Catalog No.
Product Name
Application
Product Information
Citations
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Antimicrobial Anticancer Peptide
d-(KLAKLAK)2 is a pro-apoptotic peptide that targets both antimicrobial and anticancer pathways. This peptide effectively disrupts bacterial cell membranes, leading to cell lysis and leakage of cellular contents. Additionally, d-(KLAKLAK)2 induces apoptosis in tumor cells by promoting mitochondrial swelling and destabilizing mitochondrial membranes, thus inhibiting tumor cell proliferation. This compound is valuable for researchers investigating antimicrobial strategies and cancer therapies. -
Active Peptide
HKPao (Hunter-killer peptide ao) is a biologically active peptide that targets apoptotic pathways. It exhibits pro-apoptotic activity by promoting the release of cytochrome c from intracellular vesicles, contributing to its anti-obesity and anti-tumor effects. This peptide is useful for research applications focused on apoptosis, cancer biology, and metabolic disorders. -
Antimicrobial Peptide
Pantinin-1 is an antimicrobial peptide derived from the venom of the Pandinus imperator scorpion, primarily targeting microbial pathogens. It exhibits potent antimicrobial activity against Gram-positive bacteria and fungi, while displaying minimal efficacy against Gram-negative bacteria; it also shows low hemolytic activity towards human erythrocytes. Additionally, Pantinin-1 demonstrates anticancer properties by inducing apoptosis in tumor cells, making it a valuable reagent for research in antimicrobial and cancer therapies. -
Targeted Peptide
TI-16 is a targeted peptide that selectively binds to β-amyloid (Aβ) protein and effectively crosses the blood-brain barrier. By increasing intracellular free calmodulin (CaM) concentration, TI-16 helps restore calcium ion homeostasis, thereby mitigating Aβ toxicity. This peptide has been demonstrated to reduce Aβ deposition in the brain, enhance neuronal health, inhibit cell apoptosis, and improve cognitive function in mouse models. TI-16 serves as a valuable reagent for research into Alzheimer's disease pathology and therapeutic strategies. -
Antimicrobial Peptide
EP3 is an antimicrobial peptide that exhibits significant antibacterial and antifungal properties. It effectively inhibits the growth of E. gallinarum, P. pyocyanea, A. baumannii, and K. terrigena, with a minimum inhibitory concentration (MIC) of 12.85 μg/mL. Additionally, EP3 demonstrates antitumor activity by inducing apoptosis in cancer cells, making it a valuable tool for research in microbiology and cancer biology. -
Apoptosis Inducer
Bax BH3 peptide (55-74), wild type is a 20-amino acid peptide derived from the BH3 domain of Bax, a pro-apoptotic protein that promotes cell death through mitochondrial pathway activation. This peptide is effective in inducing apoptosis across various cell line models and serves as a valuable tool for studying apoptosis mechanisms and the role of BH3-only proteins in cellular processes. Researchers can utilize this peptide for investigations into cancer therapeutics and programmed cell death pathways. -
TLR-2/TLR-6 Agonist
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll-like receptors TLR-2 and TLR-6, which plays a critical role in immune response modulation. MALP-2 enhances phosphorylation of endothelial nitric oxide synthase (eNOS) and stimulates nitric oxide (NO) release from endothelial cells, promoting vasodilation. Additionally, it facilitates the adhesion of white blood cells in endothelium and supports perfusion recovery and collateral vessel growth in hypercholesterolemic Apoe-deficient mouse models during femoral artery ligation experiments. This makes MALP-2 a valuable tool for studying vascular biology and immune response in cardiovascular research. -
IRF5 Inhibitory Peptide
PTD-N5-1 is an inhibitory peptide targeting Interferon Regulatory Factor 5 (IRF5). This compound effectively blocks β-glucan-induced IL-12 production in both interferon-gamma-primed wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDCs). By suppressing IRF5-mediated IL-12 production, PTD-N5-1 plays a critical role in regulating antifungal immunity, making it valuable for research applications focused on immune response modulation. -
Immunoreactive Peptide
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide that targets NLRP1 and plays a significant role in bone formation. It induces osteoblast differentiation by up-regulating Runx2 gene expression via MAPK signaling pathways. Muramyl dipeptide is widely utilized in research focused on bone metabolism and immunological responses. -
