AChE

Cat. No.

A78534

CAS No.

513-00-8

Iso-OMPA

Synonyms: Tetraisopropyl pyrophosphoramide

Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of butyrylcholinesterase (BuChE), functioning through irreversible inhibition. This compound is primarily utilized in research to investigate the mechanisms of BuChE and the resulting effects on acetylcholine metabolism. Iso-OMPA has been shown to enhance soman toxicity in rat models, linked to the inhibition of plasma carboxylesterase (CarbE), making it a valuable tool in studies of nerve agent effects and cholinergic signaling.

Cat. No.

A78537

CAS No.

6485-40-1

(-)-Carvone (l-Carvone)

(-)-Carvone is a neurotoxin that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This compound is utilized primarily for its biological activity as a bird repellent, as well as its ability to inhibit larval growth, reduce pupation rates, and increase larval mortality. Research applications include studies on insect neurobiology and pest control strategies.

Cat. No.

A78540

CAS No.

57-64-7

Physostigmine salicylate

Synonyms: Eserine salicylate

Physostigmine salicylate is a reversible acetylcholinesterase (AChE) inhibitor that effectively crosses the blood-brain barrier, enhancing central cholinergic neurotransmission. It has demonstrated the ability to reverse memory deficits in transgenic mice models of Alzheimer's disease, making it a valuable tool in neurodegeneration research. Additionally, Physostigmine salicylate serves as an antidote for anticholinergic poisoning, highlighting its significance in pharmacological studies and therapeutic applications.

Cat. No.

A78541

CAS No.

321-64-2

Tacrine

Tacrine is a potent acetylcholinesterase (AChE) inhibitor, with an IC50 value of 109 nM. This compound is recognized for its ability to ameliorate cognitive deficits, particularly in aged rodent models. Additionally, Tacrine is associated with potential hepatotoxicity and is frequently utilized in research focusing on Alzheimer's disease and related neurodegenerative disorders.

Cat. No.

A78543

CAS No.

501-92-8

Chavicol

Synonyms: p-Hydroxyallylbenzene

Chavicol, a cholinesterase (ChE) inhibitor, demonstrates potent inhibition of acetylcholinesterase, with an IC50 of 7.42 μM. This compound exhibits anti-cancer properties, effectively suppressing the growth, survival, migration, and invasion of various cancer cell lines. Notably, Chavicol shows significant cytotoxic effects, evidenced by a notable concentration of approximately 31 μg/mL in A-549 cells. Its dual activities underscore its potential utility in cancer research and therapeutic development.

Cat. No.

A78544

CAS No.

64-47-1

Physostigmine hemisulfate

Synonyms: Eserine hemisulfate

Physostigmine hemisulfate is a reversible inhibitor of acetylcholinesterase (AChE), effectively enhancing cholinergic neurotransmission by crossing the blood-brain barrier. This compound has demonstrated the ability to reverse cognitive deficits in transgenic mouse models of Alzheimer's disease, making it a valuable tool for neurological research. Additionally, Physostigmine hemisulfate serves as an antidote for anticholinergic poisoning, underscoring its significance in pharmacological studies and clinical applications.

Cat. No.

A78546

CAS No.

123855-51-6

N-Boc-4-piperidinemethanol

N-Boc-4-piperidinemethanol is an acetylcholinesterase (AChE) inhibitor that serves as a valuable tool for neurological research. It is particularly relevant in studies focused on Alzheimer's Disease, aiding in the investigation of cholinergic dysfunction. This compound may contribute to the development of therapeutic strategies targeting AChE activity.

Cat. No.

A78547

CAS No.

41198-08-7

Profenofos

Profenofos is an insecticide that functions as an acetylcholinesterase (AChE) inhibitor, leading to neurotoxicity in target pest species. Its primary mechanism involves the inhibition of AChE, resulting in the accumulation of acetylcholine at synapses, which disrupts normal neural function. Profenofos is effective for the control of a wide range of insect pests on field crops, vegetables, and fruit crops, making it valuable for agricultural research and pest management studies.

