Catalog No.
Product Name
Application
Product Information
Citations
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Cyclic Dipeptide
Cyclo(Gly-Pro) is a cyclic dipeptide that modulates neurogenic signaling pathways. This compound has been shown to attenuate nociceptive behavior and reduce inflammatory responses in murine models. Its unique structural properties make it a valuable tool for studying pain mechanisms and inflammation in various biological research applications. -
Proangiogenic Peptide
KLTWQELYQLKYKGI is a proangiogenic peptide designed to mimic vascular endothelial growth factor (VEGF) and activate VEGF receptors. This peptide significantly enhances the attachment, spreading, and proliferation of human umbilical vein endothelial cells, as well as promoting the proliferation, migration, and osteogenic differentiation of bone marrow stromal cells (BMSCs). KLTWQELYQLKYKGI has demonstrated synergistic effects in accelerating angiogenesis and bone regeneration in rat cranial defect models, making it valuable for applications in brain tissue engineering, traumatic brain injury repair, and bone tissue engineering. -
Anti-angiogenic Peptide
Flt2-11 is an anti-angiogenic peptide that selectively binds to neuropilin-1 (NRP-1). This interaction inhibits the binding between NRP-1 and soluble VEGF receptor-1 (sVEGFR-1), thereby disrupting angiogenic signaling pathways. Flt2-11 is utilized in research focused on tumor growth, vascularization, and other conditions where angiogenesis plays a crucial role. -
Peptide
NYLTHRQ is a peptide that specifically disrupts the interaction between soluble VEGFR1 isoform i13 and β1 integrin, leading to the inhibition of VEGFR1 and VEGFR2 activation. This modulation results in a reduction of cancer cell proliferation, highlighting its potential in cancer therapeutics. NYLTHRQ is particularly relevant for research focused on tumors, including lung squamous cell carcinoma. -
Anti-angiogenesis Peptide
Apolipoprotein KV domain (67-77) is an 11-amino acid peptide that functions as an anti-angiogenesis agent. It exhibits significant antiangiogenic and antitumor activities by targeting the c-Src/ERK signaling pathway, effectively inhibiting activation mediated by vascular endothelial growth factor (VEGF). This peptide serves as a valuable tool in cancer research, aiding studies focused on angiogenesis and tumor progression. -
Anti-angiogenic Peptide
Scospondistatin is an anti-angiogenic peptide that targets endothelial cell proliferation and migration. It has been shown to effectively inhibit the growth and movement of human umbilical vein endothelial cells in vitro. This compound is useful in research applications focused on angiogenesis and related disease mechanisms. -
PDGFR Fragment
PDGFR Y1021 peptide (non-phosphorylation) is a specific non-phosphorylated fragment of the platelet-derived growth factor receptor (PDGFR). This peptide effectively inhibits the association of PLCγ with PDGFR via the PLCγ SH2 domain, thereby blocking the mitogenic response. It serves as a valuable tool in research focused on signaling pathways involving PDGFR and its role in cell growth and proliferation. -
PDGFR Fragment
PDGFR Y1021 peptide (phosphorylation) is a phosphorylated fragment of the platelet-derived growth factor receptor (PDGFR) that facilitates the binding of phospholipase C-gamma (PLCγ) through its SH2 domains. This interaction enhances the production of inositol phosphates and stimulates mitogenic responses. The peptide serves as a valuable tool for research investigating PDGFR signaling pathways and their roles in cellular proliferation and differentiation. -
Lyn Kinase Inhibitor
Lyn Peptide Inhibitor is a selective inhibitor of Lyn kinase that specifically targets the Lyn-coupled IL-5 receptor signaling pathway. This compound effectively blocks Lyn activation and disrupts the interaction between Lyn tyrosine kinase and the βc subunit of IL-3/GM-CSF/IL-5 receptors. The Lyn Peptide Inhibitor is valuable for investigating mechanisms underlying asthma, allergic reactions, and various eosinophilic disorders, providing insights into potential therapeutic approaches. -
Control Substrate For c-Src Assay
Tyrosine Kinase Peptide 1 serves as a control substrate specifically designed for c-Src assay applications. Its primary mechanism involves interacting with c-Src kinase, facilitating the assessment of kinase activity. This peptide is critical for validating experimental conditions and ensuring accurate measurement of c-Src-mediated phosphorylation events in biological research. -
Peptide Substrate
p60c-src Substrate is a specific peptide substrate designed for the p60c-src protein tyrosine kinase (PTK). This substrate serves as a valuable tool for studying kinase activity and can facilitate the synthesis of chimeric branched peptides, expanding research applications in signal transduction and protein interactions. Its efficiency and specificity make it suitable for in vitro kinase assays and related studies in cellular signaling. -
Phosphopeptide Inhibitor
Caffeic acid-pYEEIE is a phosphopeptide inhibitor that demonstrates strong binding affinity for the GST-Lck-SH2 domain. This compound serves as a valuable tool in research focused on T cell signaling and immune response modulation. Its ability to selectively inhibit specific protein interactions makes it instrumental in studying the mechanisms underlying various cellular processes and disorders. -
Phosphorylated Polypeptide
p60c-src substrate II, phosphorylated is a pentapeptide that serves as a substrate for the p60c-src protein kinase. This phosphorylated polypeptide is crucial for studying protein phosphorylation, a key post-translational modification involved in various biological regulatory processes. Researchers utilize this substrate to investigate signaling pathways, cellular signaling mechanisms, and the role of Src family kinases in cellular function and disease. -
GM1 Ganglioside Binding Peptide
Ganglioside GM1-binding peptide p3 is a synthetic peptide that specifically targets the pentasaccharide component of GM1 ganglioside. This peptide is integral to understanding GM1's role as a multifunctional receptor, particularly in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 is valuable for investigating the interactions between GM1 and its ligands in various biological contexts. -
Bioactive Peptide
DYRKtide is a bioactive peptide that serves as an optimal substrate for DYRK1A, a dual-specificity protein kinase implicated in brain development. This peptide facilitates efficient phosphorylation by DYRK1A, making it a valuable tool for studying the regulatory mechanisms of this kinase in various cellular contexts. Its applications extend to research focused on neurodevelopmental processes and the signaling pathways influenced by DYRK1A. -
