Catalog No.
Product Name
Application
Product Information
Citations
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Microtubule-Stabilizing Peptide
Davunetide is a microtubule-stabilizing peptide derived from the activity-dependent neuroprotective protein (ADNP). It exhibits neuroprotective and neurotrophic properties, enhancing cognitive function. Davunetide selectively interacts with and stabilizes neuron-specific βIII-tubulin in vitro, facilitating structural integrity within neurons. Additionally, it penetrates the blood-brain barrier and demonstrates non-toxic characteristics while effectively inhibiting amyloid beta (Aβ) aggregation and the resultant neurotoxicity, making it valuable for research in neurodegenerative diseases. -
Angiogenesis Peptide Inhibitor
ALM-201 is a peptide antagonist of angiogenesis that specifically targets microtubules. It demonstrates significant biological activity by inhibiting cell migration, tubule formation, and microvessel development. ALM-201 is suitable for research applications focused on cancer biology and the mechanisms underlying tumor vascularization. -
KRT1 Receptor-targeting Peptide
Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide characterized by a binding affinity (Kd) of 0.98 μM. This peptide, with the amino acid sequence WxEAAYQrFL, serves as an analogue of the P160 peptide. When covalently conjugated with the anticancer peptide MccJ25, it significantly enhances the cellular uptake of MccJ25 in breast cancer cells, thereby improving its anticancer efficacy. The resulting conjugate demonstrates IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cell lines, respectively, making it valuable for research in breast cancer therapy. -
Breast Cancer Targeting Peptide
P160 peptide is a breast cancer-targeting peptide that specifically binds to the keratin 1 (KRT1) receptor on breast cancer cells, exhibiting a dissociation constant (Kd) of approximately 1.1 μM. This peptide markedly enhances the cellular uptake and pro-apoptotic activity of the antimicrobial peptide MccJ25 (microcin J25). P160 peptide serves as a valuable tool in cancer research, facilitating targeted drug delivery and improving therapeutic efficacy in breast cancer models. -
Octamer Peptide
OVA Peptide (257-264) is an octameric peptide epitope derived from ovalbumin that is specifically presented by the class I major histocompatibility complex (MHC) molecule H-2Kb. This peptide is crucial for T cell recognition and activation in immunological studies. It has applications in the development of immunotherapies, vaccine research, and studies focusing on T cell responses. -
Bioactive Peptide
OVA-Q4 Peptide is a bioactive peptide that serves as a variant of the ovalbumin-derived agonist peptide (SIINFEKL). It is recognized as a class I (Kb)-restricted peptide epitope presented by the H-2Kb major histocompatibility complex in mice. This peptide is instrumental in immunological research, particularly in studies involving T cell activation and antigen presentation. OVA-Q4 is valuable for applications in vaccine development and cellular immune response assessment. -
Antigen Peptide
OVA(250-264) is an antigenic peptide derived from ovalbumin, targeting the class I MHC molecule H-2Kb. This peptide has been shown to significantly enhance the generation and infiltration of antigen-specific CD8+ T cells when used in conjunction with αMSLN (anti-MSLN antibody), thus improving antitumor efficacy in orthotopic models of pancreatic cancer. OVA(250-264) serves as a valuable tool for the development of neoantigen vaccines in immunotherapy research focused on pancreatic cancer. -
HLA-DR Binding Epitope
PADRE peptide is a pan-HLA-DR binding epitope that functions as an immunostimulant by binding to the peptide-binding groove of MHC class II molecules, facilitating the activation of CD4+ T cells. This leads to enhanced anti-tumor immune responses, inhibition of tumor growth, and prolonged survival in model systems. PADRE peptide is effective in increasing the frequency of E7-specific CD8+ T cells and improving therapeutic outcomes when combined with E7 peptide-based vaccines and poly (I:C). It is suitable for research applications in various tumor models, including melanoma, glioblastoma, and cervical cancer. -
Bioactive Peptide
CMV pp65(13-27) is a bioactive peptide derived from amino acid residues 13 to 27 of the 65 kDa lower matrix phosphoprotein of human cytomegalovirus. This peptide encompasses a nine-amino-acid sequence (LGPISGHVL) that aligns with the consensus binding motif of the major histocompatibility complex H2-Dd T-cell epitope. It is utilized in immunological research, particularly for the study of T-cell responses and the development of cytomegalovirus vaccines. -
