Catalog No.
Product Name
Application
Product Information
Citations
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Antimicrobial peptide
LL-37 amide is an antimicrobial peptide that selectively targets the formyl peptide receptor-like FPRL1. It demonstrates significant bactericidal activity against periodontal pathogens with an ED99 value of 8.5-8.7 μg/mL by inducing immune cell chemotaxis and disrupting bacterial cell membranes. Additionally, LL-37 amide modulates inflammatory responses by inhibiting the release of pro-inflammatory factors such as TNF-α and promotes angiogenesis. Its amidation modification enhances stability and reduces serum sensitivity. This reagent is valuable for research in infection-related diseases, including periodontal disease, deep tissue injuries, and wound healing. -
Hemolytic Peptide
Delta-hemolysin is a 26 amino acid hemolytic peptide derived from Staphylococcus, known for its ability to interact with and perturb cellular membranes, potentially leading to cell lysis. This peptide serves as a valuable model for investigating the mechanisms of peptide-membrane interactions and studying membrane dynamics. Despite its hemolytic properties, Delta-hemolysin exhibits limited antibacterial activity. It is primarily utilized in research exploring peptide behavior and functions in membrane biology. -
Bioactive Peptide
PMAP-23 is a bioactive peptide that functions as an antimicrobial agent, derived from porcine myeloid tissues. This peptide exhibits significant antimicrobial activity against a range of bacteria and fungi, making it valuable for research in infectious disease and immunology. Its role in modulating immune responses also positions PMAP-23 as a potential candidate for studies focused on host defense mechanisms and therapeutic applications. -
Antimicrobial Peptide
RW3 is a cationic antimicrobial hexapeptide that primarily targets the bacterial cytoplasmic membrane, disrupting cellular respiration and inhibiting cell wall synthesis. It demonstrates potent bioactivity against Gram-positive bacteria, including Bacillus subtilis 168, with a minimum inhibitory concentration (MIC) of 2 µg/mL. Additionally, RW3 induces morphological changes in murine erythrocytes. This reagent is suitable for applications in antimicrobial and antifungal research. -
Antimicrobial Peptide
Duramycin is an antimicrobial peptide derived from the lantibiotic produced by Streptomyces cinnamoneuma. It exhibits potent antimicrobial activity, particularly against gram-positive bacteria. Duramycin is utilized in research aimed at understanding and treating cystic fibrosis, making it a valuable reagent in studies of microbial infections and associated therapeutic strategies. -
Dipeptide Probe
EDA-DA TFA is a N-terminally tagged dipeptide probe designed for the selective labeling of bacterial peptidoglycan (PG). This compound utilizes click chemistry principles, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. EDA-DA TFA is invaluable in bacterial research, providing insights into cell wall biochemistry and the development of antibacterial strategies. -
Protease Peptide Substrate
FA-Gly-Leu-NH2 (FAGLA) is a dipeptide substrate specifically designed for proteases. It exhibits hydrolysis by thermophilic and neutral proteases, with pH-dependent variations in catalytic efficiency (kcat/Km). This compound is primarily utilized in biochemical research to study protease activity and functionality. -
Antimicrobial Peptide
Esculentin 1A is an antimicrobial peptide derived from frog skin, specifically designed to target gram-negative bacteria. It exhibits strong in vitro activity against Pseudomonas aeruginosa, making it a valuable tool for research into antimicrobial resistance and peptide-based therapeutics. Its broad-spectrum antimicrobial properties can be applied in studies focused on infection control and novel drug development. -
Amphipathic Peptide Antibiotic
LAH4 is an amphipathic peptide antibiotic characterized by its alpha-helical structure. It demonstrates potent antimicrobial properties, along with effective nucleic acid transfection and enhanced cell penetration capabilities. LAH4 shows a strong affinity for anionic lipids present in the outer membranes of bacteria, making it a valuable tool for plasmid DNA delivery in various research applications. -
PACE4 Inhibitor
