Catalog No.
Product Name
Application
Product Information
Citations
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Fluorogenic Peptide Substrate
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate designed to specifically detect cathepsin B activity across a wide pH range. This substrate undergoes cleavage by cathepsin B, resulting in fluorescence which can be quantitatively measured. It is particularly valuable in studies related to protease activity, cell signaling, and understanding pathological processes where cathepsin B is involved. -
Drp1-Fis1 Inhibitor
P110 heptapeptide is an inhibitor of the Drp1-Fis1 interaction, targeting mitochondrial dynamics to modulate cellular functions. This peptide exhibits anti-inflammatory, immunomodulatory, and neuroprotective properties, making it advantageous in research focused on neurodegenerative disorders, ischemic injury, and sepsis. P110 heptapeptide effectively reduces pathological actions linked to Drp1 without interfering with its essential physiological roles, providing a valuable tool for studying neurological and inflammatory diseases. -
Antimicrobial Peptide
Plantaricin A is an antimicrobial peptide derived from Lactobacillus plantarum that targets bacterial membranes. It exhibits notable antimicrobial activity, particularly against Staphylococcus aureus, by increasing membrane potential and elevating intracellular reactive oxygen species levels. Additionally, Plantaricin A inhibits efflux pump function through binding and structural alteration of MepA, NorA, and LmrS, enhancing synergistic effects with other antibiotics such as Ciprofloxacin. Its anti-inflammatory properties also promote wound healing and exhibit potential in permeabilizing cancerous pituitary cells. -
Anti-aging Peptide
Palmitoyl tripeptide-38 is an anti-aging peptide that promotes skin rejuvenation by stimulating collagen production and enhancing skin elasticity. This bioactive compound has been shown to reduce the appearance of fine lines and wrinkles, making it suitable for use in cosmetic research focused on age-related skin conditions. Its efficacy in promoting cellular regeneration makes it a valuable tool for developing anti-aging formulations and skincare products. -
Anti-oxidant Peptide
Arg-Tyr is an antioxidant peptide that effectively scavenges hydroxyl radicals and hydrogen peroxide. This dipeptide exhibits significant protective properties against oxidative stress, making it valuable for research applications focused on cellular protection and oxidative damage mitigation. Its potential therapeutic implications are of interest in studies related to aging, neurodegenerative diseases, and inflammation. -
Antioxidative Peptide
AHK is a bioactive peptide recognized for its antioxidative properties. It effectively neutralizes free radicals, contributing to cellular protection and longevity. This peptide is commonly utilized in cosmetic formulations to enhance skin health and combat oxidative stress, making it a valuable compound in both dermatological and anti-aging research applications. -
CD47 Agonist Peptide
Cys-PKHB1 is a CD47 agonist peptide designed to mimic thrombospondin-1. This compound has demonstrated antitumor efficacy by inducing mitochondrial alterations, the generation of reactive oxygen species (ROS), and calcium-dependent cell death in breast cancer cells. Cys-PKHB1 also promotes immune activation through immunogenic cell death, making it a valuable tool for research in cancer immunotherapy and tumor biology. -
Algicidal Peptide
Malformin C is an algicidal peptide derived from Aspergillus, demonstrating dose-dependent algicidal activity against various algal species. The compound increases reactive oxygen species (ROS) levels in algal cells, leading to inhibited superoxide dismutase (SOD) activity and elevated malondialdehyde (MDA) content. This mechanism suggests potential applications in algal population control and studies related to oxidative stress in aquatic environments. -
Peptide
Ac2-26 (mouse) is an active peptide derived from the N-terminal of Annexin A1 (AnxA1) that primarily targets the formyl peptide receptor (FPR) signaling pathway. This peptide plays a critical role in regulating the inflammatory response by promoting chemokine release while inhibiting reactive oxygen species (ROS) production. Ac2-26 (mouse) is valuable for investigating mechanisms of inflammation, including conditions such as rheumatoid arthritis. -
