Peptides

Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.

SPL-410 is an orally active, highly potent and selective hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a) inhibitor, with an IC50 of 9 nM.

BMS-193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over ??1, α1, Y2, Y4 and Y5 receptors respectively.

GB110 is a Novel potent non-peptide PAR2 agonist. GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM.

AR234960, a non-peptide MAS (a G protein-coupled receptor) agonist, increases both mRNA and protein levels of CTGF via ERK1/2 signaling in HEK293-MAS cells and adult human cardiac fibroblasts.

Thrombin is a trypsin-like allosteric serine protease. Thrombin enables site-specific cleavage of fusion proteins with an accessible Thrombin recognition sequence and can be used to digest GST-tagged proteins.

H-Ala-Ala-Tyr-OH can be synthesized mutant peptides.

AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.

H-Gly-Gly-Pro-OH is a peptide with 3 amino acid.

Angiotensin I is formed by the action of renin on angiotensinogen.

LEP (116-130) (mouse) is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.

Myelin Basic Protein (87-99) is a self-antigen in multiple sclerosis (MS).

Angiotensin II (Ang II) is an octapeptide hormone that plays a central role in cardiovascular homeostasis.

Angiotensin III is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II, a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system by angiotensinases located in red blood cells and the vascular beds of most tissues.

Dynamin Inhibitory Peptide is a peptide inhibitor of the GTPase dynamin.

PKA inhibitor fragment (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor.

Secretin (human),gastrointestinal peptide that stimulates pancreatic and biliary secretion.

Melanocyte stimulating hormone release inhibiting factor is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body.

PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM).

Anti-Inflammatory Peptide 1, belongs to the group of synthetic oligopeptides corresponding to a region of high amino-acid sequence similarity between uteroglobin and lipocortin I.

Glucagon (19-29) (human) is a potent Ca 2+ /Mg 2+ -ATPase inhibitor.

N/A

Epidermal Growth Factor Receptor Peptide (985-996) exists on the cell surface and is activated by the binding of its specific ligands, including epidermal growth factor and transforming growth factor.

Cadherin Peptide, avian, is a class of type-1 transmembrane proteins.

Fas C- Terminal Tripeptide is a tri-peptide with the sequence AC-SER-LEU-VAL-OH.

Myelin Basic Protein (68-82), guinea pig is a peptide.

Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity.

Acetyl Angiotensinogen (1-14),porcine, The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor.

Thrombin Receptor Activator for Peptide 5 (TRAP-5), coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response.

N/A

N/A

Big Endothelin-1 (1–38), human, is the biologically inactive precursor of endothelin-1 (ET-1), a potent endogenous vasoconstrictive peptide. Upon enzymatic cleavage by endothelin-converting enzymes (ECEs), Big Endothelin-1 is processed into the active ET-1 form, which plays a critical role in the regulation of vascular tone and blood pressure. This peptide is widely used as a research tool for investigating endothelin signaling pathways, cardiovascular physiology, and related pathophysiological processes.

BNP (1-32), human is a brain natriuretic peptide secreted by the human heart in response to cardiac volume or pressure.

Corticotropin Releasing Factor, bovine, neurotransmitter and CRF receptor antagonist.

N/A

Peptide YY (PYY) is a short (36-amino acid) peptide released by cells in the ileum and colon in response to feeding. It is also known as peptide tyrosine tyrosine or pancreatic peptide YY3-36.

FLAG tag Peptide is a 8 amino acid peptide with an enterokinase-cleavage site used for the purification of recombinant proteins.

Influenza Hemagglutinin (HA) Peptide is a tag peptide derived from an epitope of the influenza hemagglutinin protein.

Bax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.

Bax inhibitor peptide V5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.

Bax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.

DAPK Substrate Peptide, synthetic peptide substrate for death associated protein kinase (DAPK) (Km = 9 uM).

TLQP 21, VGF-derived peptide; spans residues 556-576 of the precursor sequence.

Calcineurin inhibitory peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 uM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).

Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.

Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.

Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.

Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.

Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).

Amyloid b-peptide (1-40) (rat)