MMH-165-26 is a ligand targeting RelA/p65, playing a crucial role in modulating nuclear factor kappa B (NF-κB) signaling. This compound significantly reduces the expression levels of RelA/p65 and exhibits notable cytotoxicity in MEC-1 cells, with an LC50 of 0.37 μM. MMH-165-26 is a valuable tool for the development of proteolysis-targeting chimeras (PROTACs), such as JP-163-16, enhancing its utility in cancer research and therapeutic applications.
MMH-165-26 is a ligand targeting RelA/p65, playing a crucial role in modulating nuclear factor kappa B (NF-κB) signaling. This compound significantly reduces the expression levels of RelA/p65 and exhibits notable cytotoxicity in MEC-1 cells, with an LC50 of 0.37 μM. MMH-165-26 is a valuable tool for the development of proteolysis-targeting chimeras (PROTACs), such as JP-163-16, enhancing its utility in cancer research and therapeutic applications.
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