Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory/antibacterial Agent
Plumericin is an anti-inflammatory and antibacterial agent that primarily targets key signaling pathways involved in inflammation and cellular stress response. It has been shown to reduce apoptosis, activate Nrf-2, and inhibit both NF-κB and AhR activation, while also blocking STAT3 signaling. Plumericin exhibits inhibitory effects on Mycobacterium tuberculosis growth, making it a valuable compound for studying chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis. -
CRFR Agonist
Urocortin II, human is a selective agonist of the type-2 corticotropin-releasing factor (CRF2) receptor, exhibiting key biological activities that include promoting satiety and providing neuroprotective effects. This peptide also demonstrates bactericidal and antiparasitic properties, as well as pro-inflammatory activity. Additionally, Urocortin II, human can activate the NF-κB pathway and ERK1/2 MAP kinase, making it relevant for research in pulmonary arterial hypertension and cardiac protection. Its diverse applications extend to studies in infection, inflammation, metabolic disorders, neurological conditions, and cardiovascular diseases. -
Flavones
Flavanone is a naturally occurring flavone that functions as an inhibitor of human estrogen synthetase (aromatase). It targets the ERK/p38/NF-κB signaling pathway, demonstrating potential in mitigating oncogenic processes. Flavanone has shown oral bioactivity and possesses antitumor efficacy, making it a valuable reagent for research in cancer biology and hormone-related studies. -
Anti-inflammatory Agent
Fluorofenidone is an orally active anti-inflammatory agent that exhibits anti-fibrotic and antioxidant properties. It functions by downregulating ACSL4 expression, upregulating GPX4, and inhibiting the NF-κB signaling pathway, thereby alleviating inflammation and fibrosis. In preclinical models, Fluorofenidone has demonstrated efficacy in ameliorating cholestasis and fibrosis by modulating the hepatic Erk/Egr-1 signaling and TGFβ1/Smad pathways. This compound is particularly relevant for research into chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF), and non-small cell lung cancer (NSCLC). -
IKKε Inhibitor
IKKε-IN-1 is a selective inhibitor of IKKε, a key enzyme involved in the NF-κB signaling pathway. This compound effectively reduces cell viability, inhibits colony formation, and diminishes cell migration in various cancer cell lines. Additionally, IKKε-IN-1 induces autophagy, illustrating its potential as a research tool in the study of multiple cancer types, including colorectal, hepatocellular, bladder, breast, lung, and cervical cancers. -
Anti-inflammatory Agent
Hexadecanamide is a fatty acid amide that serves as an anti-inflammatory agent, exhibiting protective effects against Staphylococcus aureus and SARA-induced mastitis. It functions by suppressing S. aureus-mediated NF-κB activation and enhancing blood-milk barrier integrity. Additionally, Hexadecanamide activates PPARα and has been shown to improve sperm motility in vitro. This compound is relevant for research applications involving mastitis and asthenozoospermia. -
PPARγ Activator
Convallatoxin is a PPARγ activator derived from the plant Adonis amurensis. It exhibits significant anti-inflammatory effects by mitigating colitic inflammation through the activation of PPARγ and the suppression of NF-κB signaling pathways. Additionally, Convallatoxin serves as a substrate for P-glycoprotein, identifying Val982 as a critical amino acid for its transport. This compound also enhances ligand-induced micro-opioid receptor (MOR) endocytosis, demonstrating high potency and efficacy, making it valuable for research in inflammation and cellular signaling. -
PPAR Agonist
4-O-Methyl honokiol is a natural neolignan derived from Magnolia officinalis that functions as a selective PPARγ agonist. It exhibits significant inhibition of NF-κB activity, making it a valuable tool for studying mechanisms of inflammation and cancer. Its biological activity is particularly relevant in research focused on metabolic regulation and inflammatory responses. -
Anti-inflammatory Agent
Adelmidrol is an anti-inflammatory agent that primarily targets peroxisome proliferator-activated receptor gamma (PPARγ). This compound mediates significant reductions in NF-κB translocation and COX-2 expression, contributing to its anti-inflammatory effects. Adelmidrol is utilized in research focused on inflammation pathways and therapeutic potential in various inflammatory conditions. -
