AChE

Cat. No.

A68030

CAS No.

62732-44-9

Ipidacrine

Synonyms: NIK-247 free base; Amiridine free base

Ipidacrine is a potent and selective inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), exhibiting IC50 values of 1 μM and 1.9 μM, respectively. This compound also acts as a partial agonist on M2-cholinergic receptors, promoting neuromuscular transmission and providing a moderate anti-pain effect. Ipidacrine is relevant for research into Alzheimer's disease, ischemic stroke, and diabetic complications, enhancing erectile function and exhibiting effects on ionic channels in neuronal membranes. Its applications extend to studying various deficits in central and peripheral cholinergic disorders.

Cat. No.

A68221

CAS No.

90043-86-0

Ipidacrine hydrochloride

Synonyms: NIK-247; Amiridine

Ipidacrine hydrochloride is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 1 μM and 1.9 μM, respectively. This compound also acts as a partial agonist at M2-cholinergic receptors and exhibits reversible cholinesterase inhibition. Ipidacrine hydrochloride facilitates neuromuscular transmission and demonstrates moderate analgesic properties. It shows promise in preclinical models for various conditions, including Alzheimer’s disease, ischemic stroke, facial nerve neuropathy, and diabetes-associated erectile dysfunction, highlighting its potential in investigating cholinergic system-related disorders.

Cat. No.

A68429

CAS No.

61-12-1

Dibucaine hydrochloride

Synonyms: Cinchocaine hydrochloride

Dibucaine hydrochloride is a sodium channel inhibitor that effectively blocks the influx of sodium ions, thereby preventing the propagation of action potentials in excitable tissues. This compound exhibits potent activity as an anesthetic and is utilized in various research applications, including studies of nerve conduction and muscle excitability. Additionally, it serves as a significant inhibitor of serum cholinesterase, contributing to its utility in pharmacological investigations and the development of anesthetic protocols.

Cat. No.

A68641

CAS No.

1215713-38-4

Dibucaine-d9 hydrochloride

Synonyms: Cinchocaine-d9 hydrochloride

Dibucaine-d9 hydrochloride is a deuterium-labeled derivative of Dibucaine hydrochloride, primarily functioning as a sodium channel inhibitor. This compound exhibits strong inhibition of serum cholinesterase (SChE) activity, making it valuable in pharmacological studies related to analgesia and local anesthesia. Its stable isotope labeling facilitates advanced metabolic research and provides insights into drug metabolism and distribution.

Cat. No.

A69482

CAS No.

93944-58-2

α-Amylase-IN-3

α-Amylase-IN-3 is a potent inhibitor of α-Amylase, exhibiting an IC50 of 18.04 μM, and also targets acetylcholinesterase (AChE) with IC50s of 21.04 μM and 22.2 μM, respectively. This compound demonstrates antioxidant activity, making it valuable for studies related to diabetes and diseases associated with oxidative stress. Its biochemical properties make α-Amylase-IN-3 a useful tool for researchers investigating metabolic disorders and neuroprotective mechanisms.

Cat. No.

A69505

CAS No.

1038094-94-8

α-Amylase/α-Glucosidase-IN-7

α-Amylase/α-Glucosidase-IN-7 is a competitive dual inhibitor targeting α-glucosidase and α-amylase, demonstrating IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, this compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 9.25 µM and 10.06 µM. α-Amylase/α-Glucosidase-IN-7 is valuable for research applications related to diabetes and Alzheimer’s disease.

Cat. No.

A69568

CAS No.

523-88-6

Dibromsalicil

Dibromsalicil is a selective inhibitor of carboxylesterases (CES), exhibiting inhibitory activity with IC50 values of 72.7 nM against human intestinal carboxylesterase (hiCE) and 53.5 nM against rabbit liver carboxylesterase (rCE). This compound demonstrates minimal activity against human liver carboxylesterase (hCE1) and cholinesterase, making it a valuable tool for research applications focused on drug metabolism and enzymatic activity modulation. Its specificity for hiCE and rCE positions Dibromsalicil as an important reagent for studying carboxylesterase-related pathways.

Cat. No.

A69587

CAS No.