Bioactive Peptide
TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a bioactive peptide that functions as a specific activator of the Nod1 receptor. This compound is known to induce immune responses and modulate inflammatory pathways, making it valuable for research in immunology and host-pathogen interactions. TriDAP can be utilized to study the mechanisms of innate immunity and the role of pattern recognition receptors in various disease models. -
Bioactive Peptide
C12-iE-DAP (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid) is a bioactive peptide that functions as a potent NOD1 agonist. Its lauroyl (C12) modification enhances cellular uptake and potency, promoting immune responses through NOD1 activation. This compound is valuable for research into immune signaling pathways and the modulation of innate immune responses. -
PD-L1 Binding Peptide
WL12 is a PD-L1 binding peptide that specifically targets the programmed death ligand 1. This peptide can be radiolabeled with various radionuclides to create radiotracers, facilitating the assessment of PD-L1 expression in tumors. It is a valuable tool for cancer research, particularly in studies focused on immune checkpoint blockade and tumor immunology. -
Inhibitor Peptide
PD-L1 inhibitory peptide is an inhibitor peptide that targets programmed cell death ligand 1 (PD-L1). By binding to PD-L1, it effectively alleviates immunosuppression and enhances the antitumor activity of T cells. This peptide is valuable for cancer research, particularly in the study of immune checkpoint regulation and therapeutic interventions. -
Immunogenic Peptide
Asudemotide is an immunogenic peptide derived from the human DEP domain-containing protein 1A. It functions as an immunostimulant, promoting a robust tumor immune response, particularly in esophageal cancer. The peptide displays a specific sequence of H-Glu-Tyr-Tyr-Glu-Leu-Phe-Val-Asn-Ile-OH, making it a valuable tool for research in cancer immunotherapy and the study of immune responses to tumors. -
Polypeptide
Human membrane-bound PD-L1 polypeptide serves as a crucial immunological target for the induction of PD-L1 antibody production. This polypeptide is essential for studies aimed at understanding immune checkpoint mechanisms and developing cancer immunotherapies. Its role in elevating PD-L1 expression on tumor cells makes it invaluable for research on tumor-immune interactions and checkpoint blockade strategies. -
PD-L1 Binding Peptide
RK-10 is a PD-L1 binding peptide that specifically targets programmed death-ligand 1 (PD-L1). This peptide can be conjugated with fluorescent dyes such as Cy5 or biotin for the detection of PD-L1 expressing tumors via flow cytometry or immunohistochemistry. RK-10 serves as a valuable tool for research applications related to non-small cell lung cancer (NSCLC), breast cancer, squamous cell carcinoma, and melanoma, facilitating studies on tumor immunology and therapeutic responses. -
Cell-Penetrating Peptide
Pep-1 (uncapped) is a cell-penetrating peptide that facilitates receptor-mediated endocytosis. It demonstrates the capacity to traverse the blood-tumor barrier and specifically targets glioma cells, enhancing the uptake of nanoparticles by these tumor cells. This characteristic makes Pep-1 (uncapped) a valuable reagent for the development of targeted drug delivery systems aimed at glioma therapy. -
Anti-aging Peptide
Palmitoyl hexapeptide-12 is an anti-aging peptide known for its bioactive properties. It effectively reduces interleukin-6 (IL-6) levels, contributing to its ability to mitigate signs of aging. This peptide is utilized in research related to photoaging and skin aging issues, making it a valuable tool for studies focused on dermatological applications and regenerative medicine. -
IL-6 Inhibitor
Palmitoyl Tetrapeptide-3 is a synthetic peptide that acts as an interleukin-6 (IL-6) inhibitor, primarily targeting inflammatory pathways in skin cells. It effectively reduces IL-6 secretion in keratinocytes and mitigates the inflammatory response induced by UVB radiation exposure. This compound exhibits anti-inflammatory and anti-aging properties, promoting the production of elastic fibers in the papillary dermis, thereby contributing to a reduction in skin wrinkles and overall skin rejuvenation. Its applications include studies in dermatology, skin biology, and anti-aging research. -
IL-23R Inhibitor