Stable Isotope
5-Aminosalicylic acid-d3 is a deuterium-labeled derivative of 5-Aminosalicylic acid, primarily utilized as a stable isotope in research. This compound acts as a specific agonist of the peroxisome proliferator-activated receptor gamma (PPARγ) and exhibits inhibitory effects on p21-activated kinase 1 (PAK1) and nuclear factor kappa B (NF-κB). Its applications include studying metabolic pathways and investigating inflammatory responses, making it a valuable tool in pharmacological and biochemical research. -
PPARγ Activator
5-Aminosalicylic acid-13C6 hydrochloride is a labeled variant of 5-Aminosalicylic acid, functioning primarily as a PPARγ agonist. This compound exhibits significant biological activity by inhibiting p21-activated kinase 1 (PAK1) and the transcription factor NF-κB. It is commonly utilized in research concerning metabolic disorders, inflammation, and immune response pathways. -
Carnitine Palmitoyltransferase I Upregulator, Peroxisome Proliferator-Activated Receptor α Upregulator, Nuclear Factor Erythroid 2-Related Factor 2 Activator, Nuclear Factor-Kappa B Inhibitor, Nuclear Factor Kappa B Kinase Subunit Beta Inhibitor, Sterol Regulatory Element-Binding Protein 1 Downregulator, Acetyl-CoA Carboxylase Downregulator, Acyl-CoA:Cholesterol Acyl Transferase 1 Inhibitor, Acyl-CoA:Cholesterol Acyl Transferase 2 Inhibitor
Esculeogenin A is a potent upregulator of Carnitine Palmitoyltransferase I and Peroxisome Proliferator-Activated Receptor α, while also acting as an activator of Nuclear Factor Erythroid 2-Related Factor 2. This compound exhibits key biological activities, including hepatoprotective, hypolipidemic, and antioxidant effects. Esculeogenin A modulates essential molecular targets such as SREBP1, NF-κB, and ACAT1/ACAT2, leading to enhanced hepatic fatty acid oxidation and diminished inflammation. It is applicable in research focused on nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia, showcasing its potential to improve liver function and mitigate the risk of associated metabolic disorders. -
Arachidonic Acid Metabolite
(±)8(9)-EET is an arachidonic acid metabolite produced via the cytochrome P450 epoxide pathway. This compound serves as an effective substrate for both COX-1 and COX-2 enzymes, leading to significant biological activities such as PPARα activation in HEK293 cells. Additionally, it inhibits NF-κB activation induced by IL-1β through both PPARα-dependent and independent mechanisms. The (8S,9R)-isomer of (±)8(9)-EET is known to induce vasoconstriction, resulting in reduced renal plasma flow and glomerular filtration rate, making it important for studies related to vascular physiology and renal function. -
Stable Isotope
5-Aminosalicylic acid-13C6 is a stable isotope-labeled form of 5-Aminosalicylic acid, commonly known as Mesalamine. This compound functions as a specific agonist for peroxisome proliferator-activated receptor gamma (PPARγ) and exhibits inhibitory activity against p21-activated kinase 1 (PAK1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). It is valuable in biological research for investigating inflammatory pathways and therapeutic mechanisms in conditions such as inflammatory bowel disease. -
Anti-inflammatory Agent
(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside functions as an anti-inflammatory agent. This diarylheptanol glycoside, derived from Tacca plantaginea, effectively inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 9.4 μM. Additionally, it activates PPAR transcriptional activity (EC50 = 9.9 μM) and exhibits a specific activating effect on PPAR β(δ) with an EC50 of 23.1 μM. Non-toxic to cells at tested concentrations, this compound is suitable for research on inflammatory conditions. -
COX-2 Inhibitor/PPAR-γ Activator
Zaltoprofen sulfoxide is a selective COX-2 inhibitor with an IC50 of 45.38 nM, as well as a PPAR-γ activator. This compound effectively inhibits NF-κB and MAPK inflammatory signaling pathways, making it a valuable tool in the study of inflammation and acute lung injury models. It is particularly relevant for research focused on LPS-induced acute lung injury. -
PPARδ Agonist
