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Donepezil-d4

Stable Isotope

Donepezil-d4 is a deuterium-labeled analog of Donepezil, a potent and selective acetylcholinesterase (AChE) inhibitor that exhibits IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the compound's bioavailability and metabolic pathways in biological systems. Donepezil-d4 serves as a valuable tool for elucidating the pharmacological effects of AChE inhibition in various neurological studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1219908-72-1
Applications	Stable Isotope
Formula	C₂₄H₂₅D₄NO₃
Molecular Weight	383.52
Synonyms	E2020-d4 free base
SMILES	O=C1C2=CC(OC)=C(OC)C=C2CC1C([2H])([2H])C3CCN(CC3)C([2H])([2H])C4=CC=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.