Catalog No.
Product Name
Application
Product Information
Citations
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Antigenic Peptide
TP53 neoepitope is a high-affinity antigenic peptide that targets HLA-A molecules. It is designed to elicit CD8+ T cell-mediated cytotoxicity against tumor cells harboring TP53 mutations, specifically hotspot mutations such as R175H and R273H. This peptide is promising for research applications in the immunotherapy of solid tumors with TP53 alterations, providing insights into potential therapeutic interventions targeting mutant TP53 pathways. -
Inhibitor Of The Binding Of DQ8 Peptide To MHC Class II Molecule
D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. By occupying a pocket in the DQ8 peptide binding groove, D-α-Methyl DOPA disrupts the presentation of DQ8 peptides to CD4+ T cells. This inhibition may play a role in modulating the immune response, potentially slowing the development or progression of type 1 diabetes and celiac disease. This compound is valuable in immunological research focused on T cell activation and autoimmune disease mechanisms. -
Peptide
MUC5AC motif peptide is a 16-amino acid fragment derived from mucin 5, targeting mucin-related signaling pathways. This peptide plays a crucial role in modulating mucosal immunity and has applications in studying respiratory diseases and gastrointestinal disorders. Its capacity to influence cellular adhesion and immune responses makes it a valuable tool for research in mucosal biology and therapeutic interventions. -
Dipeptide
Gamma-glutamyl-beta-cyanoalanine is a dipeptide that acts as a neurotoxin, primarily found in the seeds of common vetch. This compound is of interest in biological research due to its potential effects on neurotransmission and its role in studying neurotoxic mechanisms. It may serve as a valuable tool for investigating neurodegenerative conditions and metabolic processes influenced by dipeptides. -
Tetrapeptide
Amogastrin is a tetrapeptide that primarily stimulates gastric extraction of 99mTc pertechnetate. This compound plays a significant role in the imaging of gastric mucosal diseases, facilitating enhanced diagnostic capabilities. Additionally, Amogastrin is involved in the stimulation of prostate hormone production, making it relevant for research in endocrinology and gastrointestinal studies. -
Prostate Specific Antigen 1 Peptide
PSA1 (141-150) is a peptide derived from Prostate Specific Antigen 1, targeting prostate cancer cells. This peptide is utilized in immunotherapy research to investigate immune responses and develop potential treatment strategies for prostate cancer. Its role in enhancing immune recognition makes it a valuable tool in cancer studies. -
PAR Agonist
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a selective agonist for proteinase-activated receptor-4 (PAR-4), demonstrating no activity on PAR-1 or PAR-2. This compound is instrumental in studies investigating the role of PAR-4 in various cellular processes, including apoptosis and inflammation. Its biological activity can be effectively countered by a specific PAR-4 antagonist, allowing for detailed examination of PAR-4-mediated signaling pathways in research applications. -
Bioactive Peptide
TFLLRN-NH2 is a bioactive peptide that acts as an agonist for protease-activated receptor 1 (PAR-1). This peptide is involved in various biological processes, including thrombosis and inflammation. Its use in research facilitates the study of PAR-1 signaling pathways and their implications in cardiovascular and other diseases. -
Thrombin Receptor Activating Peptide
TRAP-7 is a thrombin receptor (PAR) activating peptide that functions by stimulating total inositol phosphate (IP) accumulation, as well as the phosphorylation of a specific endogenous substrate for activated protein kinase C (PKC). This compound is valuable in the study of signaling pathways related to thrombosis and cardiovascular diseases, providing insights into PAR-mediated cellular responses and potential therapeutic interventions. -
Bioactive Peptide
YFLLRNP is a bioactive peptide that acts as a partial agonist of the protease-activated receptor 1 (PAR-1). At low concentrations, it selectively activates the G12/13 signaling pathway without triggering Gq or Gi pathways. This unique signaling profile makes YFLLRNP valuable for research into cellular mechanisms influenced by PAR-1 and for studies on cardiovascular and inflammatory responses. -
PAR-3 Agonist Peptide