PPARδ Agonist 11 is a selective agonist for peroxisome proliferator-activated receptor delta (PPARδ), exhibiting an EC50 of 20 nM. This compound effectively reduces nitrite oxide levels and pro-inflammatory cytokines, such as TNFα and IL-6, in LPS-stimulated RAW264.7 cells, demonstrating its anti-inflammatory activity through the NF-κB pathway. Additionally, PPARδ Agonist 11 shows good stability in human liver microsomes and plasma, and it alleviates Carrageenan-induced foot edema, making it a valuable tool for research in inflammation and metabolic disorders. -
TrxR1 Inhibitor
Aurothioglucose is a potent inhibitor of thioredoxin reductase 1 (TrxR1), exhibiting an IC50 value of 65 nM. This compound effectively inhibits the DNA binding activity of NF-κB in vitro, highlighting its role in modulating key transcriptional pathways. Additionally, Aurothioglucose demonstrates anti-HIV and anti-rheumatic properties, making it a valuable reagent for research in infectious diseases and autoimmune disorders. -
Anti-cancer Agent
CPS-11 (N-(Hydroxymethyl)thalidomide) is a thalidomide analogue that serves as a potent anti-cancer agent. It primarily targets the inhibition of NF-κB while activating NFAT and repressing cytokine expression via increased reactive oxygen species (ROS) levels. CPS-11 demonstrates a broader activity spectrum and enhanced potency against multiple myeloma (MM) cell lines, making it a significant candidate for cancer research applications. -
Metalloporphyrin Catalytic Antioxidant
AEOL-10150 pentachloride is a metalloporphyrin-catalyzed antioxidant that acts as a mimetic of superoxide dismutase. It effectively scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), while also modulating the NF-κB signaling pathway, demonstrating potent antioxidant and anti-inflammatory properties. This compound has been shown to reduce tissue damage from radiation and chemical agents, and it can enhance the effects of radiotherapy in targeting prostate tumors. -
Xanthone Glycoside
Swertianolin is a xanthone glycoside extracted from various plants within the Gentianaceae family, such as Gentiana campestris and Swertia punicea. It inhibits p38 phosphorylation and NF-κB activation, leading to reduced nitric oxide (NO) and reactive oxygen species (ROS) production. Swertianolin demonstrates potent anti-Helicobacter pylori activity, with an IC50 of 6.1 μM and a minimum bactericidal concentration of 91.7 μM. Additionally, it has been shown to modulate immune function in sepsis, making it applicable for research in Alzheimer's disease, hepatitis B, Helicobacter pylori infections, and sepsis. -
ROS Inhibitor
Isodeoxyelephantopin is a sesquiterpene lactone with a primary mechanism as a reactive oxygen species (ROS) inhibitor. It demonstrates significant biological activity by inducing ROS generation and suppressing NF-κB activation, thereby contributing to its anticancer properties. Additionally, Isodeoxyelephantopin modulates long non-coding RNA (LncRNA) expression, making it a valuable reagent for breast cancer research and related fields. -
IKKβ Inhibitor
IKKβ-IN-7 is a selective inhibitor of IKKβ, exhibiting an IC50 value of 9.44 μM. This compound induces DNA damage, S-phase cell cycle arrest, and apoptosis, while also promoting reactive oxygen species accumulation and loss of mitochondrial membrane potential. By inhibiting the phosphorylation of p65 and IκBα, IKKβ-IN-7 effectively restricts p65 nuclear translocation and modulates NF-κB-regulated gene expression. This agent demonstrates significant antitumor activity in xenograft models, particularly in colorectal cancer, while exhibiting low cytotoxicity in normal cells. IKKβ-IN-7 serves as a valuable tool for research in the field of colorectal cancer. -
Anti-inflammatory Agent
Anti-inflammatory agent 21 is an orally active compound that targets the inflammatory response through its inhibitory effects on nitric oxide production, demonstrating an IC50 value of 0.76 μM. This agent induces reactive oxygen species accumulation and effectively blocks the NF-κB/MAPK signaling pathway. Research applications include investigating its potential to mitigate cartilage destruction and reduce inflammatory cell infiltration in models of arthritis. -
Anti-inflammatory Agent
Dihydromyristicin is a plant-derived flavonoid known for its potent anti-inflammatory effects. It exerts its biological activity by attenuating endotoxic inflammation through the suppression of reactive oxygen species (ROS)-mediated activation of the PI3K/Akt/NF-κB signaling pathways. This compound is valuable in research applications focusing on inflammation-related studies and potential therapeutic interventions. -
