Catalog No.
Product Name
Application
Product Information
Citations
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Peptide Hormone
CCK (26-31) sulfated is a peptide hormone fragment that plays a crucial role in gastrointestinal function and neuroendocrine signaling. This bioactive peptide is involved in stimulating digestive processes, modulating appetite, and influencing anxiety-related behavior. Research applications include studies on gut-brain interactions, appetite regulation, and the pharmacological effects of peptide hormones in both physiological and pathological contexts. -
C-terminal heptapeptide of CCK
CCK (27-33) is the C-terminal heptapeptide derived from cholecystokinin (CCK), which primarily targets CCK receptors. This peptide plays a significant role in stimulating gallbladder contraction and promoting pancreatic enzyme secretion, making it crucial for investigating digestive processes. CCK (27-33) is utilized in research applications focusing on gastrointestinal physiology and receptor signaling pathways. -
Acidic Peptide
Minigastrin is an acidic peptide that primarily targets the gastrin receptor. It plays a crucial role in stimulating gastric acid secretion and is utilized in research applications involving gastrointestinal physiology and pathology. Minigastrin can be employed to investigate peptide-peptide interactions and their implications in digestive disorders. -
Human Gastrin I Peptide
Gastrin I (1-14), human is the 1-14 fragment of the human gastrin I peptide, which acts as an endogenous gastrointestinal hormone. This peptide plays a crucial role in regulating gastric acid secretion, influencing digestive processes. It is predominantly used in research applications focused on gastrointestinal physiology and peptic disorders. -
Neuropeptide
Neuropeptide SF (human) serves as a neuropeptide that primarily targets the regulation of paraventricular corticotrophin-releasing hormone (CRH) release. This neuropeptide enhances the release of adrenocorticotropic hormone (ACTH) and increases plasma corticosterone levels, playing a crucial role in modulating circadian functions, including motor center activity and the hypothalamic-pituitary-adrenal (HPA) axis. It is useful for research applications focused on stress response and circadian rhythm regulation. -
Neuropeptide
Neuropeptide SF (human) acetate is a neuropeptide that targets the paraventricular nucleus to enhance corticotrophin-releasing hormone (CRH) release. It is known to elevate plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone, playing a vital role in the regulation of circadian functions, including motor activity and the hypothalamic-pituitary-adrenal (HPA) axis. This reagent is useful in research applications related to stress response, endocrine signaling, and neuroendocrine regulation. -
CRH Receptor Ligand
Stresscopin-related peptide (human) is a specific ligand for the corticotropin-releasing hormone (CRH) receptor type 2. It is known to suppress food intake, delay gastric emptying, and reduce heat-induced edema. This peptide plays a crucial role in maintaining homeostasis following stress and is valuable for research into stress-related disorders and physiological responses. -
CXCR4 Inhibitor
Peptide R is a cyclic peptide that functions as a specific antagonist of the CXCR4 receptor. It demonstrates significant efficacy in remodeling tumor stroma, making it a valuable tool for tumor research. Its ability to modulate the tumor microenvironment highlights its potential applications in cancer therapy and investigation into tumor progression mechanisms. -
peptide
Polyphemusin II-Derived Peptide (T140) is a potent CXCR4 inhibitor that effectively blocks HIV-1 entry into host cells. Its mechanism involves disrupting the interaction between CXCR4 and the HIV-1 envelope glycoprotein, offering a targeted approach to HIV research. Additionally, T140 has been shown to inhibit the binding of the anti-CXCR4 monoclonal antibody (12G5) to its receptor, making it a valuable tool for studying CXCR4-related pathways and potential therapeutic interventions in viral infections. -
Radiolabeled Peptide
Pentixather is a radiolabeled peptide that specifically targets the CXCR4 receptor. By interfering with the CXCR4/CXCL12 signaling axis, Pentixather disrupts the interaction between leukemic cells and the bone marrow microenvironment, thereby promoting the release of leukemic cells from the protective niche and increasing their sensitivity to therapeutics. This compound is valuable for research applications in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). -
apoE-mimetic Peptide
