Nitric oxide and hydrogen sulfide-releasing hybrid molecules
NOSH-aspirin (NBS-1120) is a hybrid molecule designed to release both nitric oxide and hydrogen sulfide. This compound demonstrates potent inhibition of pancreatic cancer cell proliferation and induces apoptosis, making it a valuable tool in cancer research. Additionally, NOSH-aspirin has been shown to suppress NF-κB and FoxM1 activity in mouse models of pancreatic cancer. Its neuroprotective effects are evident in rat models of Parkinson's disease, where it alleviates motor deficits and reduces neuroinflammation associated with microglial and astrocytic activation. NOSH-aspirin is suitable for studies involving pancreatic cancer and neurodegenerative disorders.
NOSH-aspirin (NBS-1120) is a hybrid molecule designed to release both nitric oxide and hydrogen sulfide. This compound demonstrates potent inhibition of pancreatic cancer cell proliferation and induces apoptosis, making it a valuable tool in cancer research. Additionally, NOSH-aspirin has been shown to suppress NF-κB and FoxM1 activity in mouse models of pancreatic cancer. Its neuroprotective effects are evident in rat models of Parkinson's disease, where it alleviates motor deficits and reduces neuroinflammation associated with microglial and astrocytic activation. NOSH-aspirin is suitable for studies involving pancreatic cancer and neurodegenerative disorders.
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