G-Protein antagonist peptide

Catalog No.: A58572
Peptide
G-Protein antagonist peptide is a peptide that inhibits G protein binding to its receptors. This compound competitively and reversibly obstructs M2 muscarinic receptor activation of Gi or Go and impedes Gs activation by β-adrenoceptors. Its biological activity makes it a valuable tool for studies involving G protein-coupled receptors and their signaling pathways, contributing to research in pharmacology and neurobiology.
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Size Price Stock Qty
1mg
$170.00
In stock
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionG-Protein antagonist peptide is a peptide that inhibits G protein binding to its receptors. This compound competitively and reversibly obstructs M2 muscarinic receptor activation of Gi or Go and impedes Gs activation by β-adrenoceptors. Its biological activity makes it a valuable tool for studies involving G protein-coupled receptors and their signaling pathways, contributing to research in pharmacology and neurobiology.
Product Information
Catalog NumA58572
FormulaC57H64N12O9S
Molecular Weight1093.26
CAS Number143675-79-0
Sequence{Glp}-Gln-Trp-Phe-Trp-Trp-Met-NH2
Sequence shortening{Glp}QWFWWM-NH2
SMILESC([C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@@H](CCSC)C(N)=O)=O)=O)NC([C@@H](NC([C@@H](CC=3C=4C(NC3)=CC=CC4)NC([C@@H](NC(=O)[C@H]5NC(=O)CC5)CCC(N)=O)=O)=O)CC6=CC=CC=C6)=O)C=7C=8C(NC7)=CC=CC8
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