NF-κB/PON1 Pathway Inhibitor
NF-κB/PON1-IN-1 is an NF-κB/PON1 pathway inhibitor that exhibits pronounced antioxidant properties with an IC50 of 45.76 µM. This compound demonstrates hepatoprotective activity, making it valuable for research focused on inflammation and oxidative stress. Its mechanism of action positions it as a potential therapeutic tool in studies investigating liver-related diseases and cellular protection. -
Antioxidant Agent
N-Acetyldopamine dimer-2 is a dimeric form of N-acetyldopamine that serves as an effective antioxidant agent. It demonstrates significant antioxidant and anti-inflammatory activities by inhibiting the oxidation of low-density lipoproteins (LDL), as well as reducing reactive oxygen species (ROS) generation, nitric oxide (NO) production, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity. This compound is valuable for research in oxidative stress and inflammation-related studies. -
Antitumor Agent
IKKβ-IN-6 is an antitumor agent that primarily targets IKKβ (IC50: 18.24 μM), effectively inhibiting its activity. This inhibition leads to reduced phosphorylation of p65 and IκBα, obstructing the nuclear translocation of p65 and modulating NF-κB-controlled gene expression. Additionally, IKKβ-IN-6 interacts with topoisomerase I, resulting in DNA damage, increased reactive oxygen species (ROS) levels, loss of mitochondrial membrane potential, and S-phase cell cycle arrest. This compound is particularly relevant for research focused on colorectal cancer. -
Apoptosis Inducer
Artocarpin is a potent apoptosis inducer that targets various signaling molecules, including NF-κB, Erk1/2, p38 MAPK, and Akt kinases. It stimulates the production of reactive oxygen species (ROS) and activates both p53-dependent and independent apoptotic pathways, resulting in G1-phase cell cycle arrest and autophagic cell death. Artocarpin displays significant cytotoxic and bactericidal effects against cancer cells, reduces bacterial burden, and possesses anti-inflammatory, analgesic, and anti-angiogenic properties, making it valuable for cancer and inflammatory research applications. -
Anti-inflammatory Agent
Zaluzanin C is a sesquiterpene lactone that acts as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting mitochondrial reactive oxygen species (mtROS) production and blocking the NF-κB signaling pathway, leading to a reduction in TNF-α levels. Additionally, Zaluzanin C has been shown to prevent the differentiation of 3T3-L1 preadipocytes into mature adipocytes, making it a valuable reagent for research in inflammation and adipogenesis. -
RANKL Inhibitor
RANKL-IN-2 is a selective inhibitor of RANKL, exhibiting Kd values of 3.21 μM and 4.625 μM in surface plasmon resonance and microscale thermophoresis assays, respectively. By binding to RANKL, it disrupts the RANKL-RANK interaction, thereby suppressing osteoclastogenesis through the inhibition of reactive oxygen species, MAPK, and NF-κB signaling pathways. RANKL-IN-2 demonstrates efficacy in preventing RANKL-induced osteoclast formation, bone resorption, and the expression of osteoclast-specific genes and proteins in vitro. Additionally, RANKL-IN-2 has shown potential in preventing bone loss in ovariectomized mouse models, making it a valuable tool for osteoporosis research. -
Anti-inflammatory Agent
8-Deoxylactucin is an orally active sesquiterpene lactone that functions as an anti-inflammatory agent by inhibiting LPS-induced nitric oxide production in RAW264.7 macrophages, with an IC50 of 4.35 μM. It exerts its effects primarily by blocking the NF-κB signaling pathway. Additionally, 8-Deoxylactucin has demonstrated hepatoprotective properties in a murine model of acute hepatitis induced by LPS and D-galactosamine. This compound is valuable for research on inflammatory diseases and liver injury mechanisms. -
PDE4 Inhibitor
Glaucine, a selective phosphodiesterase 4 (PDE4) inhibitor, is an alkaloid sourced from Glaucium flavum. It demonstrates significant biological activities such as bronchodilation, anti-inflammatory effects, and anticancer properties. With a Ki of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes, Glaucine promotes relaxation of isolated human bronchi through calcium channel antagonism. Furthermore, it inhibits NF-κB activation, which downregulates MMP-9 expression, thereby impairing the migration and invasion of breast cancer cells. Glaucine is relevant for research applications in asthma and breast cancer. -