COG112 is an antennapedia-linked apoE-mimetic peptide that targets inflammatory pathways. It effectively attenuates nitric oxide production and inhibits the expression of CXC chemokines such as KC and MIP-2. Additionally, COG112 reduces the nuclear translocation of NF-κB and inhibits the phosphorylation of IκB-α, thereby preventing its degradation. This peptide is valuable for research applications focused on modulating inflammatory responses, particularly in the context of Citrobacter rodentium infection. -
Inflammatory Peptide
Peptide 78 is an inflammatory peptide that functions as a chemotactic cytokine, belonging to the IL-8 or C-X-C chemokine supergene family. This 78 amino acid protein is essential for the recruitment of neutrophils to sites of inflammation, particularly in rheumatoid arthritis (RA) pathology. Its role in promoting neutrophil migration makes Peptide 78 a valuable tool for research into inflammatory diseases and immune responses. -
Secretoneurin Peptide Fragment
Secretoneurin, rat, is a 33-amino acid polypeptide derived from the proteolytic processing of secretogranin II (SgII). This peptide plays a significant role in neuropharmacology by stimulating dopamine release in the rat striatum, both in vivo and in vitro. Additionally, Secretoneurin exhibits a potent chemotactic effect on monocytes and eosinophils, while showing no significant activity against granulocytes. This makes it valuable for research applications focused on neurobiology and immune response mechanisms. -
Peptide
Amylin (8-37), human is a peptide fragment derived from human Amylin, targeting vasodilation pathways. This compound exhibits direct vasodilatory effects in the isolated mesenteric resistance artery of rat models. As a derivative of human Amylin, it plays a role in the study of metabolic conditions associated with insulin deficiency and is relevant for research into the pathophysiology of type II diabetes mellitus. -
Angiotensin II-Related Peptide
(Des-Asp1,Ile8)-Angiotensin II is a modified peptide that targets angiotensin II receptors. It plays a crucial role in elucidating the functional dynamics of the renin-angiotensin system. This reagent is valuable for research applications involving cardiovascular physiology, hypertension, and peptide-receptor interaction studies. -
Bioactive Peptide
Biotin-Ahx-Angiotensin II human is a biochemically active peptide that targets the angiotensin II receptor. This compound plays a crucial role in regulating blood pressure and fluid balance, making it invaluable for cardiovascular research. It can be utilized in various applications, including receptor binding studies and the investigation of angiotensin signaling pathways. -
Angiogenin Peptide
Angiogenin (108-122) is a peptide derived from the angiogenin protein, known for its role in promoting angiogenesis. This peptide has been demonstrated to enhance endothelial cell proliferation and capillary tube formation, making it useful in studying vascular biology and therapeutic angiogenesis. Its applications include research in cancer, wound healing, and cardiovascular disorders, where modulation of angiogenic activity is critical. -
AR1 Receptor Inverse Agonist
Angiotensin II antipeptide is an inverse agonist of the angiotensin II type 1 (AR1) receptor. This peptide, derived from the sequence complementary to angiotensin II, demonstrates significant interaction with the AR1 receptor, altering its activity and signaling pathways. Its biological activity makes it a valuable tool in research focusing on cardiovascular physiology, hypertension, and related signaling mechanisms. -
Ang I Peptide
5-Valine-angiotensin I is an angiotensin I peptide that primarily targets the renin-angiotensin system. This compound is known to induce muscle contraction and is valuable for studying the physiological and pathological roles of angiotensin peptides. As a precursor to angiotensin II and angiotensin fragment 1-7, it plays a critical role in fluid volume regulation and aldosterone release, making it significant in cardiovascular and renal research. -
Peptide
Hippuryl-Phe-Arg-OH is a peptide substrate specifically designed for the active site of angiotensin I converting enzyme (ACE). This compound is utilized in biochemical assays to study ACE activity and inhibition, making it valuable for research in cardiovascular diseases and hypertension. Its use facilitates the investigation of the enzyme's role in the renin-angiotensin system and potential therapeutic interventions. -
Tool Peptide