PACE4 Inhibitory Peptide C23 (Ac-(DLeu)LLLRVK-Amba) is a potent peptidomimetic compound that selectively inhibits the proprotein convertase PACE4. This peptide demonstrates significant antiproliferative effects on prostate cancer cell lines with a Ki value of 5 nM and IC50 values of 25 μM and 40 μM for DU145 and LNCaP cells, respectively. Additionally, PACE4 Inhibitory Peptide C23 is effective in suppressing tumor growth in vivo in LNCaP xenograft mouse models, making it a valuable tool for research in cancer biology and therapeutic development. -
Competence-stimulating Peptide
Competence-stimulating peptide activates the Com-dependent quorum sensing system in Streptococcus mutans. This peptide plays a crucial role in regulating competence and enhances bacteriocin production, making it a valuable tool for studies focused on microbial communication and pathogenesis. Applications include investigations into bacterial virulence, quorum sensing mechanisms, and potential therapeutic interventions against dental caries. -
Antimicrobial Peptide
Peceleganan is an artificial antimicrobial peptide comprising a hybrid of cecropin A (1-10) and melittin B (3-18). This peptide exhibits potent antimicrobial activity, making it effective in inhibiting wound infections. Its unique mechanism of action promotes the disruption of bacterial cell membranes, positioning Peceleganan as a valuable tool for research in antimicrobial strategies and wound healing applications. -
Macrocyclic Lipopeptide Antibiotic
Malacidin B is a macrocyclic lipopeptide antibiotic that exerts its antibacterial effects through a calcium-dependent mechanism. It has demonstrated significant activity against a range of Gram-positive bacteria, making it a valuable tool for researchers studying antibiotic resistance and developing new antimicrobial therapies. Its unique structure and mechanism of action provide avenues for exploring novel treatments in bacterial infections. -
Mating Pheromone-encoding Peptide
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candida albicans, primarily targeting the mating type locus MTLa. This compound induces cell growth arrest in Candida albicans, making it a valuable tool for investigating the mechanisms of mating and biological signaling in this organism. Additionally, SP1 is applicable in research focused on the prevention and treatment of Candida albicans infections. -
Polypeptide Antibiotics
Polymyxin B2 Sulfate is a polypeptide antibiotic that exerts its antibacterial effects primarily against gram-negative bacteria. Its mechanism of action involves binding to lipopolysaccharide molecules on the bacterial cell membrane, leading to membrane disruption and leakage of cellular contents. This compound is valuable in antibiotic development and the treatment of drug-resistant bacterial strains. -
Peptide Antibiotic
A83586C is a novel peptide antibiotic that specifically targets Gram-positive bacteria. It exhibits potent antibacterial activity, making it a valuable tool for studying bacterial infections and developing new therapeutic strategies. Its unique mode of action allows researchers to explore mechanisms of resistance and efficacy in various biological contexts. -
Antimicrobial Peptide
Bac8c is an antimicrobial peptide that targets bacterial membranes, exhibiting potent antibacterial activity against both Gram-negative and Gram-positive bacteria. Its minimum inhibitory concentrations (MIC) demonstrate effectiveness against Staphylococcus aureus, MRSA, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa at 2, 8, 4, 4, and 4 μg/mL, respectively. Bac8c is valuable for research in antibacterial resistance and the development of novel antimicrobial therapies. -
Antibiotic Peptide
BMAP-28 is an antibiotic peptide that acts as an inducer of the mitochondrial permeability transition pore. It triggers cell death by promoting the opening of this pore, making it a valuable tool for studying microbial infections and cancer mechanisms. Researchers can utilize BMAP-28 to explore its potential therapeutic applications and the underlying processes involved in cell apoptosis. -
Antibiotic/Antimicrobial Peptide
Aurein 2.4 is an antibiotic antimicrobial peptide that primarily targets Gram-positive bacteria. It exhibits potent antibacterial activity, making it a valuable reagent for research focused on antimicrobial resistance and the development of novel antibacterial therapies. Its unique mechanism of disrupting bacterial membranes positions Aurein 2.4 as a relevant tool in studies investigating the efficacy of peptide-based antibiotics. -
Proteoglycan Aggregates Activator