Hsp70-targeting Peptide
A17 peptide is an Hsp70-targeting peptide that binds to the ATP-binding domains of Hsp70, specifically inhibiting its chaperone activity. This inhibition enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. A17 peptide is valuable in anticancer chemotherapy research, particularly in studies related to multiple myeloma and other malignancies. -
HSP70/DnaK Substrate Peptide
HSP70/DnaK substrate peptide is a specific peptide recognized and bound by the HSP70/DnaK molecular chaperone. This substrate peptide is essential for probing the functional mechanisms of HSP70/DnaK, facilitating the investigation of its role in protein folding, stabilization, and stress response pathways. It serves as a valuable tool for research applications focused on understanding molecular chaperone activity and cellular proteostasis. -
Antimicrobial Peptide
Metalnikowin I is a proline-rich antimicrobial peptide that functions as an inhibitor of DnaK, a heat shock protein involved in cellular stress response. This peptide exhibits significant antimicrobial activity against a variety of pathogens, making it a valuable tool for studying host defense mechanisms and potential therapeutic applications. Its derivation from insects highlights its evolutionary role in innate immunity, offering insights into novel antimicrobial strategies. -
Tah1 Binding Peptide
Hsp90β decapeptide is derived from the C-terminal region of Hsp90β and features the conserved TPR-domain sequence MEEVD. This peptide effectively binds to the Tah1 protein, exhibiting a binding affinity with a dissociation constant (Kd) of 1.0 μM. Its ability to modulate Hsp90-Tah1 interactions makes Hsp90β decapeptide a valuable tool for researching protein chaperone activity and cellular stress responses. -
Tumor Cell Adhesion Peptide
HYD-1 is a D-amino acid tumor cell adhesion peptide that specifically targets the mechanisms involved in cell adhesion and migration. It consists of overlapping linear peptide elements that inhibit migration and activate ERK signaling pathways, thereby supporting adhesion in breast, prostate, ovarian, and pancreatic tumor cells. Importantly, HYD-1 does not impact tumor cell cycle distribution, making it particularly useful for research applications focused on prostate cancer. -
Antagonist
Peptide E5 is an antagonist that targets the CXCR4/CXCL12 signaling axis. By blocking this interaction, Peptide E5 downregulates CXCR4 expression and inhibits the phosphorylation of key downstream proteins, Akt and Erk, leading to apoptosis in breast cancer cells. Additionally, Peptide E5 suppresses cellular migration and adhesion, as well as the recruitment of endothelial progenitor cells, thereby inhibiting tumor angiogenesis. This peptide is a valuable tool for research related to breast cancer and tumor microenvironment interactions. -
Peptide Inhibitor
MEK1 Derived Peptide Inhibitor 1 is a selective peptide inhibitor targeting MEK1, effectively blocking the in vitro activation of ERK2 with an IC50 value of 30 μM. This compound is valuable for studies focused on the MEK/ERK signaling pathway, allowing researchers to investigate cellular processes regulated by this pathway. Its cell-permeable properties make it suitable for various biological applications in cancer research and signal transduction studies. -
CXCR4 Antagonist
Peptide R analogue 10 is a potent CXCR4 antagonist, demonstrating enhanced antagonistic activity, specificity, and plasma stability compared to its predecessor, Peptide R. This compound effectively inhibits CXCL12-mediated cell migration, ERK phosphorylation, and CXCR4 internalization. Peptide R analogue 10 is valuable for research applications involving CXCR4 overexpression in models of leukemia and colon cancer. -
Bioactive Peptide
ERKtide is a bioactive peptide that acts as a specific substrate for extracellular regulated protein kinase 2 (ERK2). ERK2 plays a crucial role in cellular signaling pathways influenced by mitogenic stimuli, impacting various physiological processes. This peptide can be utilized in studies focused on signal transduction, cellular response to growth factors, and the mechanisms underlying cell proliferation and differentiation. -
CK2 Peptide Substrate
