Quercetagitrin, a flavone glycoside, is derived from the African marigold (Tagetes erecta) and exhibits notable anti-inflammatory properties. It effectively inhibits Tau accumulation, reversing neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse models by suppressing NF-κB activation. Additionally, Quercetagitrin acts as a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). This compound enhances glucose uptake in mature C2C12 myoblasts, making it relevant for studies related to Alzheimer’s disease and type 2 diabetes.
Quercetagitrin, a flavone glycoside, is derived from the African marigold (Tagetes erecta) and exhibits notable anti-inflammatory properties. It effectively inhibits Tau accumulation, reversing neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse models by suppressing NF-κB activation. Additionally, Quercetagitrin acts as a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). This compound enhances glucose uptake in mature C2C12 myoblasts, making it relevant for studies related to Alzheimer’s disease and type 2 diabetes.
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