PACE4 Inhibitory Peptide C23 (Ac-(DLeu)LLLRVK-Amba) is a potent peptidomimetic compound that selectively inhibits the proprotein convertase PACE4. This peptide demonstrates significant antiproliferative effects on prostate cancer cell lines with a Ki value of 5 nM and IC50 values of 25 μM and 40 μM for DU145 and LNCaP cells, respectively. Additionally, PACE4 Inhibitory Peptide C23 is effective in suppressing tumor growth in vivo in LNCaP xenograft mouse models, making it a valuable tool for research in cancer biology and therapeutic development.
PACE4 Inhibitory Peptide C23 (Ac-(DLeu)LLLRVK-Amba) is a potent peptidomimetic compound that selectively inhibits the proprotein convertase PACE4. This peptide demonstrates significant antiproliferative effects on prostate cancer cell lines with a Ki value of 5 nM and IC50 values of 25 μM and 40 μM for DU145 and LNCaP cells, respectively. Additionally, PACE4 Inhibitory Peptide C23 is effective in suppressing tumor growth in vivo in LNCaP xenograft mouse models, making it a valuable tool for research in cancer biology and therapeutic development.
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