotic
Albaflavenone is a sesquiterpene antibiotic characterized by a zizaene skeleton. It exhibits potent antibacterial activity against Bacillus subtilis, making it valuable for studies in microbial resistance and antibiotic efficacy. Albaflavenone can be utilized in research applications focused on the development of novel antimicrobial agents. -
Germination Self-inhibitor
Methyl (Z)-ferulate is a natural germination self-inhibitor primarily derived from the leaves of Tetragonia tetragonoides. It effectively blocks germination in rust fungi by reversibly inhibiting the degradation of the germination pore plug through modulation of existing enzyme activity. In addition to its antifungal properties, Methyl (Z)-ferulate exhibits antioxidant activity, demonstrating significant scavenging capabilities against DPPH and ABTS+ radicals. This compound is valuable for research applications focused on plant defense mechanisms and antioxidant strategies. -
Antimicrobial Agent
Antimicrobial agent-3 is a broad-spectrum antimicrobial compound exhibiting efficacy against bacterial, fungal, and tubercular pathogens. Its mechanism of action involves disrupting microbial cell integrity, thereby facilitating elimination of infections. This reagent is useful in research applications aimed at developing new therapeutic strategies to combat resistant strains of pathogens and improving understanding of antimicrobial resistance mechanisms. -
C. albicans Nmt Inhibitor
SC-58272 is a potent and selective inhibitor of N-myristoyltransferase (Nmt) in Candida albicans, exhibiting an IC50 of 56 nM against the strain B311. This compound demonstrates a 250-fold selectivity for the fungal enzyme when compared to the human counterpart. SC-58272 is valuable for research applications involving fungal pathogenesis and the study of myristoylation processes in C. albicans. -
Parasite
Aspyrone is a polyketide fungal metabolite primarily targeting various parasites. Exhibiting broad-spectrum biological activity, it demonstrates antifungal efficacy against 13 fungi at a concentration of 20 μg/mL and is effective against a range of 21 bacteria in a disc assay at 100 μg per disc. Additionally, Aspyrone shows potent nematocidal activity against Pratylenchus penetrans at concentrations ranging from 10 to 1,000 mg/L, making it a valuable compound for research in both parasitology and microbiology. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 2 selectively targets chitin synthase, demonstrating potent inhibitory effects with an IC50 of 0.09 mM and a Ki of 0.12 mM. This compound exhibits significant antimicrobial activity in vitro and can enhance the effects of fluconazole and polyoxin B, making it a valuable tool for investigating chitin biosynthesis and potential applications in antifungal research. -
Antifungal Agent
3-Oxobetulin is an antifungal agent that targets fungal pathogens. It exhibits significant antifungal activity against the white rot fungus L. betulina and the brown rot fungus L. sulphureus. This compound is useful for research applications focused on the development of antifungal treatments and understanding fungal resistance mechanisms. -
Antifungal Agent
Antifungal Agent 90 (Compound 7n) is an antifungal compound that inhibits ergosterol biosynthesis, a critical component of fungal cell membranes. This agent demonstrates strong antifungal activity against Valsa mali and Botrytis cinerea, with effective concentration (EC50) values of 4.26 μg/mL and 1.41 μg/mL, respectively. It serves as a valuable tool in the study of fungal infections and the development of antifungal therapies. -
Antifungal Agent
KOS-2079 is an antifungal agent that exhibits potent inhibitory activity against Aspergillus flavus (MIC = 1.10 μg/mL) and Aspergillus fumigatus (MIC = 1.32 μg/mL). This compound is valuable for research applications focused on fungal infections, providing insights into mechanisms of resistance and potential therapeutic strategies. KOS-2079 serves as a critical tool in the study of antifungal efficacy and the biology of pathogenic fungi. -
Antibiotic
Burnettramic acid A is a potent antibiotic derived from Aspergillus burnettii, targeting various bacterial and fungal pathogens. It demonstrates significant antibacterial and antifungal activities, with IC50 values of 0.2 μg/mL against Saccharomyces cerevisiae, 0.5 μg/mL against Candida albicans, 2.3 μg/mL against Bacillus subtilis, and 5.9 μg/mL against Staphylococcus aureus. Additionally, Burnettramic acid A exhibits cytotoxic effects on NS-1 cancer cells, with an IC50 of 13.8 μg/mL, making it a valuable candidate for further research in antimicrobial and anticancer applications. -
Antifungal Agent
Antifungal agent 21 is a novel antifungal compound targeting fungal pathogens. Its primary mechanism involves disrupting fungal cell wall synthesis, leading to cellular instability and eventual cell death. This agent exhibits potent antifungal activity against a broad spectrum of fungi, making it a valuable tool in agricultural research and the development of effective agrochemical solutions for crop protection. -
Antifungal Agent
Antifungal Agent 53 is a potent inhibitor of the cytochrome P450 enzyme CYP51 in Candida albicans, demonstrating significant antifungal activity. This compound effectively prevents the formation of fungal biofilms, contributing to its efficacy against fungal infections. Additionally, Antifungal Agent 53 has favorable safety profiles, making it a valuable tool in antifungal research applications. -
Antibiotic/Antimicrobial Peptide
Aurein 2.5 is an antibiotic antimicrobial peptide that exhibits potent antibacterial and antifungal activity. It targets microbial membranes, disrupting their integrity and leading to cell death. This compound is valuable for research applications focused on exploring novel antimicrobial therapies and understanding peptide-microbe interactions. -
Antifungal Agent
Cinnamon bark oil, derived from Cinnamomum zeylanicum Blume, acts as an antifungal agent targeting various fungi responsible for respiratory tract mycoses. This compound has demonstrated significant biological activity in inhibiting fungal growth, making it a valuable tool for research in mycology and respiratory infections. Its potential applications extend to studies focused on natural antifungal therapies and the development of alternative treatment strategies. -
Succinate Dehydrogenase Inhibitor
Succinate dehydrogenase-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH). This indene amino acid derivative exhibits significant antifungal activity in vitro, with effective concentrations against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L). It is a valuable tool for research applications focused on inhibiting SDH in microbial pathogens. -
Antibiotic
Amphotericin B trihydrate is a polyene antibiotic primarily targeting fungal cell membranes by binding to ergosterol, leading to cell membrane disruption and cell death. This compound exhibits broad-spectrum antifungal activity and is also effective against leishmaniasis, making it valuable in the study of fungal infections and parasitic diseases. Its unique mechanism of action allows for diverse research applications in microbiology and infectious disease studies.
