Fig. 1 · Structure
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Protriptyline hydrochloride
Antidepressant Agent
Protriptyline hydrochloride is a potent tricyclic antidepressant with a primary mechanism of action involving the inhibition of acetylcholinesterase (AChE), with an IC50 of 0.06 mM, as well as the reduction of amyloid beta (Aβ) self-assembly. This compound exhibits significant antidepressant activity and is valuable for research related to depression and Alzheimer's disease. It serves as a useful reagent for studying neurochemical pathways implicated in mood disorders and neurodegenerative conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1225-55-4 |
| Applications | Antidepressant Agent |
| Formula | C19H22ClN |
| Molecular Weight | 299.84 |
| SMILES | CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.