Cat. No.

A78549

CAS No.

86831-54-1

Rhodiosin

Rhodiosin is a dual inhibitor of CYP2D6 and acetylcholinesterase (AChE), extracted from the root of Rhodiola rosea. It exhibits an IC50 value of 0.761 μM for CYP2D6 and a Ki of 0.769 μM. This compound demonstrates notable antioxidant and neuroprotective properties, contributing to the regulation of the HIF-1α signaling pathway, which is vital for central nervous system protection. Rhodiosin serves as a valuable tool for research in neuropharmacology and metabolic studies.

Cat. No.

A78552

CAS No.

40581-17-7

Violanthin

Violanthin is a cholinesterase (ChE) inhibitor derived from the stems of Dendrobium officinale. It exhibits significant antioxidant and antibacterial properties, making it a valuable compound for biological research. Violanthin effectively inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM, indicating its potential application in studies related to neurodegenerative diseases and cholinergic signaling.

Cat. No.

A78556

CAS No.

3779-42-8

AChE-IN-84

AChE-IN-84 is a potent inhibitor of acetylcholinesterase (AChE), a key enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine. This compound demonstrates significant biological activity in modulating cholinergic signaling pathways, making it an essential tool for studying neurodegenerative diseases such as Alzheimer's. AChE-IN-84 is useful in research applications focusing on cognitive enhancement and synaptic function restoration.

Cat. No.

A78557

CAS No.

2597-03-7

Phenthoate

Phenthoate is a cholinesterase (ChE) inhibitor that functions primarily as an organophosphorus pesticide. This compound demonstrates low toxicity in animals while effectively inhibiting acetylcholinesterase (AChE), which can provide insights into neurotoxicity and enzyme regulation. Phenthoate is widely used in research applications examining the biochemical pathways of neurotransmission and potential environmental impacts of pesticide exposure.

Cat. No.

A78558

CAS No.

795316-16-4

ACG548B

ACG548B is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 1.78 µM and 0.496 µM, respectively. It exhibits strong affinity and selectivity for AChE over BChE and choline kinase (ChoK). ACG548B is suitable for research applications focused on myasthenia gravis and the mechanisms of neuromuscular blockade.

Cat. No.

A78560

CAS No.

30044-78-1

Pseudocoptisine chloride

Synonyms: Isocoptisine chloride

Pseudocoptisine chloride is a quaternary alkaloid derived from the benzylisoquinoline structure, isolated from Corydalis tuber. This compound functions as an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 of 12.8 μM. Pseudocoptisine chloride exhibits notable anti-inflammatory and anti-amnestic properties, making it a valuable reagent for research related to neurodegenerative diseases and cognitive function studies.

Cat. No.

A78565

CAS No.

7630-74-2

Dehydronuciferine

Dehydronuciferine acts as an inhibitor of cholinesterase, specifically targeting acetylcholinesterase (AChE) with an IC50 value of 25 μg/mL. This compound is derived from the leaves of Nelumbo nucifera (lotus) and demonstrates potential in research applications related to neurodegenerative diseases and cognitive disorders. Its ability to modulate cholinergic signaling makes it a valuable tool for studying cholinergic system functions and developing therapeutic strategies.

Cat. No.

A78567

CAS No.

510-77-0

Galanthaminone

Synonyms: (-)-Narwedine; Narwedin

Galanthaminone is a competitive and reversible inhibitor of cholinesterase (ChE), primarily targeting acetylcholinesterase (AChE). This compound demonstrates significant biological activity in enhancing cholinergic transmission and is utilized in the study of mild to moderate Alzheimer's disease and related memory impairments. Its application in research aids in understanding the mechanisms underlying cognitive decline and potential therapeutic interventions.

Cat. No.

A78568

CAS No.

