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Catalog No.
Product Name
Application
Product Information
Citations
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NF-κB Inhibitor
N,N-Diethylacetamide is an NF-κB inhibitor that exhibits significant anti-inflammatory activity. By inhibiting the NF-κB pathway, it effectively suppresses the expression of nitric oxide (NO) and inducible nitric oxide synthase (iNOS), as well as downregulating pro-inflammatory cytokines such as TNF-α and IL-6, all while leaving the MAPK pathway unaffected. This compound is valuable in research studies focused on inflammatory responses associated with conditions such as preterm birth. -
ADAM17 (TACE) Inhibitor
BMS-561392 is a selective inhibitor of ADAM17 (TACE), effectively modulating the secretion of TNF-α through the regulation of key signaling pathways, including p44 MAPK and NF-κB. This compound has been shown to influence the survival of central nervous system cells, such as oligodendrocytes and microglia, by promoting microglial apoptosis and exacerbating astrogliosis in mouse spinal cord injury models. BMS-561392 is valuable for research applications focused on spinal cord injury and inflammatory diseases. -
PDE Inhibitor
Theophylline sodium glycinate is a potent phosphodiesterase (PDE) inhibitor with significant effects on airway smooth muscle relaxation. It acts primarily by inhibiting PDE3, which contributes to its anti-inflammatory properties through the upregulation of IL-10 and the inhibition of NF-κB translocation into the nucleus. Additionally, Theophylline sodium glycinate has been shown to induce apoptosis. This reagent is valuable for research applications related to asthma and chronic obstructive pulmonary disease (COPD). -
PTEN/NF-κB Inhibitor
Coelonin is a dihydrophenanthrene that functions as a potent PTEN and NF-κB inhibitor. It demonstrates significant anti-inflammatory activity by inhibiting LPS-induced PTEN phosphorylation. Coelonin negatively regulates the PI3K/AKT pathway, leading to decreased NF-κB activation and p27Kip1 degradation. Additionally, it promotes the stabilization of IκBα by inhibiting its phosphorylation and degradation, thereby increasing its expression. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
CD40 Inhibitor
KGYY15 is a CD40-targeting peptide that specifically functions as a CD40 inhibitor, exhibiting a weak inhibition of the CD40-CD40L interaction with an IC50 of over 1 mM. At a concentration of 100 μM, KGYY15 can activate the NF-κB pathway by approximately 33%. This compound is valuable for research applications aimed at understanding the modulation of immune responses and investigating the role of CD40 signaling in various biological contexts. -
TNF-α Inhibitor
IA-14069 is an orally active inhibitor of tumor necrosis factor-α (TNF-α), directly targeting TNF-α and interfering with TNF-α-mediated signaling pathways, including p-IκBα and NF-κB p65 activities. This compound demonstrates a suppressive effect on Dextran sodium sulfate (DSS)-induced colitis, making it valuable for research into inflammatory conditions. IA-14069 is particularly relevant for studies focused on rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). -
ACE Inhibitor
Fosfenopril is a potent angiotensin-converting enzyme (ACE) inhibitor. It exhibits anti-inflammatory properties by reducing lipopolysaccharide (LPS)-induced inflammation through the inhibition of TLR4/NF-κB signaling pathways in monocytes. This compound is valuable for research applications focused on cardiovascular diseases, inflammation, and the modulation of the immune response. -
PDE Inhibitor
Theophylline monohydrate is a potent phosphodiesterase (PDE) inhibitor that primarily targets PDE3, promoting relaxation of airway smooth muscle. This compound exhibits anti-inflammatory properties by increasing interleukin-10 (IL-10) levels and inhibiting the nuclear translocation of NF-κB. Additionally, Theophylline monohydrate is known to induce apoptosis in certain cell types. It is widely utilized in research related to asthma and chronic obstructive pulmonary disease (COPD). -
CHIKV Virus Inhibitor
Ethyl palmitate, also known as Ethyl hexadecanoate, functions as a CHIKV virus inhibitor, exhibiting an EC50 value of 0.0068 μM. This compound has demonstrated the ability to reduce pro-inflammatory cytokines such as TNF-α and IL-6, along with downregulating NF-κB in endotoxemic rat models, indicating its potential for anti-inflammatory applications. Ethyl palmitate serves as a valuable tool for research in virology and inflammation-related studies. -
