Catalog No.
Product Name
Application
Product Information
Citations
- Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
- Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
- Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
-
T cell activator
beta-Interleukin I (163-171), human, a peptide. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). -
Fibronectin Inhibitor
RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor with IC50 value of 10 μM. - Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.
-
non-peptide angiotensin II receptor antagonist
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. - Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It works to raise the concentration of glucose in the bloodstream. Its effect is opposite that of insulin, which lowers the glucose.
- Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
-
gonadotropin-releasing hormone agonist
Buserelin Acetate is a gonadotropin-releasing hormone agonist (GnRH agonist). - Octreotide is a somatostatin analog that binds to the somatostatin receptor, mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production.
- Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function.
-
Antimicrobial Peptide
Protegrin-1 is an antimicrobial peptide that exhibits potent antibacterial activity by activating ERK, COX2, and NFκB pathways, while inhibiting apoptosis and nitric oxide production. It demonstrates significant bactericidal effects against various pathogens, including Staphylococcus aureus, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, with minimal inhibitory concentrations ranging from 10 to 20 µM. Additionally, Protegrin-1 shows antiviral activity against the dengue virus NS2B-NS3 and possesses anti-inflammatory properties, making it a valuable tool in the research of inflammatory diseases and infections. -
Antiangiogenic TSP Peptide
ABT-510 acetate is an anti-angiogenic Thrombospondin-1 analogue that targets angiogenesis and promotes apoptosis in ovarian tumors. Its efficacy has been demonstrated in murine models, significantly inhibiting tumor growth in epithelial ovarian cancer and reducing angiogenesis and inflammation in inflammatory bowel disease. This compound is a valuable tool for research focused on cancer biology and inflammatory conditions. -
Mitochondrial Derived Peptide
SHLP2 (Small humanin-like peptide 2) is a mitochondrial-derived peptide that primarily targets mitochondrial function. It regulates apoptosis and inhibits cell death through its interaction with mitochondrial complex 1. SHLP2 enhances mitochondrial metabolism by improving respiration and biogenesis, while reducing reactive oxygen species (ROS) and diminishing mtDNA oxidation. Additionally, SHLP2 plays a role in energy homeostasis by activating hypothalamic neurons. This peptide is utilized in research focusing on mitochondrial dysfunction and age-related diseases such as age-related macular degeneration and Parkinson's disease. -
MMP2-Cleavable Polypeptide
GPLGIAGQ is an MMP2-cleavable polypeptide utilized as a stimulus-sensitive linker in liposomal and micellar nanocarriers for targeted tumor delivery. This compound enables the synthesis of innovative MMP2-targeted photosensitizers, enhancing the efficacy of photodynamic therapy (PDT) applications. Its selective cleavage by MMP2 facilitates precise drug release in the tumor microenvironment, making it a valuable tool in cancer research and therapy. -
Slimming Peptide
Tripeptide-41 (CG-Lipoxyn) is a signaling peptide that activates the NF-kB pathway. By inhibiting the expression of C/EBP and increasing cAMP levels, this tripeptide plays a critical role in stimulating lipolysis, promoting the hydrolysis of lipids into triglycerides. Tripeptide-41 is particularly useful in cosmetic formulations aimed at reducing fat accumulation and enhancing body contouring. -
Peptide
BPC 157 acetate is a bioactive peptide with a primary mechanism of promoting wound healing and tissue repair. It demonstrates significant biological activities, including enhancing tendon healing, providing neuroprotection, and offering gastrointestinal protection. This peptide is valuable in research applications related to tendon injuries, burn recovery, gastric ulcers, and various neurological disorders. -
Bioactive Peptide
Jak3tide is a biologically active peptide that serves as a substrate for Janus kinase 3 (JAK3). It contains a phosphorylation site at Tyr7, making it suitable for kinase assay applications. This peptide can be utilized in various research settings to study JAK3-mediated signaling pathways and its role in cellular activities. -
Peptide
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from amino acids 475 to 491 of the mouse JAK2 protein. This peptide serves as a substrate for the examination of JAK2 phosphorylation at tyrosine residues 8 and 9, providing insights into its regulatory mechanisms. It is valuable for studying JAK2-related signaling pathways and their implications in various cellular processes and diseases, including hematopoiesis and immune response. -
FGFR Activator
FGL peptide is a fibroblast growth factor receptor (FGFR) activator that effectively penetrates the blood-brain barrier. It initiates NCAM-FGFR and FGFR1 signaling pathways, which modulate the expression of genes involved in apoptosis, signal transduction, and metabolic regulation. FGL peptide is primarily utilized in research focused on traumatic brain injury, offering insights into its underlying molecular mechanisms and potential therapeutic targets. -