Compstatin Control Peptide
Compstatin Control Peptide serves as a negative control for Compstatin, a potent inhibitor of the complement system component C3. This peptide allows for the assessment of the specificity and efficacy of Compstatin in experimental settings. It is ideally used in research focused on complement-mediated processes and immunological responses. -
NRP-1 Targeting Peptide
CK3 peptide is an NRP-1 targeting peptide characterized by the amino acid sequence CLKADKAKC. It selectively binds to NRP-1 on breast cancer cells, facilitating targeted imaging and therapeutic applications. In vivo studies utilizing single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate significant accumulation of CK3 peptide in xenograft tumors within nude mice. This peptide is suitable for molecular imaging research in breast cancer. -
Pro-Inflammatory Peptide
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a potent leukocyte chemoattractant. It plays a significant role in mediating inflammatory responses and can be employed in research related to various immune system disorders, including allergic asthma. This reagent is ideal for studies investigating the mechanisms of inflammation and the effects of immune modulation. -
Tumor Penetrating Peptide
RPARPAR is a CendR tumor-penetrating peptide that specifically targets neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) receptors on tumor cells. Its unique mechanism facilitates cellular internalization, promotes vascular extravasation, and enhances penetration into tumor tissues. RPARPAR is particularly valuable in research applications focused on tumor targeting and the development of efficient drug delivery systems using nanocarriers. -
LPS Peptide Mimic
RS 09 is an LPS peptide mimic that acts as an agonist for Toll-like receptor 4 (TLR4). By binding to TLR4, RS 09 activates the nuclear factor kappa B (NF-κB) signaling pathway, which is crucial for mediating immune responses. This compound is valuable in research focused on enhancing antigen-specific immune responses and studying TLR4-related signaling pathways in various in vivo models. -
Mast Cell Degranulating Peptide
Granuliberin R is a mast cell degranulating peptide derived from the skin of the amphibian Rana rugosa. This dodecapeptide stimulates rat peritoneal mast cells, inducing granule release and histamine secretion. Granuliberin R is useful for research applications focused on mast cell biology and the mechanisms of allergic responses. -
14-Membered Linear Peptide
Mast Cell Degranulating Peptide HR-2 is a 14-membered linear peptide derived from the venom of the giant hornet, Vespa orientalis. It effectively induces mast cell degranulation, leading to the release of histamine. This peptide is utilized in research applications focused on understanding allergic responses, inflammation processes, and the mechanisms of mast cell activation. -
Integrin ligand
VSLRGDTRG is a synthetic peptide derived from cadherin 17 (CDH17) that functions as a ligand for the α2β1 integrin. This peptide promotes the conformational activation of β1 integrin via the RGD motif, leading to enhanced cell adhesion and increased phosphorylation of FAK and ERK1/2. VSLRGDTRG is applicable in cancer research, specifically in studies involving tumors expressing CDH17, including colon and pancreatic cancers, where it may aid in understanding mechanisms of tumor proliferation and metastasis. -
Anti-aging Peptide
Hexapeptide-11 is an anti-aging peptide that targets fibroblasts to prevent premature cell senescence induced by oxidative stress. It promotes the synthesis of hyaluronic acid in keratinocytes, thereby enhancing skin barrier function through upregulation of HAS2 and EGR3, while downregulating HYAL2 expression. Additionally, Hexapeptide-11 has been shown to improve skin elasticity, making it valuable for research in dermatological and cosmetic applications. -
HSP60-derived Peptide
DiaPep277 is a 24 amino acid peptide derived from the HSP60 protein, specifically from positions 437-460. This peptide has been shown to halt the progression of β-cell destruction in NOD mice and exerts immune modulatory effects on diabetogenic T cells. DiaPep277 is primarily utilized in research studies focused on diabetes and immune response modulation, making it a valuable tool for understanding autoimmune mechanisms and potential therapeutic interventions. -
BiP Peptide Substrate
BiP substrate is a specific peptide substrate that targets BiP (Binding immunoglobulin protein), enabling the assessment of BiP ATPase activity. This reagent plays a crucial role in studies of protein folding and endoplasmic reticulum stress responses. Its application facilitates the exploration of cellular mechanisms related to protein metabolism and stress signaling pathways in various biological contexts. -
Hsp72 Antagonist
A8 peptide is an Hsp72 antagonist that inhibits tumor progression and metastasis. By disrupting the interaction between Hsp72 and TLR2, A8 peptide enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. This reagent is valuable for research in cancer biology, particularly in exploring mechanisms of drug resistance and metastasis. -
regenerative peptide
Rusalatide acetate (TP508 amide acetate), a regenerative peptide, mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. - D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain.
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non-peptide CCR1 antagonist
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. -
non-peptide nociceptin receptor (NOP) agonist
MT-7716 free base (W-212393) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention. -
integrin-ligand interactions inhibitor
RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. -
oxytocin receptor ligand
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma. - Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease.
- Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.
- L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
- Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.
- Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction.
- Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively.
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nAChR antagonist
α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM.
- Fertirelin is a GnRH and LH-RH analogue; it also becomes the treatment choice for reversing cow follicular cysts.
- Insulin (human) is a polypeptide hormone that regulates the level of glucose.
- Ceruletide is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.
- Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells.