Phosphodiesterase 4 Inhibitor
Tanimilast is a selective phosphodiesterase 4 inhibitor that exhibits potent activity with an IC50 of 0.026 nM. By increasing intracellular cAMP levels, Tanimilast effectively disrupts the NF-κB signaling pathway, leading to significant anti-inflammatory effects. This compound is particularly applicable in the study of obstructive lung diseases, making it a valuable tool for research in pulmonary health and related therapies. -
MMP Inhibitor
Ecliptasaponin A is a pentacyclic triterpenoid saponin that functions as a robust inhibitor of matrix metalloproteinases (MMPs). It demonstrates significant anti-tumor properties by activating the ASK1/JNK pathway, leading to apoptosis and autophagy in lung cancer cells. Additionally, Ecliptasaponin A exerts anti-inflammatory and anti-fibrotic effects by inhibiting the HMGB1/TLR4/NF-κB signaling pathway, impacting COX-2 and MMP-9 expression. Its chondroprotective effects are attributed to the downregulation of MMP13 and modulation of inflammatory factors, while it also promotes ovarian function by enhancing ESR1 receptor expression. -
Chloride Channel Inhibitor
Shikonin is a potent inhibitor of the TMEM16A chloride channel, exhibiting an IC50 value of 6.5 μM. This compound functions as a specific inhibitor of pyruvate kinase M2 (PKM2) and also modulates inflammatory pathways by inhibiting TNF-α and NF-κB activation. In addition, Shikonin decreases exosome secretion by impairing glycolytic processes and effectively inhibits AIM2 inflammasome activation. Its diverse activities make it a valuable reagent for investigating cellular signaling and inflammatory responses in research applications. -
NF-κB Inhibitor
Malvidin-3-glucoside chloride is an orally active NF-κB inhibitor, primarily targeting inflammatory pathways induced by TNF-α. It effectively decreases IκB-α degradation and p65 nuclear translocation, consequently enhancing endothelial nitric oxide synthase (eNOS) activity and nitric oxide production. This compound exhibits significant anti-inflammatory and antioxidant properties by suppressing pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, while also regulating intestinal microbiota and metabolites. Malvidin-3-glucoside chloride serves as a valuable tool for researching chronic inflammatory diseases, including atherosclerosis and inflammatory bowel disease, with potential applications in preventing vascular inflammation and promoting intestinal health. -
LT Inhibitor
Tryptanthrin is a potent inhibitor of leukotriene (LT) biosynthesis, targeting the inflammatory pathways involved in various diseases. This indole quinazoline compound exhibits significant anticancer properties by suppressing the expression of key inflammatory mediators such as NOS1, COX-2, and NF-κB. Additionally, Tryptanthrin modulates cytokine levels, influencing the expression of IL-2, IL-10, and TNF-α, making it a valuable reagent for research applications in inflammation and cancer biology. -
MAO-A/B Inhibitor
1,4-Naphthoquinone serves as a potent inhibitor targeting monoamine oxidase A and B (MAO-A/B) with competitive inhibition of MAO-B (Ki=1.4 μM) and non-competitive inhibition of MAO-A (Ki=7.7 μM). This compound exhibits broad-spectrum biological activity, inhibiting various DNA polymerases alongside notable anti-tumor, anti-inflammatory, and antibacterial properties. Its mechanism includes the induction of oxidative stress, glutathione (GSH) depletion, suppression of DNA synthesis, and blockage of NF-κB nuclear translocation. 1,4-Naphthoquinone is applicable in research involving melanoma and colon cancer cell growth, endothelial cell function, and models of lipopolysaccharide (LPS)-induced inflammation. -
p300 Histone Acetylatransferase Inhibitor
Curcumin, a natural phenolic compound, functions as a specific inhibitor of the p300/CREB-binding protein histone acetyltransferase. It effectively represses the acetylation of both histone and nonhistone proteins, thereby modulating chromatin transcription. Curcumin exhibits significant biological activities, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic effects, while also inhibiting NF-κB and MAPKs. Additionally, it promotes stabilization of the Nrf2 protein through modification of Keap1 cysteines, making it valuable for research in diverse therapeutic contexts. -
HDAC6 Inhibitor