Angiotensin II type 1 receptor (181-187) is a peptide derived from the second extracellular loop of the angiotensin II receptor, playing a critical role in the renin-angiotensin system. This 9-amino acid sequence acts as a key localization epitope for angiotensin II receptor autoantibodies (AT1RaAb). It is utilized in research applications to detect and quantify AT1RaAb levels in serum, facilitating studies on cardiovascular and renal pathophysiology. -
Bioactive Peptide
Renin substrate, angiotensinogen (1-14), rat is a bioactive peptide that serves as a substrate for the enzyme renin. Derived from the first 14 amino acid residues of rat angiotensinogen, this synthetic peptide is essential for studying the renin-angiotensin system. It enables researchers to investigate cardiovascular regulation and hypertension-related mechanisms. -
Angiotensin peptide
Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen, serving as a precursor for all angiotensin peptides. This bioactive peptide plays a crucial role in the renin-angiotensin system, influencing blood pressure regulation and fluid balance. It is primarily utilized in research applications focused on cardiovascular physiology, metabolism, and the pathophysiology of hypertension and related disorders. -
Brain Natriuretic Peptide
Brain Natriuretic Peptide (1-32), rat is a 32-amino acid polypeptide that primarily targets natriuretic peptide receptors in the cardiovascular system. It plays a crucial role in regulating blood pressure and fluid balance by promoting natriuresis and vasodilation. This reagent is valuable for research into heart failure, hypertension, and other cardiovascular conditions, as well as for studying the physiological effects of heart stretch on cardiac function. -
Natriuretic Peptide
C-Type Natriuretic Peptide (1-53), human, is a bioactive fragment of the natriuretic peptide family that primarily targets the regulation of electrolyte-fluid balance and vascular tone. This peptide plays a crucial role in cardiovascular homeostasis by promoting natriuresis and vasodilation. Research applications include studies on heart failure, hypertension, and other cardiovascular disorders, making it a valuable tool for elucidating the physiological and pathological roles of natriuretic peptides in the cardiovascular system. -
Cardiac Developmental Peptide
ELA-32 (human) is a potent cardiac developmental peptide that acts primarily through the G-protein-coupled apelin receptor. This peptide plays a crucial role in cardiovascular development and function, making it a valuable tool for studying cardiac biology and related disorders. ELA-32 can be utilized in research applications focused on cardiac tissue differentiation, regeneration, and signaling pathways involved in heart development. -
Cardiac developmental peptide
1-Methyl-3-phenylpropylamine is a potent cardiac developmental peptide that acts through the G-protein–coupled apelin receptor. It plays a crucial role in cardiovascular development and function, making it a valuable tool for research in heart health and related developmental biology. This compound is ideal for studies investigating the mechanisms of cardiac tissue regeneration and the effects of apelin in cardiac diseases. -
Bioactive Peptide
Apelin-16, human, bovine is a bioactive peptide that serves as an endogenous ligand for the G-protein-coupled APJ receptor. This 16-amino acid fragment of the pre-proprotein Apelin plays a significant role in various physiological processes, including regulation of blood pressure and metabolism. It is widely utilized in research focused on cardiovascular health, obesity, and neurobiology to explore its therapeutic potential and mechanisms of action. -
Neuropeptide
Neuromedin B-30 is a neuropeptide initially isolated from porcine brain and spinal cord, targeting smooth muscle tissues. Its biological activities include stimulating smooth muscle contraction, promoting local vasodilation, increasing vascular permeability, and contributing to neurogenic inflammation and hyperalgesia. Neuromedin B-30 plays a significant role in appetite regulation, thermoregulation, and behavioral stress responses, as well as modulating secretory functions in the gastrointestinal system. It is a valuable reagent for research in neurobiology, smooth muscle physiology, and inflammatory processes. -
Bioactive Peptide
Biotin-Bradykinin is a bioactive peptide that targets the bradykinin receptor, playing a significant role in modulating inflammatory responses and pain pathways. This compound is widely used in research applications related to cardiovascular studies, pain management, and cellular signaling mechanisms. Its biotin labeling facilitates easy detection and analysis in biochemical assays and cellular experiments. -