Peptide
MOG (89-113), human is a peptide derived from the myelin oligodendrocyte glycoprotein, which plays a critical role in myelin sheath formation and stability. This peptide fragment is utilized in research applications related to demyelinating diseases, including multiple sclerosis, where it serves as a target for studying immune responses and T cell activation. Its role in the modulation of inflammation makes it a valuable tool for understanding neuroinflammatory processes. -
WT1 Peptide
WT1 126-134 peptide is a peptide derived from the Wilms' tumor oncogene protein (RMFPNAPYL) that targets HLA-A0201. This peptide is known to induce cytotoxic CD8 T cells, which are capable of identifying and eliminating WT1-positive tumor cells. Additionally, WT1 126-134 peptide forms highly stable complexes with H-2Db (mouse) or HLA-A0201 (human), demonstrating a strong affinity (Kd = 0.2 nM) for humanized monoclonal antibodies (IgG1). It is applicable in immunotherapy as a vaccine for T cell activation or as a target for antibody development. -
Nucleoprotein Peptide
H2-D b restricted epitopes VSV Nucleoprotein (52-59) is a 9-mer peptide specifically derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). This peptide interacts with MHC class I molecules, facilitating the presentation to CD8+ T cells and promoting the activation of cytotoxic T lymphocytes (CTLs). It is particularly valuable in research focused on CTL vaccine development for infectious diseases, including Ebola virus, enhancing understanding of immune responses in viral infections. -
Polypeptide
MBP (111-129) is a polypeptide that represents an immunodominant epitope cluster restricted by HLA-DRB1*0401. This compound functions as an antagonist for the HD4-1C2 T cell receptor and as an agonist for the MS2-3C8 T cell receptor. MBP (111-129) is valuable for research in multiple sclerosis and T cell biology, providing insights into immune responses and potential therapeutic interventions. -
HLA-B7-Derived Peptide
Allotrap 07 is a synthetic peptide derived from residues 75-84 of the HLA-B7 molecule, a class I major histocompatibility complex (MHC) protein. This peptide is known for its ability to promote donor-specific tolerance in rat cardiac allografts when used in conjunction with Cyclosporin A, leading to a significant extension of graft survival. Allotrap 07 is a valuable tool for researchers exploring mechanisms of immune tolerance and transplant biology. -
MHC Peptide
SEIDLILGY is a nonapeptide that acts as a ligand for major histocompatibility complex class I (MHC) molecules, derived from mouse sources. This compound is primarily used to stimulate sensory neurons expressing the vomeronasal receptor V2rf2, facilitating studies in neural signaling and sensory processing. Its unique properties make it an invaluable tool for research in neurobiology and immunology. -
Melanoma Antigen-Derived Peptide
VLPDVFIRCV is a melanoma antigen-derived peptide that targets MHC-I class molecules. It has been shown to induce cytotoxic T lymphocytes (CTLs) capable of specifically lysing T2 cells pre-loaded with this peptide in chromium release assays. While VLPDVFIRCV does not activate immune responses against natural tumor cells, it is valuable for vaccine design research and studies focused on immune modulation in melanoma. -
HLA-A*0201-binding Peptide
Adipophilin-derived peptide is an HLA-A*0201-binding peptide that plays a crucial role in immune recognition and response. This peptide is particularly relevant in cancer research, as it may facilitate the study of tumor-associated antigens and their interactions with the immune system. Its application in immunotherapy and vaccine development makes it a valuable reagent for advancing cancer immunology studies. -
Antigenic Peptide
TP53 neoepitope is a high-affinity antigenic peptide that targets HLA-A molecules. It is designed to elicit CD8+ T cell-mediated cytotoxicity against tumor cells harboring TP53 mutations, specifically hotspot mutations such as R175H and R273H. This peptide is promising for research applications in the immunotherapy of solid tumors with TP53 alterations, providing insights into potential therapeutic interventions targeting mutant TP53 pathways. -
Inhibitor Of The Binding Of DQ8 Peptide To MHC Class II Molecule
D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. By occupying a pocket in the DQ8 peptide binding groove, D-α-Methyl DOPA disrupts the presentation of DQ8 peptides to CD4+ T cells. This inhibition may play a role in modulating the immune response, potentially slowing the development or progression of type 1 diabetes and celiac disease. This compound is valuable in immunological research focused on T cell activation and autoimmune disease mechanisms. -
