Neuromedin (B-30)

Catalog No.: A59107
Neuropeptide
Neuromedin B-30 is a neuropeptide initially isolated from porcine brain and spinal cord, targeting smooth muscle tissues. Its biological activities include stimulating smooth muscle contraction, promoting local vasodilation, increasing vascular permeability, and contributing to neurogenic inflammation and hyperalgesia. Neuromedin B-30 plays a significant role in appetite regulation, thermoregulation, and behavioral stress responses, as well as modulating secretory functions in the gastrointestinal system. It is a valuable reagent for research in neurobiology, smooth muscle physiology, and inflammatory processes.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNeuromedin B-30 is a neuropeptide initially isolated from porcine brain and spinal cord, targeting smooth muscle tissues. Its biological activities include stimulating smooth muscle contraction, promoting local vasodilation, increasing vascular permeability, and contributing to neurogenic inflammation and hyperalgesia. Neuromedin B-30 plays a significant role in appetite regulation, thermoregulation, and behavioral stress responses, as well as modulating secretory functions in the gastrointestinal system. It is a valuable reagent for research in neurobiology, smooth muscle physiology, and inflammatory processes.
Product Information
Catalog NumA59107
FormulaC157H243N51O38S
Molecular Weight3484.99
CAS Number98537-35-0
SequenceLeu-Ser-Trp-Asp-Leu-Pro-Glu-Pro-Arg-Ser-Arg-Ala-Gly-Lys-Ile-Arg-Val-His-Pro-Arg-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
Sequence shorteningLSWDLPEPRSRAGKIRVHPRGNLWATGHFM-NH2
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(=O)N1[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC6=CN=CN6)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)[C@@H](C)O)=O)C)=O)=O)CC(C)C)=O)CC(N)=O)=O)=O)CCCNC(=N)N)=O)CCC3)CC8=CN=CN8)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCCN)=O)=O)C)=O)CCCNC(=N)N)=O)CO)=O)CCCNC(=N)N)=O)CCC2)CCC(O)=O)=O)CCC1)CC(C)C)=O)CC(O)=O)=O)NC([C@@H](NC([C@H](CC(C)C)N)=O)CO)=O)C=9C=%10C(NC9)=CC=CC%10
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