PACE4 Inhibitor
Multi-Leu peptide is a potent inhibitor of the proprotein convertase PACE4, exhibiting a Ki value of 22 nM. This peptide competitively binds to the active site of PACE4, mimicking its substrate sequence and effectively blocking its catalytic activity. Multi-Leu peptide is valuable for elucidating the role of PACE4 in various biological processes, including its involvement in the progression of prostate cancer. -
CaMKII Inhibitor
Autocamtide-2-related inhibitory peptide is a selective inhibitor of Calcium/Calmodulin-dependent protein kinase II (CaMKII), exhibiting an IC50 value of 40 nM. This peptide effectively modulates CaMKII activity, making it a valuable tool for studying calcium signaling pathways and their implications in various physiological and pathological processes. Its high specificity and potency simplify the investigation of CaMKII-related mechanisms in cellular signaling research. -
Autophagy Activator
Soybean peptide QRPR is an autophagy activator that enhances cellular autophagy by increasing the expression and activity of key signaling proteins, including PIK3, AKT, and mTOR. This peptide has shown potential in reducing inflammatory responses, making it valuable for research in cellular stress responses and inflammatory diseases. Its role in modulating autophagy pathways positions it as an important tool for studies aimed at understanding cellular homeostasis and therapeutic interventions. -
Fluorescent Peptide Substrate
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate specifically designed for the assessment of cathepsin enzyme activity. This compound exhibits a high degree of specificity, facilitating the study of cathepsin-mediated biological processes. It is valuable in research applications involving proteolytic activity and enzyme kinetics, enabling researchers to investigate the roles of cathepsins in various physiological and pathological conditions. -
Abz-Tripeptide Substrate
Abz-FRF(4NO2) is an Abz-tripeptide substrate designed for research into enzyme activity, particularly in the study of cysteine proteases such as Cathepsin X. Its structure allows for the assessment of proteolytic activity, making it a valuable tool in enzymatic studies and drug development. This reagent can facilitate investigations into enzyme kinetics and substrate specificity in various biological contexts. -
Polypeptide
Hepcidin-1 (mouse) is a polypeptide hormone that plays a critical role in the regulation of iron homeostasis. It promotes the expression of mRNA levels associated with TRAP, cathepsin K, and MMP-9, leading to increased TRAP-5b protein secretion. Additionally, Hepcidin-1 (mouse) inhibits ferroportin 1 (FPN1) protein levels, resulting in elevated intracellular iron concentrations and facilitating osteoclast differentiation. This reagent is valuable for research into iron metabolism and bone biology. -
peptides
KYS-1 is a selective substrate for cathepsin E, exhibiting a Km value of 1.9 μM. This compound is optimized for use in studies involving cathepsin E activity, particularly at an optimal pH of approximately 4.0. KYS-1 is valuable for investigating the role of cathepsin E in various biological processes and can aid in enzyme kinetics studies and therapeutic research involving proteolytic pathways. -
Peptide
Suc-Val-Pro-Phe-SBzl is a peptide-based inhibitor targeting Cathepsin G (CatG) enzymes, exhibiting IC50 values ranging from 111 to 225 µM. This compound demonstrates significant biological activity, making it a valuable tool for research applications aimed at elucidating the role of CatG in various physiological and pathological processes. It is particularly useful for studies involving inflammation, immune response, and tissue remodeling. -
Polypeptide
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide designed as a substrate for cathepsin D, pepsin, and pepsinogen. This compound is valuable in biochemical analysis and can facilitate the study of proteolytic enzyme activity. Its unique structure allows for detailed investigations into polypeptide interactions and enzyme mechanisms. -
Polypeptide
Phe-Arg-Arg-Gly is a polypeptide primarily utilized for agent coupling in biochemical applications. This compound plays a crucial role in enhancing protein interaction and stability, making it valuable for various research applications, including peptide synthesis and biomolecule conjugation. Its ability to facilitate molecular assembly further supports its use in developing targeted therapeutic agents and research tools. -
peptides
Cathepsin E substrate e is a selective substrate for the enzyme Cathepsin E, designed to facilitate monitoring of its proteolytic activity. This substrate employs a close proximity of a Mca donor and a Dnp acceptor to create a near-complete intramolecular quenching effect in its intact form. Upon cleavage by Cathepsin E, the spatial separation of Mca and Dnp generates a significant increase in fluorescence, making it an effective tool for studying Cathepsin E activity and its role in various biological processes. -
Fluorogenic Peptide Substrate
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate designed to specifically detect cathepsin B activity across a wide pH range. This substrate undergoes cleavage by cathepsin B, resulting in fluorescence which can be quantitatively measured. It is particularly valuable in studies related to protease activity, cell signaling, and understanding pathological processes where cathepsin B is involved. -
