IA-14069 is an orally active inhibitor of tumor necrosis factor-α (TNF-α), directly targeting TNF-α and interfering with TNF-α-mediated signaling pathways, including p-IκBα and NF-κB p65 activities. This compound demonstrates a suppressive effect on Dextran sodium sulfate (DSS)-induced colitis, making it valuable for research into inflammatory conditions. IA-14069 is particularly relevant for studies focused on rheumatoid arthritis (RA) and inflammatory bowel disease (IBD).
IA-14069 is an orally active inhibitor of tumor necrosis factor-α (TNF-α), directly targeting TNF-α and interfering with TNF-α-mediated signaling pathways, including p-IκBα and NF-κB p65 activities. This compound demonstrates a suppressive effect on Dextran sodium sulfate (DSS)-induced colitis, making it valuable for research into inflammatory conditions. IA-14069 is particularly relevant for studies focused on rheumatoid arthritis (RA) and inflammatory bowel disease (IBD).
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