Peptide
MUC5AC motif peptide is a 16-amino acid fragment derived from mucin 5, targeting mucin-related signaling pathways. This peptide plays a crucial role in modulating mucosal immunity and has applications in studying respiratory diseases and gastrointestinal disorders. Its capacity to influence cellular adhesion and immune responses makes it a valuable tool for research in mucosal biology and therapeutic interventions. -
Tetrapeptide
Amogastrin is a tetrapeptide that primarily stimulates gastric extraction of 99mTc pertechnetate. This compound plays a significant role in the imaging of gastric mucosal diseases, facilitating enhanced diagnostic capabilities. Additionally, Amogastrin is involved in the stimulation of prostate hormone production, making it relevant for research in endocrinology and gastrointestinal studies. -
Prostate Specific Antigen 1 Peptide
PSA1 (141-150) is a peptide derived from Prostate Specific Antigen 1, targeting prostate cancer cells. This peptide is utilized in immunotherapy research to investigate immune responses and develop potential treatment strategies for prostate cancer. Its role in enhancing immune recognition makes it a valuable tool in cancer studies. -
PAR Agonist
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a selective agonist for proteinase-activated receptor-4 (PAR-4), demonstrating no activity on PAR-1 or PAR-2. This compound is instrumental in studies investigating the role of PAR-4 in various cellular processes, including apoptosis and inflammation. Its biological activity can be effectively countered by a specific PAR-4 antagonist, allowing for detailed examination of PAR-4-mediated signaling pathways in research applications. -
Bioactive Peptide
TFLLRN-NH2 is a bioactive peptide that acts as an agonist for protease-activated receptor 1 (PAR-1). This peptide is involved in various biological processes, including thrombosis and inflammation. Its use in research facilitates the study of PAR-1 signaling pathways and their implications in cardiovascular and other diseases. -
Thrombin Receptor Activating Peptide
TRAP-7 is a thrombin receptor (PAR) activating peptide that functions by stimulating total inositol phosphate (IP) accumulation, as well as the phosphorylation of a specific endogenous substrate for activated protein kinase C (PKC). This compound is valuable in the study of signaling pathways related to thrombosis and cardiovascular diseases, providing insights into PAR-mediated cellular responses and potential therapeutic interventions. -
Bioactive Peptide
YFLLRNP is a bioactive peptide that acts as a partial agonist of the protease-activated receptor 1 (PAR-1). At low concentrations, it selectively activates the G12/13 signaling pathway without triggering Gq or Gi pathways. This unique signaling profile makes YFLLRNP valuable for research into cellular mechanisms influenced by PAR-1 and for studies on cardiovascular and inflammatory responses. -
PAR-3 Agonist Peptide
Protease-Activated Receptor-3 (PAR-3) (1-6), human is a peptide that functions as an agonist for the proteinase-activated receptor 3 (PAR-3). This compound is involved in various biological processes, including inflammation and cell signaling pathways. It is frequently utilized in research to explore the physiological roles of PAR-3 in cellular responses and disease mechanisms. -
PAR-2 Negative Control Peptide
LRGILS-NH2 is a reverse-sequence peptide serving as a negative control for protease-activated receptor-2 (PAR-2) studies. This inactive version allows researchers to discern the specific effects of PAR-2 activation when used alongside the active peptide SLIGRL-NH2. LRGILS-NH2 is critical for validating experimental results in various biological assays involving PAR-2 signaling pathways. -
Bioactive Peptide
SFNGGP-NH2 is a bioactive peptide that targets Protease-Activated Receptors (PARs), specifically PAR-3. This peptide plays a role in modulating thrombin signaling pathways and has been implicated in itch responses, particularly in cutaneous mast cells. Studies suggest that while PAR-3 does not induce itching independently, its co-expression with PAR-4 enhances thrombin activity, indicating its role as a cofactor in transmembrane signaling. This makes SFNGGP-NH2 valuable for research on itch mechanisms and thrombin-related physiological processes. -
Bone Forming Peptide