23560-59-0

Heptenophos

Heptenophos is a potent inhibitor of acetylcholinesterase (AChE) and plasma carboxylesterase (CES). By obstructing AChE activity, Heptenophos leads to the accumulation of acetylcholine at cholinergic synapses, which can result in symptoms characteristic of organophosphate poisoning. Its rapid toxicity in animal models, such as male albino mice, allows for the investigation of detoxification strategies, particularly in conjunction with agents like obidoxime and Memantine. This compound is widely utilized in research exploring the mechanisms underlying organophosphate effects and potential antidotal treatments.

Cat. No.

A70157

CAS No.

41303-74-6

N-Desmethyl Galanthamine

Synonyms: Norgalanthamine

N-Desmethyl Galanthamine is a potent cholinesterase inhibitor, specifically targeting acetylcholinesterase (AChE) with an IC50 value of 2.76 μM. As a metabolite of Galanthamine, it holds significant relevance in neuropharmacological research. This compound is utilized in studies related to Alzheimer's disease, providing insights into therapeutic strategies aimed at enhancing cholinergic transmission.

Cat. No.

A70406

CAS No.

1646-87-3

Aldicarb sulfoxide

Aldicarb sulfoxide is a metabolite of aldicarb that primarily interacts with glutathione-linked enzymes in CHO-K1 cells. This compound exhibits inhibitory activity against cholinesterase (ChE) and carboxylesterase (CaE), with an IC50 of 10 μM in zebrafish models. Its mechanism of action and biological activity make it a valuable tool for research on neurotoxicology and enzymatic regulation.

Cat. No.

A70611

CAS No.

16655-82-6

3-Hydroxycarbofuran

3-Hydroxycarbofuran is a reversible inhibitor of acetylcholinesterase (AChE), acting primarily by competing with acetylcholine at the enzyme's active site. This compound serves as a significant metabolite of Carbofuran and exhibits notable biological activity in the modulation of cholinergic signaling. It is utilized in research related to neurobiology, toxicology, and pesticide biochemistry, providing insights into the effects of AChE inhibition on synaptic transmission and potential neurotoxic mechanisms.

Cat. No.

A70655

CAS No.

3735-33-9

Phosmet oxon

Synonyms: Imidoxon; Oxoimidan

Phosmet oxon is a potent metabolite of phosmet, functioning primarily as a cholinesterase inhibitor. This compound exhibits significant neurotoxic activity, making it relevant in studies investigating insecticidal mechanisms and their effects on cholinergic signaling pathways. Phosmet oxon's utility extends to research on pesticide metabolism and its implications for environmental toxicology and safety assessments.

Cat. No.

A70702

CAS No.

22672-74-8

Isocorybulbine

Synonyms: (+)-Isocorybulbine

Isocorybulbine is a primary metabolite of Corydaline, produced in human liver microsomes and liver cells. It exhibits significant biological activities, including anti-acetylcholinesterase and anti-allergic effects. This compound is valuable for metabolic studies of Corydaline, contributing to research in pharmacology and potential therapeutic applications.

Cat. No.

A70830

CAS No.

120013-84-5

Donepezil N-oxide

Donepezil N-oxide is an acetylcholinesterase (AChE) inhibitor derived from Donepezil. It exhibits significant biological activity by inhibiting AChE in human erythrocytes, which is crucial for regulating acetylcholine levels in neurological pathways. This reagent is utilized in research focused on Alzheimer's disease and other cognitive disorders where modulation of cholinergic transmission is a key area of investigation.

Cat. No.

A70877

CAS No.

2496-91-5

Demeton-S sulfone

Demeton-S sulfone is the oxidative metabolite of the organophosphorus insecticide Disulfoton, primarily targeting acetylcholinesterase. This compound exhibits significant acetylcholinesterase inhibition, which is essential for studying neurotoxic effects related to organophosphate exposure. It serves as a crucial reagent for evaluating the biochemical pathways of organophosphate metabolism and understanding their environmental and health impacts.

Cat. No.

A70883

CAS No.

1634-78-2

Malaoxon

Malaoxon is a pesticide metabolite that serves as an inhibitor of acetylcholinesterase, impacting neurotransmitter regulation. This compound has been shown to induce cellular death in cultured human pulmonary cells, making it relevant for studies on pulmonary toxicity and its underlying mechanisms. Its application extends to research focused on the toxicological effects of pesticide exposure in human respiratory systems.

Cat. No.

A71420

CAS No.

