PPARδ Agonist 11 is a selective agonist for peroxisome proliferator-activated receptor delta (PPARδ), exhibiting an EC50 of 20 nM. This compound effectively reduces nitrite oxide levels and pro-inflammatory cytokines, such as TNFα and IL-6, in LPS-stimulated RAW264.7 cells, demonstrating its anti-inflammatory activity through the NF-κB pathway. Additionally, PPARδ Agonist 11 shows good stability in human liver microsomes and plasma, and it alleviates Carrageenan-induced foot edema, making it a valuable tool for research in inflammation and metabolic disorders.
PPARδ Agonist 11 is a selective agonist for peroxisome proliferator-activated receptor delta (PPARδ), exhibiting an EC50 of 20 nM. This compound effectively reduces nitrite oxide levels and pro-inflammatory cytokines, such as TNFα and IL-6, in LPS-stimulated RAW264.7 cells, demonstrating its anti-inflammatory activity through the NF-κB pathway. Additionally, PPARδ Agonist 11 shows good stability in human liver microsomes and plasma, and it alleviates Carrageenan-induced foot edema, making it a valuable tool for research in inflammation and metabolic disorders.
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