pTH-Related Protein (1-37) is a bone-forming peptide that serves as a functional analogue of parathyroid hormone-related protein (pTHrP). This peptide plays a crucial role in the physiological regulation of bone formation and remodeling. Its utilization in research encompasses studies on bone health, osteoporosis, and other metabolic bone disorders, making it a valuable tool for exploring therapeutic interventions in skeletal-related conditions in human, mouse, and rat models. -
Polypeptide
Osteostatin (1-5) amide is a polypeptide derived from the C-terminal region of parathyroid hormone-related protein (PTHrP). It functions primarily by inhibiting bone resorption, making it an important tool in studies of bone metabolism and related disorders. This fragment is relevant for research applications involving bone density regulation and osteoclast activity across various species, including human, bovine, canine, equine, murine, rabbit, and rat models. -
Ras Peptide
G12 (Ras 5-17) is a synthetic wild-type Ras peptide composed of amino acids 5-17 (KLVVVGAGGVGKS). This peptide serves as a valuable control for studies involving mutation variants of Ras, such as V12. Research applications include investigating Ras signaling pathways and exploring the functional impacts of mutations in cancer biology and therapeutic development. -
Peptide
KRAS G12D (8-16) is a peptide derived from the mutant KRAS G12D protein, known for its role in oncogenic signaling pathways. This peptide serves as a valuable tool for research into KRAS-related cancers, facilitating studies of protein interactions, signaling mechanisms, and the development of targeted therapies. Its application in various assays aids in unraveling the complexities of KRAS mutations in tumor biology. -
KRAS G12D targeting peptide
KLVVVGADGVGKSALTI is a peptide specifically designed to target the KRAS G12D mutation. This peptide plays a crucial role in tumor biology research by facilitating the study of KRAS-mediated signaling pathways and their implications in cancer progression. Its application in experimental models aids in understanding the therapeutic potential of targeting KRAS in oncological studies. -
Nuclear Localization Signal Peptide
BIMAX2 is a high-affinity nuclear localization signal (NLS) peptide that acts by competitively binding to importin α, thereby inhibiting the interaction between classical nuclear localization signal-cargo proteins and importin α. This mechanism allows for the investigation of the role of RBBP4 in regulating nuclear import efficiency and its impact on cell senescence. BIMAX2 is a valuable tool for studies in cell biology, particularly in the context of nuclear transport and aging-related research. -
Neuropeptide Y Y2 Receptor
JNJ-5207787 is a selective nonpeptidic antagonist of the neuropeptide Y Y2 receptor, designed to penetrate the blood-brain barrier effectively. It demonstrates strong inhibition of peptide YY (PYY) binding, with pIC50 values of 7.0 and 7.1 for the human and rat Y2 receptors, respectively. This compound exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors, making it a valuable tool for research into neuropeptide Y signaling pathways and their roles in various physiological processes. -
Neuropeptide
N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) is a selective agonist of the neuropeptide Y Y2 receptor. This compound has been shown to attenuate cardiac vagal activity in anesthetized rat models, making it a valuable tool for studying cardiac function and neuropeptide signaling. Its application in research can provide insights into cardiovascular regulation and potential therapeutic targets for heart-related conditions. -
Neuropeptide Y Receptor Antagonist
Peptide YY (PYY) (3-36), porcine is a neuropeptide Y receptor antagonist that plays a significant role in appetite regulation. By modulating the activity of the neuropeptide Y system, it is utilized in research related to metabolic disorders and feeding behavior. This peptide is valuable for studies investigating energy homeostasis and its implications in obesity and appetite control. -
NPY-5 Receptor Antagonist
Neuropeptide Y5 receptor ligand-1 is a potent antagonist of the neuropeptide Y5 (NPY-5) receptor. This carbazole derivative is utilized in research applications focused on the role of NPY-5 in various physiological processes, including regulation of appetite, anxiety, and circadian rhythms. By inhibiting NPY-5 receptor activity, it provides valuable insights into neuropeptide signaling pathways and their implications in metabolic and neurobehavioral disorders. -
Y2 Receptor Agonist