Protease-Activated Receptor-3 (PAR-3) (1-6), human is a peptide that functions as an agonist for the proteinase-activated receptor 3 (PAR-3). This compound is involved in various biological processes, including inflammation and cell signaling pathways. It is frequently utilized in research to explore the physiological roles of PAR-3 in cellular responses and disease mechanisms. -
PAR-2 Negative Control Peptide
LRGILS-NH2 is a reverse-sequence peptide serving as a negative control for protease-activated receptor-2 (PAR-2) studies. This inactive version allows researchers to discern the specific effects of PAR-2 activation when used alongside the active peptide SLIGRL-NH2. LRGILS-NH2 is critical for validating experimental results in various biological assays involving PAR-2 signaling pathways. -
Bioactive Peptide
SFNGGP-NH2 is a bioactive peptide that targets Protease-Activated Receptors (PARs), specifically PAR-3. This peptide plays a role in modulating thrombin signaling pathways and has been implicated in itch responses, particularly in cutaneous mast cells. Studies suggest that while PAR-3 does not induce itching independently, its co-expression with PAR-4 enhances thrombin activity, indicating its role as a cofactor in transmembrane signaling. This makes SFNGGP-NH2 valuable for research on itch mechanisms and thrombin-related physiological processes. -
Bone Forming Peptide
pTH-Related Protein (1-37) is a bone-forming peptide that serves as a functional analogue of parathyroid hormone-related protein (pTHrP). This peptide plays a crucial role in the physiological regulation of bone formation and remodeling. Its utilization in research encompasses studies on bone health, osteoporosis, and other metabolic bone disorders, making it a valuable tool for exploring therapeutic interventions in skeletal-related conditions in human, mouse, and rat models. -
Polypeptide
Osteostatin (1-5) amide is a polypeptide derived from the C-terminal region of parathyroid hormone-related protein (PTHrP). It functions primarily by inhibiting bone resorption, making it an important tool in studies of bone metabolism and related disorders. This fragment is relevant for research applications involving bone density regulation and osteoclast activity across various species, including human, bovine, canine, equine, murine, rabbit, and rat models. -
Ras Peptide
G12 (Ras 5-17) is a synthetic wild-type Ras peptide composed of amino acids 5-17 (KLVVVGAGGVGKS). This peptide serves as a valuable control for studies involving mutation variants of Ras, such as V12. Research applications include investigating Ras signaling pathways and exploring the functional impacts of mutations in cancer biology and therapeutic development. -
Peptide
KRAS G12D (8-16) is a peptide derived from the mutant KRAS G12D protein, known for its role in oncogenic signaling pathways. This peptide serves as a valuable tool for research into KRAS-related cancers, facilitating studies of protein interactions, signaling mechanisms, and the development of targeted therapies. Its application in various assays aids in unraveling the complexities of KRAS mutations in tumor biology. -
KRAS G12D targeting peptide
KLVVVGADGVGKSALTI is a peptide specifically designed to target the KRAS G12D mutation. This peptide plays a crucial role in tumor biology research by facilitating the study of KRAS-mediated signaling pathways and their implications in cancer progression. Its application in experimental models aids in understanding the therapeutic potential of targeting KRAS in oncological studies. -
Nuclear Localization Signal Peptide
BIMAX2 is a high-affinity nuclear localization signal (NLS) peptide that acts by competitively binding to importin α, thereby inhibiting the interaction between classical nuclear localization signal-cargo proteins and importin α. This mechanism allows for the investigation of the role of RBBP4 in regulating nuclear import efficiency and its impact on cell senescence. BIMAX2 is a valuable tool for studies in cell biology, particularly in the context of nuclear transport and aging-related research. -
Neuropeptide Y Y2 Receptor
JNJ-5207787 is a selective nonpeptidic antagonist of the neuropeptide Y Y2 receptor, designed to penetrate the blood-brain barrier effectively. It demonstrates strong inhibition of peptide YY (PYY) binding, with pIC50 values of 7.0 and 7.1 for the human and rat Y2 receptors, respectively. This compound exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors, making it a valuable tool for research into neuropeptide Y signaling pathways and their roles in various physiological processes. -
Neuropeptide