IL-23R inhibitor peptide-1 is a potent interleukin-23 receptor inhibitor with an IC50 of 0.0069 μM. It is designed to modulate the signaling pathway of IL-23, which plays a critical role in the pathogenesis of various autoimmune diseases. This reagent is suitable for research applications focused on inflammatory responses and therapeutic strategies targeting IL-23 signaling. -
Biased Agonist for Neuropeptide/Chemokine Receptors
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a biased agonist targeting neuropeptide and chemokine receptors, specifically activating the G12 pathway. This compound binds to IL-8 and GRP receptors, resulting in the inhibition of ERK-2 activation while simultaneously promoting JNK activity. It is known to enhance neutrophil migration and calcium mobilization, contributing to its utility in inflammation research. Additionally, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acts as a bombesin antagonist and has demonstrated potential in inhibiting the growth of small cell lung cancer. -
HAT Binding Peptide
Humanized anti-tac (HAT) binding peptide is designed to specifically interact with the Fc region of HAT, a humanized monoclonal antibody targeting the low-affinity p55 subunit of the interleukin IL-2 receptor. This peptide is valuable for developing affinity chromatography media, enabling the purification of specific monoclonal antibodies. It serves as an essential tool for researchers studying immunological responses and antibody interactions in various biological contexts. -
CD44-Hyaluronan Inhibitor
IGFBP-3 peptide is an 18-amino acid fragment of insulin-like growth factor binding protein-3, known to inhibit the interaction between CD44 and hyaluronan. This peptide effectively binds to Humanin and hyaluronan, thereby blocking their functional interactions. IGFBP-3 peptide serves as a useful tool for researching CD44-related signaling pathways and its role in cellular adhesion and migration. -
Cyclic Dipeptide
Cyclo(Gly-Pro) is a cyclic dipeptide that modulates neurogenic signaling pathways. This compound has been shown to attenuate nociceptive behavior and reduce inflammatory responses in murine models. Its unique structural properties make it a valuable tool for studying pain mechanisms and inflammation in various biological research applications. -
Proangiogenic Peptide
KLTWQELYQLKYKGI is a proangiogenic peptide designed to mimic vascular endothelial growth factor (VEGF) and activate VEGF receptors. This peptide significantly enhances the attachment, spreading, and proliferation of human umbilical vein endothelial cells, as well as promoting the proliferation, migration, and osteogenic differentiation of bone marrow stromal cells (BMSCs). KLTWQELYQLKYKGI has demonstrated synergistic effects in accelerating angiogenesis and bone regeneration in rat cranial defect models, making it valuable for applications in brain tissue engineering, traumatic brain injury repair, and bone tissue engineering. -
Anti-angiogenic Peptide
Flt2-11 is an anti-angiogenic peptide that selectively binds to neuropilin-1 (NRP-1). This interaction inhibits the binding between NRP-1 and soluble VEGF receptor-1 (sVEGFR-1), thereby disrupting angiogenic signaling pathways. Flt2-11 is utilized in research focused on tumor growth, vascularization, and other conditions where angiogenesis plays a crucial role. -
Peptide
NYLTHRQ is a peptide that specifically disrupts the interaction between soluble VEGFR1 isoform i13 and β1 integrin, leading to the inhibition of VEGFR1 and VEGFR2 activation. This modulation results in a reduction of cancer cell proliferation, highlighting its potential in cancer therapeutics. NYLTHRQ is particularly relevant for research focused on tumors, including lung squamous cell carcinoma. -
Anti-angiogenesis Peptide
Apolipoprotein KV domain (67-77) is an 11-amino acid peptide that functions as an anti-angiogenesis agent. It exhibits significant antiangiogenic and antitumor activities by targeting the c-Src/ERK signaling pathway, effectively inhibiting activation mediated by vascular endothelial growth factor (VEGF). This peptide serves as a valuable tool in cancer research, aiding studies focused on angiogenesis and tumor progression. -
Anti-angiogenic Peptide
Scospondistatin is an anti-angiogenic peptide that targets endothelial cell proliferation and migration. It has been shown to effectively inhibit the growth and movement of human umbilical vein endothelial cells in vitro. This compound is useful in research applications focused on angiogenesis and related disease mechanisms. -
PDGFR Fragment
