Catalog No.
Product Name
Application
Product Information
Citations
- Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
- Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
- Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
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T cell activator
beta-Interleukin I (163-171), human, a peptide. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). -
Fibronectin Inhibitor
RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor with IC50 value of 10 μM. - Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.
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non-peptide angiotensin II receptor antagonist
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. - Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It works to raise the concentration of glucose in the bloodstream. Its effect is opposite that of insulin, which lowers the glucose.
- Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
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gonadotropin-releasing hormone agonist
Buserelin Acetate is a gonadotropin-releasing hormone agonist (GnRH agonist). - Octreotide is a somatostatin analog that binds to the somatostatin receptor, mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production.
- Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function.
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Antimicrobial Peptide
Protegrin-1 is an antimicrobial peptide that exhibits potent antibacterial activity by activating ERK, COX2, and NFκB pathways, while inhibiting apoptosis and nitric oxide production. It demonstrates significant bactericidal effects against various pathogens, including Staphylococcus aureus, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, with minimal inhibitory concentrations ranging from 10 to 20 µM. Additionally, Protegrin-1 shows antiviral activity against the dengue virus NS2B-NS3 and possesses anti-inflammatory properties, making it a valuable tool in the research of inflammatory diseases and infections. -
Antiangiogenic TSP Peptide
ABT-510 acetate is an anti-angiogenic Thrombospondin-1 analogue that targets angiogenesis and promotes apoptosis in ovarian tumors. Its efficacy has been demonstrated in murine models, significantly inhibiting tumor growth in epithelial ovarian cancer and reducing angiogenesis and inflammation in inflammatory bowel disease. This compound is a valuable tool for research focused on cancer biology and inflammatory conditions. -
Mitochondrial Derived Peptide
SHLP2 (Small humanin-like peptide 2) is a mitochondrial-derived peptide that primarily targets mitochondrial function. It regulates apoptosis and inhibits cell death through its interaction with mitochondrial complex 1. SHLP2 enhances mitochondrial metabolism by improving respiration and biogenesis, while reducing reactive oxygen species (ROS) and diminishing mtDNA oxidation. Additionally, SHLP2 plays a role in energy homeostasis by activating hypothalamic neurons. This peptide is utilized in research focusing on mitochondrial dysfunction and age-related diseases such as age-related macular degeneration and Parkinson's disease. -
MMP2-Cleavable Polypeptide
GPLGIAGQ is an MMP2-cleavable polypeptide utilized as a stimulus-sensitive linker in liposomal and micellar nanocarriers for targeted tumor delivery. This compound enables the synthesis of innovative MMP2-targeted photosensitizers, enhancing the efficacy of photodynamic therapy (PDT) applications. Its selective cleavage by MMP2 facilitates precise drug release in the tumor microenvironment, making it a valuable tool in cancer research and therapy. -
Slimming Peptide
Tripeptide-41 (CG-Lipoxyn) is a signaling peptide that activates the NF-kB pathway. By inhibiting the expression of C/EBP and increasing cAMP levels, this tripeptide plays a critical role in stimulating lipolysis, promoting the hydrolysis of lipids into triglycerides. Tripeptide-41 is particularly useful in cosmetic formulations aimed at reducing fat accumulation and enhancing body contouring. -
Peptide
BPC 157 acetate is a bioactive peptide with a primary mechanism of promoting wound healing and tissue repair. It demonstrates significant biological activities, including enhancing tendon healing, providing neuroprotection, and offering gastrointestinal protection. This peptide is valuable in research applications related to tendon injuries, burn recovery, gastric ulcers, and various neurological disorders. -
Bioactive Peptide
Jak3tide is a biologically active peptide that serves as a substrate for Janus kinase 3 (JAK3). It contains a phosphorylation site at Tyr7, making it suitable for kinase assay applications. This peptide can be utilized in various research settings to study JAK3-mediated signaling pathways and its role in cellular activities. -
Peptide
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from amino acids 475 to 491 of the mouse JAK2 protein. This peptide serves as a substrate for the examination of JAK2 phosphorylation at tyrosine residues 8 and 9, providing insights into its regulatory mechanisms. It is valuable for studying JAK2-related signaling pathways and their implications in various cellular processes and diseases, including hematopoiesis and immune response. -
FGFR Activator
FGL peptide is a fibroblast growth factor receptor (FGFR) activator that effectively penetrates the blood-brain barrier. It initiates NCAM-FGFR and FGFR1 signaling pathways, which modulate the expression of genes involved in apoptosis, signal transduction, and metabolic regulation. FGL peptide is primarily utilized in research focused on traumatic brain injury, offering insights into its underlying molecular mechanisms and potential therapeutic targets. -