Peptide
Bradykinin (2-9) is a truncated peptide derived from the parent Bradykinin sequence, specifically produced through the cleavage by Aminopeptidase P. This peptide retains significant biological activity, including roles in vasodilation and inflammation modulation. It is utilized in research to study the physiological effects of kinins and their involvement in cardiovascular and pain pathways. -
Peptide
T-kinin (Ile-Ser-bradykinin) is a peptide that specifically targets bradykinin pathways. It demonstrates significant biological activity in modulating inflammatory responses. T-kinin is primarily utilized in research related to the mechanisms of inflammation and related signaling pathways. -
PTH2 receptor Agonist
TIP 39, Tuberoinfundibular Neuropeptide, is an endogenous agonist of the PTH2 receptor, exhibiting antihypertensive effects. This peptide selectively activates the PTH2 receptor without affecting the PTH1 receptor, leading to increased cAMP production, adenylate cyclase activation, and enhanced intracellular calcium mobilization. TIP 39 is conserved across humans, mice, and rats, making it a valuable tool for research into nociception and inflammation-related pain mechanisms. -
CGRP Agnalogue
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a CGRP analogue that targets the CGRP receptor and modulates adenylate cyclase activity. This peptide fragment, derived from the rat CGRP sequence, exhibits key biological activities associated with pain modulation and vasodilation. It is suitable for research applications studying neurogenic inflammation, cardiovascular regulation, and the pathophysiology of migraine headaches. -
Adenylate Cyclase Activator
Small Cardioactive Peptide B (SCPB) functions primarily as an adenylate cyclase activator. It significantly enhances adenylate cyclase activity in cardiac and gill tissue fractions, exhibiting EC50 values of 0.1 μM and 1.0 μM, respectively. This peptide is valuable for research exploring cardiac function and signaling pathways associated with neural regulation in various biological systems. -
VIP-secretin-like Peptide
Helodormin is a VIP-secretin-like peptide derived from the venom of the Mexican monster lizard (Heloderma suspectum). It primarily targets intracellular signaling pathways by activating adenylate cyclase, leading to various cellular responses. This reagent is valuable for investigating the evolutionary relationships and functional mechanisms within the secretin and VIP peptide families in biochemical research. -
βARK Substrate
RESA peptide is a substrate for β-adrenergic receptor kinase (βARK) that facilitates βARK-mediated phosphorylation. Its N-terminal acidic residues enhance both the efficiency of phosphorylation and the binding affinity to the kinase. This peptide is valuable for studies investigating βARK signaling pathways and the regulation of adrenergic receptors, contributing to the understanding of cardiac function and other physiological processes. -
α1 Adrenergic Receptor Inhibitor
Conopeptide rho-TIA is a peptide originating from the venom of the predatory sea snail Conus tulipa, serving as a highly selective noncompetitive inhibitor of the human α1B-adrenergic receptor. It also acts as a competitive inhibitor for both the α1A- and α1D-adrenergic receptors. By selectively binding to these receptor subtypes, conopeptide rho-TIA offers valuable insights for the development of novel, subtype-selective α1-adrenergic receptor therapies. Its unique mechanism of action makes it a potent tool for cardiovascular and pharmacological research. -
Peptide
G-Protein antagonist peptide is a peptide that inhibits G protein binding to its receptors. This compound competitively and reversibly obstructs M2 muscarinic receptor activation of Gi or Go and impedes Gs activation by β-adrenoceptors. Its biological activity makes it a valuable tool for studies involving G protein-coupled receptors and their signaling pathways, contributing to research in pharmacology and neurobiology. -
Adrenergic Receptor Agonist
Prenalterol hydrochloride is a selective partial agonist of the β1-adrenergic receptor, known for its positive inotropic effects. This compound has demonstrated significant efficacy in the management of acute heart failure, low output syndrome following myocardial infarction, and shock. Additionally, it has been used to alleviate orthostatic hypotension associated with Shy-Drager syndrome, making it a valuable reagent for cardiovascular research. -
Anti-aging Peptide