N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) is a selective agonist of the neuropeptide Y Y2 receptor. This compound has been shown to attenuate cardiac vagal activity in anesthetized rat models, making it a valuable tool for studying cardiac function and neuropeptide signaling. Its application in research can provide insights into cardiovascular regulation and potential therapeutic targets for heart-related conditions. -
Neuropeptide Y Receptor Antagonist
Peptide YY (PYY) (3-36), porcine is a neuropeptide Y receptor antagonist that plays a significant role in appetite regulation. By modulating the activity of the neuropeptide Y system, it is utilized in research related to metabolic disorders and feeding behavior. This peptide is valuable for studies investigating energy homeostasis and its implications in obesity and appetite control. -
NPY-5 Receptor Antagonist
Neuropeptide Y5 receptor ligand-1 is a potent antagonist of the neuropeptide Y5 (NPY-5) receptor. This carbazole derivative is utilized in research applications focused on the role of NPY-5 in various physiological processes, including regulation of appetite, anxiety, and circadian rhythms. By inhibiting NPY-5 receptor activity, it provides valuable insights into neuropeptide signaling pathways and their implications in metabolic and neurobehavioral disorders. -
Y2 Receptor Agonist
Peptide YY (13-36) is a selective agonist of the Y2 receptor subtype, targeting the neuropeptide Y (NPY) system. This peptide plays a significant role in regulating appetite, energy balance, and gastrointestinal function. It is widely utilized in research applications focused on metabolic disorders, obesity, and neurobiology across various species, including canine, mouse, porcine, and rat models. -
Y1 Agonist
(Leu31,Pro34)-Peptide YY (human) is a potent and selective agonist for the neuropeptide Y receptor subtype Y1, exhibiting a dissociation constant (KD) of 1.0 nM. This derivative of Peptide YY is utilized in research applications studying metabolic regulation, appetite control, and gastrointestinal functions. Its high specificity makes it an invaluable tool for investigating the physiological roles of Y1 receptors in various biological processes. -
NPY Y5 Receptor Agonist
(D-Trp32)-Neuropeptide Y (porcine) is a selective agonist of the neuropeptide Y (NPY) Y5 receptor. It exhibits orexigenic activity, thereby promoting increased food intake, and has been shown to inhibit Forskolin-stimulated cAMP formation. This peptide is valuable for research focusing on appetite regulation and metabolic disorders. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, bovine, is a 36-amino acid polypeptide that primarily influences the neuropeptide Y (NPY) receptor system. Acting as an agonist of the NPY receptor, it demonstrates high affinity for the NPYR4 subtype and is known to inhibit secretin- and cholecystokinin-induced pancreatic secretion. This compound is valuable in research focused on metabolic regulation, appetite control, and neuroendocrine function. -
Y1 Receptor Agonist
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a selective agonist for the neuropeptide Y Y1 receptor. This compound is known to enhance blood pressure in anesthetized rat models and stimulates food intake. It may also interact with Y4 and Y5 receptors, making it valuable for research into appetite regulation and cardiovascular function. -
Orexigenic Neuropeptide
26Rfa is a human hypothalamic peptide within the RFamide peptide family, primarily targeted at the orexigenic pathways. It functions as an endogenous ligand for the orphan G protein-coupled receptor GPR103, playing a significant role in appetite regulation. This neuropeptide is crucial for research focused on feeding behaviors and metabolic disorders, making it an important reagent in studies of energy homeostasis. -
Y1 Receptor Agonist
[Pro34]Neuropeptide Y, porcine is a selective Y1 receptor agonist that specifically targets neuropeptide Y receptors. It demonstrates significant biological activity by inducing vasoconstriction in the guinea pig caval vein, making it a valuable tool for studying vascular responses and neuropeptide signaling pathways in research applications. This compound can aid in investigating the physiological and pathological roles of neuropeptide Y in cardiovascular function. -
Y1 Receptor Agonist
(Pro34)-Peptide YY (human) is a selective full agonist of the Y1 receptor in the Peptide YY/neuropeptide Y family. This compound is primarily utilized in research exploring the physiological roles of neuropeptides, especially in the regulation of appetite, energy balance, and gut function. Its specificity for the Y1 receptor makes it an important tool for studying receptor signaling pathways and their implications in metabolic disorders. -
