CIGB-552 is a cell-penetrating peptide that targets tumor cells to exert anti-cancer effects, demonstrating an IC50 of 23 μM in H460 lung cancer cells. This peptide enhances the expression of the protein COMMD1 and significantly inhibits the NF-κB signaling pathway, leading to increased apoptosis in tumor cells. Additionally, CIGB-552 induces the accumulation of reactive oxygen species (ROS) and exhibits both anti-inflammatory and anti-angiogenic properties. It is particularly relevant for research into lung and colon cancers.
CIGB-552 is a cell-penetrating peptide that targets tumor cells to exert anti-cancer effects, demonstrating an IC50 of 23 μM in H460 lung cancer cells. This peptide enhances the expression of the protein COMMD1 and significantly inhibits the NF-κB signaling pathway, leading to increased apoptosis in tumor cells. Additionally, CIGB-552 induces the accumulation of reactive oxygen species (ROS) and exhibits both anti-inflammatory and anti-angiogenic properties. It is particularly relevant for research into lung and colon cancers.
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