Coelonin is a dihydrophenanthrene that functions as a potent PTEN and NF-κB inhibitor. It demonstrates significant anti-inflammatory activity by inhibiting LPS-induced PTEN phosphorylation. Coelonin negatively regulates the PI3K/AKT pathway, leading to decreased NF-κB activation and p27Kip1 degradation. Additionally, it promotes the stabilization of IκBα by inhibiting its phosphorylation and degradation, thereby increasing its expression. This compound is valuable for research applications focused on inflammation and related signaling pathways.
Coelonin is a dihydrophenanthrene that functions as a potent PTEN and NF-κB inhibitor. It demonstrates significant anti-inflammatory activity by inhibiting LPS-induced PTEN phosphorylation. Coelonin negatively regulates the PI3K/AKT pathway, leading to decreased NF-κB activation and p27Kip1 degradation. Additionally, it promotes the stabilization of IκBα by inhibiting its phosphorylation and degradation, thereby increasing its expression. This compound is valuable for research applications focused on inflammation and related signaling pathways.
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