Neuropeptide Y Receptor Antagonist
CGP71683 is a highly selective non-peptide antagonist of the neuropeptide Y (NPY) Y(5) receptor. This compound exhibits potent inhibition of receptor activity, making it a valuable tool for studying the physiological and pathological roles of NPY signaling. Its applications extend to obesity research and related metabolic studies, facilitating investigations into appetite regulation and energy homeostasis. -
Neuron Activator
Neuropeptide Y (1-24) (human) acts as a neuron activator and is involved in modulating synaptic transmission and neuronal excitability. This neuropeptide has been demonstrated to significantly inhibit electrically stimulated twitch responses in rat vas deferens, indicating its potential in neuromodulation. Additionally, it enhances N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus, making it a valuable tool for studying neurophysiology and neurobiology. -
Neuropeptide
Galanin-Like Peptide (rat) is a 60 amino acid neuropeptide that primarily targets galanin receptors. This peptide is crucial in the regulation of feeding behavior, body weight, and energy metabolism. Its biological activity makes it a valuable tool for research in neurobiology, obesity, and metabolic disorders, providing insights into the mechanisms underlying appetite control and energy homeostasis. -
Gastrointestinal Peptide
Peptide YY (pig) is a 36-amino acid gastrointestinal peptide primarily isolated from porcine duodenum. Its primary mechanism involves the activation of the Y2 receptor, leading to decreased appetite and food intake. In addition to its regulatory role in appetite, Peptide YY (pig) influences intestinal motility and has effects on the cardiovascular system, making it valuable for research in metabolic and gastrointestinal studies. -
Neurohormone-like Peptide
Levitide is a neurohormone-like peptide derived from the skin secretions of the South African frog Xenopus laevis. Comprised of 88 residues, Levitide features a sequence that includes the bioactive levitide peptide at the C-terminus, known for its potential role in modulating neurohormonal activities. This peptide is of interest in research applications related to neurobiology, endocrinology, and the study of amphibian physiology. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, rat is a neuropeptide Y receptor agonist, exhibiting high affinity for the NPYR4 subtype. This peptide plays a significant role in the regulation of appetite, energy balance, and pancreatic functions. It is widely utilized in research focused on metabolic disorders, neurobiology, and gastrointestinal physiology. -
Neuropeptide Y Y2 Receptor Antagonist
(R)-JNJ-31020028 is a potent and selective antagonist of the neuropeptide Y Y2 receptor, demonstrating high affinity with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively. It exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors. This compound has been shown to elicit antidepressant-like effects, making it a valuable tool for research in neuropsychiatric disorders and therapeutics targeting neuropeptide signaling pathways. -
Neuropeptide Y
Neuropeptide Y (2-36) (porcine) is a neuropeptide that interacts primarily with neuropeptide Y receptors, exhibiting high homology (97.14%) to its rat and human counterparts. This peptide functions as an agonist for Y5, Y2, and Y1 receptors, with EC50 values of 1.2, 1.6, and 3.4 nM, respectively. Neuropeptide Y (2-36) (porcine) is an important tool for research in obesity, appetite regulation, and related eating disorders, facilitating the exploration of neuropeptide signaling pathways in these conditions. -
Neuropeptide
Galanin-Like Peptide (porcine) is a 60 amino acid neuropeptide primarily known for its interaction with the GALR2 receptor, exhibiting a high affinity with an IC50 of 0.24 nM, while demonstrating a lower affinity for the GALR1 receptor (IC50 of 4.3 nM). This peptide plays a crucial role in neurobiological processes and serves as a valuable tool for research into neuropeptide signaling, neural regulation, and related physiological functions. Its unique properties make it suitable for various studies in neurobiology, including investigations of appetite regulation and stress response. -
Neuropeptide