PDGFR Y1021 peptide (non-phosphorylation) is a specific non-phosphorylated fragment of the platelet-derived growth factor receptor (PDGFR). This peptide effectively inhibits the association of PLCγ with PDGFR via the PLCγ SH2 domain, thereby blocking the mitogenic response. It serves as a valuable tool in research focused on signaling pathways involving PDGFR and its role in cell growth and proliferation. -
PDGFR Fragment
PDGFR Y1021 peptide (phosphorylation) is a phosphorylated fragment of the platelet-derived growth factor receptor (PDGFR) that facilitates the binding of phospholipase C-gamma (PLCγ) through its SH2 domains. This interaction enhances the production of inositol phosphates and stimulates mitogenic responses. The peptide serves as a valuable tool for research investigating PDGFR signaling pathways and their roles in cellular proliferation and differentiation. -
Lyn Kinase Inhibitor
Lyn Peptide Inhibitor is a selective inhibitor of Lyn kinase that specifically targets the Lyn-coupled IL-5 receptor signaling pathway. This compound effectively blocks Lyn activation and disrupts the interaction between Lyn tyrosine kinase and the βc subunit of IL-3/GM-CSF/IL-5 receptors. The Lyn Peptide Inhibitor is valuable for investigating mechanisms underlying asthma, allergic reactions, and various eosinophilic disorders, providing insights into potential therapeutic approaches. -
Control Substrate For c-Src Assay
Tyrosine Kinase Peptide 1 serves as a control substrate specifically designed for c-Src assay applications. Its primary mechanism involves interacting with c-Src kinase, facilitating the assessment of kinase activity. This peptide is critical for validating experimental conditions and ensuring accurate measurement of c-Src-mediated phosphorylation events in biological research. -
Peptide Substrate
p60c-src Substrate is a specific peptide substrate designed for the p60c-src protein tyrosine kinase (PTK). This substrate serves as a valuable tool for studying kinase activity and can facilitate the synthesis of chimeric branched peptides, expanding research applications in signal transduction and protein interactions. Its efficiency and specificity make it suitable for in vitro kinase assays and related studies in cellular signaling. -
Phosphopeptide Inhibitor
Caffeic acid-pYEEIE is a phosphopeptide inhibitor that demonstrates strong binding affinity for the GST-Lck-SH2 domain. This compound serves as a valuable tool in research focused on T cell signaling and immune response modulation. Its ability to selectively inhibit specific protein interactions makes it instrumental in studying the mechanisms underlying various cellular processes and disorders. -
Phosphorylated Polypeptide
p60c-src substrate II, phosphorylated is a pentapeptide that serves as a substrate for the p60c-src protein kinase. This phosphorylated polypeptide is crucial for studying protein phosphorylation, a key post-translational modification involved in various biological regulatory processes. Researchers utilize this substrate to investigate signaling pathways, cellular signaling mechanisms, and the role of Src family kinases in cellular function and disease. -
GM1 Ganglioside Binding Peptide
Ganglioside GM1-binding peptide p3 is a synthetic peptide that specifically targets the pentasaccharide component of GM1 ganglioside. This peptide is integral to understanding GM1's role as a multifunctional receptor, particularly in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 is valuable for investigating the interactions between GM1 and its ligands in various biological contexts. -
Bioactive Peptide
DYRKtide is a bioactive peptide that serves as an optimal substrate for DYRK1A, a dual-specificity protein kinase implicated in brain development. This peptide facilitates efficient phosphorylation by DYRK1A, making it a valuable tool for studying the regulatory mechanisms of this kinase in various cellular contexts. Its applications extend to research focused on neurodevelopmental processes and the signaling pathways influenced by DYRK1A. -
Compstatin Control Peptide
Compstatin Control Peptide serves as a negative control for Compstatin, a potent inhibitor of the complement system component C3. This peptide allows for the assessment of the specificity and efficacy of Compstatin in experimental settings. It is ideally used in research focused on complement-mediated processes and immunological responses. -
NRP-1 Targeting Peptide