PDE4 Inhibitor
LT-104A is a selective phosphodiesterase 4 (PDE4) inhibitor that effectively elevates intracellular cyclic AMP (cAMP) levels, exhibiting an EC50 of 1.9 μM and inhibiting PDE4D3 activity with an IC50 of 9.3 μM. By activating the cAMP-PKA-CREB anti-inflammatory signaling pathway, LT-104A suppresses expression of NF-κB-related genes such as Il1b and Nos2. This compound is valuable for research focused on inflammation-related diseases and therapeutic interventions aimed at modulating inflammatory responses. -
Stable Isotope
Vinpocetine-d5 is a deuterium-labeled derivative of Vinpocetine, which primarily inhibits voltage-gated sodium channels. It serves as a phosphodiesterase (PDE) inhibitor, effectively disrupting NF-κB-dependent inflammatory responses by directly targeting the IκB kinase complex (IKK), with an IC50 of 17.17 μM in a cell-free system. This compound is valuable in research related to cerebrovascular disorders and inflammation, enabling the tracking and analysis of Vinpocetine's biological effects in various applications. -
isoquinoline alkaloid
Antidesmone is an isoquinoline alkaloid derived from Antidesma membranaceum, known for its ability to inhibit the activities of MAPK and NF-κB pathways. This compound demonstrates significant potential in preventing acute lung injury in vivo, making it valuable for research into inflammatory diseases and related therapeutic interventions. Its mechanistic insights can facilitate studies aimed at understanding the pathophysiology of lung injuries and exploring novel treatment strategies. -
Neuroprotective Agent
Deoxysappanone B is a homoisoflavone compound that exhibits neuroprotective properties by targeting the IκB kinase (IKK)-NF-κB and p38/ERK MAPK signaling pathways. This compound demonstrates significant anti-neuroinflammatory activity by inhibiting the production of neuroinflammatory mediators. Deoxysappanone B is a valuable tool for research concerning neuritis and inflammation-related neurological disorders, offering insights into potential therapeutic strategies for neurodegenerative diseases. -
PI3K/Akt Inhibitor, MAPK Inhibitor, NF-κB Inhibitor, Nrf2/ARE Activator
JRN73958 is a potent inhibitor of the PI3K/Akt, MAPK, and NF-κB signaling pathways. This compound effectively reduces LPS/IFNγ-induced activation of these pathways, making it a valuable tool for investigating their roles in cancer biology, particularly in leukemia research. Additionally, JRN73958 acts as an Nrf2/ARE activator, further expanding its utility in studies related to oxidative stress and cell survival mechanisms. -
p38 MAPK Inhibitor
Ganoderterpene A is a potent inhibitor of p38 MAPK, demonstrating significant anti-inflammatory and anti-apoptotic activity. It effectively attenuates LPS-induced inflammation and apoptosis by suppressing the MAPK and TLR-4/NF-κB signaling pathways in BV-2 cells. This compound is valuable for research applications focused on neuroinflammation and cellular stress responses. -
MAPK/NF-κB Inhibitor
Masticadienonic acid is a selective inhibitor of the MAPK pathway (including p38, ERK, and JNK) and the NF-κB signaling cascade, while also acting as an agonist of the Nrf2 pathway. This compound effectively reduces the release of proinflammatory cytokines such as TNFα, IL-1β, and IL-6, and it restores the expression of intestinal tight junction proteins, including ZO-1 and occludin. Its regulatory effects on intestinal flora and inflammation make it suitable for research applications in inflammatory bowel disease and leishmaniasis. -
Potassium-competitive Acid Blocker
KFP-H008 is an orally active potassium-competitive acid blocker that targets H+-K+-ATPase to inhibit gastric acid secretion. This compound has shown efficacy in reducing ethanol-induced gastric ulcer index and decreasing malonaldehyde levels, along with the expression of pro-inflammatory cytokines in vivo. KFP-H008 also downregulates p-p38 MAPK and p65 NF-κB expression, demonstrating its potential in mitigating gastric inflammation. This reagent is valuable for research into acid-related diseases, including gastric ulcers and gastric epithelial cell damage. -
PAR2 Antagonist