HDAC6-IN-71 is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 13.68 nM for HDAC6 and 443.12 nM for HDAC1. This compound effectively reduces nitric oxide production in mouse macrophages, with an IC50 of 2.31 μM. By inhibiting the HDAC6-NF-κB signaling pathway, HDAC6-IN-71 leads to decreased phosphorylation of IκB-α and IKK-α/β, and downregulates the expression of key inflammatory mediators such as COX-2 and iNOS. Its efficacy has been demonstrated in models of ulcerative colitis, highlighting its potential for therapeutic applications in inflammatory diseases. -
HDACs/NF-κB Dual Inhibitor
Homobutein is a natural chalcone that functions as a potent dual inhibitor of histone deacetylases (HDACs) and nuclear factor kappa B (NF-κB), exhibiting IC50 values of 190 μM and 38 μM, respectively. This compound also acts as a chelator for iron (II and III) cations and demonstrates a range of biological activities, including anticancer, anti-inflammatory, antiparasitic, and antioxidant effects. Homobutein is valuable for research applications involving cellular signaling pathways and the investigation of potential therapeutic strategies in cancer and inflammatory diseases. -
MDA-9/Syntenin Inhibitor
PDZ1i (113B7) is a selective inhibitor of MDA-9/Syntenin, targeting its PDZ1 domain. This compound effectively inhibits radiation-induced invasion of glioblastoma (GBM) cells and enhances their radiosensitivity by disrupting key signaling pathways, including Src/EphA2, EGFRvIII/FAK, and NF-κB. PDZ1i also decreases the secretion of invasion-related proteases such as MMP-2, MMP-9, and ADAM9. Its anti-tumor efficacy has been demonstrated in nude mice models with intracranial U1242-luc and GBM xenografts, making PDZ1i a valuable tool for researching glioblastoma, as well as breast and prostate cancers. -
PARP1 Inhibitor
DPQ hydrochloride is a potent and selective inhibitor of PARP-1 (poly(ADP-ribose) polymerase 1), effectively blocking PARP-1-mediated DNA damage repair and reducing NAD+/ATP consumption. This compound demonstrates significant anti-inflammatory properties by inhibiting the activation of the NF-κB pathway, leading to a decrease in pro-inflammatory cytokines such as TNF-α and IL-6, as well as mitigating oxidative stress. DPQ hydrochloride is ideal for research applications related to inflammation and can be utilized in studies of conditions such as acute lung injury, myocardial infarction, and neurodegenerative diseases. -
PARP-1 Inhibitor
DPQ is a selective inhibitor of PARP-1, effectively blocking PARP-1-mediated DNA repair mechanisms and reducing the consumption of NAD+ and ATP. This inhibition leads to a decrease in NF-κB pathway activation, resulting in lowered expression of pro-inflammatory cytokines such as TNF-α and IL-6, along with a reduction in oxidative stress levels. DPQ is applicable in research focused on inflammation-related conditions including acute lung injury, myocardial infarction, and neurodegenerative diseases. -
C/EBPβ Inhibitor
Helenalin acetate is a potent C/EBPβ inhibitor that also functions as a natural NF-κB inhibitor. It exhibits significant anti-inflammatory and anticancer properties, making it a valuable tool for research into inflammatory diseases and cancer biology. This compound can be utilized in studies aimed at understanding the regulation of gene expression mediated by C/EBPβ and its role in various pathological conditions. -
HDAC3 Inhibitor
HDAC3-IN-T247 is a potent and selective inhibitor of HDAC3 (histone deacetylase 3), demonstrating an IC50 of 0.24 µM. This compound selectively enhances the acetylation of NF-κB in HCT116 cells, making it valuable for studies in cancer and viral pathogenesis. HDAC3-IN-T247 exhibits significant anticancer properties by inhibiting the proliferation of cancer cells and can also activate HIV gene expression in latently infected cells, thus serving as a useful tool for investigations in oncology and HIV research. -
Ferroptosis Inhibitor
5-Hydroxy-6,7-dimethoxyflavone is a potent inhibitor of ferroptosis, acting primarily to mitigate H1N1 virus-induced cell death. This compound enhances the expression of SLC7A11 and GPX4, thereby providing protective effects against ferroptosis. Additionally, it reduces inflammatory responses and apoptosis by inhibiting the activation of NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone is valuable for research related to H1N1 influenza virus infection and ferroptosis regulation. -
NF-κB Inhibitor