CK2 Substrate Peptide (RRRADDSDDDDD) serves as a specific substrate for Casein Kinase 2 (CK2), exhibiting a Km of 13 μM. This peptide is crucial for studying CK2's role in various biological processes and provides valuable insights into the mechanisms underlying neurological diseases, including Alzheimer's Disease. Research applications include elucidating CK2-mediated phosphorylation events and investigating potential therapeutic targets. -
Casein Kinase II Substrate
Casein Kinase II Receptor Peptide serves as a substrate for casein kinase II, exhibiting a Km value of 500 µM. This peptide is utilized for assessing casein kinase II activity in crude enzyme preparations, facilitating research in signal transduction and cellular regulation. Its application is crucial for understanding various biological processes influenced by casein kinase II. -
CK2 Peptide Substrate
Casein Kinase II Substrate is specifically designed for use as a peptide substrate in studies involving casein kinase II (CK2). This substrate can be selectively phosphorylated by CK2, making it a valuable tool for investigating the enzyme's activity and regulatory mechanisms. It is suitable for various research applications, including signal transduction studies and the exploration of phosphoprotein functions in cellular processes. -
Activin Receptor
Myostatin inhibitory peptide 7 targets the Activin Receptor and is composed of 23 amino acids, specifically derived from the amino acids 21 to 43 of the mouse myostatin prodomain. This peptide effectively inhibits myostatin with a dissociation constant (Kd) of 29.7 nM, making it valuable for investigating muscle atrophic disorders and related research applications. -
Myostatin Inhibitor
Myostatin Inhibitory Peptide 2 is a specific inhibitor of myostatin, exhibiting a dissociation constant (Kd) of 35.9 nM. This peptide plays a significant role in regulating muscle growth and is particularly beneficial for research focused on muscle atrophic disorders. By modulating myostatin activity, it provides insights into potential therapeutic approaches for enhancing muscle regeneration and combatting muscle-wasting conditions. -
TGF-β1 Inhibitory Peptide
P17 Peptide is a selective inhibitor of human TGF-β1, functioning by blocking its activity. This peptide is valuable for studying the role of TGF-β1 in various biological processes and disease states, including fibrosis and cancer. Its inhibitory effects facilitate research into therapeutic strategies targeting TGF-β signaling pathways. -
SMAD2 activator
Myristoyl tetrapeptide-12 is a specific activator of SMAD2, promoting the recruitment of SMAD3 to DNA. This peptide exhibits significant biological activity in stimulating hair growth, with notable effects on eyelash enhancement. Its applications are particularly relevant in research focusing on hair follicle biology and regenerative medicine. -
Active Peptide
a-TGF (34-43), rat is an active peptide that plays a crucial role in modulating immune responses. This peptide segments contribute to the regulatory pathways in the immune system, making it valuable for studies related to immunity and immune modulation. Researchers can utilize a-TGF (34-43), rat to explore its effects on cellular signaling and immune function. -
Competitive peptide
PTD-DBM is a competitive peptide that inhibits the interaction between CXXC5 and Dvl, leading to the upregulation of β-catenin, α-SMA, and type I collagen. This mechanism supports its role in promoting skin wound healing by enhancing cellular processes involved in tissue regeneration and remodeling. PTD-DBM is valuable for research applications focused on regenerative medicine and skin biology. -
Octapeptide
β-Catenin peptide is an octapeptide that plays a crucial role in cell signaling by promoting thymocyte positive selection. This peptide is particularly relevant in immunological research, where it may aid in understanding T cell development and function. Its application extends to studies focused on the mechanisms of thymocyte maturation and selection processes within the immune system. -
Tool Peptide
PKA Regulatory Subunit II Substrate is a tool peptide that mimics the phosphorylation of proteins through interaction with cyclic AMP-dependent protein kinase (PKA). This substrate plays a crucial role in evaluating the activities of protein phosphatases and is widely utilized in research focusing on kinase signaling pathways and enzymatic regulation. Its specificity makes it an essential reagent for studying cellular signaling mechanisms and developing therapeutic interventions. -