CK3 peptide is an NRP-1 targeting peptide characterized by the amino acid sequence CLKADKAKC. It selectively binds to NRP-1 on breast cancer cells, facilitating targeted imaging and therapeutic applications. In vivo studies utilizing single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate significant accumulation of CK3 peptide in xenograft tumors within nude mice. This peptide is suitable for molecular imaging research in breast cancer. -
Pro-Inflammatory Peptide
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a potent leukocyte chemoattractant. It plays a significant role in mediating inflammatory responses and can be employed in research related to various immune system disorders, including allergic asthma. This reagent is ideal for studies investigating the mechanisms of inflammation and the effects of immune modulation. -
Tumor Penetrating Peptide
RPARPAR is a CendR tumor-penetrating peptide that specifically targets neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) receptors on tumor cells. Its unique mechanism facilitates cellular internalization, promotes vascular extravasation, and enhances penetration into tumor tissues. RPARPAR is particularly valuable in research applications focused on tumor targeting and the development of efficient drug delivery systems using nanocarriers. -
LPS Peptide Mimic
RS 09 is an LPS peptide mimic that acts as an agonist for Toll-like receptor 4 (TLR4). By binding to TLR4, RS 09 activates the nuclear factor kappa B (NF-κB) signaling pathway, which is crucial for mediating immune responses. This compound is valuable in research focused on enhancing antigen-specific immune responses and studying TLR4-related signaling pathways in various in vivo models. -
Mast Cell Degranulating Peptide
Granuliberin R is a mast cell degranulating peptide derived from the skin of the amphibian Rana rugosa. This dodecapeptide stimulates rat peritoneal mast cells, inducing granule release and histamine secretion. Granuliberin R is useful for research applications focused on mast cell biology and the mechanisms of allergic responses. -
14-Membered Linear Peptide
Mast Cell Degranulating Peptide HR-2 is a 14-membered linear peptide derived from the venom of the giant hornet, Vespa orientalis. It effectively induces mast cell degranulation, leading to the release of histamine. This peptide is utilized in research applications focused on understanding allergic responses, inflammation processes, and the mechanisms of mast cell activation. -
Integrin ligand
VSLRGDTRG is a synthetic peptide derived from cadherin 17 (CDH17) that functions as a ligand for the α2β1 integrin. This peptide promotes the conformational activation of β1 integrin via the RGD motif, leading to enhanced cell adhesion and increased phosphorylation of FAK and ERK1/2. VSLRGDTRG is applicable in cancer research, specifically in studies involving tumors expressing CDH17, including colon and pancreatic cancers, where it may aid in understanding mechanisms of tumor proliferation and metastasis. -
Anti-aging Peptide
Hexapeptide-11 is an anti-aging peptide that targets fibroblasts to prevent premature cell senescence induced by oxidative stress. It promotes the synthesis of hyaluronic acid in keratinocytes, thereby enhancing skin barrier function through upregulation of HAS2 and EGR3, while downregulating HYAL2 expression. Additionally, Hexapeptide-11 has been shown to improve skin elasticity, making it valuable for research in dermatological and cosmetic applications. -
HSP60-derived Peptide
DiaPep277 is a 24 amino acid peptide derived from the HSP60 protein, specifically from positions 437-460. This peptide has been shown to halt the progression of β-cell destruction in NOD mice and exerts immune modulatory effects on diabetogenic T cells. DiaPep277 is primarily utilized in research studies focused on diabetes and immune response modulation, making it a valuable tool for understanding autoimmune mechanisms and potential therapeutic interventions. -
BiP Peptide Substrate
BiP substrate is a specific peptide substrate that targets BiP (Binding immunoglobulin protein), enabling the assessment of BiP ATPase activity. This reagent plays a crucial role in studies of protein folding and endoplasmic reticulum stress responses. Its application facilitates the exploration of cellular mechanisms related to protein metabolism and stress signaling pathways in various biological contexts. -
Hsp72 Antagonist
A8 peptide is an Hsp72 antagonist that inhibits tumor progression and metastasis. By disrupting the interaction between Hsp72 and TLR2, A8 peptide enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. This reagent is valuable for research in cancer biology, particularly in exploring mechanisms of drug resistance and metastasis.