Ginsenoside Rg6 is an NF-κB inhibitor that effectively attenuates TNF-α-induced NF-κB transcriptional activity, exhibiting an IC50 of 29.34 μM in HepG2 cells. In addition to its role in modulating NF-κB activity, Ginsenoside Rg6 demonstrates significant apoptotic effects, making it a valuable tool for research in inflammation and cancer biology. -
CXCR Inhibitor
Corydalmine, a CXCR inhibitor, demonstrates significant antifungal activity by inhibiting spore germination in various plant pathogenic and saprophytic fungi. Additionally, it serves as an oral analgesic agent, exhibiting potent analgesic effects. Corydalmine has been shown to alleviate Vincristine-induced neuropathic pain in murine models through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, making it a valuable tool for pain research and therapeutic applications. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-3 is a dual inhibitor targeting CYP51 and PD-L1, exhibiting potent antifungal activity with IC50 values of 0.205 μM and 0.039 μM, respectively. This compound induces early apoptosis in fungal cells by reducing levels of intracellular IL-2, NLRP3, and NF-κBp65 proteins. Additionally, CYP51/PD-L1-IN-3 causes mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately resulting in fungal lysis and cell death. This compound serves as a valuable tool for research in fungal infections and immune modulation. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-2 is a quinazoline compound that functions as a dual inhibitor of CYP51 and PD-L1, exhibiting IC50 values of 0.263 μM and 0.017 μM, respectively. It displays notable antifungal activity by triggering early apoptosis in fungal cells, leading to significant reductions in intracellular IL-2, NLRP3, and NF-κBp65 protein levels. Additionally, CYP51/PD-L1-IN-2 induces mitochondrial damage and reactive oxygen species (ROS) accumulation, culminating in fungal lysis and subsequent cell death. This compound is valuable for research exploring antifungal mechanisms and cancer immunotherapy. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-1 is a dual inhibitor targeting both CYP51 and PD-L1, exhibiting an IC50 of 0.884 μM for CYP51 and 0.083 μM for PD-L1. This quinazoline compound demonstrates notable antifungal activity by inducing early apoptosis in fungal cells while significantly reducing intracellular levels of IL-2, NLRP3, and NF-κBp65. Additionally, CYP51/PD-L1-IN-1 contributes to mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately leading to fungal lysis and cell death. This compound is valuable for research focused on antifungal therapies and immune modulation. -
CXCR Inhibitor
Corydalmine hydrochloride is a potent CXCR inhibitor that demonstrates significant biological activity by inhibiting spore germination in certain plant pathogenic and saprophytic fungi. Additionally, it exhibits notable analgesic properties, effectively alleviating Vincristine-induced neuropathic pain in murine models. This effect is mediated through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, highlighting its potential applications in pain management research and fungal inhibition studies. -
IKKε Inhibitor
IKKε-IN-1 is a selective inhibitor of IKKε, a key enzyme involved in the NF-κB signaling pathway. This compound effectively reduces cell viability, inhibits colony formation, and diminishes cell migration in various cancer cell lines. Additionally, IKKε-IN-1 induces autophagy, illustrating its potential as a research tool in the study of multiple cancer types, including colorectal, hepatocellular, bladder, breast, lung, and cervical cancers. -
Carnitine Palmitoyltransferase I Upregulator, Peroxisome Proliferator-Activated Receptor α Upregulator, Nuclear Factor Erythroid 2-Related Factor 2 Activator, Nuclear Factor-Kappa B Inhibitor, Nuclear Factor Kappa B Kinase Subunit Beta Inhibitor, Sterol Regulatory Element-Binding Protein 1 Downregulator, Acetyl-CoA Carboxylase Downregulator, Acyl-CoA:Cholesterol Acyl Transferase 1 Inhibitor, Acyl-CoA:Cholesterol Acyl Transferase 2 Inhibitor
Esculeogenin A is a potent upregulator of Carnitine Palmitoyltransferase I and Peroxisome Proliferator-Activated Receptor α, while also acting as an activator of Nuclear Factor Erythroid 2-Related Factor 2. This compound exhibits key biological activities, including hepatoprotective, hypolipidemic, and antioxidant effects. Esculeogenin A modulates essential molecular targets such as SREBP1, NF-κB, and ACAT1/ACAT2, leading to enhanced hepatic fatty acid oxidation and diminished inflammation. It is applicable in research focused on nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia, showcasing its potential to improve liver function and mitigate the risk of associated metabolic disorders. -