Peptide YY (13-36) is a selective agonist of the Y2 receptor subtype, targeting the neuropeptide Y (NPY) system. This peptide plays a significant role in regulating appetite, energy balance, and gastrointestinal function. It is widely utilized in research applications focused on metabolic disorders, obesity, and neurobiology across various species, including canine, mouse, porcine, and rat models. -
Y1 Agonist
(Leu31,Pro34)-Peptide YY (human) is a potent and selective agonist for the neuropeptide Y receptor subtype Y1, exhibiting a dissociation constant (KD) of 1.0 nM. This derivative of Peptide YY is utilized in research applications studying metabolic regulation, appetite control, and gastrointestinal functions. Its high specificity makes it an invaluable tool for investigating the physiological roles of Y1 receptors in various biological processes. -
NPY Y5 Receptor Agonist
(D-Trp32)-Neuropeptide Y (porcine) is a selective agonist of the neuropeptide Y (NPY) Y5 receptor. It exhibits orexigenic activity, thereby promoting increased food intake, and has been shown to inhibit Forskolin-stimulated cAMP formation. This peptide is valuable for research focusing on appetite regulation and metabolic disorders. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, bovine, is a 36-amino acid polypeptide that primarily influences the neuropeptide Y (NPY) receptor system. Acting as an agonist of the NPY receptor, it demonstrates high affinity for the NPYR4 subtype and is known to inhibit secretin- and cholecystokinin-induced pancreatic secretion. This compound is valuable in research focused on metabolic regulation, appetite control, and neuroendocrine function. -
Y1 Receptor Agonist
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a selective agonist for the neuropeptide Y Y1 receptor. This compound is known to enhance blood pressure in anesthetized rat models and stimulates food intake. It may also interact with Y4 and Y5 receptors, making it valuable for research into appetite regulation and cardiovascular function. -
Orexigenic Neuropeptide
26Rfa is a human hypothalamic peptide within the RFamide peptide family, primarily targeted at the orexigenic pathways. It functions as an endogenous ligand for the orphan G protein-coupled receptor GPR103, playing a significant role in appetite regulation. This neuropeptide is crucial for research focused on feeding behaviors and metabolic disorders, making it an important reagent in studies of energy homeostasis. -
Y1 Receptor Agonist
[Pro34]Neuropeptide Y, porcine is a selective Y1 receptor agonist that specifically targets neuropeptide Y receptors. It demonstrates significant biological activity by inducing vasoconstriction in the guinea pig caval vein, making it a valuable tool for studying vascular responses and neuropeptide signaling pathways in research applications. This compound can aid in investigating the physiological and pathological roles of neuropeptide Y in cardiovascular function. -
Y1 Receptor Agonist
(Pro34)-Peptide YY (human) is a selective full agonist of the Y1 receptor in the Peptide YY/neuropeptide Y family. This compound is primarily utilized in research exploring the physiological roles of neuropeptides, especially in the regulation of appetite, energy balance, and gut function. Its specificity for the Y1 receptor makes it an important tool for studying receptor signaling pathways and their implications in metabolic disorders. -
Neuropeptide Y Receptor Antagonist
CGP71683 is a highly selective non-peptide antagonist of the neuropeptide Y (NPY) Y(5) receptor. This compound exhibits potent inhibition of receptor activity, making it a valuable tool for studying the physiological and pathological roles of NPY signaling. Its applications extend to obesity research and related metabolic studies, facilitating investigations into appetite regulation and energy homeostasis. -
Neuron Activator
Neuropeptide Y (1-24) (human) acts as a neuron activator and is involved in modulating synaptic transmission and neuronal excitability. This neuropeptide has been demonstrated to significantly inhibit electrically stimulated twitch responses in rat vas deferens, indicating its potential in neuromodulation. Additionally, it enhances N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus, making it a valuable tool for studying neurophysiology and neurobiology. -
Neuropeptide
Galanin-Like Peptide (rat) is a 60 amino acid neuropeptide that primarily targets galanin receptors. This peptide is crucial in the regulation of feeding behavior, body weight, and energy metabolism. Its biological activity makes it a valuable tool for research in neurobiology, obesity, and metabolic disorders, providing insights into the mechanisms underlying appetite control and energy homeostasis.