NLRP3-targeting Renalase Peptide
RP-220 is a renalase peptide that specifically targets the NLRP3 inflammasome. It exhibits significant anti-inflammatory and anti-apoptotic properties, evidenced by its ability to inhibit apoptosis in renal tubular epithelial cells under alkaline stress through activation of the MAPK signaling pathway. Additionally, RP-220 reduces NLRP3 expression, limits macrophage infiltration, and mitigates kidney tissue damage in models of acute kidney injury (AKI). This reagent is particularly relevant for research into systemic lupus erythematosus (SLE) and its associated complication, lupus nephritis (LN). -
Peptide
Corisin is a peptide derived from Staphylococcus nepalensis, known for its ability to induce apoptosis in targeted cells. This compound plays a significant role in studies related to pulmonary fibrosis, demonstrating potential implications in understanding disease mechanisms and therapeutic approaches. Its unique biological activity positions Corisin as a valuable tool for researchers investigating apoptosis and fibrotic processes. -
Hair-generating Peptide
Octapeptide-2 is a biomimetic peptide designed to mimic the effects of thymosin-β4, targeting hair follicle regeneration. This compound exhibits significant biological activities, including promoting hair growth, reducing cell apoptosis, and enhancing keratinocyte proliferation. Octapeptide-2 is particularly relevant for research focused on hair loss conditions, such as alopecia areata, and is instrumental in exploring potential therapeutic strategies for follicular disorders. -
Toxin Depsipeptide
Cereulide is a toxin depsipeptide produced by Bacillus cereus, primarily targeting mitochondrial function. It induces apoptosis in various cell types, leading to mitochondrial dysfunction and affecting multiple organ systems, including the liver, pancreas, brain, and intestines, as well as the immune and nervous systems. This compound is valuable for research into cellular apoptosis mechanisms and the pathological effects of bacterial toxins on human health. -
Anti-tumor Peptide
ARF(26–44), cell-permeable is a cell-penetrating peptide derived from the p14ARF tumor suppressor protein and functions as an inhibitor of FoxM1. This peptide exhibits marked anti-tumor activity, demonstrating the ability to increase apoptosis and decrease proliferation and angiogenesis in mouse models of hepatocellular carcinoma (HCC). ARF(26–44), cell-permeable serves as a valuable tool for research focusing on tumor therapy and the molecular mechanisms underlying cancer progression. -
Amino Acid Neuropeptide
Argipressin diacetate, an amino acid neuropeptide, primarily targets G-protein coupled receptors, including Avpr1a (V1a), Avpr1b (V1b), and Avpr2 (V2). It plays a crucial role in regulating fluid balance, osmolality, and cardiovascular function. This compound is also influential in centrally mediated metabolic processes, making it valuable for research in neuroendocrine regulation and metabolic disorders. -
Bioactive Peptide
KLA peptide is a bioactive peptide that targets mitochondrial membranes to induce apoptosis through membrane disruption. Its cationic amphipathic structure facilitates cellular uptake and interaction with mitochondrial components. KLA peptide is valuable for research applications in cancer, inflammation, and neurological diseases, allowing for the exploration of apoptotic pathways and therapeutic interventions. -
Anti-cancerous Peptide
Cr-ACP1 is an anti-cancerous peptide that selectively binds to DNA, inducing cell cycle arrest in the G0-G1 phase. This mechanism triggers apoptosis, making Cr-ACP1 a potent agent against various cancer types. Notably, it demonstrates significant anticancer effects in colon cancer and epidermoid carcinoma research applications. -
Antifungal Peptide
Periplanetasin-2 is an antifungal peptide that exerts its effects primarily through the induction of oxidative stress by generating reactive oxygen species (ROS) and promoting lipid peroxidation. In addition to its antifungal activity, Periplanetasin-2 can also trigger apoptosis in target cells. This compound is valuable for research applications aimed at understanding fungal pathogenesis and evaluating potential therapeutic strategies against fungal infections. -
Fas Mimetic Peptide/Fas/FasL Antagonist
Kp7-6 is a Fas mimetic peptide that acts as a Fas/FasL antagonist. It selectively binds to the Fas receptor and Fas ligand, disrupting receptor complexes and inhibiting downstream apoptotic signaling pathways. This includes the suppression of caspase-8 and caspase-3 activation, thereby preventing β-cell apoptosis and reducing FasL-induced lymphoid cytotoxicity. In preclinical models, Kp7-6 has demonstrated efficacy in reducing tumor volume and enhancing T cell infiltration in pancreatic neuroendocrine tumors, and it has also been shown to protect against concanavalin A-induced liver injury. The compound is relevant for research in type 2 diabetes, inflammation, and cancer biology. -
N-Formyl Peptide Receptor Agonist
WKYMVm is a selective agonist of the N-formyl peptide receptor, specifically FPR2. It exhibits significant anti-inflammatory properties, demonstrating potential to reduce lung and spinal cord injuries. Additionally, WKYMVm influences metabolic pathways by regulating lipid metabolism and leptin signaling, contributing to obesity management. Its role extends to immune cell regulation, where it promotes chemotactic migration and inhibits phagocyte apoptosis. The compound may have variable effects in tumor biology, with potential to either support or hinder tumor progression based on the tumor type. -
Bioactive Peptide