COX-2 Inhibitor/PPAR-γ Activator
Zaltoprofen sulfoxide is a selective COX-2 inhibitor with an IC50 of 45.38 nM, as well as a PPAR-γ activator. This compound effectively inhibits NF-κB and MAPK inflammatory signaling pathways, making it a valuable tool in the study of inflammation and acute lung injury models. It is particularly relevant for research focused on LPS-induced acute lung injury. -
TrxR1 Inhibitor
Aurothioglucose is a potent inhibitor of thioredoxin reductase 1 (TrxR1), exhibiting an IC50 value of 65 nM. This compound effectively inhibits the DNA binding activity of NF-κB in vitro, highlighting its role in modulating key transcriptional pathways. Additionally, Aurothioglucose demonstrates anti-HIV and anti-rheumatic properties, making it a valuable reagent for research in infectious diseases and autoimmune disorders. -
ROS Inhibitor
Isodeoxyelephantopin is a sesquiterpene lactone with a primary mechanism as a reactive oxygen species (ROS) inhibitor. It demonstrates significant biological activity by inducing ROS generation and suppressing NF-κB activation, thereby contributing to its anticancer properties. Additionally, Isodeoxyelephantopin modulates long non-coding RNA (LncRNA) expression, making it a valuable reagent for breast cancer research and related fields. -
IKKβ Inhibitor
IKKβ-IN-7 is a selective inhibitor of IKKβ, exhibiting an IC50 value of 9.44 μM. This compound induces DNA damage, S-phase cell cycle arrest, and apoptosis, while also promoting reactive oxygen species accumulation and loss of mitochondrial membrane potential. By inhibiting the phosphorylation of p65 and IκBα, IKKβ-IN-7 effectively restricts p65 nuclear translocation and modulates NF-κB-regulated gene expression. This agent demonstrates significant antitumor activity in xenograft models, particularly in colorectal cancer, while exhibiting low cytotoxicity in normal cells. IKKβ-IN-7 serves as a valuable tool for research in the field of colorectal cancer. -
NF-κB Inhibitor/TRP Modulator
Cannabitwinol is a selective NF-κB inhibitor and thermosensitive TRP modulator. It effectively inhibits TNFα-induced NF-κB-driven transcription and IL-8 release, exhibiting notable anti-inflammatory and antioxidant properties. Cannabitwinol selectively activates cold-activated TRP channels, such as TRPA1 (EC50 = 3.0 μM), while antagonizing TRPM8 (IC50 = 3.9 μM), with minimal interaction with heat-activated TRP channels like TRPV1 and TRPV2. This compound is applicable in research focused on inflammatory skin diseases, cold allodynia, and hyperalgesia. -
NF-κB Inhibitor
Bengamide B is a potent inhibitor of NF-κB with an IC50 of 85 nM. This compound effectively reduces LPS-induced expression of pro-inflammatory cytokines, including TNF-α, IL-6, and MCP-1, demonstrating significant anti-inflammatory activity. Additionally, Bengamide B displays antitumor efficacy, with an IC50 of 2 nM against HCT-116 colorectal cancer cells, making it a valuable reagent for research in inflammation and oncology. -
SEAP Inhibitor
Cycloepoxydon is a potent inhibitor of secreted alkaline phosphatase (SEAP) expression, targeting both NF-κB and AP-1 signaling pathways. It effectively reduces PMA-induced SEAP expression with IC50 values ranging from 1-2 μg/mL (4.2-8.4 μM) for NF-κB and 3-5 μg/mL (12.6-21 μM) for AP-1. This compound is valuable for research applications involving inflammation, cancer biology, and signal transduction studies. -
NF-κB Inhibitor
2,4,5-Trimethoxybenzoic acid is an NF-κB inhibitor with notable anti-inflammatory properties. This compound, derived from purple perilla extracts, effectively inhibits LPS-induced inflammatory responses by blocking the activation of NF-κB and STAT signaling pathways. It has been shown to suppress M1 macrophage phenotype-mediated inflammation, making it a valuable tool for research into diabetes and related inflammatory conditions. -
LUBAC Inhibitor
HOIPIN-8 is a highly potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC), exhibiting an IC50 value of 11 nM. As a derivative of HOIPIN-1, it offers significantly enhanced inhibition, demonstrating a 255-fold increase in potency for petit-LUBAC, along with 10-fold and 4-fold increases in inhibiting LUBAC and TNF-α-mediated NF-κB activation, respectively. HOIPIN-8 serves as an essential research tool for investigating the cellular functions of LUBAC and its role in various biological processes. -