Link N peptide is a proteoglycan aggregates activator that targets the extracellular matrix. It specifically activates the p38 mitogen-activated protein kinase (MAPK) pathway, leading to enhanced expression of type I and II collagens in human intervertebral disc cells. This peptide is valuable for investigating intervertebral disc degeneration and related pathologies. -
Modification of Protein/Polypeptide
N-ε-propargyloxycarbonyl-L-lysine is a lysine-based unnatural amino acid utilized primarily for the modification of proteins and polypeptides. This compound serves as a versatile bio-conjugation reagent for fluorescent probes across various organisms, including E. coli and mammalian cells. Featuring an alkyne group, N-ε-propargyloxycarbonyl-L-lysine is suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient conjugation with azide-containing molecules for diverse research applications. -
Caspase-1/4 Fluorometric Peptide Substrate
Ac-YVAD-AFC is a fluorometric peptide substrate specifically targeting caspase-1 and caspase-4. It exhibits an excitation wavelength of 400 nm and an emission wavelength of 505 nm, making it suitable for assessing caspase activity in various biological samples. This compound is commonly used in research applications focused on apoptosis, inflammation, and disease mechanisms involving these caspases. -
Fluorogenic Peptide Substrate
Ac-Leu-Arg-AMC is a fluorogenic peptide substrate designed for the quantitative analysis of protease activity. This compound is particularly useful in studies of proteolytic enzymes, enabling the detection of enzyme activity through fluorescence measurement. Its specificity for certain proteases makes it ideal for applications in biochemical assays and research involving protein degradation pathways. -
Bioactive Peptide
Gly-Pro-AMC is a bioactive peptide that serves as a substrate for dipeptidylaminopeptidase IV, exhibiting fluorescence with an excitation/emission wavelength of 353/442 nm. Its key biological activity lies in the selective hydrolysis by DPP-IV, making it valuable for research applications focused on enzyme kinetics and substrate specificity. This substrate is ideal for studies investigating metabolic processes related to peptide signaling and regulation in various biological contexts. -
Fluorogenic Peptide Substrate
Gly-Gly-AMC is a fluorogenic peptide substrate utilized for measuring protease activity. This compound is particularly effective in evaluating the bacterial protease activities of Pseudomonas aeruginosa and Staphylococcus aureus. Researchers can leverage Gly-Gly-AMC for applications in enzymatic assays and studies focused on bacterial pathogenicity and proteolytic processes. -
Polypeptide/Protein Marker
Fmoc-Lys(5-FITC)-OH serves as a fluorescent marker for polypeptides and proteins, utilizing fluorescein isothiocyanate (FITC) to label amines. This compound exhibits sensitivity to pH and Cu2+ ions, making it valuable for various biochemical applications. Its fluorescent properties facilitate the study of protein interactions, localization, and dynamics in biological systems. Researchers can employ Fmoc-Lys(5-FITC)-OH in assays requiring specific protein visualization and tracking. -
Calmodulin-Binding Peptide
CBP-501 is a cell-permeable calmodulin-binding peptide that acts as a G2-abrogating agent. It effectively inhibits the activity of several Ser216-specific kinases, including MAPKAP-K2, C-Tak1, CHK1, and CHK2, with IC50 values of 0.9 μM, 1.4 μM, 3.4 μM, and 6.5 μM, respectively. This compound is primarily utilized in cancer research to explore its therapeutic potential in modulating cell cycle progression and targeting tumor proliferation. -
Chk Kinase Inhibitor
CBP501 Affinity Peptide is a Chk kinase inhibitor that effectively disrupts G2 cell cycle arrest triggered by DNA-damaging agents. This reagent is valuable for cancer research, enabling studies on cell cycle regulation and therapeutic responses to genotoxic stress. Its application can facilitate the investigation of DNA damage repair pathways and their implications in oncogenesis. -
Tumor-homing Peptide
mUNO is a tumor-homing peptide with the sequence "CSPGAK" that specifically targets mouse CD206, a marker expressed on tumor-associated macrophages. This peptide facilitates the selective binding of therapeutics or imaging agents to these macrophages, enhancing localization in tumor environments. mUNO also demonstrates the ability to interact with human recombinant CD206, making it a valuable tool for cancer research and the development of targeted therapies. -
Targeting Peptide
