(±)8(9)-EET is an arachidonic acid metabolite produced via the cytochrome P450 epoxide pathway. This compound serves as an effective substrate for both COX-1 and COX-2 enzymes, leading to significant biological activities such as PPARα activation in HEK293 cells. Additionally, it inhibits NF-κB activation induced by IL-1β through both PPARα-dependent and independent mechanisms. The (8S,9R)-isomer of (±)8(9)-EET is known to induce vasoconstriction, resulting in reduced renal plasma flow and glomerular filtration rate, making it important for studies related to vascular physiology and renal function.
(±)8(9)-EET is an arachidonic acid metabolite produced via the cytochrome P450 epoxide pathway. This compound serves as an effective substrate for both COX-1 and COX-2 enzymes, leading to significant biological activities such as PPARα activation in HEK293 cells. Additionally, it inhibits NF-κB activation induced by IL-1β through both PPARα-dependent and independent mechanisms. The (8S,9R)-isomer of (±)8(9)-EET is known to induce vasoconstriction, resulting in reduced renal plasma flow and glomerular filtration rate, making it important for studies related to vascular physiology and renal function.
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