NF-κB/PON1 Pathway Inhibitor
NF-κB/PON1-IN-1 is an NF-κB/PON1 pathway inhibitor that exhibits pronounced antioxidant properties with an IC50 of 45.76 µM. This compound demonstrates hepatoprotective activity, making it valuable for research focused on inflammation and oxidative stress. Its mechanism of action positions it as a potential therapeutic tool in studies investigating liver-related diseases and cellular protection. -
RANKL Inhibitor
RANKL-IN-2 is a selective inhibitor of RANKL, exhibiting Kd values of 3.21 μM and 4.625 μM in surface plasmon resonance and microscale thermophoresis assays, respectively. By binding to RANKL, it disrupts the RANKL-RANK interaction, thereby suppressing osteoclastogenesis through the inhibition of reactive oxygen species, MAPK, and NF-κB signaling pathways. RANKL-IN-2 demonstrates efficacy in preventing RANKL-induced osteoclast formation, bone resorption, and the expression of osteoclast-specific genes and proteins in vitro. Additionally, RANKL-IN-2 has shown potential in preventing bone loss in ovariectomized mouse models, making it a valuable tool for osteoporosis research. -
IRAK4 Inhibitor
UR241-2 is a selective inhibitor of IRAK4, targeting the IL-1–induced IRAK1/4 signaling pathway. It effectively suppresses NF-κB activation and the phosphorylation of p65 and p38, contributing to a reduction in leukemia stem cell clonogenicity. UR241-2 also serves as a valuable ligand for developing PROTAC degraders targeting IRAK4, making it a suitable tool for research in acute myeloid leukemia. -
Carbonic Anhydrase Inhibitor
(E)-Dehydrodiconiferyl alcohol is a dual inhibitor of human carbonic anhydrases IX and XII. This compound demonstrates significant biological activity by inhibiting NF-κB nuclear translocation in the connective tissues of healing areas. Its unique mechanism supports research in cancer biology and therapeutic approaches for inflammatory conditions. -
BRD 4/p38α/BRDT Inhibitor
SB-284851-BT is a selective inhibitor of BRD4, p38α, and BRDT. It effectively inhibits BRD4-BD1 with an IC50 of 1.7 µM, p38α with a Kd of 0.47 nM, and exhibits additional inhibitory activity against BRDT and BRD4 with IC50 values of 18 µM and 3.7 µM, respectively. SB-284851-BT significantly reduces IL-8 production through p38α inhibition and downregulates crucial oncogenic pathways such as c-Myc and NF-κB via BRD4 inhibition. This compound has potential applications in cancer research and therapeutic development targeting cellular signaling pathways. -
BRD4 BD1 Inhibitor
ZL0516 is a selective inhibitor of the BRD4 bromodomain 1 (BD1), demonstrating potent activity in modulating epigenetic regulation. It effectively suppresses inflammatory bowel disease (IBD) through inhibition of the BRD4/NF-κB signaling pathway, which plays a critical role in inflammation and immune responses. This compound is primarily utilized in research focusing on the development of therapeutic strategies for IBD and related inflammatory conditions. -
Inflammatory Pathway Inhibitor, Oxidative Stress Inhibitor, Cancer Pathway Inhibitor
Matairesinol is an orally active bioactive compound that functions as an inflammatory pathway, oxidative stress, and cancer pathway inhibitor. It effectively inhibits the phosphorylation of MAPK, JNK, and NF-κB, while downregulating RANKL-induced NFATc1 expression and activity, and suppressing the activation of the PI3K/AKT/FOXO1 pathway. Matairesinol is applicable in research on sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis, and various cancer models. -
JNK Inhibitor
Salicortin is a phenolic glycoside that functions as a JNK inhibitor. It effectively inhibits osteoclast differentiation and bone resorption by down-regulating the JNK and NF-κB/NFATc1 signaling pathways. Salicortin exhibits a range of biological activities, including anti-amnesic, anti-adipogenic, and immune-modulatory effects, making it a valuable tool for research in bone metabolism, neurobiology, and immunology. -
NF-κB Inhibitor
Esculentoside H (EsH) is a saponin with inhibitory effects on the NF-κB signaling pathway. It exhibits notable anti-tumor activity, primarily through the modulation of TNF release. EsH has been shown to suppress colon cancer cell migration by inhibiting JNK1/2 and reducing the expression of matrix metalloproteinases-9 (MMP-9), making it a valuable tool for research in cancer biology and therapeutic interventions.