MACTIDE is a high-affinity targeting peptide specific for CD206, known for its stability and efficacy in drug delivery applications. This peptide significantly enhances the targeting of therapeutic agents, making it a valuable tool in cancer research, particularly in studies focused on breast cancer. Its utility extends to investigations aimed at improving the precision of drug action through enhanced tumor targeting. -
MEMs-targeting Peptide
UNO peptide is a MEMs-targeting peptide that specifically binds to CD206 on MRC1-expressing tumor-associated macrophages (TAMs). It demonstrates potential in modulating the tumor microenvironment and influencing immune responses. UNO peptide is valuable for research applications focused on the role of MRC1-expressing TAMs in breast cancer and other solid tumors. -
p38 MAPK Activator
OVA-E1 peptide is an activator of p38 MAPK, derived from the original SIINFEKL sequence (OVA 257-264). This peptide effectively stimulates both p38 and JNK signaling pathways in both mutant and wild-type thymocytes. It serves as a valuable tool for studying MAPK pathways and their roles in cellular responses such as inflammation and stress signaling in various research applications. -
Peptide
(Thr17)-c-Jun (11-23) is a bioactive peptide derived from the c-Jun protein, specifically targeting the transcriptional regulation pathway. This peptide is involved in cell growth, differentiation, and apoptosis, making it essential for studies related to cancer research and signal transduction. Researchers can utilize (Thr17)-c-Jun (11-23) to investigate the molecular mechanisms of gene expression mediated by the Jun/Fos protein family. -
p38 MAPK Inhibitor, JNK Inhibitor
HE4-1 leech peptide is a selective inhibitor of p38 MAPK and c-Jun N-terminal kinase (JNK). It effectively suppresses macrophage migration while maintaining normal macrophage immunological functions, such as phagocytosis, lysozyme activity, and the expression of various inflammatory factors. This peptide is primarily utilized in research focused on atherosclerosis and inflammation-related studies. -
Cyclic Hexapeptide
RA-V is a cyclic hexapeptide that targets key oncogenic signaling pathways. It exhibits inhibitory activity against Wnt, Myc, and Notch with IC50 values of 50, 75, and 93 ng/mL, respectively. RA-V is a valuable tool for investigating cancer-related signaling mechanisms, providing insights into tumor biology and potential therapeutic strategies. -
Peptide Spacer
Gly-Gly-Phe-Gly functions as a peptide spacer, serving as an important component in drug conjugation applications. It is effectively utilized in the synthesis of antibody-drug conjugates (ADCs), facilitating the conjugation of cytotoxic agents like Doxorubicin and Puxitatug samrotecan. This spacer enhances the stability and pharmacokinetics of ADCs, making it valuable for research in targeted cancer therapies. -
Peptide
MC-Ala-Ala-Asn-PAB-PNP is a peptide designed for the synthesis of specifically activated micromolecular target coupling bodies. Its unique structure allows for selective binding in biochemical applications, making it suitable for studies involving targeted drug delivery and molecular recognition. This reagent is essential for researchers aiming to explore peptide interactions and develop novel therapeutic strategies. -
Chromogenic Peptide Substrate
Gly-Pro-pNA hydrochloride is a chromogenic peptide substrate specifically designed for the detection of dipeptidyl peptidase IV (DPP IV) activity. This compound serves as a valuable tool in the study of aminopeptidases and is particularly relevant in the context of diabetes research, where it may be explored for its potential as an experimental antidiabetic agent. The substrate's unique properties enable sensitive colorimetric assays, facilitating the assessment of enzymatic activity. -
Dipeptide
H-Pro-Val-OH is a dipeptide consisting of proline and valine, known for its ability to catalyze the Michael addition reaction of acetone to trans-β-nitrostyrene. This compound also acts as a substrate for fibroblast enzymes and prolinase, making it valuable for biochemical analysis. Its diverse applications make H-Pro-Val-OH an important tool for studying peptide interactions and enzyme activity in various research contexts. -
Dipeptide
H-Ser-Pro-OH is a dipeptide comprising serine and proline, acting as a substrate for prolinase I (PD I) and prolinase II (PD II). This compound is valuable in biochemical research for the synthesis of polypeptides, facilitating studies on peptide interactions and enzymatic functions. Its unique structure makes it a useful tool in the exploration of protein synthesis and modification. -
Dipeptide
