IKKβ-IN-6 is an antitumor agent that primarily targets IKKβ (IC50: 18.24 μM), effectively inhibiting its activity. This inhibition leads to reduced phosphorylation of p65 and IκBα, obstructing the nuclear translocation of p65 and modulating NF-κB-controlled gene expression. Additionally, IKKβ-IN-6 interacts with topoisomerase I, resulting in DNA damage, increased reactive oxygen species (ROS) levels, loss of mitochondrial membrane potential, and S-phase cell cycle arrest. This compound is particularly relevant for research focused on colorectal cancer.
IKKβ-IN-6 is an antitumor agent that primarily targets IKKβ (IC50: 18.24 μM), effectively inhibiting its activity. This inhibition leads to reduced phosphorylation of p65 and IκBα, obstructing the nuclear translocation of p65 and modulating NF-κB-controlled gene expression. Additionally, IKKβ-IN-6 interacts with topoisomerase I, resulting in DNA damage, increased reactive oxygen species (ROS) levels, loss of mitochondrial membrane potential, and S-phase cell cycle arrest. This compound is particularly relevant for research focused on colorectal cancer.
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