AChE Inhibition in Cx. pipiens Larvae
Cell-based study · Cx. pipiens larvae [1]
Pyridostigmine bromide was introduced into the reaction mixture to assess AChE inhibition activity in Cx. pipiens larvae. The reported IC50 was 135.54 µM.
| Endpoint | Reported result | Reference |
|---|---|---|
| AChE inhibition activity | IC50 135.54 µM | [1] |
Literature-Reported Treatment Conditions
- Treatment concentration
- 10 to 250 µM
- Exposure duration
- Change in absorbance was monitored at 412 nm for 13 min
- Method
- inhibitors were introduced in the reaction mixture
- Reported limits
- Not stated in the sentences used: vehicle.
Methods and source locations
Compound reported in the paper: Pyridostigmine bromide
Literature evidence for the named compound in the stated model; no Adooq product-use or lot-performance claim.
Result > In vitro and in vivo AChE inhibition assay (S73); Materials and methods > In vitro acetylcholinesterase inhibition assay (S131, S135, S136, S139, S140, S141, S142)
AChE inhibition activity: AChE inhibition activity; comparator: the control included every other reaction component except the substrate — Result > In vitro and in vivo AChE inhibition assay (S73); Materials and methods > In vitro acetylcholinesterase inhibition assay (S141)