593-81-7

Trimethylammonium chloride

Synonyms: Hegzadesil; Trimethylamine hydrochloric acid; Trimethylamine monohydrochloride

Trimethylammonium chloride is a non-competitive inhibitor of acetylcholinesterase, targeting the enzymatic activity responsible for the hydrolysis of the neurotransmitter acetylcholine. By reversibly blocking the deacetylation process of acetylcholinesterase, this reagent plays a critical role in studies related to neurobiology and the modulation of synaptic transmission. Its application extends to research investigating cholinergic signaling pathways and potential therapeutic strategies for neurological disorders.

Cat. No.

A72584

CAS No.

23526-45-6

Vomifoliol

Vomifoliol is a cholinesterase (ChE) inhibitor that exhibits significant antiacetylcholinesterase activity, comparable to that of abscisic acid (ABA). Additionally, this compound shows moderate antileishmanial activity, making it a valuable tool for research into neurodegenerative disorders and parasitic infections. Its unique structure, featuring a modified 2,4-pentadiene side chain, further contributes to its biological activity, offering potential applications in pharmacological studies.

Cat. No.

A72813

CAS No.

22248-79-9

Tetrachlorvinphos

Tetrachlorvinphos is an organophosphorus compound that primarily acts as a cholinesterase inhibitor. This metabolite is commonly utilized in agricultural settings for pest control due to its effectiveness against a variety of insects. With low toxicity to mammals, tetrachlorvinphos serves as a useful tool for studying pesticide interactions and their effects on non-target organisms.

Cat. No.

A73134

CAS No.

2734300-40-2

(Z)-Tetrachlorvinphos-d6

(Z)-Tetrachlorvinphos-d6 is a deuterated form of Tetrachlorvinphos, an organophosphorus pesticide that primarily acts as a cholinesterase inhibitor. This stable isotope is utilized in research to trace metabolic pathways and analyze pesticide residues in various biological matrices. With low toxicity to mammals, it provides a safe and useful tool for studying the environmental impact and biochemical interactions of pesticide application.

Cat. No.

A73152

CAS No.

22781-23-3

Bendiocarb

Bendiocarb is a carbamate compound that primarily acts as an inhibitor of the enzyme acetylcholinesterase. This inhibition results in increased levels of acetylcholine, which plays a crucial role in neurotransmission and muscle contraction. Bendiocarb is utilized in research applications focusing on neurobiology and the study of cholinergic systems, as well as in the examination of potential neurotoxic effects.

Cat. No.

A73198

CAS No.

1212-37-9

Neostigmine iodide

Neostigmine iodide is a reversible inhibitor of acetylcholinesterase, enhancing muscle tone and function. This compound is primarily utilized in the management of myasthenia gravis, aiming to improve muscle strength in affected patients. Additionally, Neostigmine iodide is employed in anesthetic procedures to counteract the effects of nondepolarizing muscle relaxants, such as rocuronium, thereby facilitating recovery from anesthesia.

Cat. No.

A73326

CAS No.

38455-99-1

BuChE-IN-14

BuChE-IN-14 is a selective inhibitor of acetylcholinesterase (AChE), primarily targeting endogenous metabolite pathways. In vitro studies demonstrated a concentration-dependent inhibition of AChE activity in rat brain tissue, leading to increased extracellular acetylcholine (ACh) levels in the hippocampus and striatum. This compound shows potential for addressing memory impairments linked to cholinergic dysfunction, making it valuable for research into neurodegenerative diseases and cognitive enhancement.

Cat. No.

A73493

CAS No.

3761-42-0

Fenthion sulfone

Fenthion sulfone is a drug derivative primarily recognized for its potential as a pesticide metabolite. It exhibits significant biological activity by interacting with cholinesterase enzymes, leading to the inhibition of acetylcholine breakdown. This compound is utilized in research applications related to toxicology and environmental studies, particularly in assessing the effects of organophosphate compounds on biological systems.

Cat. No.

A73983

CAS No.

1665292-06-7

FF-C1

FF-C1 is a non-competitive inhibitor of Ceramide Synthase 6 (CerS6), exhibiting an IC50 of 7.89 μM. By inhibiting intestinal CerS6, FF-C1 effectively lowers serum ceramide levels, offering protective effects against metabolic dysfunction-associated steatohepatitis. This compound is also reported to inhibit acetylcholinesterase, highlighting its potential applications in studying metabolic disorders and neurodegenerative diseases.