Drp1-Fis1 Inhibitor
P110 heptapeptide is an inhibitor of the Drp1-Fis1 interaction, targeting mitochondrial dynamics to modulate cellular functions. This peptide exhibits anti-inflammatory, immunomodulatory, and neuroprotective properties, making it advantageous in research focused on neurodegenerative disorders, ischemic injury, and sepsis. P110 heptapeptide effectively reduces pathological actions linked to Drp1 without interfering with its essential physiological roles, providing a valuable tool for studying neurological and inflammatory diseases. -
Antimicrobial Peptide
Plantaricin A is an antimicrobial peptide derived from Lactobacillus plantarum that targets bacterial membranes. It exhibits notable antimicrobial activity, particularly against Staphylococcus aureus, by increasing membrane potential and elevating intracellular reactive oxygen species levels. Additionally, Plantaricin A inhibits efflux pump function through binding and structural alteration of MepA, NorA, and LmrS, enhancing synergistic effects with other antibiotics such as Ciprofloxacin. Its anti-inflammatory properties also promote wound healing and exhibit potential in permeabilizing cancerous pituitary cells. -
Anti-aging Peptide
Palmitoyl tripeptide-38 is an anti-aging peptide that promotes skin rejuvenation by stimulating collagen production and enhancing skin elasticity. This bioactive compound has been shown to reduce the appearance of fine lines and wrinkles, making it suitable for use in cosmetic research focused on age-related skin conditions. Its efficacy in promoting cellular regeneration makes it a valuable tool for developing anti-aging formulations and skincare products. -
Anti-oxidant Peptide
Arg-Tyr is an antioxidant peptide that effectively scavenges hydroxyl radicals and hydrogen peroxide. This dipeptide exhibits significant protective properties against oxidative stress, making it valuable for research applications focused on cellular protection and oxidative damage mitigation. Its potential therapeutic implications are of interest in studies related to aging, neurodegenerative diseases, and inflammation. -
Antioxidative Peptide
AHK is a bioactive peptide recognized for its antioxidative properties. It effectively neutralizes free radicals, contributing to cellular protection and longevity. This peptide is commonly utilized in cosmetic formulations to enhance skin health and combat oxidative stress, making it a valuable compound in both dermatological and anti-aging research applications. -
CD47 Agonist Peptide
Cys-PKHB1 is a CD47 agonist peptide designed to mimic thrombospondin-1. This compound has demonstrated antitumor efficacy by inducing mitochondrial alterations, the generation of reactive oxygen species (ROS), and calcium-dependent cell death in breast cancer cells. Cys-PKHB1 also promotes immune activation through immunogenic cell death, making it a valuable tool for research in cancer immunotherapy and tumor biology. -
Algicidal Peptide
Malformin C is an algicidal peptide derived from Aspergillus, demonstrating dose-dependent algicidal activity against various algal species. The compound increases reactive oxygen species (ROS) levels in algal cells, leading to inhibited superoxide dismutase (SOD) activity and elevated malondialdehyde (MDA) content. This mechanism suggests potential applications in algal population control and studies related to oxidative stress in aquatic environments. -
Peptide
Ac2-26 (mouse) is an active peptide derived from the N-terminal of Annexin A1 (AnxA1) that primarily targets the formyl peptide receptor (FPR) signaling pathway. This peptide plays a critical role in regulating the inflammatory response by promoting chemokine release while inhibiting reactive oxygen species (ROS) production. Ac2-26 (mouse) is valuable for investigating mechanisms of inflammation, including conditions such as rheumatoid arthritis. -
Hsp70-targeting Peptide
A17 peptide is an Hsp70-targeting peptide that binds to the ATP-binding domains of Hsp70, specifically inhibiting its chaperone activity. This inhibition enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. A17 peptide is valuable in anticancer chemotherapy research, particularly in studies related to multiple myeloma and other malignancies. -
HSP70/DnaK Substrate Peptide
HSP70/DnaK substrate peptide is a specific peptide recognized and bound by the HSP70/DnaK molecular chaperone. This substrate peptide is essential for probing the functional mechanisms of HSP70/DnaK, facilitating the investigation of its role in protein folding, stabilization, and stress response pathways. It serves as a valuable tool for research applications focused on understanding molecular chaperone activity and cellular proteostasis. -
Antimicrobial Peptide
Metalnikowin I is a proline-rich antimicrobial peptide that functions as an inhibitor of DnaK, a heat shock protein involved in cellular stress response. This peptide exhibits significant antimicrobial activity against a variety of pathogens, making it a valuable tool for studying host defense mechanisms and potential therapeutic applications. Its derivation from insects highlights its evolutionary role in innate immunity, offering insights into novel antimicrobial strategies.