Calcineurin Substrate
PKA RII peptide is a specific substrate for Protein Kinase A (PKA) that becomes phosphorylated at a serine residue. This modified peptide can be utilized as a tool for detecting calcineurin activity in various biological assays. Its application in studies related to signal transduction pathways enhances understanding of cellular processes influenced by PKA and calcineurin interactions. -
Neuropeptide
Kiss2 peptide is a neuropeptide that acts as a positive regulator of reproduction. It specifically binds to its receptor, Kiss2R (GPR54), in COS-7 cells, activating PKA and PKC signaling pathways via Gas and Gaq proteins. This interaction subsequently enhances cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) activities, making Kiss2 peptide valuable for research in reproductive biology and neuroendocrine signaling. -
Substrate Peptide
Cys-Kemptide is a cysteine-terminated substrate peptide specifically designed for the assessment of protein kinase A (PKA) activity. This peptide serves as an effective tool in phosphorylation studies, enabling researchers to quantify PKA-mediated protein modifications. Its application is critical in the investigation of signaling pathways and the role of PKA in various biological processes. -
Bioactive Peptide
Kemptide, 5-FAM labeled is a bioactive peptide that acts as a synthetic substrate for Protein Kinase A (PKA), with a Km value of 16 μM. This fluorescently labeled variant facilitates real-time monitoring of PKA activity in various biological assays. Kemptide's unique properties make it a valuable tool for studying signal transduction pathways and assessing kinase activity in research applications. -
Active peptides
d-(RYTVELA) is a specific inhibitor of human thymocyte proliferation, exhibiting an IC50 of 1 nM. It selectively disrupts IL-1-induced signaling pathways, making it valuable for studying immune responses and thymocyte biology. This peptide is useful in research applications related to immunology and cellular signaling. -
Peptide
Interleukin II (60-70) is a peptide fragment derived from the Interleukin II polypeptide. It plays a crucial role in the immune response by modulating T cell proliferation and activation. This fragment is useful for research applications focused on cytokine signaling pathways, immune cell interactions, and the study of T cell dynamics in various experimental settings. -
Anti-inflammatory Peptide
IIIM1 is an orally active anti-inflammatory peptide that functions by stimulating the proliferation of regulatory T cells and promoting the production of RA1. This molecule effectively ameliorates symptoms associated with experimental autoimmune encephalomyelitis (EAE) by regulating cytokine balance. IIIM1 is a valuable tool for research focused on multiple sclerosis (MS) and its underlying immunological mechanisms. -
IL-23 Inhibitor
IL-23 cyclic peptide inhibitor 105 targets the interleukin-23 (IL-23) pathway, serving as a specific inhibitor of this pro-inflammatory cytokine. It exhibits significant potential in modulating inflammatory responses associated with disorders such as inflammatory bowel disease (IBD). This compound is a valuable tool for researchers investigating the role of IL-23 in various inflammatory conditions and developing therapeutic strategies targeting IL-23 signaling. -
Peptide Fragment
IL4RPep-1 is a peptide fragment that specifically targets the interleukin-4 receptor (IL-4R). It demonstrates selective accumulation in atherosclerotic plaques while minimizing enrichment in normal tissues. This property makes IL4RPep-1 a promising candidate for use as a targeted delivery system or molecular imaging probe in atherosclerosis research. -
Antitumor Agent
Myelopeptide-2 is an antitumor peptide that enhances the mitogenic response of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. It effectively restores interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression, supporting immune homeostasis. This reagent holds potential applications in antitumor and antiviral research, providing valuable insights into immune modulation and therapeutic strategies. -
Peptide
BMP-4 is a cell-penetrating peptide that binds heparin, identified by the sequence RKKNPNCRRH. This compound exhibits notable anti-inflammatory and anti-chondrogenic properties, making it a valuable tool in research related to arthritis and related inflammatory conditions. Its unique mechanism allows for enhanced cellular interactions, facilitating studies on cell signaling and tissue response. -