Neuropeptide Y (human) free acid is the deamidated variant of Neuropeptide Y, a key neuropeptide involved in various physiological processes. This compound lacks amidation at the C-terminal tyrosine, which is essential for triggering G protein signaling pathways. Its study is crucial for understanding neuropeptide signaling mechanisms, potential roles in appetite regulation, stress response, and various neurological disorders. This reagent is valuable for research in neurobiology and pharmacology, particularly in exploring the functional implications of peptide modifications. -
Neuropeptide YY Receptor Antagonist
GR231118 is a selective antagonist for the human neuropeptide Y (NPY) Y1 receptor, exhibiting a competitive inhibition with a pKi of 10.4. This compound also demonstrates potent agonist activity at the human NPY Y4 receptor (pEC50=8.6; pKi=9.6) and weak agonist activity at both human and rat NPY Y2 and Y5 receptors. Additionally, GR231118 has significant affinity for the mouse NPY Y6 receptor (pKi=8.8), making it a valuable tool for studying neuropeptide Y signaling pathways and their implications in various physiological and pathological conditions. -
Neuropeptide Y Y1 Receptor Antagonist
BIBO3304 free base is a potent nonpeptide antagonist of the neuropeptide Y Y1 receptor. It demonstrates subnanomolar affinity for human and rat Y1 receptors, with IC50 values of 0.38 nM and 0.72 nM, respectively. This compound effectively inhibits food intake stimulated by neuropeptide Y (NPY) and fasting conditions, making it a valuable tool for studies related to appetite regulation and metabolic disorders. -
Y2 Receptor Agonist
Neuropeptide Y (22-36) is a peptide fragment that acts as a selective agonist for the Y2 receptor. With subnanomolar affinity, it modulates various physiological processes, including appetite regulation, circadian rhythms, and stress response. This compound is valuable in neurobiological research, particularly in studies exploring the role of neuropeptides in neuroendocrine function and behavioral responses. -
Neuropeptide FF Receptor Agonist
Neuropeptide SF (mouse, rat) is a potent agonist of the neuropeptide FF receptors, exhibiting Ki values of 48.4 nM for NPFF1 and 12.1 nM for NPFF2. This compound enhances the sustained current of heterologously expressed acid-sensing ion channel 3 (ASIC3), making it a valuable tool in studies related to pain modulation and neuropeptide signaling. Neuropeptide SF is ideal for research investigating neurophysiological processes and receptor interactions within neural pathways. -
Neuropeptide Y Receptor Antagonist
PD 160170 is a neuropeptide Y receptor antagonist that specifically targets neuropeptide Y receptors involved in the regulation of various physiological processes. This compound demonstrates significant biological activity in promoting red blood cell transfusion independence and increasing hemoglobin levels, making it a valuable tool for research in myelodysplastic syndromes and associated anemias. Its mechanism of action may provide insights into the modulation of erythropoiesis and potential therapeutic avenues for hematological disorders. -
Galanin/Galanin Receptor Ligand
Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, acting primarily through the modulation of galanin signaling pathways. This peptide demonstrates significant biological activity in neuropeptide signaling and is relevant for research applications focusing on neurobiology, appetite regulation, and stress response mechanisms. Its use can enhance understanding of galanin's role in various physiological and pathological processes. -
Neuropeptide Y
Neuropeptide Y (3-36) (porcine) is an agonist specifically targeting the neuropeptide Y (NPY) receptor subtype Y2. This peptide has been demonstrated to stimulate feeding behavior in rat models. Its high selectivity for the Y2 receptor makes it a valuable tool for investigating NPY signaling pathways and their implications in appetite regulation and related metabolic disorders. -
Neuropeptide
Galanin-Like Peptide (human) is a 60 amino acid neuropeptide that primarily targets neuropeptide signaling pathways. This peptide is crucial in regulating feeding behavior, body weight, and energy metabolism. It serves as an important tool in research focused on understanding obesity, metabolic disorders, and appetite control. -
Neuropeptide Y1Receptor Antagonist
BMS-193885 (L-Lactic acid) is a potent and selective antagonist of the neuropeptide Y1 receptor. It exhibits a Ki value of 3.3 nM, demonstrating its high affinity for the receptor while competitively inhibiting neuropeptide Y binding. This compound is relevant for research applications related to appetite regulation and obesity, as it effectively reduces food intake and body weight through central Y1 receptor inhibition.