K-14585 is a peptide that acts as a competitive antagonist of protease-activated receptor 2 (PAR2). It effectively inhibits PAR2-mediated interleukin-8 (IL-8) production, as well as phosphorylation of NF-κB and p38 MAPK signaling pathways. Additionally, K-14585 significantly reduces calcium mobilization induced by the PAR2 agonist SLIGKV in primary human keratinocytes, making it a valuable tool for studying PAR2-related biological processes and inflammatory responses. -
NF-κB/MAPK Inhibitor
Isonardosinone is a nardosinone-type sesquiterpene that primarily targets the NF-κB and MAPK signaling pathways. It effectively inhibits the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide-induced BV2 microglial cells, demonstrating significant anti-inflammatory activity. This compound is valuable for research applications focused on inflammation and neurodegenerative diseases. -
p38 MAPK Inhibitor
Anti-inflammatory agent 7 is a selective p38 MAPK inhibitor that modulates the NF-κB/MAPK signaling pathway to inhibit proinflammatory cytokine production. This reagent demonstrates significant anti-inflammatory activity in LPS-treated RAW 264.7 cells and in in vivo models, making it a valuable tool for studying inflammatory responses and developing therapeutic strategies for related diseases. -
Anti-Osteoporosis Compound
Anti-osteoporosis agent-11, a selective anti-osteoporosis compound, targets osteoclasts to impede their differentiation. This compound exhibits potent inhibitory activity with an IC50 value of 0.36 μM, effectively suppressing osteoclast formation, bone resorption, and the expression of osteoclast-specific genes. Its mechanism involves the blockade of RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways, making it a valuable tool for research in osteoporosis treatment and bone metabolism studies. -
Carbonic Anhydrase Inhibitor
(E)-Dehydrodiconiferyl alcohol is a dual inhibitor of human carbonic anhydrases IX and XII. This compound demonstrates significant biological activity by inhibiting NF-κB nuclear translocation in the connective tissues of healing areas. Its unique mechanism supports research in cancer biology and therapeutic approaches for inflammatory conditions. -
PPAR Agonist
Mesalamine impurity P is an impurity derivative of Mesalamine, a specific agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). This compound exhibits significant biological activity by inhibiting p21-activated kinase 1 (PAK1) and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). It is utilized in research applications focusing on inflammatory bowel disease and metabolic disorders, contributing to the understanding of PPARγ modulation in therapeutic contexts. -
Stable Isotope
5-Aminosalicylic Acid-d3 hydrochloride is a deuterium-labeled derivative of 5-Aminosalicylic Acid (Mesalamine), functioning as a stable isotope. It acts as a selective peroxisome proliferator-activated receptor gamma (PPARγ) agonist and also demonstrates inhibitory effects on p21-activated kinase 1 (PAK1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). This compound is primarily utilized in research applications related to inflammation, colitis, and other gastrointestinal disorders. -
Arachidonic Acid Metabolite
8(9)-EET is an arachidonic acid metabolite produced through the cytochrome P450 epoxide pathway. It serves as an effective substrate for cyclooxygenases COX-1 and COX-2 and exhibits significant biological activity by activating PPARα in HEK293 cells. Additionally, 8(9)-EET inhibits NF-κB activity induced by IL-1β, functioning both in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET specifically induces vasoconstriction, leading to reduced renal plasma flow and glomerular filtration rate, making it a relevant compound for studies in renal and cardiovascular research. -
PPARγ Agonist
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid serves as a PPARγ agonist, primarily impacting inflammatory processes. This electrophilic oxo-derivative of docosahexaenoic acid (DHA) is produced in activated macrophages through a COX-2-catalyzed mechanism during inflammation. Its biological activity includes modulation of the NF-κB signaling pathway, inhibition of pro-inflammatory cytokine production, and reduction of nitric oxide synthesis, demonstrating significant anti-inflammatory properties. This compound is particularly valuable for research applications focused on inflammatory diseases and metabolic disorders.