H-Pro-Lys-OH is a dipeptide comprised of proline and lysine, functioning as a substrate for iminodipeptidase (prolinase). This compound plays a vital role in polypeptide synthesis and is valuable in studies related to protein structure and function. Its usefulness extends to applications in enzyme assays and the development of therapeutic peptides. -
Dipeptide
H-Pro-Met-OH is a dipeptide composed of proline and methionine, specifically designed for use as a substrate in prolinase assays. This compound facilitates the synthesis of polypeptides, making it a valuable tool in peptide research and development. Its biochemical properties allow for diverse applications in studies related to protein synthesis and enzymatic activity. -
Fluorescence Peptide
Abz-SDK(Dnp)P-OH is a fluorescence peptide that serves as a substrate for angiotensin I-converting enzyme (ACE). The compound features a fluorescent donor-acceptor pair composed of Abz and Dnp (2,4-dinitrophenyl), enabling its use in fluorescence-based assays. Its primary applications include studying ACE activity and facilitating research in cardiovascular biology and related therapeutic areas. -
Antihypertensive Peptide
H-Trp-Phe-OH is a dipeptide composed of tryptophan and phenylalanine that functions as an antihypertensive agent through the inhibition of angiotensin-converting enzyme (ACE). This compound demonstrates dose-dependent increases in nitric oxide levels while simultaneously reducing endothelin-1 (ET-1) levels, making it valuable in studies of cardiovascular function and regulation. Research has shown that H-Trp-Phe-OH can enhance ovarian weight in female mice when administered via subcutaneous injection, thereby contributing to its potential applications in reproductive and hypertensive research. -
Antihypertensive Peptide
αs1-CN f(143–149) is an antihypertensive peptide derived from casein that functions as an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 6.58 μM. This peptide demonstrates significant potential for regulating blood pressure and may be utilized in research focused on hypertension and cardiovascular health. Its oral bioactivity enhances its applicability in therapeutic development and nutritional studies involving blood pressure management. -
ACE2PD α1 Helix Peptide
SBP1 peptide is a 23-amino acid synthetic fragment derived from the α1 helix of the ACE2 PD region. This peptide demonstrates micromolar affinity for the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, facilitating insights into viral entry mechanisms. It is useful in research applications focused on viral pathogenesis and the development of therapeutic strategies targeting ACE2 interactions. -
Antihypertensive Peptide
YKYY is an antihypertensive peptide that functions as an Angiotensin I-converting enzyme (ACE) inhibitor, with an IC50 of 64.2 μM. Isolated from the peptic digest of wakame (Undaria pinnatifida), YKYY exhibits potential for modulating blood pressure. This compound is valuable for research investigating mechanisms of hypertension and the development of novel antihypertensive therapies. -
Antihypertensive Peptide
Tyrosylhistidine is a dipeptide comprised of tyrosine and histidine, exhibiting antihypertensive properties. It has demonstrated the ability to significantly reduce blood pressure in murine models of spontaneous hypertension. This compound serves as a valuable tool for research in cardiovascular physiology and antihypertensive drug development. -
ACE Substrate Peptide
AC-SDKP-NH2 is a substrate peptide of Angiotensin-converting enzyme (ACE). It exhibits significant anti-inflammatory and anti-fibrotic activities by directly targeting tissues, thereby preventing or reversing excessive fibrosis without impacting blood pressure or left ventricular hypertrophy (LVH). AC-SDKP-NH2 effectively attenuates inflammation, as well as cell differentiation, proliferation, and migration, resulting in reduced fibrosis in cardiac, vascular, and renal tissues in mouse models. This reagent is applicable in cardiovascular research, particularly in studies related to hypertension and fibrosis-associated conditions. -
Peptide Fragment
[Tyr6]-Angiotensin II is a peptide fragment that functions as a selective antagonist of the angiotensin II receptor. This compound exhibits biological activity by modulating cardiovascular responses and renal function, making it valuable for research on hypertension and related disorders. Its ability to influence the renin-angiotensin system positions it as a useful tool in studies aimed at understanding the physiological and pathophysiological roles of angiotensin peptides.