Beta-interleukin II Polypeptide
β-Interleukin II (44-56) is a peptide fragment corresponding to amino acids 44-56 of the beta-interleukin II polypeptide. This cytokine plays a critical role in modulating immune responses, primarily functioning in communication among leukocytes. Research applications include studies on immune system regulation, inflammation, and potential therapeutic strategies targeting cytokine signaling pathways. -
MSP-1 Peptide Segment
MSP-1 P2 is a synthetic peptide derived from merozoite surface protein-1 (MSP-1), specifically designed to stimulate immune responses. This peptide effectively induces umbilical cord blood lymphocytes to produce key cytokines, including IFN-γ and IL-13, through a mechanism primarily involving CD4+ T cells. MSP-1 P2 is suitable for research applications aimed at assessing T cell responses and evaluating cytokine production in various experimental settings. -
Anti-allergen Peptide
Acetyl hexapeptide-49 is an anti-allergen peptide known for its bioactive properties. This compound exerts a protective effect on mammalian skin cells, alleviating irritation and enhancing cell vitality. Its applications primarily lie in cosmetic formulations aimed at reducing allergic reactions and promoting skin health. -
Active peptides
SPA4 is a Toll-like receptor 4 (TLR4)-interacting peptide that specifically inhibits the lipopolysaccharide (LPS)-induced production of the pro-inflammatory cytokine TNF-α. This compound demonstrates its biological activity without adversely affecting cell viability or size. SPA4 is useful in research applications related to inflammation, cytokine signaling, and TLR4-mediated pathways. -
Synthetic Peptide
Endotoxin inhibitor is a synthetic peptide that effectively binds to lipid A, resulting in the detoxification of lipopolysaccharides (LPS). This compound suppresses LPS-induced cytokine release in vivo, providing a means to mitigate inflammatory responses. With its low toxicity and reduced lethality, the endotoxin inhibitor is a valuable tool for research focused on sepsis, inflammation, and immune response modulation. -
Bioactive Peptide
EGF Receptor Substrate 2 (Phospho-Tyr5) is a bioactive peptide that serves as a substrate for tyrosine phosphatases. This compound is integral for detecting protein tyrosine phosphatase activity, making it valuable for research into signaling pathways involving the epidermal growth factor receptor (EGFR). Its utility extends to studies on cell growth, differentiation, and various cancer research applications. -
Bioactive Peptide
KRpTIRR is a bioactive peptide that contains phosphothreonine, functioning as a substrate for various phosphatases. Its biochemical properties make it suitable for studying phosphatase activity and regulation in cellular signaling pathways. Researchers utilize KRpTIRR to investigate protein dephosphorylation processes and their implications in physiological and pathological conditions. -
Cell-Permeable Peptide Inhibitor
CNI103 is a potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. By selectively inhibiting the interaction between calcineurin and NFATc3, with a binding affinity of KD=16 nM, CNI103 effectively prevents NFATc3 activation both in vitro and in vivo. This reagent is valuable for investigating mechanisms involved in acute respiratory distress syndrome (ARDS) and other inflammatory diseases. -
Bioactive Peptide
RRLIEDAEpYAARG is a bioactive peptide that serves as a substrate for phosphatases. This compound is valuable for studying dephosphorylation processes and investigating protein signaling pathways. Its application in biochemical assays aids in the characterization of phosphatase activity and regulation in various biological contexts. -
Antibacterial Peptide
Golotimod hydrochloride is an immunomodulating peptide that targets antibacterial pathways. This compound enhances the efficacy of antituberculosis therapy by promoting thymic and splenic cell proliferation and improving macrophage functionality. Additionally, Golotimod hydrochloride inhibits STAT3 signaling, thereby modulating the severity and duration of oral mucositis in animal models subjected to radiation or combined treatments. Furthermore, it shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2).