97230-46-1

Picfeltarraenin IB

Picfeltarraenin IB is a triterpenoid derived from Picria fel-terrae Lour that acts as a cholinesterase (ChE) inhibitor. This compound exhibits significant biological activity by inhibiting acetylcholinesterase (AChE), thereby modulating cholinergic signaling. It is primarily utilized in research settings focusing on therapeutic applications for herpes infections, cancer, and inflammation.

Cat. No.

A78570

CAS No.

103548-82-9

Huperzine B

Huperzine B is a Lycopodium alkaloid that acts primarily as a selective inhibitor of acetylcholinesterase (AChE). This compound demonstrates significant potential for enhancing cholinergic neurotransmission, which is crucial in the context of neurodegenerative disorders such as Alzheimer's disease. Research applications include studies focused on cognitive enhancement and memory preservation.

Cat. No.

A78571

CAS No.

209394-46-7

Ladostigil hemitartrate

Synonyms: TV-3326 hemitartrate

Ladostigil hemitartrate is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), with established IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound is capable of crossing the blood-brain barrier and exhibits neuroprotective, antioxidant, and anti-inflammatory properties. Ladostigil hemitartrate is relevant for research into neurological disorders, including depression and Alzheimer's disease. Additionally, it functions as a click chemistry reagent, featuring an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc).

Cat. No.

A78572

CAS No.

621-87-4

Phenoxyacetone

Synonyms: Phenoxy-2-propanone

Phenoxyacetone is a competitive inhibitor of acetylcholinesterase (AChE), targeting the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine. By inhibiting AChE, phenoxyacetone enhances cholinergic signaling, making it valuable for studying neurological conditions characterized by impaired neurotransmission. This compound is suitable for research applications focused on neuropharmacology and the exploration of treatments for Alzheimer's disease and other memory-related disorders.

Cat. No.

A78573

CAS No.

23141-27-7

Vincosamide

Vincosamide is a potent acetylcholinesterase (AChE) inhibitor derived from the extract of Psychotria leiocarpa. It exhibits anti-inflammatory properties, making it a valuable compound for studying neurodegenerative diseases related to cholinergic dysfunction. Research applications include exploring potential therapeutic strategies for conditions such as Alzheimer's disease and other disorders characterized by altered AChE activity.

Cat. No.

A78575

CAS No.

2631-40-5

Isoprocarb

Isoprocarb is a cholinesterase (ChE) inhibitor that functions as a carbamate insecticide. It effectively targets pests such as rice paddy lice and leafhoppers, making it valuable in agricultural research. Its role in inhibiting acetylcholinesterase (AChE) provides insights into neuromuscular function and the mechanisms of toxicity, contributing to studies on pest control and environmental impact assessments.

Cat. No.

A78576

CAS No.

2425632-57-9

BChE-IN-17

BChE-IN-17 is a potent and selective inhibitor of butyrylcholinesterase (BChE) with IC50 values of 10.5 nM for equivalent BChE and 32.5 nM for human BChE. This compound demonstrates a remarkable over 1000-fold selectivity for BChE compared to acetylcholinesterase (AChE). Additionally, BChE-IN-17 exhibits low neurotoxicity and offers moderate neuroprotective effects, making it a valuable reagent for research in neurodegenerative diseases and cholinergic signaling pathways.

Cat. No.

A78577

CAS No.

13241-32-2

Neoeriocitrin

Neoeriocitrin, a potent acetylcholinesterase (AChE) inhibitor isolated from Drynaria Rhizome, demonstrates significant biological activity in promoting proliferation and osteogenic differentiation in MC3T3-E1 cells. This compound is valuable for research in neurodegenerative diseases, where AChE inhibition is critical, as well as in studies focused on bone biology and regenerative medicine.

Cat. No.

A78578

CAS No.

17472-50-3

Cyclanoline chloride

Cyclanoline chloride is a potent cholinesterase inhibitor that disrupts the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. This compound is primarily utilized in research applications focusing on neurodegenerative diseases and paralysis, as it contributes to understanding the role of neurotransmitter regulation in synaptic function. Its inhibitory effects on cholinesterase make it a valuable tool for studying cholinergic signaling pathways.