MOTS-c (human) is a bioactive peptide derived from mitochondria that modulates the AMPK/PGC-1α pathway, thereby enhancing insulin sensitivity. This peptide inhibits the folate cycle and de novo purine synthesis, elevating AICAR levels to activate AMPK, which regulates the Nrf2/Keap1 antioxidant pathway and suppresses the NF-κB inflammatory pathway. MOTS-c promotes mitochondrial biogenesis and energy metabolism, resulting in improvements in glucose and lipid metabolism, anti-oxidative stress, and neuroprotection. It is applicable in research studying type 2 diabetes, traumatic brain injury, inflammatory diseases, and age-related metabolic disorders. -
PACE4 Inhibitor
Multi-Leu peptide is a potent inhibitor of the proprotein convertase PACE4, exhibiting a Ki value of 22 nM. This peptide competitively binds to the active site of PACE4, mimicking its substrate sequence and effectively blocking its catalytic activity. Multi-Leu peptide is valuable for elucidating the role of PACE4 in various biological processes, including its involvement in the progression of prostate cancer. -
CaMKII Inhibitor
Autocamtide-2-related inhibitory peptide is a selective inhibitor of Calcium/Calmodulin-dependent protein kinase II (CaMKII), exhibiting an IC50 value of 40 nM. This peptide effectively modulates CaMKII activity, making it a valuable tool for studying calcium signaling pathways and their implications in various physiological and pathological processes. Its high specificity and potency simplify the investigation of CaMKII-related mechanisms in cellular signaling research. -
Autophagy Activator
Soybean peptide QRPR is an autophagy activator that enhances cellular autophagy by increasing the expression and activity of key signaling proteins, including PIK3, AKT, and mTOR. This peptide has shown potential in reducing inflammatory responses, making it valuable for research in cellular stress responses and inflammatory diseases. Its role in modulating autophagy pathways positions it as an important tool for studies aimed at understanding cellular homeostasis and therapeutic interventions. -
Fluorescent Peptide Substrate
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate specifically designed for the assessment of cathepsin enzyme activity. This compound exhibits a high degree of specificity, facilitating the study of cathepsin-mediated biological processes. It is valuable in research applications involving proteolytic activity and enzyme kinetics, enabling researchers to investigate the roles of cathepsins in various physiological and pathological conditions. -
Abz-Tripeptide Substrate
Abz-FRF(4NO2) is an Abz-tripeptide substrate designed for research into enzyme activity, particularly in the study of cysteine proteases such as Cathepsin X. Its structure allows for the assessment of proteolytic activity, making it a valuable tool in enzymatic studies and drug development. This reagent can facilitate investigations into enzyme kinetics and substrate specificity in various biological contexts. -
Polypeptide
Hepcidin-1 (mouse) is a polypeptide hormone that plays a critical role in the regulation of iron homeostasis. It promotes the expression of mRNA levels associated with TRAP, cathepsin K, and MMP-9, leading to increased TRAP-5b protein secretion. Additionally, Hepcidin-1 (mouse) inhibits ferroportin 1 (FPN1) protein levels, resulting in elevated intracellular iron concentrations and facilitating osteoclast differentiation. This reagent is valuable for research into iron metabolism and bone biology. -
peptides
KYS-1 is a selective substrate for cathepsin E, exhibiting a Km value of 1.9 μM. This compound is optimized for use in studies involving cathepsin E activity, particularly at an optimal pH of approximately 4.0. KYS-1 is valuable for investigating the role of cathepsin E in various biological processes and can aid in enzyme kinetics studies and therapeutic research involving proteolytic pathways. -
Peptide
Suc-Val-Pro-Phe-SBzl is a peptide-based inhibitor targeting Cathepsin G (CatG) enzymes, exhibiting IC50 values ranging from 111 to 225 µM. This compound demonstrates significant biological activity, making it a valuable tool for research applications aimed at elucidating the role of CatG in various physiological and pathological processes. It is particularly useful for studies involving inflammation, immune response, and tissue remodeling. -
Polypeptide
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide designed as a substrate for cathepsin D, pepsin, and pepsinogen. This compound is valuable in biochemical analysis and can facilitate the study of proteolytic enzyme activity. Its unique structure allows for detailed investigations into polypeptide interactions and enzyme mechanisms. -
Polypeptide
Phe-Arg-Arg-Gly is a polypeptide primarily utilized for agent coupling in biochemical applications. This compound plays a crucial role in enhancing protein interaction and stability, making it valuable for various research applications, including peptide synthesis and biomolecule conjugation. Its ability to facilitate molecular assembly further supports its use in developing targeted therapeutic agents and research tools. -
peptides
Cathepsin E substrate e is a selective substrate for the enzyme Cathepsin E, designed to facilitate monitoring of its proteolytic activity. This substrate employs a close proximity of a Mca donor and a Dnp acceptor to create a near-complete intramolecular quenching effect in its intact form. Upon cleavage by Cathepsin E, the spatial separation of Mca and Dnp generates a significant increase in fluorescence, making it an effective tool for studying Cathepsin E activity and its role in various biological processes.