Palmitoyl pentapeptide 4 is a bioactive peptide that primarily targets skin aging mechanisms. It promotes collagen synthesis and enhances skin elasticity, leading to visible anti-aging effects. This peptide is widely utilized in cosmetic formulations aimed at reducing the appearance of fine lines and wrinkles, making it a valuable reagent in dermatological research and cosmetic development. -
Collagen Mimetic Peptide
P15 is a collagen mimetic peptide characterized by the sequence GTPGPQGIAGQRGVV, designed to replicate the cell-binding domain of human type I collagen. It effectively promotes the adhesion, proliferation, and differentiation of osteoblasts, making it a valuable tool in bone regeneration research. Biomaterials modified with P15 are utilized for studies aimed at enhancing bone healing and tissue engineering applications. -
COLIV-peptide
COLIV-peptide is a specific binding peptide that targets Collagen IV, a critical non-cellular component found in atherosclerotic plaques. This peptide facilitates the investigation of atherosclerosis by allowing researchers to study the role of Collagen IV in plaque formation and progression. COLIV-peptide can be utilized in various applications, including diagnostics and therapeutic research related to cardiovascular diseases. -
Dynamin Inhibitor
DynaMin inhibitory peptide, myristoylated is a specific inhibitor of dynamin, targeting the interaction between dynamin and amphiphysin. This membrane-permeant peptide effectively disrupts endocytosis processes, making it valuable for studying vesicle trafficking and membrane dynamics in various cellular contexts. Its ability to inhibit endocytic pathways allows for investigations into related cellular mechanisms and potential therapeutic applications in modulating cellular uptake processes. -
Drp1 Inhibitor
Drp1 peptide inhibitor P110 is a selective inhibitor of Dynamin-related protein 1 (Drp1), targeting mitochondrial dynamics. This compound exhibits neuroprotective effects by inhibiting Drp1 activation, preventing MPTP-induced mitochondrial translocation, and mitigating dopaminergic neuron loss along with associated behavioral deficits. Research applications include studies on Alzheimer's disease, as well as models of Huntington's disease, cerebral ischemic injury, and myocardial infarction, where P110 has demonstrated the ability to reduce mitochondrial damage and alleviate organ injury. -
Peptide
ACT1 is a peptide that enhances the stability and activity of endogenous connexin 43 (Cx43) at gap junctions. This stabilization promotes intercellular communication in breast cancer cells, thereby enhancing the efficacy of therapeutic agents such as Tamoxifen and Lapatinib. ACT1 serves as a valuable tool in research focused on breast cancer mechanisms and treatment strategies. -
Bioactive Peptide
Connexin mimetic peptide 40GAP27 is a bioactive peptide that targets the gap junction connexin 40 (Cx40). It is primarily utilized to study the effects of oxidative stress on gap junction intercellular communication. Research has demonstrated that 40GAP27 can attenuate endothelium-dependent subintimal smooth muscle hyperpolarization, providing insights into vascular function and pathology. This peptide is a valuable tool for investigations into cardiovascular health and the role of gap junctions in cellular signaling. -
Integrin Binding Peptide
GRGDSPK is an integrin binding peptide that functions as a competitive and reversible inhibitor of integrin-fibronectin interactions. This peptide is instrumental in elucidating the roles of integrins in bone formation and resorption, making it valuable for research in cell adhesion and tissue engineering. Its ability to modulate integrin activity enables studies on cellular responses in various biological contexts. -
Peptide
REDV is a peptide derived from the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. It effectively mediates cell adhesion by binding to the integrin α4β1, facilitating interactions with plasma fibronectin. This peptide is widely utilized in research applications focused on cell adhesion mechanisms and the effects of gene vectors incorporating REDV on cellular behavior. -
Collagen Receptor Antagonist
α2β1 Integrin Ligand Peptide serves as an antagonist of the α2β1 integrin receptor, which is essential for mediating cellular responses to extracellular matrix components, specifically collagen. This peptide disrupts integrin signaling, making it a valuable tool for exploring collagen-related pathways and studying cellular adhesion processes. Its applications include research in fibrosis, tissue remodeling, and other disorders where integrin-collagen interactions are pivotal.
